| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Esam S B Salem, Nadja Grobe, Khalid M Elase. Insulin treatment attenuates renal ADAM17 and ACE2 shedding in diabetic Akita mice. American journal of physiology. Renal physiology. vol 306. issue 6. 2014-05-14. PMID:24452639. |
the aim of the present study was to determine the effect of insulin on ace2 shedding and adam17 in type 1 diabetic akita mice. |
2014-05-14 |
2023-08-12 |
mouse |
| Esam S B Salem, Nadja Grobe, Khalid M Elase. Insulin treatment attenuates renal ADAM17 and ACE2 shedding in diabetic Akita mice. American journal of physiology. Renal physiology. vol 306. issue 6. 2014-05-14. PMID:24452639. |
treatment of akita mice with insulin implants for 20 wk normalized hyperglycemia and decreased urinary ace2 and albumin excretion. |
2014-05-14 |
2023-08-12 |
mouse |
| Esam S B Salem, Nadja Grobe, Khalid M Elase. Insulin treatment attenuates renal ADAM17 and ACE2 shedding in diabetic Akita mice. American journal of physiology. Renal physiology. vol 306. issue 6. 2014-05-14. PMID:24452639. |
insulin also normalized renal ace2 and adam17 but had no effect on tissue inhibitor of metalloproteinase 3 (timp3) protein expression. |
2014-05-14 |
2023-08-12 |
mouse |
| Jan Wysocki, Laura Garcia-Halpin, Minghao Ye, Christoph Maier, Kurt Sowers, Kevin D Burns, Daniel Batll. Regulation of urinary ACE2 in diabetic mice. American journal of physiology. Renal physiology. vol 305. issue 4. 2013-12-31. PMID:23761674. |
in stz mice, urinary ace2 was also increased, and insulin decreased it partly but significantly after several weeks of administration. |
2013-12-31 |
2023-08-12 |
mouse |
| Harshita Chodavarapu, Nadja Grobe, Hari K Somineni, Esam S B Salem, Malav Madhu, Khalid M Elase. Rosiglitazone treatment of type 2 diabetic db/db mice attenuates urinary albumin and angiotensin converting enzyme 2 excretion. PloS one. vol 8. issue 4. 2013-11-26. PMID:23646149. |
we investigated the effect of the insulin sensitizer, rosiglitazone, on albuminuria, renal adam17 protein expression and ace2 shedding in db/db diabetic mice. |
2013-11-26 |
2023-08-12 |
mouse |
| Koichi Yamamoto, Masao Takeda, Mitsuru Ohishi, Hiromi Rakug. Response to comment on: Takeda et al. Loss of ACE2 exaggerates high-calorie diet-induced insulin resistance by reduction of GLUT4 in mice. Diabetes 2013;62:223-233. Diabetes. vol 62. issue 7. 2013-09-09. PMID:23801721. |
loss of ace2 exaggerates high-calorie diet-induced insulin resistance by reduction of glut4 in mice. |
2013-09-09 |
2023-08-12 |
mouse |
| Kavaljit H Chhabra, Eric Lazartigue. Comment on: Takeda et al. Loss of ACE2 exaggerates high-calorie diet-induced insulin resistance by reduction of GLUT4 in mice. Diabetes 2013;62:223-233. Diabetes. vol 62. issue 7. 2013-09-09. PMID:23801722. |
loss of ace2 exaggerates high-calorie diet-induced insulin resistance by reduction of glut4 in mice. |
2013-09-09 |
2023-08-12 |
mouse |
| Patricia C Underwood, Gail K Adle. The renin angiotensin aldosterone system and insulin resistance in humans. Current hypertension reports. vol 15. issue 1. 2013-06-24. PMID:23242734. |
angiotensin ii (angii) is the predominant raas component contributing to insulin resistance; however, other players such as aldosterone, renin, and ace2 are also involved. |
2013-06-24 |
2023-08-12 |
Not clear |
| Patricia C Underwood, Gail K Adle. The renin angiotensin aldosterone system and insulin resistance in humans. Current hypertension reports. vol 15. issue 1. 2013-06-24. PMID:23242734. |
this review examines the role of local angii activity on insulin resistance development in skeletal muscle, adipocytes, and pancreas, followed by a discussion of the other raas components implicated in insulin resistance, including ace2, ang1-7, renin, and aldosterone. |
2013-06-24 |
2023-08-12 |
Not clear |
| Li Yuan, Ying Wang, Chunli Lu, Xiaoya L. Angiotensin-Converting Enzyme 2 Deficiency Aggravates Glucose Intolerance via Impairment of Islet Microvascular Density in Mice with High-Fat Diet. Journal of diabetes research. vol 2013. 2013-05-15. PMID:23671869. |
there was no difference of body weight, area under curve of glucose (aucg), area under curve of insulin from 0 to 5 min (augi0-5), mvd, and rvc (relative content of vegf) between wt and ace2 ko mice with regular chow diet. |
2013-05-15 |
2023-08-12 |
mouse |
