| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Meng, Zhiying Liao, Yanting Ji, Dong Wang, Yang Han, Chaolin Huang, Xujuan Hu, Jingyi Chen, Hengrui Zhang, Zonghong Li, Changliang Wang, Hui Sun, Jiaqi Sun, Lihua Chen, Jiaxiang Yin, Jincun Zhao, Tao Xu, Huisheng Li. FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection. Signal transduction and targeted therapy. vol 9. issue 1. 2024-04-24. PMID:38654010. |
in the current study, we utilized islet organoids derived from human embryonic stem cells (hescs), animal models and covid-19 patients to discover that fibroblast growth factor 7 (fgf7) enhances ace2 expression within the islets, facilitating sars-cov-2 infection and resulting in impaired insulin secretion. |
2024-04-24 |
2024-04-26 |
human |
| Erik Duijvelaar, Xiaoke Pan, Harm Jan Bogaard, Etto C Eringa, Jurjan Ama. Imatinib treatment improves hyperglycaemic dysregulation in severe COVID-19: a secondary analysis of blood biomarkers in a randomised controlled trial. Critical care (London, England). vol 28. issue 1. 2024-02-29. PMID:38424569. |
sars-cov-2 can induce insulin resistance, which is, among others, mediated by adipose tissue dysfunction and reduced angiotensin-converting enzyme 2 (ace2) enzymatic activity. |
2024-02-29 |
2024-03-03 |
mouse |
| Yifan Zhao, Xiaorong Han, Cheng Li, Yucheng Liu, Jiayu Cheng, Binay Kumar Adhikari, Yonggang Wan. COVID-19 and the cardiovascular system: a study of pathophysiology and interpopulation variability. Frontiers in microbiology. vol 14. 2023-06-23. PMID:37350790. |
this article introduces the pathophysiological mechanism of covid-19-mediated cardiovascular disease and analyzes the mechanism and recent progress of the interaction between sars-cov-2 and the cardiovascular system from the roles of angiotensin-converting enzyme 2 (ace2), cellular and molecular mechanisms, endothelial dysfunction, insulin resistance, iron homeostasis imbalance, and psychosocial factors, respectively. |
2023-06-23 |
2023-08-14 |
Not clear |
| Dhruv Patel, Brooke Kania, Ahmed Salem, Wadah Akroush, Minha Naseer, David McNamara, Carlos Pere. COVID-19 Viral Infection Presenting With Diabetic Ketoacidosis, Hyperosmolar Hyperglycemic Syndrome, or Mixed Hyperglycemic Crisis: A Case Series. Journal of community hospital internal medicine perspectives. vol 13. issue 2. 2023-05-11. PMID:37168059. |
this virus binds to ace2 receptors in the pancreas and damages the islets, ultimately decreasing insulin release. |
2023-05-11 |
2023-08-14 |
Not clear |
| Qi Chen, Yuanyuan Gao, Fengying Yang, Hongjun Deng, Ying Wang, Li Yua. Angiotensin-Converting Enzyme 2 improves hepatic insulin resistance by regulating GABAergic signaling in the liver. The Journal of biological chemistry. 2022-10-20. PMID:36265585. |
the angiotensin-converting enzyme 2 (ace2)/angiotensin 1-7 (a1-7)/mas axis and the gabaergic signaling system have both been shown to have the dual potential to improve insulin resistance (ir) and hepatic steatosis associated with obesity in the liver. |
2022-10-20 |
2023-08-14 |
mouse |
| Qi Chen, Yuanyuan Gao, Fengying Yang, Hongjun Deng, Ying Wang, Li Yua. Angiotensin-Converting Enzyme 2 improves hepatic insulin resistance by regulating GABAergic signaling in the liver. The Journal of biological chemistry. 2022-10-20. PMID:36265585. |
notwithstanding this evidence, the functional relationship between ace2 and gaba signal in the liver under insulin resistance remains elusive. |
2022-10-20 |
2023-08-14 |
mouse |
