| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Yin, Sha Sha, Tingting Chen, Conghui Wang, Juan Hong, Pinghui Jie, Rong Zhou, Lin Li, Masahiro Sokabe, Ling Che. Sigma-1 (σ₁) receptor deficiency reduces β-amyloid(25-35)-induced hippocampal neuronal cell death and cognitive deficits through suppressing phosphorylation of the NMDA receptor NR2B. Neuropharmacology. vol 89. 2015-07-15. PMID:25286118. |
of aβ(25-35) impaired spatial memory with approximately 25% death of pyramidal cells in the hippocampal ca1 region of wt mice (aβ(25-35)-wt mice), whereas it did not cause such impairments in σ1r(+/-) mice (aβ(25-35)-σ1r(+/-) mice). |
2015-07-15 |
2023-08-13 |
mouse |
| X Chen, J Hu, L Jiang, S Xu, B Zheng, C Wang, J Zhang, X Wei, L Chang, Q Wan. Brilliant Blue G improves cognition in an animal model of Alzheimer's disease and inhibits amyloid-β-induced loss of filopodia and dendrite spines in hippocampal neurons. Neuroscience. vol 279. 2015-07-08. PMID:25193238. |
here we report that systematic administration of bbg diminishes spatial memory impairment and cognitive deficits in a mouse ad model produced by injecting soluble aβ peptide into the hippocampal ca1 region. |
2015-07-08 |
2023-08-13 |
mouse |
| Seico Benner, Toshihiro Endo, Nozomi Endo, Masaki Kakeyama, Chiharu Tohyam. Early deprivation induces competitive subordinance in C57BL/6 male mice. Physiology & behavior. vol 137. 2015-06-16. PMID:25089814. |
analyzing gene expression changes in brain regions controlling emotion, stress, spatial memory, and executive function revealed reduced bdnf and c-fos in hippocampal ca1, enhanced c-fos in the basolateral amygdala, reduced map2 while enhanced hsd11β2 in prefrontal cortex of ed males. |
2015-06-16 |
2023-08-13 |
mouse |
| Bruce C Harland, David A Collings, Neil McNaughton, Wickliffe C Abraham, John C Dalrymple-Alfor. Anterior thalamic lesions reduce spine density in both hippocampal CA1 and retrosplenial cortex, but enrichment rescues CA1 spines only. Hippocampus. vol 24. issue 10. 2015-05-12. PMID:24862603. |
we found that standard-housed rats with atn lesions, compared with standard-housed controls, showed reduced spine density in hippocampal ca1 neurons (basal dendrites, -11.2%; apical dendrites, -9.6%) and in retrospenial granular b cortex (rgb) neurons (apical dendrites, -20.1%) together with spatial memory deficits on cross maze and radial-arm maze tasks. |
2015-05-12 |
2023-08-13 |
rat |
| Bruce C Harland, David A Collings, Neil McNaughton, Wickliffe C Abraham, John C Dalrymple-Alfor. Anterior thalamic lesions reduce spine density in both hippocampal CA1 and retrosplenial cortex, but enrichment rescues CA1 spines only. Hippocampus. vol 24. issue 10. 2015-05-12. PMID:24862603. |
comparison with enriched rats that received pseudo-training, which provided comparable task-related experience, but no explicit spatial memory training, suggested that basal ca1 spine density in particular was associated with spatial learning and memory performance. |
2015-05-12 |
2023-08-13 |
rat |
| A S Titiz, J M Mahoney, M E Testorf, G L Holmes, R C Scot. Cognitive impairment in temporal lobe epilepsy: role of online and offline processing of single cell information. Hippocampus. vol 24. issue 9. 2015-05-11. PMID:24799359. |
in this study, we first report marked deficits in spatial memory performance and severe cell loss in the ca1 layer of the hippocampus lower spatial coherence of firing in tle rats. |
2015-05-11 |
2023-08-13 |
rat |
| Yuhong Li, Changhua Shi, Guobing Lu, Qian Xu, Shaochen Li. Effects of electromagnetic radiation on spatial memory and synapses in rat hippocampal CA1. Neural regeneration research. vol 7. issue 16. 2015-02-24. PMID:25709623. |
