All Relations between glis3 and insulin
| Publication | Sentence | Publish Date | Extraction Date | Species |
|---|---|---|---|---|
| Hong Soon Kang, Yukimasa Takeda, Kilsoo Jeon, Anton M Jette. The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells. PloS one. vol 11. issue 6. 2017-07-26. PMID:27270601. | collectively, our study demonstrates that glis3 protein exhibits a temporal and cell type-specific pattern of expression during embryonic and neonatal pancreas development that is consistent with a regulatory role for glis3 in promoting endocrine progenitor generation, regulating insulin and ppy expression in beta and pp cells, respectively, and duct morphogenesis. | 2017-07-26 | 2023-08-13 | mouse |
| Gary T ZeRuth, Jason G Williams, Yasemin C Cole, Anton M Jette. HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity. PloS one. vol 10. issue 7. 2016-03-30. PMID:26147758. | the transcription factor gli-similar 3 (glis3) plays a critical role in the generation of pancreatic ß cells and the regulation insulin gene transcription and has been implicated in the development of several pathologies, including type 1 and 2 diabetes and polycystic kidney disease. | 2016-03-30 | 2023-08-13 | Not clear |
| Gary T ZeRuth, Jason G Williams, Yasemin C Cole, Anton M Jette. HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity. PloS one. vol 10. issue 7. 2016-03-30. PMID:26147758. | this regulation provides a novel mechanism to modulate glis3-driven gene expression and suggests that it may play a role in a number of physiological processes controlled by glis3, such as insulin transcription, as well as in glis3-associated diseases. | 2016-03-30 | 2023-08-13 | Not clear |
| Gary T ZeRuth, Yukimasa Takeda, Anton M Jette. The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription. Molecular endocrinology (Baltimore, Md.). vol 27. issue 10. 2014-04-25. PMID:23927931. | the krüppel-like protein gli-similar 3 (glis3) functions as a key regulator of insulin transcription. | 2014-04-25 | 2023-08-12 | Not clear |
| Gary T ZeRuth, Yukimasa Takeda, Anton M Jette. The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription. Molecular endocrinology (Baltimore, Md.). vol 27. issue 10. 2014-04-25. PMID:23927931. | recently, the krüppel-like transcription factor, gli-similar 3 (glis3), was shown to bind the insulin (ins) promoter and positively influence insulin transcription. | 2014-04-25 | 2023-08-12 | Not clear |
| Gary T ZeRuth, Yukimasa Takeda, Anton M Jette. The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription. Molecular endocrinology (Baltimore, Md.). vol 27. issue 10. 2014-04-25. PMID:23927931. | in this report, we examined in detail the synergistic activation of insulin transcription by glis3 with coregulators, creb-binding protein (cbp)/p300, pancreatic and duodenal homeobox 1 (pdx1), neuronal differentiation 1 (neurod1), and v-maf musculoaponeurotic fibrosarcoma oncogene homolog a (mafa). | 2014-04-25 | 2023-08-12 | Not clear |
| Gary T ZeRuth, Yukimasa Takeda, Anton M Jette. The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription. Molecular endocrinology (Baltimore, Md.). vol 27. issue 10. 2014-04-25. PMID:23927931. | our data show that glis3 expression, the binding of glis3 to glisbs, and its recruitment of cbp are required for optimal activation of the insulin promoter in pancreatic β-cells not only by glis3, but also by pdx1, mafa, and neurod1. | 2014-04-25 | 2023-08-12 | Not clear |
| Gary T ZeRuth, Yukimasa Takeda, Anton M Jette. The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription. Molecular endocrinology (Baltimore, Md.). vol 27. issue 10. 2014-04-25. PMID:23927931. | mutations in the glisbs or small interfering rna-directed knockdown of glis3 diminished insulin promoter activation by pdx1, neurod1, and mafa, and neither pdx1 nor mafa was able to stably associate with the insulin promoter when the glisbs were mutated. | 2014-04-25 | 2023-08-12 | Not clear |