| Qi Chen, Yuanyuan Gao, Fengying Yang, Hongjun Deng, Ying Wang, Li Yua. Angiotensin-Converting Enzyme 2 improves hepatic insulin resistance by regulating GABAergic signaling in the liver. The Journal of biological chemistry. 2022-10-20. PMID:36265585. |
here, we used high-fat-diet induced models of insulin resistance in c57bl/6 mice, as well as ace2 knockout and avv-mediated ace2 overexpression mouse models to address this knowledge gap. |
2022-10-20 |
2023-08-14 |
mouse |
| Qi Chen, Yuanyuan Gao, Fengying Yang, Hongjun Deng, Ying Wang, Li Yua. Angiotensin-Converting Enzyme 2 improves hepatic insulin resistance by regulating GABAergic signaling in the liver. The Journal of biological chemistry. 2022-10-20. PMID:36265585. |
our analysis showed that glutamate decarboxylase (gad)67/gaba signaling was weakened in the liver during insulin resistance, while the expression of gad67 and gaba decreased significantly in ace2 knockout mice. |
2022-10-20 |
2023-08-14 |
mouse |
| Qi Chen, Yuanyuan Gao, Fengying Yang, Hongjun Deng, Ying Wang, Li Yua. Angiotensin-Converting Enzyme 2 improves hepatic insulin resistance by regulating GABAergic signaling in the liver. The Journal of biological chemistry. 2022-10-20. PMID:36265585. |
furthermore, exogenous administration of a1-7 and avv- or lentivirus-mediated overexpression of ace2 significantly increased hepatic gaba signaling in models of insulin resistance both in vivo and in vitro. |
2022-10-20 |
2023-08-14 |
mouse |
| Marharyta Blazhynska, Emma Goulard Coderc de Lacam, Haochuan Chen, Benoît Roux, Christophe Chipo. Hazardous Shortcuts in Standard Binding Free Energy Calculations. The journal of physical chemistry letters. 2022-06-30. PMID:35771686. |
here the accuracy and convergence of the two approaches are critically compared in the case of two protein-ligand complexes (abl kinase-sh3:p41 and mdm2-p53:nvp-cgm097) and three protein-protein complexes (pig insulin dimer, sars-cov-2 spike rbd:ace2, and chea kinase-p2:chey). |
2022-06-30 |
2023-08-14 |
Not clear |
| Yongguo Dai, Hao Kou, Shuxia Gui, Xiaoling Guo, Heze Liu, Zheng Gong, Xiaoxiang Sun, Hui Wang, Yu Gu. Prenatal dexamethasone exposure induced pancreatic β-cell dysfunction and glucose intolerance of male offspring rats: Role of the epigenetic repression of ACE2. The Science of the total environment. 2022-02-27. PMID:35219660. |
dexamethasone also inhibited ace2 expression and insulin production in vitro. |
2022-02-27 |
2023-08-13 |
rat |
| Yongguo Dai, Hao Kou, Shuxia Gui, Xiaoling Guo, Heze Liu, Zheng Gong, Xiaoxiang Sun, Hui Wang, Yu Gu. Prenatal dexamethasone exposure induced pancreatic β-cell dysfunction and glucose intolerance of male offspring rats: Role of the epigenetic repression of ACE2. The Science of the total environment. 2022-02-27. PMID:35219660. |
recombinant expression of ace2 restored insulin production inhibited by dexamethasone. |
2022-02-27 |
2023-08-13 |
rat |
| Mehdi Mahmudpour, Katayoun Vahdat, Mohsen Keshavarz, Iraj Nabipou. The COVID-19-diabetes mellitus molecular tetrahedron. Molecular biology reports. 2022-01-24. PMID:35067816. |
in order to clarify the underlying complexity of covid-19 and diabetes mellitus interactions, we propose the imaginary diabetes-covid-19 molecular tetrahedron with four lateral faces consisting of sars-cov-2 entry via ace2 (lateral face 1), the viral hijacking and replication (lateral face 2), acute inflammatory responses (lateral face 3), and the resulting insulin resistance (lateral face 4). |
2022-01-24 |
2023-08-13 |
Not clear |
