| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| LilyAnne M Grieve, Abhya Rani, Gary T ZeRut. Downregulation of Glis3 in INS1 cells exposed to chronically elevated glucose contributes to glucotoxicity-associated β cell dysfunction. Islets. vol 16. issue 1. 2024-04-23. PMID:38652652. |
the krüppel-like transcription factor, glis3 has previously been shown to positively regulate insulin transcription and mutations within the glis3 locus have been associated with the development of several pathologies including type 2 diabetes mellitus. |
2024-04-23 |
2024-04-26 |
Not clear |
| LilyAnne M Grieve, Abhya Rani, Gary T ZeRut. Downregulation of Glis3 in INS1 cells exposed to chronically elevated glucose contributes to glucotoxicity-associated β cell dysfunction. Islets. vol 16. issue 1. 2024-04-23. PMID:38652652. |
crispr/cas9-mediated knockdown of glis3 indicated that the transcription factor was required to maintain normal levels of both insulin and mafa expression and reduced glis3 expression was concomitant with an upregulation of β cell disallowed genes. |
2024-04-23 |
2024-04-26 |
Not clear |
| LilyAnne M Grieve, Abhya Rani, Gary T ZeRut. Downregulation of Glis3 in INS1 cells exposed to chronically elevated glucose contributes to glucotoxicity-associated β cell dysfunction. Islets. vol 16. issue 1. 2024-04-23. PMID:38652652. |
we provide evidence that glis3 acts similarly to a pioneer factor at the insulin promoter where it permissively remodels the chromatin to allow access to a transcriptional regulatory complex including pdx1 and mafa. |
2024-04-23 |
2024-04-26 |
Not clear |
| LilyAnne M Grieve, Abhya Rani, Gary T ZeRut. Downregulation of Glis3 in INS1 cells exposed to chronically elevated glucose contributes to glucotoxicity-associated β cell dysfunction. Islets. vol 16. issue 1. 2024-04-23. PMID:38652652. |
collectively, these results suggest that decreased glis3 expression in β cells exposed to chronic hyperglycemia may contribute significantly to reduced insulin transcription and a loss of β cell identity. |
2024-04-23 |
2024-04-26 |
Not clear |
| Rocio Caro-Consuegra, Marcel Lucas-Sánchez, David Comas, Elena Bosc. Identifying signatures of positive selection in human populations from North Africa. Scientific reports. vol 13. issue 1. 2023-05-20. PMID:37210386. |
we also detect signatures of positive selection related to skin pigmentation (slc24a5, kitlg), and immunity function (il1r1, cd44, jak1) shared with european populations and candidate genes associated with haemoglobin phenotypes (hpse2, hbe1, hbg2), other immune-related (dock2) traits, and insulin processing (glis3) traits shared with west and east african populations. |
2023-05-20 |
2023-08-14 |
human |
| Lubna E Mohamed, Eman S Elhadidi, Wessam E Saad, Maram M Maher, Walaa A Yousr. Gli-similar 3 (GLIS3) rs7020763 (C>G) polymorphism in patients with type 2 diabetes mellitus. The Egyptian journal of immunology. vol 29. issue 4. 2022-10-07. PMID:36206155. |
the transcription factor gli-similar 3 (glis3) has an important role in the development, survival and proliferation of pancreatic beta-cells and insulin gene expression regulation. |
2022-10-07 |
2023-08-14 |
human |
| David W Scoville, Hong Soon Kang, Anton M Jette. Transcription factor GLIS3: Critical roles in thyroid hormone biosynthesis, hypothyroidism, pancreatic beta cells and diabetes. Pharmacology & therapeutics. vol 215. 2021-08-13. PMID:32693112. |
these studies revealed that glis3 is essential for thyroid hormone biosynthesis and identified a critical function for glis3 in the generation of pancreatic β cells and insulin gene transcription. |
2021-08-13 |
2023-08-13 |
mouse |
| David Scoville, Kristin Lichti-Kaiser, Sara Grimm, Anton Jette. GLIS3 binds pancreatic beta cell regulatory regions alongside other islet transcription factors. The Journal of endocrinology. 2021-01-10. PMID:31340201. |
our data indicates that glis3 not only regulates insulin expression, but several additional genes critical for beta cell function. |
2021-01-10 |
2023-08-13 |
mouse |
| Tyler M Hoard, Xiao Ping Yang, Anton M Jetten, Gary T ZeRut. PIAS-family proteins negatively regulate Glis3 transactivation function through SUMO modification in pancreatic β cells. Heliyon. vol 4. issue 7. 2020-10-01. PMID:30094379. |
gli-similar 3 (glis3) is krüppel-like transcription factor associated with the transcriptional regulation of insulin. |
2020-10-01 |
2023-08-13 |
Not clear |
| Anton M Jette. GLIS1-3 transcription factors: critical roles in the regulation of multiple physiological processes and diseases. Cellular and molecular life sciences : CMLS. vol 75. issue 19. 2018-09-10. PMID:29779043. |
glis3 plays a critical role in the regulation of multiple biological processes and is a key regulator of pancreatic β cell generation and maturation, insulin gene expression, thyroid hormone biosynthesis, spermatogenesis, and the maintenance of normal kidney functions. |
2018-09-10 |
2023-08-13 |
mouse |