| Masao Takeda, Koichi Yamamoto, Yukihiro Takemura, Hikari Takeshita, Kazuhiro Hongyo, Tatsuo Kawai, Hiroko Hanasaki-Yamamoto, Ryosuke Oguro, Yoichi Takami, Yuji Tatara, Yasushi Takeya, Ken Sugimoto, Kei Kamide, Mitsuru Ohishi, Hiromi Rakug. Loss of ACE2 exaggerates high-calorie diet-induced insulin resistance by reduction of GLUT4 in mice. Diabetes. vol 62. issue 1. 2013-03-08. PMID:22933108. |
loss of ace2 exaggerates high-calorie diet-induced insulin resistance by reduction of glut4 in mice. |
2013-03-08 |
2023-08-12 |
mouse |
| Masao Takeda, Koichi Yamamoto, Yukihiro Takemura, Hikari Takeshita, Kazuhiro Hongyo, Tatsuo Kawai, Hiroko Hanasaki-Yamamoto, Ryosuke Oguro, Yoichi Takami, Yuji Tatara, Yasushi Takeya, Ken Sugimoto, Kei Kamide, Mitsuru Ohishi, Hiromi Rakug. Loss of ACE2 exaggerates high-calorie diet-induced insulin resistance by reduction of GLUT4 in mice. Diabetes. vol 62. issue 1. 2013-03-08. PMID:22933108. |
this study assessed the role of endogenous ace2 in maintaining insulin sensitivity. |
2013-03-08 |
2023-08-12 |
mouse |
| Masao Takeda, Koichi Yamamoto, Yukihiro Takemura, Hikari Takeshita, Kazuhiro Hongyo, Tatsuo Kawai, Hiroko Hanasaki-Yamamoto, Ryosuke Oguro, Yoichi Takami, Yuji Tatara, Yasushi Takeya, Ken Sugimoto, Kei Kamide, Mitsuru Ohishi, Hiromi Rakug. Loss of ACE2 exaggerates high-calorie diet-induced insulin resistance by reduction of GLUT4 in mice. Diabetes. vol 62. issue 1. 2013-03-08. PMID:22933108. |
twelve-week-old male ace2 knockout (ace2ko) mice had normal insulin sensitivities when fed a standard diet. |
2013-03-08 |
2023-08-12 |
mouse |
| Masao Takeda, Koichi Yamamoto, Yukihiro Takemura, Hikari Takeshita, Kazuhiro Hongyo, Tatsuo Kawai, Hiroko Hanasaki-Yamamoto, Ryosuke Oguro, Yoichi Takami, Yuji Tatara, Yasushi Takeya, Ken Sugimoto, Kei Kamide, Mitsuru Ohishi, Hiromi Rakug. Loss of ACE2 exaggerates high-calorie diet-induced insulin resistance by reduction of GLUT4 in mice. Diabetes. vol 62. issue 1. 2013-03-08. PMID:22933108. |
in conclusion, ace2 protects against high-calorie diet-induced insulin resistance in mice. |
2013-03-08 |
2023-08-12 |
mouse |
| Kelly Putnam, Robin Shoemaker, Frederique Yiannikouris, Lisa A Cassi. The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome. American journal of physiology. Heart and circulatory physiology. vol 302. issue 6. 2012-05-07. PMID:22227126. |
hyperglycemia, insulin resistance, and/or specific cholesterol metabolites have been demonstrated to activate components required for the synthesis [angiotensinogen, renin, angiotensin-converting enzyme (ace)], degradation (ace2), or responsiveness (angiotensin ii type 1 receptors, mas receptors) to angiotensin peptides in cell types (e.g., pancreatic islet cells, adipocytes, macrophages) that mediate specific disorders of the metabolic syndrome. |
2012-05-07 |
2023-08-12 |
Not clear |
| H J Fang, J K Yan. Tissue-specific pattern of angiotensin-converting enzyme 2 expression in rat pancreas. The Journal of international medical research. vol 38. issue 2. 2010-07-15. PMID:20515569. |
double immunofluorescence labelling showed that ace2 was co-localized with both insulin and somatostatin, while it was rarely co-localized with glucagon and pancreatic polypeptide. |
2010-07-15 |
2023-08-12 |
rat |
| Ming-Jia Niu, Jin-Kui Yang, Shan-Shan Lin, Xiu-Juan Ji, Li-Min Gu. Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice. Endocrine. vol 34. issue 1-3. 2009-05-04. PMID:18956256. |
glucose tolerance test, insulin secretion test, and insulin tolerance test were performed in age-matched male ace2 knockout (ko) and wild-type (wt) mice. |
2009-05-04 |
2023-08-12 |
mouse |
| Ming-Jia Niu, Jin-Kui Yang, Shan-Shan Lin, Xiu-Juan Ji, Li-Min Gu. Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice. Endocrine. vol 34. issue 1-3. 2009-05-04. PMID:18956256. |
male ace2 ko mice displayed a selective decrease in first-phase insulin secretion in response to glucose and a progressive impairment of glucose tolerance compared with age- and sex-matched wt mice. |
2009-05-04 |
2023-08-12 |
mouse |
| Ming-Jia Niu, Jin-Kui Yang, Shan-Shan Lin, Xiu-Juan Ji, Li-Min Gu. Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice. Endocrine. vol 34. issue 1-3. 2009-05-04. PMID:18956256. |
on the other hand, insulin sensitivity of the peripheral tissue in age-matched ace2 ko and wt mice showed no difference. |
2009-05-04 |
2023-08-12 |
mouse |