| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mette Q Ludwig, Petar V Todorov, Kristoffer L Egerod, David P Olson, Tune H Per. Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex. Diabetes. vol 70. issue 9. 2021-11-08. PMID:34176785. |
the incretins glucagon-like peptide 1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) act directly in the brain to modulate feeding, and receptors for both are expressed in the dvc. |
2021-11-08 |
2023-08-13 |
Not clear |
| Michael A Nauck, Daniel R Quast, Jakob Wefers, Andreas F H Pfeiffe. The evolving story of incretins (GIP and GLP-1) in metabolic and cardiovascular disease: A pathophysiological update. Diabetes, obesity & metabolism. vol 23 Suppl 3. 2021-10-18. PMID:34310013. |
besides their role in glucose homoeostasis, the incretin hormones gip and glp-1 have additional biological functions: glp-1 at pharmacological concentrations reduces appetite, food intake, and-in the long run-body weight, and a similar role is evolving for gip, at least in animal studies. |
2021-10-18 |
2023-08-13 |
human |
| Qian Zhang, Challa Tenagne Delessa, Robert Augustin, Mostafa Bakhti, Gustav Colldén, Daniel J Drucker, Annette Feuchtinger, Cristina Garcia Caceres, Gerald Grandl, Alexandra Harger, Stephan Herzig, Susanna Hofmann, Cassie Lynn Holleman, Martin Jastroch, Susanne Keipert, Maximilian Kleinert, Patrick J Knerr, Konxhe Kulaj, Beata Legutko, Heiko Lickert, Xue Liu, Gerd Luippold, Dominik Lutter, Emilija Malogajski, Marta Tarquis Medina, Stephanie A Mowery, Andreas Blutke, Diego Perez-Tilve, Ciro Salinno, Laura Sehrer, Richard D DiMarchi, Matthias H Tschöp, Kerstin Stemmer, Brian Finan, Christian Wolfrum, Timo D Mülle. The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling. Cell metabolism. vol 33. issue 4. 2021-09-22. PMID:33571454. |
the glucose-dependent insulinotropic polypeptide (gip) regulates body weight and food intake via cns-gipr signaling. |
2021-09-22 |
2023-08-13 |
mouse |
| R Charlotte Moffett, Neil G Docherty, Carel W le Rou. The altered enteroendocrine reportoire following roux-en-Y-gastric bypass as an effector of weight loss and improved glycaemic control. Appetite. vol 156. 2021-06-24. PMID:32871202. |
in this review we catalogue the multiple alterations in secretion of gut hormones (ghrelin, obestatin, cholecystokinin, glp-1, pyy, gip, oxyntomodulin, glicentin and glp-2) occurring after rygb and summarise evidence indicating that these changes play a role in the reduction of food intake and improvements in glucose homeostasis. |
2021-06-24 |
2023-08-13 |
Not clear |
| Daniela Regazzo, Mattia Barbot, Carla Scaroni, Nora Albiger, Gianluca Occh. The pathogenic role of the GIP/GIPR axis in human endocrine tumors: emerging clinical mechanisms beyond diabetes. Reviews in endocrine & metabolic disorders. vol 21. issue 1. 2021-02-16. PMID:31933128. |
gip has a variety of effects on different systems, including the potentiation of insulin secretion from pancreatic β-cells after food intake (i.e. |
2021-02-16 |
2023-08-13 |
human |
| Nigel Irwin, Victor A Gault, Finbarr P M O'Harte, Peter R Flat. Blockade of gastric inhibitory polypeptide (GIP) action as a novel means of countering insulin resistance in the treatment of obesity-diabetes. Peptides. vol 125. 2021-02-08. PMID:31733230. |
sustained administration of peptide-based gipr inhibitors, low molecular weight gipr antagonists, gipr neutralising antibodies as well as genetic knockout of gipr's or vaccination against gip all demonstrate amelioration of insulin resistance and reduced body weight gain in response to high fat feeding. |
2021-02-08 |
2023-08-13 |
Not clear |
| Kimberley El, Jonathan E Campbel. The role of GIP in α-cells and glucagon secretion. Peptides. vol 125. 2021-02-08. PMID:31785304. |
