| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adam Skeens, Chathuranga Siriwardhana, Sophia E Massinople, Michelle M Wunder, Zachary L Ellis, Kaitlyn M Keith, Tyler Girman, Shelli L Frey, Justin Legleite. The polyglutamine domain is the primary driver of seeding in huntingtin aggregation. PloS one. vol 19. issue 3. 2024-03-14. PMID:38483973. |
huntington's disease (hd) is a fatal, neurodegenerative disease caused by aggregation of the huntingtin protein (htt) with an expanded polyglutamine (polyq) domain into amyloid fibrils. |
2024-03-14 |
2024-03-17 |
caenorhabditis_elegans |
| Franziska Hoschek, Julia Natan, Maximilian Wagner, Kirupa Sathasivam, Alshaimaa Abdelmoez, Björn von Einem, Gillian P Bates, G Bernhard Landwehrmeyer, Andreas Neuede. Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues. Molecular medicine (Cambridge, Mass.). vol 30. issue 1. 2024-03-08. PMID:38459427. |
the disease-causing mutation in huntington disease (hd) is a cag trinucleotide expansion in the huntingtin (htt) gene. |
2024-03-08 |
2024-03-11 |
mouse |
| Karin Dalene Skarping, Larissa Arning, Åsa Petersén, Huu Phuc Nguyen, Samuel Gebre-Medhi. Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome. Scientific reports. vol 14. issue 1. 2024-02-21. PMID:38383663. |
dna mismatch repair (mmr) is thought to contribute to the onset and progression of huntington disease (hd) by promoting somatic expansion of the pathogenic cag nucleotide repeat in the huntingtin gene (htt). |
2024-02-21 |
2024-02-24 |
Not clear |
| Junjiao Wu, Jie Ren, Hongfei Cui, Yali Xie, Yu Tan. Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington's disease. Inflammation and regeneration. vol 44. issue 1. 2024-02-15. PMID:38360694. |
the huntingtin (htt) mutation involves an expanded cag repeat, leading to insoluble polyq, which renders gaba |
2024-02-15 |
2024-02-18 |
human |
| Swamynathan Sowndharya, Koilmani Emmanuvel Raja. Environmental enrichment improves social isolation-induced memory impairment: The possible role of ITSN1-Reelin-AMPA receptor signaling pathway. PloS one. vol 19. issue 1. 2024-01-19. PMID:38241230. |
increased level of intersectin 1 (itsn1), huntingtin (htt), synaptotagmin -iv (syt4), variants of brain-derived neurotrophic factor (bdnf - iii), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptor (glur1) expression, and decreased variants of bdnf (iv), bdnf, reelin, apolipoprotein e receptor 2 (apoer2), very low-density lipoprotein receptor (vldlr), src family tyrosine kinase (sfks), disabled protein (dab)-1, protein kinase b (pkb/akt), glur2, mitogen-activated protein kinase (mapk) and extracellular signal-regulated kinase (erk1/2) expression. |
2024-01-19 |
2024-01-22 |
mouse |
| Francesco D'Egidio, Vanessa Castelli, Giorgia Lombardozzi, Fabrizio Ammannito, Annamaria Cimini, Michele d'Angel. Therapeutic advances in neural regeneration for Huntington's disease. Neural regeneration research. vol 19. issue 9. 2024-01-16. PMID:38227527. |
huntington's disease is a neurodegenerative disease caused by the expansion mutation of a cytosine-adenine-guanine triplet in the exon 1 of the htt gene which is responsible for the production of the huntingtin (htt) protein. |
2024-01-16 |
2024-01-18 |
Not clear |
| Nicholas S Caron, Amirah E-E Aly, Hailey Findlay Black, Dale D O Martin, Mandi E Schmidt, Seunghyun Ko, Christine Anderson, Emily M Harvey, Lorenzo L Casal, Lisa M Anderson, Seyed M R Rahavi, Gregor S D Reid, Michael N Oda, Danica Stanimirovic, Abedelnasser Abulrob, Jodi L McBride, Blair R Leavitt, Michael R Hayde. Systemic delivery of mutant huntingtin lowering antisense oligonucleotides to the brain using apolipoprotein A-I nanodisks for Huntington disease. Journal of controlled release : official journal of the Controlled Release Society. 2024-01-12. PMID:38215984. |
