| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P J Fletcher, M Davie. The involvement of 5-hydroxytryptaminergic and dopaminergic mechanisms in the eating induced by buspirone, gepirone and ipsapirone. British journal of pharmacology. vol 99. issue 3. 1990-06-06. PMID:2139586. |
gepirone (0.2 micrograms) and ipsapirone (0.04 and 0.2 micrograms) increased food intake when injected into the dorsal raphé nucleus (drn), presumably by inhibiting the activity of drn 5-hydroxytryptaminergic afferents. |
1990-06-06 |
2023-08-11 |
rat |
| P J Fletcher, M Davie. The involvement of 5-hydroxytryptaminergic and dopaminergic mechanisms in the eating induced by buspirone, gepirone and ipsapirone. British journal of pharmacology. vol 99. issue 3. 1990-06-06. PMID:2139586. |
pretreatment with haloperidol (0.1 mg kg-1, 30 min) significantly attenuated the effects of equi-effective doses of buspirone, gepirone and ipsapirone, indicating that these drugs interact with dopaminergic systems to increase feeding. |
1990-06-06 |
2023-08-11 |
rat |
| C S Aulakh, J L Hill, D L Murph. A comparison of feeding and locomotion responses to serotonin agonists in three rat strains. Pharmacology, biochemistry, and behavior. vol 31. issue 3. 1989-07-18. PMID:2977992. |
the hyperphagic effects of two selective 5-ht1a agonists (8-ohdpat and buspirone) in a free feeding paradigm and the locomotor suppressant effect of the serotonin agonist, m-chlorophenylpiperazine (m-cpp) were compared in three different rat strains: wistar, sprague-dawley (sd), and fawn-hooded (fh) rats. |
1989-07-18 |
2023-08-11 |
rat |
| C S Aulakh, J L Hill, D L Murph. A comparison of feeding and locomotion responses to serotonin agonists in three rat strains. Pharmacology, biochemistry, and behavior. vol 31. issue 3. 1989-07-18. PMID:2977992. |
administration of various doses of 8-ohdpat and buspirone produced significant increases in two-hour food intake only in wistar and sd strains and not in the fh strain. |
1989-07-18 |
2023-08-11 |
rat |
| F Gilbert, C T Dourish, C Brazell, S McClue, S M Stah. Relationship of increased food intake and plasma ACTH levels to 5-HT1A receptor activation in rats. Psychoneuroendocrinology. vol 13. issue 6. 1989-05-05. PMID:2907164. |
rats were injected with either the high affinity 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) (0.016-1.0 mg/kg, s.c.) or the novel anxiolytics buspirone, gepirone or ipsapirone (2.0-16.0 mg/kg, s.c.), and either had their food intake measured 2 hr post injection or were sacrificed 30-40 min post injection for measurement of plasma acth. |
1989-05-05 |
2023-08-11 |
rat |
| C T Dourish, M L Clark, S D Iverse. 8-OH-DPAT elicits feeding and not chewing: evidence from liquid diet studies and a diet choice test. Psychopharmacology. vol 95. issue 2. 1988-10-04. PMID:2970649. |
therefore, the effects of 8-oh-dpat and another 5-ht1a agonist gepirone on the consumption of a liquid chow diet, by free feeding male rats, were examined. |
1988-10-04 |
2023-08-11 |
rat |
| C T Dourish, M L Clark, S D Iverse. 8-OH-DPAT elicits feeding and not chewing: evidence from liquid diet studies and a diet choice test. Psychopharmacology. vol 95. issue 2. 1988-10-04. PMID:2970649. |
the doses of 8-oh-dpat and gepirone which increased liquid diet intake in this study were in the same range as those which were found previously to increase food pellet consumption by free feeding rats. |
1988-10-04 |
2023-08-11 |
rat |
| F Gilbert, C T Douris. Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPAT. Psychopharmacology. vol 93. issue 3. 1988-03-03. PMID:2893412. |
effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-oh-dpat. |
1988-03-03 |
2023-08-11 |
rat |
| F Gilbert, C T Douris. Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPAT. Psychopharmacology. vol 93. issue 3. 1988-03-03. PMID:2893412. |
the effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by the 5-ht1a receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat), were examined. |
1988-03-03 |
2023-08-11 |
rat |
| F Gilbert, C T Douris. Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPAT. Psychopharmacology. vol 93. issue 3. 1988-03-03. PMID:2893412. |
gepirone dose-dependently increased feeding 2 and 4 h after injection, the magnitude of the response being larger than previously observed with any other 5-ht1a receptor ligand. |
1988-03-03 |
2023-08-11 |
rat |
| F Gilbert, C T Douris. Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPAT. Psychopharmacology. vol 93. issue 3. 1988-03-03. PMID:2893412. |
however, gepirone, buspirone and ipsapirone did not inhibit feeding induced by 8-oh-dpat. |
1988-03-03 |
2023-08-11 |
rat |
| F Gilbert, C T Douris. Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPAT. Psychopharmacology. vol 93. issue 3. 1988-03-03. PMID:2893412. |
these results indicate that gepirone is a very efficacious appetite stimulant in rats and suggest that gepirone, buspirone and ipsapirone act as 5-ht autoreceptor agonists in the feeding model. |
1988-03-03 |
2023-08-11 |
rat |
| C T Dourish, P H Hutson, G A Kennett, G Curzo. 8-OH-DPAT-induced hyperphagia: its neural basis and possible therapeutic relevance. Appetite. vol 7 Suppl. 1986-09-18. PMID:2943219. |
buspirone, tvx q 7821) also elicit feeding. |
1986-09-18 |
2023-08-11 |
rat |