glucose-dependent insulinotropic polypeptide (gip) is an intestinally derived peptide that is secreted in response to feeding. |
2021-02-08 |
2023-08-13 |
Not clear |
| Jens Juul Holst, Mette Marie Rosenkild. GIP as a Therapeutic Target in Diabetes and Obesity: Insight From Incretin Co-agonists. The Journal of clinical endocrinology and metabolism. vol 105. issue 8. 2021-02-08. PMID:32459834. |
however, whereas glp-1 also inhibits appetite and food intake and improves glucose regulation in patients with type 2 diabetes (t2dm), gip seems to be devoid of these activities, although the 2 hormones as well as their receptors are highly related. |
2021-02-08 |
2023-08-13 |
Not clear |
| Yoshinori Kanemaru, Norio Harada, Satoko Shimazu-Kuwahara, Shunsuke Yamane, Eri Ikeguchi, Yuki Murata, Sakura Kiyobayashi, Tomonobu Hatoko, Nobuya Inagak. Absence of GIP secretion alleviates age-related obesity and insulin resistance. The Journal of endocrinology. vol 245. issue 1. 2020-10-19. PMID:31977316. |
these results demonstrate that gip is involved in age-related obesity and insulin resistance and that inhibition of gip secretion alleviates age-related fat mass gain and insulin resistance under carbohydrate-based diet feeding condition. |
2020-10-19 |
2023-08-13 |
mouse |
| Yayoi Hosoda, Fumiaki Okahara, Takuya Mori, Jun Deguchi, Noriyasu Ota, Noriko Osaki, Akira Shimotoyodom. Dietary steamed wheat bran increases postprandial fat oxidation in association with a reduced blood glucose-dependent insulinotropic polypeptide response in mice. Food & nutrition research. vol 61. issue 1. 2020-09-30. PMID:28970776. |
energy metabolism was evaluated using an indirect calorimeter, and plasma glucose, insulin, and glucose-dependent insulinotropic polypeptide (gip) levels were measured for 120 min after feeding. |
2020-09-30 |
2023-08-13 |
mouse |
| Yayoi Hosoda, Fumiaki Okahara, Takuya Mori, Jun Deguchi, Noriyasu Ota, Noriko Osaki, Akira Shimotoyodom. Dietary steamed wheat bran increases postprandial fat oxidation in association with a reduced blood glucose-dependent insulinotropic polypeptide response in mice. Food & nutrition research. vol 61. issue 1. 2020-09-30. PMID:28970776. |
the reduction of the postprandial blood gip response may be responsible for the increase in postprandial fat utilization after feeding on a diet containing steamed wb and arabinoxylan. |
2020-09-30 |
2023-08-13 |
mouse |
| Rakesh C Chandarana, Vikrant, Ashok K Varma, Anil Saran, Evans C Coutinho, Jacinta S D'Souz. Over-expression, purification and isotopic labeling of a tag-less human glucose-dependent insulinotropic polypeptide (hGIP). 3 Biotech. vol 4. issue 5. 2020-09-29. PMID:28324382. |
glucose-dependent insulinotropic polypeptide (gip), a gut peptide released in response to food intake brings about secretion of insulin in a glucose-dependent manner upon binding to its receptor, gipr. |
2020-09-29 |
2023-08-13 |
human |
| Jacqueline L Beaudry, Daniel J Drucke. Proglucagon-Derived Peptides, Glucose-Dependent Insulinotropic Polypeptide, and Dipeptidyl Peptidase-4-Mechanisms of Action in Adipose Tissue. Endocrinology. vol 161. issue 1. 2020-07-15. PMID:31782955. |
the actions of glucagon, glucagon-like peptide (glp)-1, glp-2, gip, and their rate-limiting enzyme dipeptidyl peptidase-4, include direct and indirect regulation of islet hormone secretion, food intake, body weight, all contributing to control of white and brown adipose tissue activity. |
2020-07-15 |
2023-08-13 |
Not clear |
| Jessica T Y Yue, Tony K T La. Antiobesogenic effects of central GIPR antagonism. The Journal of clinical investigation. vol 129. issue 9. 2020-06-23. PMID:31403470. |
the authors posit that an increase in circulating intestinally derived gip, as a consequence of overnutrition, acts in the brain to impair hypothalamic leptin action, resulting in increased food intake and body weight gain. |