| Gary T ZeRuth, Yukimasa Takeda, Anton M Jette. The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription. Molecular endocrinology (Baltimore, Md.). vol 27. issue 10. 2014-04-25. PMID:23927931. | we therefore propose that recruitment of cbp/p300 by glis3 provides a scaffold for the formation of a larger transcriptional regulatory complex that stabilizes the binding of pdx1, neurod1, and mafa complexes to their respective binding sites within the insulin promoter. | 2014-04-25 | 2023-08-12 | Not clear |
| Gary T ZeRuth, Yukimasa Takeda, Anton M Jette. The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription. Molecular endocrinology (Baltimore, Md.). vol 27. issue 10. 2014-04-25. PMID:23927931. | taken together, these results indicate that glis3 plays a pivotal role in the transcriptional regulation of insulin and may serve as an important therapeutic target for the treatment of diabetes. | 2014-04-25 | 2023-08-12 | Not clear |
| Takuya Awata, Hisakuni Yamashita, Susumu Kurihara, Tomoko Morita-Ohkubo, Yumi Miyashita, Shigehiro Katayama, Eiji Kawasaki, Shoichiro Tanaka, Hiroshi Ikegami, Taro Maruyama, Akira Shimada, Kazuma Takahashi, Yumiko Kawabata, Tetsuro Kobayashi, Nao Nishida, Yoriko Mawatar. A low-frequency GLIS3 variant associated with resistance to Japanese type 1 diabetes. Biochemical and biophysical research communications. vol 437. issue 4. 2013-10-21. PMID:23856252. | glis3 is a zinc finger transcription factor that is highly expressed in pancreatic beta cells, and regulates beta cell development and insulin gene expression. | 2013-10-21 | 2023-08-12 | human |
| Tatiane C Nogueira, Flavia M Paula, Olatz Villate, Maikel L Colli, Rodrigo F Moura, Daniel A Cunha, Lorella Marselli, Piero Marchetti, Miriam Cnop, Cécile Julier, Decio L Eiziri. GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS genetics. vol 9. issue 5. 2013-09-10. PMID:23737756. | glis3 plays a role in the generation of pancreatic beta cells and in insulin gene expression, but there is no information on the role of this gene on beta cell viability and/or susceptibility to immune- and metabolic-induced stress. | 2013-09-10 | 2023-08-12 | human |
| Tatiane C Nogueira, Flavia M Paula, Olatz Villate, Maikel L Colli, Rodrigo F Moura, Daniel A Cunha, Lorella Marselli, Piero Marchetti, Miriam Cnop, Cécile Julier, Decio L Eiziri. GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS genetics. vol 9. issue 5. 2013-09-10. PMID:23737756. | glis3 knockdown (kd) in ins-1e cells, primary facs-purified rat beta cells, and human islet cells decreased expression of mafa, ins2, and glut2 and inhibited glucose oxidation and insulin secretion, confirming the role of this transcription factor for the beta cell differentiated phenotype. | 2013-09-10 | 2023-08-12 | human |
| Yisheng Yang, Benny Hung-Junn Chang, Lawrence Cha. Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults. EMBO molecular medicine. vol 5. issue 1. 2013-06-06. PMID:23197416. | tam-mediated beta cell-specific inactivation of glis3 in adult mice downregulates insulin expression, leading to hyperglycaemia and subsequently enhanced beta cell apoptosis. | 2013-06-06 | 2023-08-12 | mouse |
| Kristin Lichti-Kaiser, Gary ZeRuth, Hong Soon Kang, Shivakumar Vasanth, Anton M Jette. Gli-similar proteins: their mechanisms of action, physiological functions, and roles in disease. Vitamins and hormones. vol 88. 2012-08-02. PMID:22391303. | glis3 has also been identified as a risk locus for type-1 and type-2 diabetes and additional studies have revealed a role for glis3 in pancreatic endocrine development, β-cell maintenance, and insulin regulation. | 2012-08-02 | 2023-08-12 | Not clear |
