| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xi Cao, Li-Ni Song, Jin-Kui Yan. ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders. Clinical science (London, England : 1979). vol 135. issue 3. 2021-02-11. PMID:33533405. |
however, the activation of angiotensin-converting enzyme 2 (ace2) - angiotensin (1-7) pathway, a novel branch of the ras, plays an opposite role in the ace pathway, which could reverse these consequences by improving local microcirculation, inflammation, stress state, structure remolding, and insulin signaling pathway. |
2021-02-11 |
2023-08-13 |
Not clear |
| Noé Alvarado-Vasque. Could a family history of type 2 diabetes be a risk factor to the endothelial damage in the patient with COVID-19? Medical hypotheses. vol 146. 2021-02-01. PMID:33189452. |
interestingly, both events have been reported in patients with covid-19, in whom hyperinsulinemia increases the surface expression of ace2 through a diminution of adamts17 activity; whereas hyperglycemia induces higher expression of ace2 in different tissues, including microvascular endothelial cells from the pancreatic islets, favoring chronic hyperglycemia and affecting the release of insulin. |
2021-02-01 |
2023-08-13 |
human |
| Daniela Fignani, Giada Licata, Noemi Brusco, Laura Nigi, Giuseppina E Grieco, Lorella Marselli, Lut Overbergh, Conny Gysemans, Maikel L Colli, Piero Marchetti, Chantal Mathieu, Decio L Eizirik, Guido Sebastiani, Francesco Dott. SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic Frontiers in endocrinology. vol 11. 2020-12-29. PMID:33281748. |
using multiple reagents and antibodies, we showed that ace2 is expressed in human pancreatic islets, where it is preferentially expressed in subsets of insulin producing |
2020-12-29 |
2023-08-13 |
human |
| María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo Del Valle-Mondragón, Elizabeth Soria-Castro, Juan Carlos Torres-Narváez, Elizabeth Carreón-Torres, Alicia Sánchez-Mendoza, María Esther Rubio-Ruí. Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a Metabolic Syndrome Model. PPAR research. vol 2020. 2020-12-23. PMID:33354204. |
angiotensin iii and angiotensin iv levels and insulin increased the aminopeptidase (irap) expression and decreased the angiotensin-converting enzyme 2 (ace2) expression in the hearts from mets rats. |
2020-12-23 |
2023-08-13 |
rat |
| Heleia Roca-Ho, Vanesa Palau, Javier Gimeno, Julio Pascual, María José Soler, Marta Rier. Angiotensin-converting enzyme 2 influences pancreatic and renal function in diabetic mice. Laboratory investigation; a journal of technical methods and pathology. vol 100. issue 9. 2020-11-23. PMID:32472097. |
in nod mice, ace2 deletion significantly worsened glucose homeostasis, decreased islet insulin content, increased beta cell oxidative stress, and ripk1-positive islets as compared with control mice. |
2020-11-23 |
2023-08-13 |
mouse |
| Samuel Acqua. Implications of COVID-19 Pandemic on Evolution of Diabetes in Malaria-Endemic African Region. Journal of diabetes research. vol 2020. 2020-11-05. PMID:33134395. |
use of ace2 by the covid-19 virus induces inflammation and oxidative stress, which can lead to insulin resistance. |
2020-11-05 |
2023-08-13 |
human |
| Noel Pratheepan Somasundaram, Ishara Ranathunga, Vithiya Ratnasamy, Piyumi Sachindra Alwis Wijewickrama, Harsha Anuruddhika Dissanayake, Nilukshana Yogendranathan, Kavinga Kalhari Kobawaka Gamage, Nipun Lakshitha de Silva, Manilka Sumanatilleke, Prasad Katulanda, Ashley Barry Grossma. The Impact of SARS-Cov-2 Virus Infection on the Endocrine System. Journal of the Endocrine Society. vol 4. issue 8. 2020-09-28. PMID:32728654. |