effects of electromagnetic radiation on spatial memory and synapses in rat hippocampal ca1. |
2015-02-24 |
2023-08-13 |
rat |
| Jinshan Yang, Xiang Luo, Xiaojiang Huang, Qin Ning, Minjie Xie, Wei Wan. Ephrin-A3 reverse signaling regulates hippocampal neuronal damage and astrocytic glutamate transport after transient global ischemia. Journal of neurochemistry. vol 131. issue 3. 2014-12-18. PMID:25040798. |
in consequence, neuronal loss was aggravated in the ca1 region of the hippocampus accompanied by impaired hippocampus-dependent spatial memory when clustered epha4 treatment was administered prior to transient global ischemia. |
2014-12-18 |
2023-08-13 |
Not clear |
| Zachery Beer, Caroline Chwiesko, Magdalena M Sauvag. Processing of spatial and non-spatial information reveals functional homogeneity along the dorso-ventral axis of CA3, but not CA1. Neurobiology of learning and memory. vol 111. 2014-12-09. PMID:24657342. |
we report that ventral ca1 and ca3 are recruited for both spatial and non-spatial memories, but more strongly for spatial memory (e.g. |
2014-12-09 |
2023-08-12 |
Not clear |
| Myrna M González-Ramírez, Dulce A Velázquez-Zamora, María Esther Olvera-Cortés, Ignacio González-Burgo. Changes in the plastic properties of hippocampal dendritic spines underlie the attenuation of place learning in healthy aged rats. Neurobiology of learning and memory. vol 109. 2014-10-30. PMID:24316372. |
these findings support the view that aging attenuates but does not abolish spatial memory, a process that may be associated with plastic changes in the type of dendritic spines on aged hippocampal ca1 neurons. |
2014-10-30 |
2023-08-12 |
rat |
| Z Zhao, H Liu, K Xiao, M Yu, L Cui, Q Zhu, R Zhao, G-D Li, Y Zho. Ghrelin administration enhances neurogenesis but impairs spatial learning and memory in adult mice. Neuroscience. vol 257. 2014-08-26. PMID:24211302. |
on the contrary, local infusion of ghrelin (8ng/0.5μl into ca1 region of the hippocampus) impaired spatial memory formation, but did not affect adult neurogenesis. |
2014-08-26 |
2023-08-12 |
mouse |
| Chatchada Sutalangka, Jintanaporn Wattanathorn, Supaporn Muchimapura, Wipawee Thukham-me. Moringa oleifera mitigates memory impairment and neurodegeneration in animal model of age-related dementia. Oxidative medicine and cellular longevity. vol 2013. 2014-07-15. PMID:24454988. |
the results showed that the extract improved spatial memory and neurodegeneration in ca1, ca2, ca3, and dentate gyrus of hippocampus together with the decreased mda level and ache activity but increased sod and cat activities. |
2014-07-15 |
2023-08-12 |
rat |
| Malorie Dagnas, Nicole Mon. Region- and age-specific patterns of histone acetylation related to spatial and cued learning in the water maze. Hippocampus. vol 23. issue 7. 2014-01-23. PMID:23436469. |
specifically, age-related spatial memory deficits were associated with opposite changes of h3 (increase) and h4 (decrease) acetylation in ca1 and dg. |
2014-01-23 |
2023-08-12 |
mouse |
| Katelin F Hansen, Kate Karelina, Kensuke Sakamoto, Gary A Wayman, Soren Impey, Karl Obrieta. miRNA-132: a dynamic regulator of cognitive capacity. Brain structure & function. vol 218. issue 3. 2013-11-13. PMID:22706759. |
using in situ hybridization, we show that the presentation of a spatial memory task induced a significant ~1.5-fold increase in mir-132 expression within the ca1, ca3, and gcl excitatory cell layers of the hippocampus. |
2013-11-13 |
2023-08-12 |
mouse |
| Weber Cláudio Da Silva, Gabriela Cardoso, Juliana Sartori Bonini, Fernando Benetti, Ivan Izquierd. Memory reconsolidation and its maintenance depend on L-voltage-dependent calcium channels and CaMKII functions regulating protein turnover in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 16. 2013-06-19. PMID:23576750. |
