| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rie Nishio, Akira Takeshita, Toyoyoshi Uchida, Takashi Herai, Kenichi Sakamoto, Yuichiro Shimizu, Makoto Arai, Keita Tatsushima, Noriaki Fukuhara, Mitsuo Okada, Hiroshi Nishioka, Shozo Yamada, Noriyuki Koibuchi, Hirotaka Watada, Yasuhiro Takeuch. GH-induced LH hyporesponsiveness as a potential mechanism for hypogonadism in male patients with acromegaly. Endocrine journal. vol 68. issue 8. 2021-08-30. PMID:33840669. |
these results suggest that excessive gh is the most relevant factor for hypogonadism in male acromegaly, and may cause impaired lh responsiveness as well as the suppression of lh secretion. |
2021-08-30 |
2023-08-13 |
Not clear |
| Marie Helene Schernthaner-Reiter, Giampaolo Trivellin, Thomas Roetzer, Johannes A Hainfellner, Matthew F Starost, Constantine A Strataki. Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice. Human molecular genetics. vol 29. issue 17. 2021-08-24. PMID:32821937. |
specifically targeting gh secretion rather than somatotroph proliferation may be an advantage in the medical treatment of aip-dependent human acromegaly. |
2021-08-24 |
2023-08-13 |
mouse |
| Małgorzata Rolla, Aleksandra Jawiarczyk-Przybyłowska, Jowita Halupczok-Żyła, Marcin Kałużny, Bogumil M Konopka, Izabela Błoniecka, Grzegorz Zieliński, Marek Bolanowsk. Complications and Comorbidities of Acromegaly-Retrospective Study in Polish Center. Frontiers in endocrinology. vol 12. 2021-08-18. PMID:33796075. |
in acromegaly, chronic exposure to impaired gh and igf-i levels leads to the development of typical acromegaly symptoms, and multiple systemic complications as cardiovascular, metabolic, respiratory, endocrine, and bone disorders. |
2021-08-18 |
2023-08-13 |
Not clear |
| Derya Metin Armagan, Ayse Seda Akdemir, Hande Mefkure Ozkaya, Ozge Polat Korkmaz, Nurperi Gazioglu, Pinar Kadioglu, Necmettin Tanriover, Kaya-Fatma Dagistanli, Ahmet Dirican, Melek Oztur. SNPs of miR-23b, miR-107 and HMGA2 and their Relations with the Response to Medical Treatment in Acromegaly Patients. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 129. issue 8. 2021-08-10. PMID:32838437. |
acromegaly is a chronic disease of increased growth hormone (gh) secretion and elevated insulin-like growth factor-i (igf-i) levels induced by a pituitary adenoma. |
2021-08-10 |
2023-08-13 |
Not clear |
| Przemysław Witek, Marek Bolanowski, Katarzyna Szamotulska, Agnieszka Wojciechowska-Luźniak, Aleksandra Jawiarczyk-Przybyłowska, Marcin Kałużn. The Effect of 6 Months' Treatment With Pasireotide LAR on Glucose Metabolism in Patients With Resistant Acromegaly in Real-World Clinical Settings. Frontiers in endocrinology. vol 12. 2021-08-10. PMID:33776927. |
biochemical control of acromegaly, as measured by growth hormone (gh) and insulin-like growth factor 1 (igf-1) levels, was also assessed. |
2021-08-10 |
2023-08-13 |
Not clear |
| Maria Fleseriu, Mark Molitch, Alexander Dreval, Nienke R Biermasz, Murray B Gordon, Ross D Crosby, William H Ludlam, Asi Haviv, Yossi Gilgun-Sherki, Susan D Mathia. Disease and Treatment-Related Burden in Patients With Acromegaly Who Are Biochemically Controlled on Injectable Somatostatin Receptor Ligands. Frontiers in endocrinology. vol 12. 2021-08-10. PMID:33790860. |
in addition to side effects of treatment, acromegaly patients often still experience disease symptoms even when therapy is successful in controlling gh and igf-1 levels. |
2021-08-10 |
2023-08-13 |
Not clear |