sars-cov-2 attaches to the ace2 system in the pancreas causing perturbation of insulin production resulting in hyperglycemic emergencies. |
2020-09-28 |
2023-08-13 |
Not clear |
| Antonio Ceriello, Eberhard Standl, Doina Catrinoiu, Baruch Itzhak, Nebojsa M Lalic, Dario Rahelic, Oliver Schnell, Jan Škrha, Paul Valens. Issues of Cardiovascular Risk Management in People With Diabetes in the COVID-19 Era. Diabetes care. vol 43. issue 7. 2020-06-30. PMID:32409501. |
although not only ace inhibitors and angiotensin 2 receptor blockers but also sglt2 inhibitors, glp-1 receptor agonists, pioglitazone, and probably insulin seem to increase the number of ace2 receptors on the cells utilized by sars-cov-2 for penetration, no evidence presently exists that shows this might be harmful in terms of acquiring or worsening covid-19. |
2020-06-30 |
2023-08-13 |
Not clear |
| A P O Leite, Danielle S Aragão, Marie D Nogueira, Renata O Pereira, Zaira P Jara, Patricia Fiorino, Dulce E Casarini, Vera Fara. Modulation of renin angiotensin system components by high glucose levels in the culture of collecting duct cells. Journal of cellular physiology. vol 234. issue 12. 2020-06-16. PMID:31131896. |
conversely, the increase of ace2 generating high levels of ang 1-7, a vasodilator peptide, suggesting that this peptide can induce glucose uptake and protect cells against oxidative stress, which can elicit insulin resistance. |
2020-06-16 |
2023-08-13 |
Not clear |
| Ting-Ting Shi, Fang-Yuan Yang, Chang Liu, Xi Cao, Jing Lu, Xue-Lian Zhang, Ming-Xia Yuan, Chen Chen, Jin-Kui Yan. Angiotensin-converting enzyme 2 regulates mitochondrial function in pancreatic β-cells. Biochemical and biophysical research communications. vol 495. issue 1. 2017-12-27. PMID:29128354. |
we found that ace2 over-expression restored glucose-stimulated insulin secretion (gsis) and mitochondrial membrane potential (mmp) in the presence of h |
2017-12-27 |
2023-08-13 |
Not clear |
| Gurkirat S Brar, Breanne M Barrow, Matthew Watson, Ryan Griesbach, Edwina Choung, Andrew Welch, Bela Ruzsicska, Daniel P Raleigh, Sakeneh Zraik. Neprilysin Is Required for Angiotensin-(1-7)'s Ability to Enhance Insulin Secretion via Its Proteolytic Activity to Generate Angiotensin-(1-2). Diabetes. vol 66. issue 8. 2017-09-08. PMID:28559246. |
studies show that generation of angiotensin-(1-7) by ace2 and its binding to the mas receptor (masr) improves glucose homeostasis, partly by enhancing glucose-stimulated insulin secretion (gsis). |
2017-09-08 |
2023-08-13 |
mouse |
| Vaibhav B Patel, Jun Mori, Brent A McLean, Ratnadeep Basu, Subhash K Das, Tharmarajan Ramprasath, Nirmal Parajuli, Josef M Penninger, Maria B Grant, Gary D Lopaschuk, Gavin Y Oudi. ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity. Diabetes. vol 65. issue 1. 2016-04-28. PMID:26224885. |
in conclusion, ace2 plays a novel role in heart disease associated with obesity wherein ace2 negatively regulates obesity-induced eat inflammation and cardiac insulin resistance. |
2016-04-28 |
2023-08-13 |
mouse |
| Robin Shoemaker, Frederique Yiannikouris, Sean Thatcher, Lisa Cassi. ACE2 deficiency reduces β-cell mass and impairs β-cell proliferation in obese C57BL/6 mice. American journal of physiology. Endocrinology and metabolism. vol 309. issue 7. 2016-01-18. PMID:26389599. |