2020-06-23 |
2023-08-13 |
Not clear |
| Jaber Alyami, Ella Whitehouse, Gleb E Yakubov, Susan E Pritchard, Caroline L Hoad, Elaine Blackshaw, Khaled Heissam, Sally M Cordon, H Frances J Bligh, Robin C Spiller, Ian A Macdonald, Guruprasad P Aithal, Penny A Gowland, Moira A Taylor, Luca Marcian. Glycaemic, gastrointestinal, hormonal and appetitive responses to pearl millet or oats porridge breakfasts: a randomised, crossover trial in healthy humans. The British journal of nutrition. vol 122. issue 10. 2020-06-04. PMID:31709970. |
blood samples for glucose, insulin, glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide (gip), peptide yy, gastric volumes and appetite ratings were collected 2 h postprandially, followed by an ad libitum meal and food intake records for the remainder of the day. |
2020-06-04 |
2023-08-13 |
human |
| Sine Paasch Schiellerup, Kirsa Skov-Jeppesen, Johanne Agerlin Windeløv, Maria Saur Svane, Jens Juul Holst, Bolette Hartmann, Mette Marie Rosenkild. Gut Hormones and Their Effect on Bone Metabolism. Potential Drug Therapies in Future Osteoporosis Treatment. Frontiers in endocrinology. vol 10. 2020-02-25. PMID:30863364. |
the responsible hormones appear to include glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1), known as incretin hormones due to their role in regulating glucose homeostasis by enhancing insulin release in response to food intake. |
2020-02-25 |
2023-08-13 |
human |
| Yuki Murata, Norio Harada, Shunsuke Yamane, Kanako Iwasaki, Eri Ikeguchi, Yoshinori Kanemaru, Takanari Harada, Akiko Sankoda, Satoko Shimazu-Kuwahara, Erina Joo, Hemant Poudyal, Nobuya Inagak. Medium-chain triglyceride diet stimulates less GIP secretion and suppresses body weight and fat mass gain compared with long-chain triglyceride diet. American journal of physiology. Endocrinology and metabolism. vol 317. issue 1. 2020-02-18. PMID:30990747. |
however, the effect of mct diet feeding on gip secretion and the effect of gip on body weight and fat mass under mct diet-feeding condition are unknown. |
2020-02-18 |
2023-08-13 |
mouse |
| Ryota Usui, Daisuke Yabe, Yutaka Sein. Twincretin as a potential therapeutic for the management of type 2 diabetes with obesity. Journal of diabetes investigation. vol 10. issue 4. 2020-01-13. PMID:30637966. |
conflicting results in mice might be explained by pharmacological levels of gip signal in the central nervous systems decreasing food intake and overcoming the obesogenic effects of gip at physiological levels in adipose tissues. |
2020-01-13 |
2023-08-13 |
mouse |
| Jing Chen, Baona Guo, Zihao Guo, Li Li, Jiali Jiang, Yutao Zhan, Jixiang Wu, Chuan Zhan. Association of serum gastric inhibitory polypeptide and pancreatic polypeptide levels with prolonged esophageal acid exposure time in refractory gastroesophageal reflux disease. Medicine. vol 98. issue 23. 2019-06-17. PMID:31169725. |
gastric inhibitory polypeptide (gip) and pancreatic polypeptide (pp) participate in the regulation of gastric acid secretion, blood glucose and lipid levels, and food intake. |
2019-06-17 |
2023-08-13 |
Not clear |
| Florian Kahles, Ana Liberman, Constantin Halim, Matthias Rau, Julia Möllmann, Robert Werner Mertens, Marcia Rückbeil, Irmgard Diepolder, Benedikt Walla, Sebastian Diebold, Mathias Burgmaier, Corinna Lebherz, Nikolaus Marx, Michael Lehrk. The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE Molecular metabolism. vol 14. 2019-05-27. PMID:29884547. |
the incretin hormone gip is upregulated in patients with atherosclerosis and stabilizes plaques in apoe the incretin hormones glp-1 (glucagon-like peptide-1) and gip (glucose-dependent insulinotropic peptide) are secreted by the gut after food intake leading to pancreatic insulin secretion and glucose lowering. |
2019-05-27 |
2023-08-13 |
mouse |