| Sophie Calderari, Massimiliano Ria, Christelle Gérard, Tatiane C Nogueira, Olatz Villate, Stephan C Collins, Helen Neil, Nicolas Gervasi, Christophe Hue, Nicolas Suarez-Zamorano, Cécilia Prado, Miriam Cnop, Marie-Thérèse Bihoreau, Pamela J Kaisaki, Jean-Baptiste Cazier, Cécile Julier, Mark Lathrop, Michel Werner, Decio L Eizirik, Dominique Gauguie. Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons. Genomics. vol 110. issue 2. 2018-08-10. PMID:28911974. |
we identified glis3 binding sites in insulin secreting cells (ins1) (fdr q<0.05; enrichment range 1.40-9.11 fold) sharing the motif wrgttcccartags, which were enriched in genes involved in neuronal function and autophagy and in risk genes for metabolic and neuro-behavioural diseases. |
2018-08-10 |
2023-08-13 |
rat |
| Sophie Calderari, Massimiliano Ria, Christelle Gérard, Tatiane C Nogueira, Olatz Villate, Stephan C Collins, Helen Neil, Nicolas Gervasi, Christophe Hue, Nicolas Suarez-Zamorano, Cécilia Prado, Miriam Cnop, Marie-Thérèse Bihoreau, Pamela J Kaisaki, Jean-Baptiste Cazier, Cécile Julier, Mark Lathrop, Michel Werner, Decio L Eizirik, Dominique Gauguie. Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons. Genomics. vol 110. issue 2. 2018-08-10. PMID:28911974. |
naturally-occurring coding polymorphisms in glis3 in the goto-kakizaki rat model of type 2 diabetes were associated with increased insulin production in vitro and in vivo, suggestive alteration of autophagy in pc12 and ins1 and abnormal neurogenesis in hippocampus neurons. |
2018-08-10 |
2023-08-13 |
rat |
| Chon-Kit Chou, Chin-Ju Tang, Han-Lin Chou, Chun-Yen Liu, Ming-Chong Ng, Yu-Ting Chang, Shyng-Shiou F Yuan, Eing-Mei Tsai, Chien-Chih Chi. The Potential Role of Krüppel-Like Zinc-Finger Protein Glis3 in Genetic Diseases and Cancers. Archivum immunologiae et therapiae experimentalis. vol 65. issue 5. 2018-07-02. PMID:28523428. |
gli-similar 3 (glis3) belongs to a glis subfamily of krüppel-like zinc-finger transcription factors characterized to regulate a set of downstream targets essential for cellular functions, including pancreatic development, β-cell maturation and maintenance, and insulin production. |
2018-07-02 |
2023-08-13 |
mouse |
| Chon-Kit Chou, Chin-Ju Tang, Han-Lin Chou, Chun-Yen Liu, Ming-Chong Ng, Yu-Ting Chang, Shyng-Shiou F Yuan, Eing-Mei Tsai, Chien-Chih Chi. The Potential Role of Krüppel-Like Zinc-Finger Protein Glis3 in Genetic Diseases and Cancers. Archivum immunologiae et therapiae experimentalis. vol 65. issue 5. 2018-07-02. PMID:28523428. |
the loss of the production of pancreatic hormones, such as insulin 1 and 2, is linked to the down-regulation of β cells-related genes and promotes the apoptotic death of β cells found in mutant glis3. |
2018-07-02 |
2023-08-13 |
mouse |
| Guilherme C K Duarte, Tais S Assmann, Cristine Dieter, Bianca M de Souza, Daisy Crispi. GLIS3 rs7020673 and rs10758593 polymorphisms interact in the susceptibility for type 1 diabetes mellitus. Acta diabetologica. vol 54. issue 9. 2018-05-21. PMID:28597135. |
the transcription factor gli-similar 3 (glis3) plays a key role in the development and maintenance of pancreatic beta cells as well as in the regulation of insulin gene expression in adults. |
2018-05-21 |
2023-08-13 |
Not clear |
| Yisheng Yang, Lawrence Cha. Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes. Endocrine reviews. vol 37. issue 3. 2017-12-08. PMID:27035557. |
glis3 is a key transcription factor in insulin production and β-cell differentiation during embryonic development, which perturbation forms the basis of monogenic diabetes as well as its association with t1d. |
2017-12-08 |
2023-08-13 |
human |
| Xianjie Wen, Yisheng Yan. Emerging roles of GLIS3 in neonatal diabetes, type 1 and type 2 diabetes. Journal of molecular endocrinology. vol 58. issue 2. 2017-12-07. PMID:27899417. |
glis3 cooperates with pancreatic and duodenal homeobox 1 (pdx1), v-maf musculoaponeurotic fibrosarcoma oncogene family, protein a (mafa), as well as neurogenic differentiation 1 (neurod1) and potently controls insulin gene transcription. |
2017-12-07 |
2023-08-13 |
mouse |
| Xianjie Wen, Yisheng Yan. Emerging roles of GLIS3 in neonatal diabetes, type 1 and type 2 diabetes. Journal of molecular endocrinology. vol 58. issue 2. 2017-12-07. PMID:27899417. |
glis3 also plays a role in β cell survival and likely in insulin secretion. |
2017-12-07 |
2023-08-13 |
mouse |
| Xianjie Wen, Yisheng Yan. Emerging roles of GLIS3 in neonatal diabetes, type 1 and type 2 diabetes. Journal of molecular endocrinology. vol 58. issue 2. 2017-12-07. PMID:27899417. |
in addition, glis3 is also required for the compensatory β cell proliferation and mass expansion in response to insulin resistance, which if disrupted may predispose to t2d. |
2017-12-07 |
2023-08-13 |
mouse |
| Hong Soon Kang, Yukimasa Takeda, Kilsoo Jeon, Anton M Jette. The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells. PloS one. vol 11. issue 6. 2017-07-26. PMID:27270601. |
glis3-deficiency greatly reduced, whereas exogenous glis3, induced ppy expression, as reported for insulin. |
2017-07-26 |
2023-08-13 |
mouse |