at 4 mo, while both genotypes of hf-fed mice developed a similar level of insulin resistance, adaptive hyperinsulinemia was reduced in ace2(-/y) vs. ace2(+/y) mice. |
2016-01-18 |
2023-08-13 |
mouse |
| Robin Shoemaker, Frederique Yiannikouris, Sean Thatcher, Lisa Cassi. ACE2 deficiency reduces β-cell mass and impairs β-cell proliferation in obese C57BL/6 mice. American journal of physiology. Endocrinology and metabolism. vol 309. issue 7. 2016-01-18. PMID:26389599. |
similarly, in vivo glucose-stimulated insulin secretion (gsis) was reduced in 1-mo hf-fed ace2(-/y) compared with ace2(+/y) mice, resulting in augmented hyperglycemia. |
2016-01-18 |
2023-08-13 |
mouse |
| Simone Moreira de Macedo, Talita Antunes Guimarares, Joao Marcus Oliveira Andrade, Andre Luiz Sena Guimaraes, Alfredo Mauricio Batista Batista de Paula, Anderson Jose Ferreira, Sergio Henrique Sousa Santo. Angiotensin converting enzyme 2 activator (DIZE) modulates metabolic profiles in mice, decreasing lipogenesis. Protein and peptide letters. vol 22. issue 4. 2015-12-24. PMID:25666042. |
recent studies have shown that angiotensin-converting enzyme 2 (ace2)/angiotensin (ang) -(1-7)/mas axis activation is able to improve the metabolic profile, enhance glucose tolerance and insulin sensitivity, improve metabolic parameters, and counteract deleterious effects of ang ii. |
2015-12-24 |
2023-08-13 |
mouse |
| Chun-Li Lu, Ying Wang, Li Yuan, Yang Li, Xiao-Ya L. The angiotensin-converting enzyme 2/angiotensin (1-7)/Mas axis protects the function of pancreatic β cells by improving the function of islet microvascular endothelial cells. International journal of molecular medicine. vol 34. issue 5. 2015-06-17. PMID:25175177. |
min6 cells were then co-cultured with the ms-1 cells to evaluate the effects of ace2 on insulin secretion. |
2015-06-17 |
2023-08-13 |
mouse |
| Marta Riera, Eva Márquez, Sergi Clotet, Javier Gimeno, Heleia Roca-Ho, Josep Lloreta, Nuria Juanpere, Daniel Batlle, Julio Pascual, María José Sole. Effect of insulin on ACE2 activity and kidney function in the non-obese diabetic mouse. PloS one. vol 9. issue 1. 2014-09-10. PMID:24400109. |
effect of insulin on ace2 activity and kidney function in the non-obese diabetic mouse. |
2014-09-10 |
2023-08-12 |
mouse |
| Marta Riera, Eva Márquez, Sergi Clotet, Javier Gimeno, Heleia Roca-Ho, Josep Lloreta, Nuria Juanpere, Daniel Batlle, Julio Pascual, María José Sole. Effect of insulin on ACE2 activity and kidney function in the non-obese diabetic mouse. PloS one. vol 9. issue 1. 2014-09-10. PMID:24400109. |
the increase in serum and urine ace2 activity was normalized by insulin administration at the early and late stages of diabetes in diabetic mice. |
2014-09-10 |
2023-08-12 |
mouse |
| Eva Márquez, Marta Riera, Julio Pascual, María José Sole. Albumin inhibits the insulin-mediated ACE2 increase in cultured podocytes. American journal of physiology. Renal physiology. vol 306. issue 11. 2014-07-31. PMID:24671333. |
we found that insulin increases ace2 gene and protein expression, by real-time pcr and western blotting, respectively, and enzymatic activity within the podocyte and these increases were maintained over time. |
2014-07-31 |
2023-08-12 |
mouse |
| Esam S B Salem, Nadja Grobe, Khalid M Elase. Insulin treatment attenuates renal ADAM17 and ACE2 shedding in diabetic Akita mice. American journal of physiology. Renal physiology. vol 306. issue 6. 2014-05-14. PMID:24452639. |
insulin treatment attenuates renal adam17 and ace2 shedding in diabetic akita mice. |
2014-05-14 |
2023-08-12 |
mouse |