| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lina Vandermeulen, Ivana Geric, Laura Fumagalli, Mohamed Kreir, Ashley Lu, Annelies Nonneman, Jessie Premereur, Leen Wolfs, Rafaela Policarpo, Nicola Fattorelli, An De Bondt, Ilse Van Den Wyngaert, Bob Asselbergh, Mark Fiers, Bart De Strooper, Constantin d'Ydewalle, Renzo Mancus. Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease. Molecular neurodegeneration. vol 19. issue 1. 2024-04-24. PMID:38654375. |
the discovery of genetic variants in genes predominately or exclusively expressed in myeloid cells, such as apolipoprotein e (apoe) and triggering receptor expressed on myeloid cells 2 (trem2), as the strongest risk factors for alzheimer's disease (ad) highlights the importance of microglial biology in the brain. |
2024-04-24 |
2024-04-26 |
human |
| Guang-Jun Hu, Xiao-Yang Jiang, Si-Yu Du, Kun Zhang, Zhuo Che. miR-107-5p ameliorates neurological damage, oxidative stress, and immune responses in mice with Alzheimer's disease by suppressing the Toll-like receptor 4 (TLR4)/nuclear factor-kappaB(NF-κB) pathway. The Kaohsiung journal of medical sciences. vol 40. issue 2. 2024-02-02. PMID:38305705. |
mir-107-5p expression, along with tlr4, apoe, and trem2 in hippocampal tissue homogenate, and nf-κb p65 protein expression in the nucleus and cytoplasm were assessed via rt-qpcr and western blot. |
2024-02-02 |
2024-02-04 |
mouse |
| Nicholas R W Cleland, Garrett J Potter, Courtney Buck, Daphne Quang, Dean Oldham, Mikaela Neal, Anthony Saviola, Christy S Niemeyer, Evgenia Dobrinskikh, Kimberley D Bruc. Altered metabolism and DAM-signatures in female brains and microglia with aging. Brain research. 2024-01-20. PMID:38244754. |
transcriptomic analysis revealed increased expression of disease-associated microglia (dam) genes (e.g., apoe, trem2, lpl), and genes involved in glycolysis and oxidative metabolism in microglia from aged females compared to males. |
2024-01-20 |
2024-01-23 |
mouse |
| Neriman Eren, Susanna Gerike, Berk Üsekes, Oliver Peters, Nicoleta-Carmen Cosma, Julian Hellmann-Rege. Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer's patients. Immunity & ageing : I & A. vol 20. issue 1. 2023-10-14. PMID:37833781. |
effects of autologous serum on trem2 and apoe in a personalized monocyte-derived macrophage assay of late-onset alzheimer's patients. |
2023-10-14 |
2023-10-15 |
Not clear |
| Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang, Xinyu Guo, Hong Fan, Dageng Huang, Yuqing He, Xiangwen Tang, Yixiang Ai, Youjun Liu, Hao Yang, Dingjun Ha. Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-κB Signaling Pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-09-02. PMID:37658943. |
finally, a series of molecular biological experiments including knock-down of triggering receptor expressed on myeloid cells 2 (trem2) and analysis of the level of apolipoprotein e (apoe) expression were performed to investigate the underlying mechanism of involvement of ccm-activated oecs in modulating microglia polarization, leading to neural regeneration and function recovery. |
2023-09-02 |
2023-09-07 |
rat |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. Correction: APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. 2023-08-17. PMID:37589745. |
correction: apoe and trem2 regulate amyloid-responsive microglia in alzheimer's disease. |
2023-08-17 |
2023-09-07 |
Not clear |
| Siyu Yang, Dong Chen, Lei Xie, Xiaoxiao Zou, Yanyuan Xiao, Lin Rao, Tianxiong Yao, Qing Zhang, Liping Cai, Fei Huang, Bin Yang, Lusheng Huan. Developmental dynamics of the single nucleus regulatory landscape of pig hippocampus. Science China. Life sciences. 2023-07-10. PMID:37428306. |
we examined 27 alzheimer's disease-related genes in our data and found that 15 showed cell type-specific activity (trem2, rin3 and clu), and 15 genes displayed age-associated dynamic activity (bin1, rabep1 and apoe). |
2023-07-10 |
2023-08-14 |
human |
| Martin Nwadiugwu, Hui Shen, Hong-Wen Den. Potential Molecular Mechanisms of Alzheimer's Disease from Genetic Studies. Biology. vol 12. issue 4. 2023-04-28. PMID:37106802. |
the reported causes of molecular imbalance were alterations in bile acid (ba) synthesis, pitrm1, trem2, olfactory mucosa (om) cells, cholesterol catabolism, nfkb, double-strand break (dsb) neuronal damage, p65kd silencing, tau and apoe expression. |
2023-04-28 |
2023-08-14 |
Not clear |
| Logan Brase, Shih-Feng You, Ricardo D'Oliveira Albanus, Jorge L Del-Aguila, Yaoyi Dai, Brenna C Novotny, Carolina Soriano-Tarraga, Taitea Dykstra, Maria Victoria Fernandez, John P Budde, Kristy Bergmann, John C Morris, Randall J Bateman, Richard J Perrin, Eric McDade, Chengjie Xiong, Alison M Goate, Martin Farlow, Greg T Sutherland, Jonathan Kipnis, Celeste M Karch, Bruno A Benitez, Oscar Harar. Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers. Nature communications. vol 14. issue 1. 2023-04-21. PMID:37085492. |
here, we perform single-nucleus rna-sequencing (snrna-seq) on nearly 300,000 nuclei from the parietal cortex of ad autosomal dominant (app and psen1) and risk-modifying variant (apoe, trem2 and ms4a) carriers. |
2023-04-21 |
2023-08-14 |
Not clear |