| Mario Detomas, Miriam Reuter, Timo Deutschbei. [New developments and perspectives in acromegaly]. Deutsche medizinische Wochenschrift (1946). vol 146. issue 15. 2021-08-10. PMID:34344028. |
acromegaly is a rare but severe disorder which is usually due to an excessive secretion of growth hormone (gh) by a pituitary adenoma. |
2021-08-10 |
2023-08-13 |
Not clear |
| Chiho Oba-Yamamoto, Hiraku Kameda, Hideaki Miyoshi, Tomonori Sekizaki, Takahiro Takase, Tsuyoshi Yanagimachi, Yukihiro Fujita, Hiroshi Nomoto, Kyu Yong Cho, Akinobu Nakamura, So Nagai, Tatsuya Atsum. Acromegaly Cases Exhibiting Increased Growth Hormone Levels during Oral Glucose Loading with Preadministration of Dipeptidyl Peptidase-4 Inhibitor. Internal medicine (Tokyo, Japan). vol 60. issue 15. 2021-08-03. PMID:34334589. |
objective glucose-dependent insulinotropic polypeptide (gip) is speculated to worsen growth hormone (gh) hypersecretion in acromegaly and to be a cause of paradoxical increases in gh (pi-gh) during 75-g oral glucose tolerance testing (75-g ogtt). |
2021-08-03 |
2023-08-13 |
human |
| Anne Balossier, Constantin Tuleasca, Christine Cortet-Rudelli, Gustavo Soto-Ares, Marc Levivier, Richard Assaker, Nicolas Reyn. Gamma Knife radiosurgery for acromegaly: Evaluating the role of the biological effective dose associated with endocrine remission in a series of 42 consecutive cases. Clinical endocrinology. vol 94. issue 3. 2021-07-29. PMID:32984972. |
stereotactic radiosurgery (srs) is a valuable treatment option for persistent and/or recurrent acromegaly secondary to growth hormone (gh) secreting pituitary adenoma (pa). |
2021-07-29 |
2023-08-13 |
Not clear |
| Reyna Daya, Faheem Seedat, Khushica Purbhoo, Saajidah Bulbulia, Zaheer Baya. Acromegaly with empty sella syndrome. Endocrinology, diabetes & metabolism case reports. vol 2021. 2021-07-21. PMID:34253687. |
acromegaly is a rare, chronic progressive disorder with characteristic clinical features caused by persistent hypersecretion of growth hormone (gh), mostly from a pituitary adenoma (95%). |
2021-07-21 |
2023-08-13 |
Not clear |
| Reyna Daya, Faheem Seedat, Khushica Purbhoo, Saajidah Bulbulia, Zaheer Baya. Acromegaly with empty sella syndrome. Endocrinology, diabetes & metabolism case reports. vol 2021. 2021-07-21. PMID:34253687. |
occasionally, ectopic production of gh or growth hormone-releasing hormone (ghrh) with resultant gh hypersecretion may lead to acromegaly. |
2021-07-21 |
2023-08-13 |
Not clear |
| L Duan, S R Wang, H J Zhu, R Z Wan. [Updated key points of Chinese Consensus for the Diagnosis and Treatment of Acromegaly (2021 edition)]. Zhonghua yi xue za zhi. vol 101. issue 27. 2021-07-20. PMID:34275246. |
led by the china pituitary adenoma specialist council, the chinese consensus for the diagnosis and treatment of acromegaly (2021 edition) is developed combined with the research progress of pituitary growth hormone (gh)-secreting adenoma both at home and abroad, evidence-based evidence of the diagnosis and treatment of acromegaly, and china's national conditions. |
2021-07-20 |
2023-08-13 |
Not clear |
| Donatella Treppiedi, Federica Mangili, Elena Giardino, Rosa Catalano, Marco Locatelli, Andrea Gerardo Lania, Anna Spada, Maura Arosio, Davide Calebiro, Giovanna Mantovani, Erika Peverell. Cytoskeleton Protein Filamin A Is Required for Efficient Somatostatin Receptor Type 2 Internalization and Recycling through Rab5 and Rab4 Sorting Endosomes in Tumor Somatotroph Cells. Neuroendocrinology. vol 110. issue 7-8. 2021-07-14. PMID:31574507. |
