| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christiana C Christodoulou, Eleni Zamba Papanicolao. Integrated Bioinformatics Analysis of Shared Genes, miRNA, Biological Pathways and Their Potential Role as Therapeutic Targets in Huntington's Disease Stages. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902304. |
huntington's disease (hd) is a progressive neurodegenerative disease caused by cag repeat expansion in the huntingtin gene (htt). |
2023-03-11 |
2023-08-14 |
Not clear |
| Baljit S Khakh, Steven A Goldma. Astrocytic contributions to Huntington's disease pathophysiology. Annals of the New York Academy of Sciences. 2023-03-02. PMID:36864567. |
huntington's disease (hd) is a fatal, monogenic, autosomal dominant neurodegenerative disease caused by a polyglutamine-encoding cag expansion in the huntingtin (htt) gene that results in mutant huntingtin proteins (mhtt) in cells throughout the body. |
2023-03-02 |
2023-08-14 |
mouse |
| Noria Okada, Shinsuke Nakamura, Masamitsu Shimazaw. 3-Nitropropionic Acid Enhances Ferroptotic Cell Death via NOX2-Mediated ROS Generation in STHdhQ111 Striatal Cells Carrying Mutant Huntingtin. Biological & pharmaceutical bulletin. vol 46. issue 2. 2023-02-01. PMID:36724946. |
huntington's disease (hd) is a hereditary neurodegenerative disease that involves an expansion of the cag repeats of the huntingtin (htt) gene, but the disease onset and progression do not necessarily correspond to the extent of cag repeats. |
2023-02-01 |
2023-08-14 |
mouse |
| Tariq O Faquih, N Ahmad Aziz, Sarah L Gardiner, Ruifang Li-Gao, Renée de Mutsert, Yuri Milaneschi, Stella Trompet, J Wouter Jukema, Frits R Rosendaal, Astrid Hylckama Vlieg, Ko Willems Dijk, Dennis O Mook-Kanamor. Normal range CAG repeat size variations in the HTT gene are associated with an adverse lipoprotein profile partially mediated by body mass index. Human molecular genetics. 2023-01-30. PMID:36715614. |
tandem cag repeat sizes of 36 or more in the huntingtin gene (htt) cause huntington disease. |
2023-01-30 |
2023-08-14 |
Not clear |
| Sirui Zhang, Yangfan Cheng, Huifang Shan. The updated development of blood-based biomarkers for Huntington's disease. Journal of neurology. 2023-01-24. PMID:36692635. |
huntington's disease is a progressive neurodegenerative disease caused by mutation of the huntingtin (htt) gene. |
2023-01-24 |
2023-08-14 |
Not clear |
| Andrea E Murmann, Monal Patel, Si-Yeon Jeong, Elizabeth T Bartom, A Jennifer Morton, Marcus E Pete. The length of uninterrupted CAG repeats in stem regions of repeat disease associated hairpins determines the amount of short CAG oligonucleotides that are toxic to cells through RNA interference. Cell death & disease. vol 13. issue 12. 2022-12-30. PMID:36585400. |
extended cag trinucleotide repeats (tnr) in the genes huntingtin (htt) and androgen receptor (ar) are the cause of two progressive neurodegenerative disorders: huntington's disease (hd) and spinal and bulbar muscular atrophy (sbma), respectively. |
2022-12-30 |
2023-08-14 |
Not clear |
| Elna Dickson, Amoolya Sai Dwijesha, Natalie Andersson, Sofia Lundh, Maria Björkqvist, Åsa Petersén, Rana Soylu-Kuchar. Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models. Frontiers in neuroscience. vol 16. 2022-11-21. PMID:36408416. |
structural changes and neuropathology in the hypothalamus have been suggested to contribute to the non-motor manifestations of huntington's disease (hd), a neurodegenerative disorder caused by an expanded cytosine-adenine-guanine (cag) repeat in the huntingtin (htt) gene. |
2022-11-21 |
2023-08-14 |
mouse |
| Hyuck Kim, Rocio Gomez-Pasto. HSF1 and Its Role in Huntington's Disease Pathology. Advances in experimental medicine and biology. 2022-11-17. PMID:36396925. |
this review focuses on huntington's disease (hd), a neurodegenerative disease characterized by severe protein aggregation of the huntingtin (htt) protein. |
2022-11-17 |
2023-08-14 |
Not clear |
| Sophie Lenoir, Romane A Lahaye, Hélène Vitet, Chiara Scaramuzzino, Amandine Virlogeux, Laetitia Capellano, Aurélie Genoux, Noga Gershoni-Emek, Michal Geva, Michael R Hayden, Frédéric Saudo. Pridopidine rescues BDNF/TrkB trafficking dynamics and synapse homeostasis in a Huntington disease brain-on-a-chip model. Neurobiology of disease. 2022-09-08. PMID:36075537. |
huntington disease (hd) is a neurodegenerative disorder caused by polyglutamine-encoding cag repeat expansion in the huntingtin (htt) gene. |
2022-09-08 |
2023-08-14 |
mouse |
| Meghna Dabur, Joana Angélica Loureiro, Maria Carmo Pereir. The current state of amyloidosis therapeutics and the potential role of fluorine in their treatment. Biochimie. 2022-08-13. PMID:35963462. |
in this study, we revised and emphasized the possible significance of fluorine-modified therapeutic molecules and fluorine-modified nanoparticles (nps) in the modulation of amyloidogenic proteins, including insulin, amyloid beta peptide (aβ), prion protein (prp), transthyretin (ttr) and huntingtin (htt). |