immediate postretrieval bilateral blockade of long-acting voltage-dependent calcium channels (l-vdccs), but not of glutamatergic nmda receptors, in the dorsal ca1 region of the hippocampus hinders retention of long-term spatial memory in the morris water maze. |
2013-06-19 |
2023-08-12 |
Not clear |
| Weber Cláudio Da Silva, Gabriela Cardoso, Juliana Sartori Bonini, Fernando Benetti, Ivan Izquierd. Memory reconsolidation and its maintenance depend on L-voltage-dependent calcium channels and CaMKII functions regulating protein turnover in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 16. 2013-06-19. PMID:23576750. |
these results indicate that spatial memory reconsolidation depends on the functionality of l-vdcc in dorsal ca1, that maintenance of subsequent reconsolidated memory trace depends on camkii, and these results also suggest that the role played by both l-vdcc and camkii is to promote the retrieval-dependent, synaptically localized enhancement of protein synthesis necessary to counteract a retrieval-dependent, synaptic-localized enhancement of protein degradation, which has been described as underlying the characteristic labilization of the memory trace triggered by retrieval. |
2013-06-19 |
2023-08-12 |
Not clear |
| Wei-Na Han, Christian Hölscher, Li Yuan, Wei Yang, Xiao-Hui Wang, Mei-Na Wu, Jin-Shun Q. Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats. Neurobiology of aging. vol 34. issue 2. 2013-04-29. PMID:22592020. |
we found that (1) bilateral intrahippocampal injection of aβ(25-35) resulted in a significant decline of spatial learning and memory of rats in water maze tests, together with a serious depression of in vivo hippocampal late-phase long-term potentiation (l-ltp) in ca1 region of rats; (2) pretreatment with liraglutide effectively and dose-dependently protected against the aβ(25-35)-induced impairment of spatial memory and deficit of l-ltp; (3) liraglutide injection also activated camp signal pathway in the brain, with a nearly doubled increase in the camp contents compared with control. |
2013-04-29 |
2023-08-12 |
rat |
| S J B Fretham, E S Carlson, J Wobken, P V Tran, A Petryk, M K Georgief. Temporal manipulation of transferrin-receptor-1-dependent iron uptake identifies a sensitive period in mouse hippocampal neurodevelopment. Hippocampus. vol 22. issue 8. 2012-11-16. PMID:22367974. |
however, mice that remained hippocampally iron deficient until p42 continued to have spatial memory deficits, impaired ca1 apical dendrite structure, and persistent alterations in pv and pnn expression and reduced bdnf despite iron repletion. |
2012-11-16 |
2023-08-12 |
mouse |
| Anna L Tyler, J Matthew Mahoney, Gregory R Richard, Gregory L Holmes, Pierre-Pascal Lenck-Santini, Rod C Scot. Functional network changes in hippocampal CA1 after status epilepticus predict spatial memory deficits in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 33. 2012-11-02. PMID:22895719. |
functional network changes in hippocampal ca1 after status epilepticus predict spatial memory deficits in rats. |
2012-11-02 |
2023-08-12 |
rat |
| Anna L Tyler, J Matthew Mahoney, Gregory R Richard, Gregory L Holmes, Pierre-Pascal Lenck-Santini, Rod C Scot. Functional network changes in hippocampal CA1 after status epilepticus predict spatial memory deficits in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 33. 2012-11-02. PMID:22895719. |
in this study we recorded in vivo single-unit activity in the ca1 hippocampal region of rats while they performed a spatial memory task. |
2012-11-02 |
2023-08-12 |
rat |