| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong Soon Kang, Yong-Sik Kim, Gary ZeRuth, Ju Youn Beak, Kevin Gerrish, Gamze Kilic, Beatriz Sosa-Pineda, Jan Jensen, Christophe E Pierreux, Frederic P Lemaigre, Julie Foley, Anton M Jette. Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression. Molecular and cellular biology. vol 29. issue 24. 2010-01-05. PMID:19805515. |
transcription factor glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression. |
2010-01-05 |
2023-08-12 |
mouse |
| Hong Soon Kang, Yong-Sik Kim, Gary ZeRuth, Ju Youn Beak, Kevin Gerrish, Gamze Kilic, Beatriz Sosa-Pineda, Jan Jensen, Christophe E Pierreux, Frederic P Lemaigre, Julie Foley, Anton M Jette. Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression. Molecular and cellular biology. vol 29. issue 24. 2010-01-05. PMID:19805515. |
in addition, we provide evidence that glis3 regulates insulin gene expression through two glis-binding sites in its proximal promoter, indicating that glis3 also regulates beta-cell function. |
2010-01-05 |
2023-08-12 |
mouse |
| Hisashi Hashimoto, Rieko Miyamoto, Naoki Watanabe, Dai Shiba, Kenjiro Ozato, Chikako Inoue, Yuko Kubo, Akihiko Koga, Tomoko Jindo, Takanori Narita, Kiyoshi Naruse, Kazuko Ohishi, Keiko Nogata, Tadasu Shin-I, Shuichi Asakawa, Nobuyoshi Shimizu, Tomotsune Miyamoto, Toshio Mochizuki, Takahiko Yokoyama, Hiroshi Hori, Hiroyuki Takeda, Yuji Kohara, Yuko Wakamats. Polycystic kidney disease in the medaka (Oryzias latipes) pc mutant caused by a mutation in the Gli-Similar3 (glis3) gene. PloS one. vol 4. issue 7. 2009-11-10. PMID:19609364. |
unlike human patients with glis3 mutations, the medaka pc mutant shows none of the symptoms of a pancreatic phenotype, such as impaired insulin expression and/or diabetes, suggesting that the pc mutant may be suitable for use as a kidney-specific model for human glis3 patients. |
2009-11-10 |
2023-08-12 |
mouse |
| Yisheng Yang, Benny Hung-Junn Chang, Susan L Samson, Ming V Li, Lawrence Cha. The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic acids research. vol 37. issue 8. 2009-06-24. PMID:19264802. |
the krüppel-like zinc finger protein glis3 directly and indirectly activates insulin gene transcription. |
2009-06-24 |
2023-08-12 |
rat |
| Yisheng Yang, Benny Hung-Junn Chang, Susan L Samson, Ming V Li, Lawrence Cha. The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic acids research. vol 37. issue 8. 2009-06-24. PMID:19264802. |
our aim was to examine the role of glis3 in beta cells, specifically with regard to regulation of insulin gene transcription. |
2009-06-24 |
2023-08-12 |
rat |
| Yisheng Yang, Benny Hung-Junn Chang, Susan L Samson, Ming V Li, Lawrence Cha. The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic acids research. vol 37. issue 8. 2009-06-24. PMID:19264802. |
we demonstrate that insulin 2 (ins2) mrna expression in rat insulinoma 832/13 cells is markedly increased by wild-type glis3 overexpression, but not by the ndh1 mutant. |
2009-06-24 |
2023-08-12 |
rat |
| Yisheng Yang, Benny Hung-Junn Chang, Susan L Samson, Ming V Li, Lawrence Cha. The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic acids research. vol 37. issue 8. 2009-06-24. PMID:19264802. |
glis3 also may indirectly affect insulin promoter activity through upregulation of mafa and downregulation of nkx6-1. |
2009-06-24 |
2023-08-12 |
rat |
| Yisheng Yang, Benny Hung-Junn Chang, Susan L Samson, Ming V Li, Lawrence Cha. The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic acids research. vol 37. issue 8. 2009-06-24. PMID:19264802. |
this study uncovers a role of glis3 for regulation of insulin gene expression and expands our understanding of its role in the beta cell. |
2009-06-24 |
2023-08-12 |
rat |