2022-08-13 |
2023-08-14 |
Not clear |
| S M Ayala Mariscal, M L Pigazzini, Y Richter, M Özel, I L Grothaus, J Protze, K Ziege, M Kulke, M ElBediwi, J V Vermaas, L Colombi Ciacchi, S Köppen, F Liu, J Kirstei. Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT. Nature communications. vol 13. issue 1. 2022-08-10. PMID:35948542. |
huntington's disease is a neurodegenerative disease caused by an expanded polyq stretch within huntingtin (htt) that renders the protein aggregation-prone, ultimately resulting in the formation of amyloid fibrils. |
2022-08-10 |
2023-08-14 |
Not clear |
| Elena V Grigor'eva, Anastasia A Malakhova, Diana A Sorogina, Sofia V Pavlova, Tuyana B Malankhanova, Natalia Yu Abramycheva, Sergey A Klyushnikov, Sergey N Illarioshkin, Suren M Zakia. Generation of induced pluripotent stem cell line, ICGi033-A, by reprogramming peripheral blood mononuclear cells from a patient with Huntington's disease. Stem cell research. vol 63. 2022-07-25. PMID:35872525. |
huntington's disease (hd) is a hereditary autosomal dominant neurodegenerative disease caused by the polyglutamine stretch expansion in the huntingtin (htt) protein. |
2022-07-25 |
2023-08-14 |
Not clear |
| Sonia Podvin, Sara Brin Rosenthal, William Poon, Enlin Wei, Kathleen M Fisch, Vivian Hoo. Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington's Disease. Journal of Huntington's disease. 2022-07-24. PMID:35871359. |
huntington's disease (hd) is a genetic neurodegenerative disease caused by trinucleotide repeat (cag) expansions in the human htt gene encoding the huntingtin protein (htt) with an expanded polyglutamine tract. |
2022-07-24 |
2023-08-14 |
human |
| Sandra Fienko, Christian Landles, Kirupa Sathasivam, Sean J McAteer, Rebecca E Milton, Georgina F Osborne, Edward J Smith, Samuel T Jones, Marie K Bondulich, Emily C E Danby, Jemima Phillips, Bridget A Taxy, Holly B Kordasiewicz, Gillian P Bate. Alternative processing of human HTT mRNA with implications for Huntington's disease therapeutics. Brain : a journal of neurology. 2022-07-06. PMID:35793238. |
huntington disease is caused by a cag repeat expansion in exon 1 of the huntingtin gene (htt) that is translated into a polyglutamine stretch in the huntingtin protein (htt). |
2022-07-06 |
2023-08-14 |
mouse |
| Junsheng Yang, Huilin Xu, Chaoyue Zhang, Xiaotong Yang, Weijie Cai, Xiaoli Che. A prion-like domain of TFEB mediates the co-aggregation of TFEB and mHTT. Autophagy. 2022-05-31. PMID:35635192. |
the aggregation of mutant htt (huntingtin; mhtt) is a hallmark of huntington disease (hd). |
2022-05-31 |
2023-08-13 |
Not clear |
| Yiyang Qin, Shihua Li, Xiao-Jiang Li, Su Yan. CRISPR-Based Genome-Editing Tools for Huntington's Disease Research and Therapy. Neuroscience bulletin. 2022-05-24. PMID:35608753. |
huntington's disease (hd) is an autosomal dominantly-inherited neurodegenerative disease, which is caused by cag trinucleotide expansion in exon 1 of the huntingtin (htt) gene. |
2022-05-24 |
2023-08-13 |
Not clear |
| Richard A Hickman, Phyllis L Faust, Karen Marder, Ai Yamamoto, Jean-Paul Vonsatte. The distribution and density of Huntingtin inclusions across the Huntington disease neocortex: regional correlations with Huntingtin repeat expansion independent of pathologic grade. Acta neuropathologica communications. vol 10. issue 1. 2022-04-20. PMID:35440014. |
huntington disease is characterized by progressive neurodegeneration, especially of the striatum, and the presence of polyglutamine huntingtin (htt) inclusions. |
2022-04-20 |
2023-08-13 |
human |
| E Srinivasan, Vavish Ram, R Rajasekara. A review on Huntington protein Insight into protein aggregation and therapeutic interventions. Current drug metabolism. 2022-03-23. PMID:35319359. |
mutation in huntingtin (htt) protein has been suggested to cause neuron loss in the cortex and striatum through various mechanisms including abnormal regulation of transcription, proteasomal dysfunction, post-translational modification, and other events, regulating toxicity. |
2022-03-23 |
2023-08-13 |
Not clear |
| Morgan E Rook, Amber L Southwel. Antisense Oligonucleotide Therapy: From Design to the Huntington Disease Clinic. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 2022-03-07. PMID:35254632. |
huntington disease (hd) is a fatal progressive neurodegenerative disorder caused by an inherited mutation in the huntingtin (htt) gene, which encodes mutant htt protein. |
2022-03-07 |
2023-08-13 |
human |
| Todd M Greco, Christopher Secker, Eduardo Silva Ramos, Joel D Federspiel, Jeh-Ping Liu, Alma M Perez, Ismael Al-Ramahi, Jeffrey P Cantle, Jeffrey B Carroll, Juan Botas, Scott O Zeitlin, Erich E Wanker, Ileana M Criste. Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease. Cell systems. 2022-02-12. PMID:35148841. |
huntington disease (hd) is a monogenic neurodegenerative disorder with one causative gene, huntingtin (htt). |
2022-02-12 |
2023-08-13 |
mouse |