| Eyiyemisi C Damisah, Anupama Rai, Robert A Hill, Lei Tong, Jaime Grutzendle. TREM2 and APOE do not modulate phagocytic clearance of dying cells in the live mammalian brain. bioRxiv : the preprint server for biology. 2023-03-30. PMID:36993245. |
trem2 and apoe are two major risk factors for alzheimer’s disease (ad) that have been proposed to play crucial roles in microglia pathophysiology by affecting their ability to phagocytose cellular debris or aggregated proteins. |
2023-03-30 |
2023-08-14 |
Not clear |
| Eyiyemisi C Damisah, Anupama Rai, Robert A Hill, Lei Tong, Jaime Grutzendle. TREM2 and APOE do not modulate phagocytic clearance of dying cells in the live mammalian brain. bioRxiv : the preprint server for biology. 2023-03-30. PMID:36993245. |
our findings showed that the deletion of either trem2 or apoe did not affect the dynamics of microglia engagement with dying neurons or their efficiency in phagocytosing corpses. |
2023-03-30 |
2023-08-14 |
Not clear |
| Yi-Jun Xu, Ngan Pan Bennett Au, Chi Him Eddie M. Functional and Phenotypic Diversity of Microglia: Implication for Microglia-Based Therapies for Alzheimer's Disease. Frontiers in aging neuroscience. vol 14. 2022-06-13. PMID:35693341. |
recent in-depth transcriptomic analysis identifies apoe and trem2 from microglia as the major risk factors for ad pathogenesis. |
2022-06-13 |
2023-08-14 |
Not clear |
| Qi Qin, Meng Wang, Yunsi Yin, Yi Tan. The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer's Disease. Frontiers in immunology. vol 13. 2022-06-06. PMID:35663962. |
trem2 is involved in the synaptic clearance of microglia, acting alone or with other molecules, such as apolipoprotein e (apoe). |
2022-06-06 |
2023-08-14 |
Not clear |
| Qi Qin, Meng Wang, Yunsi Yin, Yi Tan. The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer's Disease. Frontiers in immunology. vol 13. 2022-06-06. PMID:35663962. |
in this review, we systematically summarized the potential mechanisms of microglia involved in synaptic clearance, comprehensively reviewed the role of trem2 in microglia regulating synaptic clearance and proposed our hypothesis that trem2 interacts with apoe and c1q to promote synaptic clearance. |
2022-06-06 |
2023-08-14 |
Not clear |
| Hunter B Dean, Thomas Brett, Erik D Roberson, Yuhua Son. Developing a functionally valid model of the TREM2-APOE complex to better understand its role in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108854. |
triggering receptor expressed on myeloid cells 2 (trem2) and apolipoprotein e (apoe) are the most potent genetic risk factors for late-onset alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
Not clear |
| Xinyan Liang, Haijian Wu, Mark Colt, Xinying Guo, Brock Pluimer, Jianxiong Zeng, Shupeng Dong, Zhen Zha. Microglia and its genetics in Alzheimer's Disease. Current Alzheimer research. 2021-12-03. PMID:34749609. |
different microglia subtypes displaying distinct genetic profiles have been identified in ad, and these signatures often link to ad risk genes identified from the genome-wide association studies (gwas), such as apoe and trem2. |
2021-12-03 |
2023-08-13 |
Not clear |
| Andrew Folick, Suneil K Koliwad, Martin Valdearco. Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis. Frontiers in endocrinology. vol 12. 2021-11-10. PMID:34122343. |
such techniques have highlighted specific subsets of microglia notable for their capacity to regulate the expression of lipid metabolic genes, including lipoprotein lipase (lpl), apolipoprotein e (apoe) and triggering receptor expressed on myeloid cells 2 (trem2). |
2021-11-10 |
2023-08-13 |
Not clear |
| Audrey Vautheny, Charlotte Duwat, Gwennaëlle Aurégan, Charlène Joséphine, Anne-Sophie Hérard, Caroline Jan, Julien Mitja, Pauline Gipchtein, Marie-Claude Gaillard, Luc Buée, David Blum, Philippe Hantraye, Gilles Bonvento, Emmanuel Brouillet, Karine Cambon, Alexis-Pierre Bemelman. THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency. Neurobiology of disease. vol 155. 2021-09-03. PMID:34019997. |
among these genes trem2, a cell surface receptor expressed by microglia, arouses strong interest because its r47h variant confers a risk of developing ad comparable to the ε4 allele of the apoe gene. |
2021-09-03 |
2023-08-13 |
mouse |
| Liang He, Jose Davila-Velderrain, Tomokazu S Sumida, David A Hafler, Manolis Kellis, Alexander M Kulminsk. NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data. Communications biology. vol 4. issue 1. 2021-08-16. PMID:34040149. |
using nebula in alzheimer's disease cohort data sets, we found that the cell-level expression of apoe correlated with that of other genetic risk factors (including clu, cst3, trem2, c1q, and itm2b) in a cell-type-specific pattern and an isoform-dependent manner in microglia. |
2021-08-16 |
2023-08-13 |
Not clear |
| Nicholas F Fitz, Kyong Nyon Nam, Cody M Wolfe, Florent Letronne, Brittany E Playso, Bistra E Iordanova, Takashi D Y Kozai, Richard J Biedrzycki, Valerian E Kagan, Yulia Y Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamov. Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease. Nature communications. vol 12. issue 1. 2021-06-15. PMID:34099706. |
apoe and trem2 are major genetic risk factors for alzheimer's disease (ad), but how they affect microglia response to aβ remains unclear. |
2021-06-15 |
2023-08-13 |
mouse |