the high expression of somatostatin receptor 2 (sst2) in growth hormone (gh)-secreting tumors represents the rationale for the clinical use of somatostatin analogs (ssas) in acromegaly. |
2021-07-14 |
2023-08-13 |
human |
| Mubarak Algahtany, Shubham Sharma, Khalid Fahoum, Rowan Jing, Stanley Zhang, Kalman Kovacs, Fabio Rotondo, John Lee, Irene Vanek, Michael D Cusiman. The Role of Growth Hormone in Depression: A Human Model. Frontiers in neuroscience. vol 15. 2021-07-13. PMID:34248479. |
although the relationship between acromegaly and depression has been ascribed to the effects of chronic disease, the role of growth hormone (gh), and insulin like growth factor-1 (igf-1) is not clear. |
2021-07-13 |
2023-08-13 |
human |
| Giulia Carosi, Alessandra Mangone, Elisa Sala, Giulia Del Sindaco, Roberta Mungari, Arianna Cremaschi, Emanuele Ferrante, Maura Arosio, Giovanna Mantovan. Clinical and hormonal findings in patients presenting with high IGF-1 and growth hormone suppression after oral glucose load: a retrospective cohort study. European journal of endocrinology. vol 185. issue 2. 2021-07-09. PMID:34081617. |
high insulin-like growth factor 1 (igf-1) and unsuppressed growth hormone (gh) levels after glucose load confirm the diagnosis of acromegaly. |
2021-07-09 |
2023-08-13 |
Not clear |
| Virginie Atquet, Orsalia Alexopoulou, Dominique Maite. Characteristics and treatment responsiveness of patients with acromegaly and a paradoxical GH increase to oral glucose load. European journal of endocrinology. vol 185. issue 2. 2021-07-09. PMID:34085950. |
characteristics and treatment responsiveness of patients with acromegaly and a paradoxical gh increase to oral glucose load. |
2021-07-09 |
2023-08-13 |
Not clear |
| Virginie Atquet, Orsalia Alexopoulou, Dominique Maite. Characteristics and treatment responsiveness of patients with acromegaly and a paradoxical GH increase to oral glucose load. European journal of endocrinology. vol 185. issue 2. 2021-07-09. PMID:34085950. |
we aimed to investigate the clinical, biochemical, histological and radiological characteristics as well as the response to somatostatin analogs (ssa) in a large cohort of acromegaly patients with a paradoxical gh response (pr) to oral glucose tolerance test (ogtt). |
2021-07-09 |
2023-08-13 |
Not clear |
| Joseph A M J L Jansse. Mechanisms of putative IGF-I receptor resistance in active acromegaly. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 52. 2021-07-05. PMID:32339897. |
acromegaly is a disease characterized by overproduction of growth hormone (gh). |
2021-07-05 |
2023-08-13 |
Not clear |
| Joseph A M J L Jansse. Mechanisms of putative IGF-I receptor resistance in active acromegaly. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 52. 2021-07-05. PMID:32339897. |
as a consequence of excessive gh secretion, circulating insulin-like growth factor-i (igf-i) is elevated in active (untreated) acromegaly. |
2021-07-05 |
2023-08-13 |
Not clear |
| Joseph A M J L Jansse. Mechanisms of putative IGF-I receptor resistance in active acromegaly. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 52. 2021-07-05. PMID:32339897. |
although igf-i can directly improve insulin sensitivity and glucose uptake in muscles, the excessive gh secretion in active acromegaly frequently leads to insulin resistance, glucose intolerance and even diabetes. |
2021-07-05 |
2023-08-13 |
Not clear |