| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heather Dahlenburg, David Cameron, Sheng Yang, Angelica Bachman, Kari Pollock, Whitney Cary, Missy Pham, Kyle Hendrix, Jeannine White, Haley Nelson, Peter Deng, Joseph S Anderson, Kyle Fink, Jan Nolt. A novel Huntington's disease mouse model to assess the role of neuroinflammation on disease progression and to develop human cell therapies. Stem cells translational medicine. vol 10. issue 7. 2021-07-01. PMID:33710799. |
huntington's disease (hd) is a fatal autosomal-dominant neurodegenerative disease caused by a trinucleotide cag repeat expansion of the huntingtin gene (htt) that affects 1 in every 10 000 individuals in the united states. |
2021-07-01 |
2023-08-13 |
mouse |
| Sarah J Tabrizi, Michael D Flower, Christopher A Ross, Edward J Wil. Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities. Nature reviews. Neurology. vol 16. issue 10. 2021-06-24. PMID:32796930. |
huntington disease (hd) is a neurodegenerative disease caused by cag repeat expansion in the huntingtin gene (htt) and involves a complex web of pathogenic mechanisms. |
2021-06-24 |
2023-08-13 |
human |
| Chia-Lung Chuang, Fabio Demonti. Systemic manifestation and contribution of peripheral tissues to Huntington's disease pathogenesis. Ageing research reviews. vol 69. 2021-06-24. PMID:33979693. |
huntington disease (hd) is an autosomal dominant neurodegenerative disease that is caused by expansion of cytosine/adenosine/guanine repeats in the huntingtin (htt) gene, which leads to a toxic, aggregation-prone, mutant htt-polyq protein. |
2021-06-24 |
2023-08-13 |
Not clear |
| Leora Fox, Ai Yamamot. Examining aggregates through the eyes of WDFY3/Alfy. Autophagy. vol 16. issue 5. 2021-06-07. PMID:32150493. |
in this autophagic punctum, we discuss our recent findings of how the selectivity scaffold/adaptor wdfy3/alfy is required for the turnover of aggregated mutant htt (huntingtin; mhtt) in the adult brain, and how it confers resistance to huntington disease (hd)-like symptoms. |
2021-06-07 |
2023-08-13 |
mouse |
| Ronald Wetze. Exploding the Repeat Length Paradigm while Exploring Amyloid Toxicity in Huntington's Disease. Accounts of chemical research. vol 53. issue 10. 2021-06-01. PMID:32975927. |
huntington's disease (hd) is a progressive, familial neurodegenerative disease triggered by the expansion of a polyglutamine (polyq) track in the protein huntingtin (htt). |
2021-06-01 |
2023-08-13 |
Not clear |
| Sandra Franco-Iborra, Ainhoa Plaza-Zabala, Marta Montpeyo, David Sebastian, Miquel Vila, Marta Martinez-Vicent. Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease. Autophagy. vol 17. issue 3. 2021-05-25. PMID:32093570. |
mutant htt (huntingtin) impairs mitophagy in a cellular model of huntington disease. |
2021-05-25 |
2023-08-13 |
Not clear |
| Niels Henning Skotte, Mahmoud A Pouladi, Dagmar E Ehrnhoefer, Katie Huynh, Xiaofan Qiu, Signe Marie Borch Nielsen, Troels Tolstrup Nielsen, Anne Nørremølle, Michael R Hayde. Compromised IGF signaling causes caspase-6 activation in Huntington disease. Experimental neurology. vol 332. 2021-03-09. PMID:32622701. |
huntington disease (hd) is an autosomal dominant neurodegenerative disorder caused by an expansion of a polyglutamine repeat in the huntingtin (htt) protein. |
2021-03-09 |
2023-08-13 |
mouse |
| Harleen Kohli, Pravir Kumar, Rashmi K Ambast. Heliyon. vol 7. issue 2. 2021-03-05. PMID:33659724. |
huntington's disease is a neurodegenerative disease caused by cag repeat in the first exon of htt (huntingtin) gene, leading to abnormal form of htt protein containing enlarged polyglutamine strands of variable length that stick together to form aggregates and is toxic to brain causing brain damage. |
2021-03-05 |
2023-08-13 |
Not clear |
| Faezeh Sedighi, Adewale Adegbuyiro, Justin Legleite. SUMOylation Prevents Huntingtin Fibrillization and Localization onto Lipid Membranes. ACS chemical neuroscience. vol 11. issue 3. 2021-03-03. PMID:31880908. |
huntington's disease (hd), a genetic neurodegenerative disease, is caused by an expanded polyglutamine (polyq) domain in the first exon of the huntingtin protein (htt). |
2021-03-03 |
2023-08-13 |
Not clear |
| Blair R Leavitt, Holly B Kordasiewicz, Scott A Schobe. Huntingtin-Lowering Therapies for Huntington Disease: A Review of the Evidence of Potential Benefits and Risks. JAMA neurology. vol 77. issue 6. 2021-02-17. PMID:32202594. |
huntington disease (hd) is caused by a cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin gene, htt, that results in expression of variant (mutant) huntingtin protein (htt). |
2021-02-17 |
2023-08-13 |
mouse |
| Chun-Lun Ni, Divya Seth, Fabio Vasconcelos Fonseca, Liwen Wang, Tsan Sam Xiao, Phillip Gruber, Man-Sun Sy, Jonathan S Stamler, Alan M Tartakof. Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1. PloS one. vol 11. issue 9. 2021-01-13. PMID:27658206. |
expansion of the polyglutamine (polyq) tract in the huntingtin (htt) protein causes huntington's disease (hd), a fatal inherited movement disorder linked to neurodegeneration in the striatum and cortex. |