| Yoon Shin Cho, Chien-Hsiun Chen, Cheng Hu, Jirong Long, Rick Twee Hee Ong, Xueling Sim, Fumihiko Takeuchi, Ying Wu, Min Jin Go, Toshimasa Yamauchi, Yi-Cheng Chang, Soo Heon Kwak, Ronald C W Ma, Ken Yamamoto, Linda S Adair, Tin Aung, Qiuyin Cai, Li-Ching Chang, Yuan-Tsong Chen, Yutang Gao, Frank B Hu, Hyung-Lae Kim, Sangsoo Kim, Young Jin Kim, Jeannette Jen-Mai Lee, Nanette R Lee, Yun Li, Jian Jun Liu, Wei Lu, Jiro Nakamura, Eitaro Nakashima, Daniel Peng-Keat Ng, Wan Ting Tay, Fuu-Jen Tsai, Tien Yin Wong, Mitsuhiro Yokota, Wei Zheng, Rong Zhang, Congrong Wang, Wing Yee So, Keizo Ohnaka, Hiroshi Ikegami, Kazuo Hara, Young Min Cho, Nam H Cho, Tien-Jyun Chang, Yuqian Bao, Åsa K Hedman, Andrew P Morris, Mark I McCarthy, Ryoichi Takayanagi, Kyong Soo Park, Weiping Jia, Lee-Ming Chuang, Juliana C N Chan, Shiro Maeda, Takashi Kadowaki, Jong-Young Lee, Jer-Yuarn Wu, Yik Ying Teo, E Shyong Tai, Xiao Ou Shu, Karen L Mohlke, Norihiro Kato, Bok-Ghee Han, Mark Seielsta. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nature genetics. vol 44. issue 1. 2012-02-27. PMID:22158537. | glis3, which is involved in pancreatic beta cell development and insulin gene expression, is known for its association with fasting glucose levels. | 2012-02-27 | 2023-08-12 | Not clear |
| Gary T ZeRuth, Xiao-Ping Yang, Anton M Jette. Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused. The Journal of biological chemistry. vol 286. issue 25. 2011-08-30. PMID:21543335. | recently, glis3 has been linked to both type i and type ii diabetes and shown to positively regulate insulin gene expression. | 2011-08-30 | 2023-08-12 | Not clear |
| Gary T ZeRuth, Xiao-Ping Yang, Anton M Jette. Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused. The Journal of biological chemistry. vol 286. issue 25. 2011-08-30. PMID:21543335. | we further showed that sufu is able to inhibit the activation of the insulin promoter by glis3 but not the activation by a glis3 mutant deficient in its ability to bind sufu, suggesting that the inhibitory effect is dependent on the interaction between the two proteins. | 2011-08-30 | 2023-08-12 | Not clear |
| Hong Soon Kang, Gary ZeRuth, Kristin Lichti-Kaiser, Shivakumar Vasanth, Zhengyu Yin, Yong-Sik Kim, Anton M Jette. Gli-similar (Glis) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease. Histology and histopathology. vol 25. issue 11. 2011-01-03. PMID:20865670. | glis3 plays a key role in pancreatic development, particularly in the generation of ß-cells and in the regulation of insulin gene expression. | 2011-01-03 | 2023-08-12 | human |
| Josée Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, Anne U Jackson, Eleanor Wheeler, Nicole L Glazer, Nabila Bouatia-Naji, Anna L Gloyn, Cecilia M Lindgren, Reedik Mägi, Andrew P Morris, Joshua Randall, Toby Johnson, Paul Elliott, Denis Rybin, Gudmar Thorleifsson, Valgerdur Steinthorsdottir, Peter Henneman, Harald Grallert, Abbas Dehghan, Jouke Jan Hottenga, Christopher S Franklin, Pau Navarro, Kijoung Song, Anuj Goel, John R B Perry, Josephine M Egan, Taina Lajunen, Niels Grarup, Thomas Sparsø, Alex Doney, Benjamin F Voight, Heather M Stringham, Man Li, Stavroula Kanoni, Peter Shrader, Christine Cavalcanti-Proença, Meena Kumari, Lu Qi, Nicholas J Timpson, Christian Gieger, Carina Zabena, Ghislain Rocheleau, Erik Ingelsson, Ping An, Jeffrey O'Connell, Jian'an Luan, Amanda Elliott, Steven A McCarroll, Felicity Payne, Rosa Maria Roccasecca, François Pattou, Praveen Sethupathy, Kristin Ardlie, Yavuz Ariyurek, Beverley Balkau, Philip Barter, John P Beilby, Yoav Ben-Shlomo, Rafn Benediktsson, Amanda J Bennett, Sven Bergmann, Murielle Bochud, Eric Boerwinkle, Amélie Bonnefond, Lori L Bonnycastle, Knut Borch-Johnsen, Yvonne Böttcher, Eric Brunner, Suzannah J Bumpstead, Guillaume Charpentier, Yii-Der Ida Chen, Peter Chines, Robert Clarke, Lachlan J M Coin, Matthew N Cooper, Marilyn Cornelis, Gabe Crawford, Laura Crisponi, Ian N M Day, Eco J C de Geus, Jerome Delplanque, Christian Dina, Michael R Erdos, Annette C Fedson, Antje Fischer-Rosinsky, Nita G Forouhi, Caroline S Fox, Rune Frants, Maria