| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32840654. |
apoe and trem2 regulate amyloid-responsive microglia in alzheimer's disease. |
2021-05-31 |
2023-08-13 |
human |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32840654. |
using single-nucleus rna sequencing of postmortem human brain with varied apoe and trem2 genotypes and neuropathology, we identified distinct microglia subpopulations, including a subpopulation of cd163-positive amyloid-responsive microglia (arm) that are depleted in cases with apoe and trem2 risk variants. |
2021-05-31 |
2023-08-13 |
human |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32840654. |
we validated our single-nucleus rna sequencing findings in an expanded cohort of ad cases, demonstrating that apoe and trem2 risk variants are associated with a significant reduction in cd163-positive amyloid-responsive microglia. |
2021-05-31 |
2023-08-13 |
human |
| Meliha Karsak, Konstantin Glebov, Marina Scheffold, Thomas Bajaj, Amit Kawalia, Ilker Karaca, Sebastian Rading, Johannes Kornhuber, Oliver Peters, Monica Diez-Fairen, Lutz Frölich, Michael Hüll, Jens Wiltfang, Martin Scherer, Steffi Riedel-Heller, Anja Schneider, Michael T Heneka, Klaus Fliessbach, Ahmed Sharaf, Holger Thiele, Martina Lennarz, Frank Jessen, Wolfgang Maier, Christian Kubisch, Zoya Ignatova, Peter Nürnberg, Pau Pastor, Jochen Walter, Alfredo Ramire. A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2. Human mutation. vol 41. issue 1. 2021-05-19. PMID:31464095. |
in a whole-exome sequencing study of a family with probable ad-type dementia without pathogenic variants in known autosomal dominant dementia disease genes and negative for the apolipoprotein e (apoe) ε4 allele, we identified an extremely rare trem2 coding variant, that is, a glycine-to-tryptophan substitution at amino acid position 145 (nm_018965.3:c.433g>t/p.[gly145trp]). |
2021-05-19 |
2023-08-13 |
Not clear |
| Daniel L Kober, Melissa D Stuchell-Brereton, Colin E Kluender, Hunter B Dean, Michael R Strickland, Deborah F Steinberg, Samantha S Nelson, Berevan Baban, David M Holtzman, Carl Frieden, Jennifer Alexander-Brett, Erik D Roberson, Yuhua Song, Tom J Bret. Functional insights from biophysical study of TREM2 interactions with apoE and Aβ Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-04-10. PMID:33090700. |
functional insights from biophysical study of trem2 interactions with apoe and aβ triggering receptor expressed on myeloid cells-2 (trem2) is an immune receptor expressed on microglia that also can become soluble (strem2). |
2021-04-10 |
2023-08-13 |
Not clear |
| Milica A Margeta, Sophia M Letcher, Robert P Igo, Jessica N Cooke Bailey, Louis R Pasquale, Jonathan L Haines, Oleg Butovsky, Janey L Wigg. Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4. Investigative ophthalmology & visual science. vol 61. issue 8. 2021-01-07. PMID:32614373. |
here we sought to identify genetic associations between poag and variants in apoe and trem2, genes associated with alzheimer disease (ad) that critically regulate microglial neurodegeneration-associated molecular signature. |
2021-01-07 |
2023-08-13 |
Not clear |
| Bailey A Loving, Kimberley D Bruc. Lipid and Lipoprotein Metabolism in Microglia. Frontiers in physiology. vol 11. 2020-09-28. PMID:32411016. |
increased expression of genes such as apolipoprotein e (apoe), triggering receptor expressed on myeloid cells 2 (trem2) and lipoprotein lipase (lpl) in microglia during development, damage, and disease, suggest that increased lipid metabolism is needed to fuel protective cellular functions such as phagocytosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Vrushali Mangale, Amber R Syage, H Atakan Ekiz, Dominic D Skinner, Yuting Cheng, Colleen L Stone, R Marshall Brown, Ryan M O'Connell, Kim N Green, Thomas E Lan. Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system. Glia. vol 68. issue 11. 2020-09-15. PMID:32449994. |
evaluation of spinal cord demyelination revealed a marked increase in white matter damage in plx5622-treated mice that corresponded with elevated expression of transcripts encoding disease-associated proteins osteopontin (spp1), apolipoprotein e (apoe), and triggering receptor expressed on myeloid cells 2 (trem2) that were enriched within macrophages. |
2020-09-15 |
2023-08-13 |
mouse |
| Ruma Raha-Chowdhury, James W Henderson, Animesh Alexander Raha, Romina Vuono, Anastasia Bickerton, Elizabeth Jones, Robert Fincham, Kieren Allinson, Anthony Holland, Shahid H Zama. Choroid Plexus Acts as Gatekeeper for TREM2, Abnormal Accumulation of ApoE, and Fibrillary Tau in Alzheimer's Disease and in Down Syndrome Dementia. Journal of Alzheimer's disease : JAD. vol 69. issue 1. 2020-09-09. PMID:30909239. |
choroid plexus acts as gatekeeper for trem2, abnormal accumulation of apoe, and fibrillary tau in alzheimer's disease and in down syndrome dementia. |
2020-09-09 |
2023-08-13 |
Not clear |
| C E Murray, A King, C Troakes, A Hodges, T Lashle. APOE ε4 is also required in TREM2 R47H variant carriers for Alzheimer's disease to develop. Neuropathology and applied neurobiology. vol 45. issue 2. 2020-09-01. PMID:29411406. |
