| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charlotte Jendresen, Vibeke Årskog, Michael R Daws, Lars N G Nilsso. The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway. Journal of neuroinflammation. vol 14. issue 1. 2017-10-11. PMID:28320424. |
triggering receptor expressed on myeloid cells 2 (trem2) and apolipoprotein e (apoe) are genetically linked to alzheimer's disease. |
2017-10-11 |
2023-08-13 |
human |
| Felix L Yeh, Yuanyuan Wang, Irene Tom, Lino C Gonzalez, Morgan Shen. TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron. vol 91. issue 2. 2017-08-22. PMID:27477018. |
trem2 binds to apolipoproteins, including apoe and clu/apoj, and thereby facilitates uptake of amyloid-beta by microglia. |
2017-08-22 |
2023-08-13 |
human |
| Michelle K Lupton, Lachlan Strike, Narelle K Hansell, Wei Wen, Karen A Mather, Nicola J Armstrong, Anbupalam Thalamuthu, Katie L McMahon, Greig I de Zubicaray, Amelia A Assareh, Andrew Simmons, Petroula Proitsi, John F Powell, Grant W Montgomery, Derrek P Hibar, Eric Westman, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Velas, Simon Lovestone, Henry Brodaty, David Ames, Julian N Trollor, Nicholas G Martin, Paul M Thompson, Perminder S Sachdev, Margaret J Wrigh. The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973105. |
an ad polygenic risk score combining common risk variants excluding apolipoprotein e (apoe), and a single nucleotide polymorphism in trem2, were both associated with reduced hippocampal volume in healthy older adults and those with mci. |
2016-12-13 |
2023-08-13 |
Not clear |
| Amanda Heslegrave, Wendy Heywood, Ross Paterson, Nadia Magdalinou, Johan Svensson, Per Johansson, Annika Öhrfelt, Kaj Blennow, John Hardy, Jonathan Schott, Kevin Mills, Henrik Zetterber. Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease. Molecular neurodegeneration. vol 11. 2016-11-08. PMID:26754172. |
the discovery that heterozygous missense mutations in the gene encoding triggering receptor expressed on myeloid cells 2 (trem2) are risk factors for alzheimer's disease (ad), with only the apolipoprotein e (apoe) ε4 gene allele conferring a higher risk, has led to increased interest in immune biology in the brain. |
2016-11-08 |
2023-08-13 |
Not clear |
| Charles C Bailey, Lindsey B DeVaux, Michael Farza. The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E. The Journal of biological chemistry. vol 290. issue 43. 2016-02-16. PMID:26374897. |
furthermore, the alzheimer disease-associated r47h mutation, and other artificial mutations introduced in the same location, markedly reduced the affinity of trem2 for apoe. |
2016-02-16 |
2023-08-13 |
human |
| Xianwu Li, Kathleen S Montine, C Dirk Keene, Thomas J Montin. Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 5. 2015-07-30. PMID:25593125. |
we tested the hypothesis that apoe ε4 inheritance modulates both the pge2 pathway and trem2 expression using primary murine microglia from targeted replacement (tr) apoe3/3 and apoe4/4 mice. |
2015-07-30 |
2023-08-13 |
mouse |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Qiao-Quan Zhang, Lei Cao, Meng-Shan Tan, Li-Ze Gu, Hui-Fu Wang, Zheng-Zheng Ding, Ying-Dong Zhang, Jin-Tai Y. Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 13. 2015-07-07. PMID:25047746. |
triggering receptor expressed on myeloid cells 2 (trem2) gene is a recently identified susceptibility gene for alzheimer's disease (ad), as its low-frequency variants increase the risk of this disease with an odds ratio similar to that of an apoe ɛ4 allele. |
2015-07-07 |
2023-08-13 |
mouse |
| Basavaraj V Hooli, Antonio R Parrado, Kristina Mullin, Wai-Ki Yip, Tian Liu, Johannes T Roehr, Dandi Qiao, Frank Jessen, Oliver Peters, Tim Becker, Alfredo Ramirez, Christoph Lange, Lars Bertram, Rudolph E Tanz. The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk. Neurology. vol 83. issue 15. 2014-12-17. PMID:25186855. |
recently, 2 independent studies reported that a rare missense variant, rs75932628 (r47h), in exon 2 of the gene encoding the "triggering receptor expressed on myeloid cells 2" (trem2) significantly increases the risk of alzheimer disease (ad) with an effect size comparable to that of the apoe ε4 allele. |
2014-12-17 |
2023-08-13 |
Not clear |