huntington disease (hd) is a dominantly inherited neurodegenerative disorder caused by a cag trinucleotide expansion mutation in the htt gene which codes for a toxic mutant huntingtin (mhtt) protein. |
2024-01-12 |
2024-01-15 |
mouse |
| Elsa C Kuijper, Maurice Overzier, Ernst Suidgeest, Oleh Dzyubachyk, Cecile Maguin, Jean-Baptiste Pérot, Julien Flament, Yavuz Ariyurek, Hailiang Mei, Ronald A M Buijsen, Louise van der Weerd, Willeke van Roon-Mo. Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice. Neurobiology of disease. 2023-12-01. PMID:38040383. |
in huntington disease, cellular toxicity is particularly caused by toxic protein fragments generated from the mutant huntingtin (htt) protein. |
2023-12-01 |
2023-12-10 |
mouse |
| Himanshi Gupta, Shakti Sah. High-throughput virtual screening of potential inhibitors of GPR52 using docking and biased sampling method for Huntington's disease therapy. Molecular diversity. 2023-12-01. PMID:38038795. |
huntington's disease (hd) is a rare and progressive neurodegenerative disorder caused by polyglutamine (poly-q) mutations of the huntingtin (htt) gene resulting in chorea, cognitive, and psychiatric dysfunctions. |
2023-12-01 |
2023-12-10 |
Not clear |
| Hong Zhang, Si Wu, Laura S Itzhaki, Sarah Perret. Interaction between Huntingtin exon 1 and HEAT repeat structure probed by chimeric model proteins. Protein science : a publication of the Protein Society. 2023-10-19. PMID:37853955. |
huntington disease (hd) is associated with aggregation of huntingtin (htt) protein containing over 35 continuous q residues within the n-terminal exon 1 encoded region. |
2023-10-19 |
2023-11-08 |
Not clear |
| Adela G Buciuc, Paula Traugott, Carlos R Dange. An Unusual Presentation of Serotonin Syndrome and Subsequent Catatonia in a Patient With a Family History of Huntington's Disease. Cureus. vol 15. issue 9. 2023-09-18. PMID:37720123. |
malignant catatonia's underlying pathophysiological mechanisms are poorly understood, but it is clinically difficult to distinguish it from nms. huntington's disease (hd) is an autosomal dominant neurodegenerative disorder characterized by cag expansion in exon 1 of the huntingtin (htt) gene. |
2023-09-18 |
2023-10-07 |
Not clear |
| Huichun Tong, Tianqi Yang, Li Liu, Caijuan Li, Yize Sun, Qingqing Jia, Yiyang Qin, Laiqiang Chen, Xianxian Zhao, Gongke Zhou, Sen Yan, Xiao-Jiang Li, Shihua L. Aberrant splicing of mutant huntingtin in Huntington's disease knock-in pigs. Neurobiology of disease. 2023-09-16. PMID:37716514. |
huntington's disease (hd) is an autosomal-dominant inherited neurodegenerative disease caused by a cag repeat expansion in exon1 of the huntingtin gene (htt). |
2023-09-16 |
2023-10-07 |
mouse |
| Costanza Ferrari Bardile, Carola I Radulescu, Mahmoud A Poulad. Oligodendrocyte pathology in Huntington's disease: from mechanisms to therapeutics. Trends in molecular medicine. 2023-08-17. PMID:37591764. |
there is new recognition of the role of olgs in the pathogenesis of neurodegenerative diseases (ndds), including huntington's disease (hd), a prototypic ndd caused by a polyglutamine tract expansion in huntingtin (htt), which results in gain- and loss-of-function effects. |
2023-08-17 |
2023-09-07 |
Not clear |
| Sitong Yang, Jingjing Ma, Han Zhang, Laiqiang Chen, Yuxuan Li, Mingtian Pan, Hongcheng Zhu, Jun Liang, Dajian He, Shihua Li, Xiao-Jiang Li, Xiangyu Gu. Mutant HTT does not affect glial development but impairs myelination in the early disease stage. Frontiers in neuroscience. vol 17. 2023-08-04. PMID:37539389. |