Grazia Franzosi, Pilar Galan, Mark O Goodarzi, Jürgen Graessler, Christopher J Groves, Scott Grundy, Rhian Gwilliam, Ulf Gyllensten, Samy Hadjadj, Göran Hallmans, Naomi Hammond, Xijing Han, Anna-Liisa Hartikainen, Neelam Hassanali, Caroline Hayward, Simon C Heath, Serge Hercberg, Christian Herder, Andrew A Hicks, David R Hillman, Aroon D Hingorani, Albert Hofman, Jennie Hui, Joe Hung, Bo Isomaa, Paul R V Johnson, Torben Jørgensen, Antti Jula, Marika Kaakinen, Jaakko Kaprio, Y Antero Kesaniemi, Mika Kivimaki, Beatrice Knight, Seppo Koskinen, Peter Kovacs, Kirsten Ohm Kyvik, G Mark Lathrop, Debbie A Lawlor, Olivier Le Bacquer, Cécile Lecoeur, Yun Li, Valeriya Lyssenko, Robert Mahley, Massimo Mangino, Alisa K Manning, María Teresa Martínez-Larrad, Jarred B McAteer, Laura J McCulloch, Ruth McPherson, Christa Meisinger, David Melzer, David Meyre, Braxton D Mitchell, Mario A Morken, Sutapa Mukherjee, Silvia Naitza, Narisu Narisu, Matthew J Neville, Ben A Oostra, Marco Orrù, Ruth Pakyz, Colin N A Palmer, Giuseppe Paolisso, Cristian Pattaro, Daniel Pearson, John F Peden, Nancy L Pedersen, Markus Perola, Andreas F H Pfeiffer, Irene Pichler, Ozren Polasek, Danielle Posthuma, Simon C Potter, Anneli Pouta, Michael A Province, Bruce M Psaty, Wolfgang Rathmann, Nigel W Rayner, Kenneth Rice, Samuli Ripatti, Fernando Rivadeneira, Michael Roden, Olov Rolandsson, Annelli Sandbaek, Manjinder Sandhu, Serena Sanna, Avan Aihie Sayer, Paul Scheet, Laura J Scott, Udo Seedorf, Stephen J Sharp, Beverley Shields, Gunnar Sigurethsson, Eric J G Sijbrands, Angela Silveira, Laila Simpson, Andrew Singleton, Nicholas L Smith, Ulla Sovio, Amy Swift, Holly Syddall, Ann-Christine Syvänen, Toshiko Tanaka, Barbara Thorand, Jean Tichet, Anke Tönjes, Tiinamaija Tuomi, André G Uitterlinden, Ko Willems van Dijk, Mandy van Hoek, Dhiraj Varma, Sophie Visvikis-Siest, Veronique Vitart, Nicole Vogelzangs, Gérard Waeber, Peter J Wagner, Andrew Walley, G Bragi Walters, Kim L Ward, Hugh Watkins, Michael N Weedon, Sarah H Wild, Gonneke Willemsen, Jaqueline C M Witteman, John W G Yarnell, Eleftheria Zeggini, Diana Zelenika, Björn Zethelius, Guangju Zhai, Jing Hua Zhao, M Carola Zillikens, Ingrid B Borecki, Ruth J F Loos, Pierre Meneton, Patrik K E Magnusson, David M Nathan, Gordon H Williams, Andrew T Hattersley, Kaisa Silander, Veikko Salomaa, George Davey Smith, Stefan R Bornstein, Peter Schwarz, Joachim Spranger, Fredrik Karpe, Alan R Shuldiner, Cyrus Cooper, George V Dedoussis, Manuel Serrano-Ríos, Andrew D Morris, Lars Lind, Lyle J Palmer, Frank B Hu, Paul W Franks, Shah Ebrahim, Michael Marmot, W H Linda Kao, James S Pankow, Michael J Sampson, Johanna Kuusisto, Markku Laakso, Torben Hansen, Oluf Pedersen, Peter Paul Pramstaller, H Erich Wichmann, Thomas Illig, Igor Rudan, Alan F Wright, Michael Stumvoll, Harry Campbell, James F Wilson, Richard N Bergman, Thomas A Buchanan, Francis S Collins, Karen L Mohlke, Jaakko Tuomilehto, Timo T Valle, David Altshuler, Jerome I Rotter, David S Siscovick, Brenda W J H Penninx, Dorret I Boomsma, Panos Deloukas, Timothy D Spector, Timothy M Frayling, Luigi Ferrucci, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson, Cornelia M van Duijn, Yurii S Aulchenko, Antonio Cao, Angelo Scuteri, David Schlessinger, Manuela Uda, Aimo Ruokonen, Marjo-Riitta Jarvelin, Dawn M Waterworth, Peter Vollenweider, Leena Peltonen, Vincent Mooser, Goncalo R Abecasis, Nicholas J Wareham, Robert Sladek, Philippe Froguel, Richard M Watanabe, James B Meigs, Leif Groop, Michael Boehnke, Mark I McCarthy, Jose C Florez, Inês Barros. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature genetics. vol 42. issue 2. 2010-02-17. PMID:20081858. | these include nine loci newly associated with fasting glucose (in or near adcy5, madd, adra2a, cry2, fads1, glis3, slc2a2, prox1 and c2cd4b) and one influencing fasting insulin and homa-ir (near igf1). | 2010-02-17 | 2023-08-12 | human |