apoe ε4 is also required in trem2 r47h variant carriers for alzheimer's disease to develop. |
2020-09-01 |
2023-08-13 |
Not clear |
| Daria Bortolotti, Valentina Gentili, Antonella Rotola, Elisabetta Caselli, Roberta Rizz. HHV-6A infection induces amyloid-beta expression and activation of microglial cells. Alzheimer's research & therapy. vol 11. issue 1. 2020-08-06. PMID:31831060. |
we evaluated the effect of hhv-6a infection on microglial cell expression aβ and the activation status, determined by trem2, apoe, cytokines, and tau expression. |
2020-08-06 |
2023-08-13 |
Not clear |
| Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádk. Intersection of pathological tau and microglia at the synapse. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31277708. |
furthermore, ad risk genes such as triggering receptor expressed on myeloid cells 2 (trem2) and apolipoprotein e (apoe) are enriched in the innate immune system and modulate the neuroinflammatory response of microglia to tau pathology. |
2020-07-30 |
2023-08-13 |
Not clear |
| R Guerreiro, T Orme, A C Naj, A B Kuzma, G D Schellenberg, J Bra. Is APOE ε4 required for Alzheimer's disease to develop in TREM2 p.R47H variant carriers? Neuropathology and applied neurobiology. vol 45. issue 2. 2020-03-03. PMID:30229991. |
is apoe ε4 required for alzheimer's disease to develop in trem2 p.r47h variant carriers? |
2020-03-03 |
2023-08-13 |
Not clear |
| Yang Shi, David M Holtzma. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nature reviews. Immunology. vol 18. issue 12. 2019-08-15. PMID:30140051. |
interplay between innate immunity and alzheimer disease: apoe and trem2 in the spotlight. |
2019-08-15 |
2023-08-13 |
Not clear |
| Yang Shi, David M Holtzma. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nature reviews. Immunology. vol 18. issue 12. 2019-08-15. PMID:30140051. |
this function of apoe is likely linked to triggering receptor expressed on myeloid cells 2 (trem2), which is expressed by microglia in the cns. |
2019-08-15 |
2023-08-13 |
Not clear |
| Yang Shi, David M Holtzma. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nature reviews. Immunology. vol 18. issue 12. 2019-08-15. PMID:30140051. |
here, we review the rapidly growing literature on the role of disease-associated microglia, trem2 and apoe in the pathogenesis of alzheimer disease and present an integrated view of innate immune function in alzheimer disease. |
2019-08-15 |
2023-08-13 |
Not clear |
| Melanie Hüttenrauch, Isabella Ogorek, Hans Klafki, Markus Otto, Christine Stadelmann, Sascha Weggen, Jens Wiltfang, Oliver Wirth. Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia. Acta neuropathologica communications. vol 6. issue 1. 2019-06-12. PMID:30340518. |
our data further indicate that gpnmb is part of a microglia activation state that is only present under neurodegenerative conditions and that is characterized by the up-regulation of a subset of genes including trem2, apoe and cst7. |
2019-06-12 |
2023-08-13 |
mouse |
| Duygu Gezen-Ak, İrem L Atasoy, Esin Candaş, Merve Alaylıoğlu, Erdinç Dursu. The Transcriptional Regulatory Properties of Amyloid Beta 1-42 may Include Regulation of Genes Related to Neurodegeneration. Neuromolecular medicine. vol 20. issue 3. 2019-05-14. PMID:29948923. |
for this purpose, we investigated the acute effect of aβ1-42 on the transcriptional levels of genes that have roles in the mechanisms that produce aβ itself: alpha secretase (adam10), beta secretase (bace1), the gamma secretase complex (ps-1, ps-2, nicastrin), the substrate app, apoe (the significant risk factor for sporadic form of the ad), trem2 (recently indicated as a contributor to ad risk), nmdar subunits and pkczeta (contributors of memory and learning), and key elements of tau pathology such as tau, gsk3α, gsk3β, and cdk5. |
2019-05-14 |
2023-08-13 |
Not clear |
| Cody M Wolfe, Nicholas F Fitz, Kyong Nyon Nam, Iliya Lefterov, Radosveta Koldamov. The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives. International journal of molecular sciences. vol 20. issue 1. 2019-04-03. PMID:30587772. |
the role of apoe and trem2 in alzheimer's disease-current understanding and perspectives. |
2019-04-03 |
2023-08-13 |
Not clear |
| Susanne Krasemann, Charlotte Madore, Ron Cialic, Caroline Baufeld, Narghes Calcagno, Rachid El Fatimy, Lien Beckers, Elaine O'Loughlin, Yang Xu, Zain Fanek, David J Greco, Scott T Smith, George Tweet, Zachary Humulock, Tobias Zrzavy, Patricia Conde-Sanroman, Mar Gacias, Zhiping Weng, Hao Chen, Emily Tjon, Fargol Mazaheri, Kristin Hartmann, Asaf Madi, Jason D Ulrich, Markus Glatzel, Anna Worthmann, Joerg Heeren, Bogdan Budnik, Cynthia Lemere, Tsuneya Ikezu, Frank L Heppner, Vladimir Litvak, David M Holtzman, Hans Lassmann, Howard L Weiner, Jordi Ochando, Christian Haass, Oleg Butovsk. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. vol 47. issue 3. 2017-10-18. PMID:28930663. |
trem2 (triggering receptor expressed on myeloid cells 2) induced apoe signaling, and targeting the trem2-apoe pathway restored the homeostatic signature of microglia in als and ad mouse models and prevented neuronal loss in an acute model of neurodegeneration. |
2017-10-18 |
2023-08-13 |
mouse |