huntington's disease (hd) is caused by expanded cag repeats in the huntingtin gene (htt) and is characterized by late-onset neurodegeneration that primarily affects the striatum. |
2023-08-04 |
2023-08-14 |
Not clear |
| Hélène Vitet, Julie Bruyère, Hao Xu, Claire Séris, Jacques Brocard, Yah-Se Abada, Benoît Delatour, Chiara Scaramuzzino, Laurent Venance, Frédéric Saudo. Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning. eLife. vol 12. 2023-07-11. PMID:37431882. |
here, studying the corticostriatal network both in microfluidic devices and in mice, we find that phosphorylation of the huntingtin protein (htt) increases axonal transport of svps and synaptic glutamate release by recruiting the kinesin motor kif1a. |
2023-07-11 |
2023-08-14 |
mouse |
| Jeremy M Van Raamsdonk, Hilal H Al-Shekaili, Laura Wagner, Tim W Bredy, Laura Chan, Jacqueline Pearson, Claudia Schwab, Zoe Murphy, Rebecca S Devon, Ge Lu, Michael S Kobor, Michael R Hayden, Blair R Leavit. Huntingtin Decreases Susceptibility to a Spontaneous Seizure Disorder in FVN/B Mice. Aging and disease. 2023-05-18. PMID:37199581. |
huntington disease (hd) is an adult-onset neurodegenerative disorder that is caused by a trinucleotide cag repeat expansion in the htt gene that codes for the protein huntingtin (htt in humans or htt in mice). |
2023-05-18 |
2023-08-14 |
mouse |
| Alyssa R Stonebraker, Maryssa Beasley, Sophia Massinople, Michelle Wunder, Peng Li, Stephen J Valentine, Justin Legleite. Cholesterol impacts the formation of huntingtin/lipid complexes and subsequent aggregation. Protein science : a publication of the Protein Society. 2023-04-13. PMID:37052951. |
huntington's disease (hd) is a neurodegenerative disease resulting from an expansion of the polyglutamine (polyq) domain within the huntingtin protein (htt). |
2023-04-13 |
2023-08-14 |
Not clear |
| Raffaella Bonavita, Gianluca Scerra, Rosaria Di Martino, Silvia Nuzzo, Elena Polishchuk, Mariagrazia Di Gennaro, Sarah V Williams, Maria Gabriella Caporaso, Carmen Caiazza, Roman Polishchuk, Massimo D'Agostino, Angeleen Fleming, Maurizio Renn. The HSPB1-p62/SQSTM1 functional complex regulates the unconventional secretion and transcellular spreading of the HD-associated mutant huntingtin protein. Human molecular genetics. 2023-03-27. PMID:36971475. |
huntington disease (hd) has autosomal dominant inheritance and is caused by mutations leading to an abnormal expansion in the polyglutamine (polyq) tract of the huntingtin (htt) protein, leading to the formation of htt inclusion bodies in neurons of affected patients. |
2023-03-27 |
2023-08-14 |
Not clear |
| Kizito-Tshitoko Tshilenge, Carlos Galicia Aguirre, Joanna Bons, Akos A Gerencser, Nathan Basisty, Sicheng Song, Jacob Rose, Alejandro Lopez-Ramirez, Swati Naphade, Ashley Loureiro, Elena Battistoni, Mateus Milani, Cameron Wehrfritz, Anja Holtz, Claudio Hetz, Sean D Mooney, Birgit Schilling, Lisa M Ellerb. Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets. Molecular & cellular proteomics : MCP. 2023-03-23. PMID:36958627. |
huntington's disease (hd) is a neurodegenerative disease caused by a cag repeat expansion in the huntingtin (htt) gene. |
2023-03-23 |
2023-08-14 |
human |
| Christiana C Christodoulou, Eleni Zamba Papanicolao. Integrated Bioinformatics Analysis of Shared Genes, miRNA, Biological Pathways and Their Potential Role as Therapeutic Targets in Huntington's Disease Stages. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902304. |
huntington's disease (hd) is a progressive neurodegenerative disease caused by cag repeat expansion in the huntingtin gene (htt). |
2023-03-11 |
2023-08-14 |
Not clear |