2021-01-13 |
2023-08-13 |
Not clear |
| Robyn L McAdam, Andrew Morton, Sarah L Gordon, Julia F Alterman, Anastasia Khvorova, Michael A Cousin, Karen J Smilli. Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the htt Neurobiology of disease. vol 134. 2021-01-13. PMID:31614197. |
loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the htt huntington's disease (hd) is caused by cag repeat expansion within the htt gene, with the dysfunction and eventual loss of striatal medium spiny neurons a notable feature. |
2021-01-13 |
2023-08-13 |
mouse |
| Robyn L McAdam, Andrew Morton, Sarah L Gordon, Julia F Alterman, Anastasia Khvorova, Michael A Cousin, Karen J Smilli. Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the htt Neurobiology of disease. vol 134. 2021-01-13. PMID:31614197. |
to test this hypothesis, primary cultures of either hippocampal or striatal neurons were prepared from either wild-type mice or a knock-in hd mouse model which contains 140 poly-glutamine repeats in the huntingtin protein (htt |
2021-01-13 |
2023-08-13 |
mouse |
| Ivó H Hernández, Jorge R Cabrera, María Santos-Galindo, Manuel Sánchez-Martín, Verónica Domínguez, Ramón García-Escudero, María J Pérez-Álvarez, Belén Pintado, José J Luca. Pathogenic SREK1 decrease in Huntington's disease lowers TAF1 mimicking X-linked dystonia parkinsonism. Brain : a journal of neurology. vol 143. issue 7. 2020-12-30. PMID:32533168. |
huntington's disease is caused by a polyglutamine-encoding cag repeat expansion in the huntingtin (htt) gene leading to several toxic interactions of both the expanded cag-containing mrna and the polyglutamine-containing protein, while x-linked dystonia parkinsonism is caused by a retrotransposon insertion in the taf1 gene, which decreases expression of this core scaffold of the basal transcription factor complex tfiid. |
2020-12-30 |
2023-08-13 |
mouse |
| Nivethitha Manickam, Risna Kanjirassery Radhakrishnan, Jemi Feiona Vergil Andrews, Divya Bharathi Selvaraj, Mahesh Kandasam. Cell cycle re-entry of neurons and reactive neuroblastosis in Huntington's disease: Possibilities for neural-glial transition in the brain. Life sciences. vol 263. 2020-12-30. PMID:33049278. |
the abnormal expansion of the cag repeats in the exon 1 of the huntingtin gene (htt gene) has been associated with the onset and progression of movement disorders, psychiatric disturbance and cognitive decline in hd. |
2020-12-30 |
2023-08-13 |
human |
| Andrea Gallardo-Orihuela, Irati Hervás-Corpión, Carmen Hierro-Bujalance, Daniel Sanchez-Sotano, Gema Jiménez-Gómez, Francisco Mora-López, Antonio Campos-Caro, Monica Garcia-Alloza, Luis M Valo. Transcriptional correlates of the pathological phenotype in a Huntington's disease mouse model. Scientific reports. vol 9. issue 1. 2020-11-23. PMID:31822756. |
huntington disease (hd) is a fatal neurodegenerative disorder without a cure that is caused by an aberrant expansion of cag repeats in exon 1 of the huntingtin (htt) gene. |
2020-11-23 |
2023-08-13 |
mouse |
| Mingjue Zhao, Felicia Siew Hong Cheah, Arnold Sia Chye Tan, Mulias Lian, Gui Ping Phang, Anupriya Agarwal, Samuel S Chon. Robust Preimplantation Genetic Testing of Huntington Disease by Combined Triplet-Primed PCR Analysis of the HTT CAG Repeat and Multi-Microsatellite Haplotyping. Scientific reports. vol 9. issue 1. 2020-11-04. PMID:31712634. |
huntington disease (hd) is a lethal neurodegenerative disorder caused by expansion of a cag repeat within the huntingtin (htt) gene. |
2020-11-04 |
2023-08-13 |
Not clear |
| Yu-Hsien Lin, Houda Ouns Maaroufi, Emad Ibrahim, Lucie Kucerova, Michal Zurove. Expression of Human Mutant Huntingtin Protein in Frontiers in immunology. vol 10. 2020-10-29. PMID:31681295. |
expression of human mutant huntingtin protein in the pathogenic effect of mutant htt (mhtt) which causes huntington disease (hd) are not restricted to nervous system. |
2020-10-29 |
2023-08-13 |
human |
| Endan Li, Hee Ra Park, Chang Pyo Hong, Younghoon Kim, Jiwoo Choi, Suji Lee, Hyun Jung Park, Bomi Lee, Tae Aug Kim, Seong Jin Kim, Hyun Sook Kim, Jihwan Son. Neural stem cells derived from the developing forebrain of YAC128 mice exhibit pathological features of Huntington's disease. Cell proliferation. vol 53. issue 10. 2020-10-29. PMID:32865873. |
huntington's disease (hd) is a devastating neurodegenerative disease caused by polyglutamine (polyq) expansion in the huntingtin (htt) gene. |
2020-10-29 |
2023-08-13 |
mouse |
| Qiong Liu, Siying Cheng, Huiming Yang, Louyin Zhu, Yongcheng Pan, Liang Jing, Beisha Tang, Shihua Li, Xiao-Jiang L. Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 33. 2020-10-06. PMID:32747555. |
huntington disease (hd) is an ideal model for investigating selective neurodegeneration, as expanded polyq repeats in the ubiquitously expressed huntingtin (htt) cause the preferential neurodegeneration in the striatum of the hd patient brains. |
2020-10-06 |
2023-08-13 |
mouse |