| Mehdi Mahmudpour, Katayoun Vahdat, Mohsen Keshavarz, Iraj Nabipou. The COVID-19-diabetes mellitus molecular tetrahedron. Molecular biology reports. 2022-01-24. PMID:35067816. |
the entrance of sars-cov-2 using ace2 receptor triggers an array of multiple molecular signaling beyond that of the angiotensin ii/ace2-ang-(1-7) axis, such as down-regulation of pgc-1 α/irisin, increased srebp-1c activity, upregulation of cd36 and sirt1 inhibition leading to insulin resistance. |
2022-01-24 |
2023-08-13 |
Not clear |
| Indu G Rajapaksha, Lakmie S Gunarathne, Khashayar Asadi, Ross Laybutt, Sof Andrikopoulous, Ian E Alexander, Mathew J Watt, Peter W Angus, Chandana B Herat. Angiotensin Converting Enzyme-2 Therapy Improves Liver Fibrosis and Glycemic Control in Diabetic Mice With Fatty Liver. Hepatology communications. 2021-12-24. PMID:34951153. |
moreover, ace2 therapy significantly increased islet numbers, leading to an increased insulin protein content in β-cells and plasma insulin levels with subsequent reduction in plasma glucose levels compared with controls. |
2021-12-24 |
2023-08-13 |
mouse |
| Sharmin Afroz, Shadreen Fairuz, Jahanara Alam Joty, Md Nazim Uddin, Md Atiar Rahma. Virtual screening of functional foods and dissecting their roles in modulating gene functions to support post COVID-19 complications. Journal of food biochemistry. vol 45. issue 12. 2021-12-10. PMID:34676581. |
seventy-one suggested compounds out of one-hundred and thirty-nine (139) docked compounds in network pharmacology recommended 169 gene ontology (go) items and 99 kyoto encyclopedia of genes and genomes signaling pathways preferably akt signaling pathway, mapk signaling pathway, ace2 receptor signaling pathway, insulin signaling pathway, and ppar signaling pathway. |
2021-12-10 |
2023-08-13 |
Not clear |
| Hayder M Al-Kuraishy, Ali I Al-Gareeb, M Alblihed, Susana G Guerreiro, Natália Cruz-Martins, Gaber El-Saber Batih. COVID-19 in Relation to Hyperglycemia and Diabetes Mellitus. Frontiers in cardiovascular medicine. vol 8. 2021-12-07. PMID:34124187. |
sars-cov-2 infects the pancreas through angiotensin-converting enzyme 2 (ace2), where it is highly expressed compared to other organs, leading to pancreatic damage with subsequent impairment of insulin secretion and development of hyperglycemia even in non-dm patients. |
2021-12-07 |
2023-08-13 |
Not clear |
| Hayder M Al-Kuraishy, Ali I Al-Gareeb, M Alblihed, Susana G Guerreiro, Natália Cruz-Martins, Gaber El-Saber Batih. COVID-19 in Relation to Hyperglycemia and Diabetes Mellitus. Frontiers in cardiovascular medicine. vol 8. 2021-12-07. PMID:34124187. |
in addition, some antidiabetic agents and also insulin may reduce sars-cov-2 infectivity and severity through the modulation of the ace2 receptor expression. |
2021-12-07 |
2023-08-13 |
Not clear |
| Bushra Memon, Essam M Abdelali. ACE2 function in the pancreatic islet: Implications for relationship between SARS-CoV-2 and diabetes. Acta physiologica (Oxford, England). 2021-12-07. PMID:34561952. |
importantly, ace2 plays a crucial role in glucose homoeostasis and insulin secretion by regulating beta cell physiology. |
2021-12-07 |
2023-08-13 |
human |
| Bushra Memon, Essam M Abdelali. ACE2 function in the pancreatic islet: Implications for relationship between SARS-CoV-2 and diabetes. Acta physiologica (Oxford, England). 2021-12-07. PMID:34561952. |
herein, we detail the function of ace2 in pancreatic beta cells crucial for regulating insulin sensitivity, secretion, and glucose metabolism. |
2021-12-07 |
2023-08-13 |
human |