| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mandi E Schmidt, Caodu Buren, James P Mackay, Daphne Cheung, Louisa Dal Cengio, Lynn A Raymond, Michael R Hayde. Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease. BMC biology. vol 16. issue 1. 2019-05-13. PMID:29945611. |
huntington disease (hd) is a fatal neurodegenerative disorder caused by a cag expansion in the huntingtin (htt) gene, leading to selective and progressive neuronal death predominantly in the striatum. |
2019-05-13 |
2023-08-13 |
mouse |
| Paulina Jędrak, Paweł Mozolewski, Grzegorz Węgrzyn, Mariusz R Więckowsk. Mitochondrial alterations accompanied by oxidative stress conditions in skin fibroblasts of Huntington's disease patients. Metabolic brain disease. vol 33. issue 6. 2019-05-13. PMID:30120672. |
huntington disease (hd) is an autosomal dominant neurodegenerative disorder manifesting as progressive impairment of motor function and different neuropsychiatric symptoms caused by an expansion of cag repeats in huntingtin gene (htt). |
2019-05-13 |
2023-08-13 |
Not clear |
| Tanut Kunkanjanawan, Richard Carter, Kwan-Sung Ahn, Jinjing Yang, Rangsun Parnpai, Anthony W S Cha. Induced Pluripotent HD Monkey Stem Cells Derived Neural Cells for Drug Discovery. SLAS discovery : advancing life sciences R & D. vol 22. issue 6. 2019-02-21. PMID:28027448. |
huntington's disease (hd) is a neurodegenerative disease caused by an expansion of cag trinucleotide repeat (polyglutamine [polyq]) in the huntingtin ( htt) gene, which leads to the formation of mutant htt (mhtt) protein aggregates. |
2019-02-21 |
2023-08-13 |
monkey |
| Kalina Wiatr, Wojciech J Szlachcic, Marta Trzeciak, Marek Figlerowicz, Maciej Figie. Huntington Disease as a Neurodevelopmental Disorder and Early Signs of the Disease in Stem Cells. Molecular neurobiology. vol 55. issue 4. 2019-02-04. PMID:28497201. |
huntington disease (hd) is a dominantly inherited disorder caused by a cag expansion mutation in the huntingtin (htt) gene, which results in the htt protein that contains an expanded polyglutamine tract. |
2019-02-04 |
2023-08-13 |
Not clear |
| b' Daniela Vidinsk\\xc3\\xa1, Petra Vochozkov\\xc3\\xa1, Petra \\xc5\\xa0matl\\xc3\\xadkov\\xc3\\xa1, Taras Ardan, Ji\\xc5\\x99\\xc3\\xad Kl\\xc3\\xadma, \\xc5\\xa0tefan Juh\\xc3\\xa1s, Jana Juh\\xc3\\xa1sov\\xc3\\xa1, Bo\\xc5\\xbeena Bohuslavov\\xc3\\xa1, Monika Baxa, Ivona Valekov\\xc3\\xa1, Jan Motl\\xc3\\xadk, Zdenka Ellederov\\xc3\\xa. Gradual Phenotype Development in Huntington Disease Transgenic Minipig Model at 24 Months of Age. Neuro-degenerative diseases. vol 18. issue 2-3. 2019-01-30. PMID:29870995.' |
huntington disease (hd) is an incurable neurodegenerative disease caused by the expansion of a polyglutamine sequence in a gene encoding the huntingtin (htt) protein, which is expressed in almost all cells of the body. |
2019-01-30 |
2023-08-13 |
Not clear |
| Wan Song, Nóra Zsindely, Anikó Faragó, J Lawrence Marsh, László Boda. Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease. Human molecular genetics. vol 27. issue 4. 2019-01-07. PMID:29281014. |
huntington's disease (hd) is a dominantly inherited neurodegenerative disease caused by alterations in the huntingtin gene (htt). |
2019-01-07 |
2023-08-13 |
drosophila_melanogaster |
| Arianna Novati, Libo Yu-Taeger, Irene Gonzalez Menendez, Leticia Quintanilla Martinez, Huu Phuc Nguye. Sexual behavior and testis morphology in the BACHD rat model. PloS one. vol 13. issue 6. 2018-12-11. PMID:29883458. |
huntington disease (hd) is an autosomal dominant neurodegenerative disorder caused by a mutation in the huntingtin (htt) gene, which results in brain neurodegeneration and peripheral pathology affecting different organs including testis. |
2018-12-11 |
2023-08-13 |
human |
| Ching-Chi Chang, Tzu-Chin Lin, Hsiao-Li Ho, Chien-Yin Kuo, Hsin-Hua Li, Tatiana A Korolenko, Wei-Jen Chen, Te-Jen Lai, Ying-Jui Ho, Chih-Li Li. GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling. International journal of molecular sciences. vol 19. issue 9. 2018-12-11. PMID:30149534. |
huntington's disease (hd) is a progressive and fatal neurodegenerative disease caused by cag repeat expansion in the coding region of huntingtin (htt) protein. |
2018-12-11 |
2023-08-13 |
Not clear |
| Chaohua Peng, Gaochun Zhu, Xiangqian Liu, He L. Mutant Huntingtin Causes a Selective Decrease in the Expression of Synaptic Vesicle Protein 2C. Neuroscience bulletin. vol 34. issue 5. 2018-11-06. PMID:29713895. |
huntington's disease (hd) is a neurodegenerative disease caused by a polyglutamine expansion in the huntingtin (htt) protein. |
2018-11-06 |
2023-08-13 |
mouse |
| Xiaoyu Dong, Shuyan Con. Bioinformatic analysis of microRNA expression in Huntington's disease. Molecular medicine reports. vol 18. issue 3. 2018-10-26. PMID:30015953. |
huntington's disease (hd) is an inherited, progressive neurodegenerative disease caused by a cag expansion in the huntingtin (htt) gene and various dysfunctions of biological processes in hd have been proposed. |
2018-10-26 |
2023-08-13 |
Not clear |
| Andreas Reif, Anass Chiki, Jonathan Ricci, Hilal A Lashue. Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy. Journal of visualized experiments : JoVE. issue 136. 2018-09-10. PMID:30010666. |
huntington's disease (hd) is an inherited fatal neurodegenerative disease caused by a cag expansion (≥36) in the first exon of the hd gene, resulting in the expression of the huntingtin protein (htt) or n-terminal fragments thereof with an expanded polyglutamine (polyq) stretch. |
2018-09-10 |
2023-08-13 |
Not clear |
| Kuo-Hsuan Chang, Yih-Ru Wu, Chiung-Mei Che. Down-regulation of miR-9* in the peripheral leukocytes of Huntington's disease patients. Orphanet journal of rare diseases. vol 12. issue 1. 2018-09-04. PMID:29258536. |
huntington's disease (hd), caused by expansion of a polyglutamine tract within huntingtin (htt) protein, is an autosomal dominant neurodegenerative disease associated with a progressive neurodegeneration of striatum and cerebral cortex. |
2018-09-04 |
2023-08-13 |
Not clear |
| Zahra Dargaei, Jee Yoon Bang, Vivek Mahadevan, C Sahara Khademullah, Simon Bedard, Gustavo Morrone Parfitt, Jun Chul Kim, Melanie A Woodi. Restoring GABAergic inhibition rescues memory deficits in a Huntington's disease mouse model. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 7. 2018-09-03. PMID:29382760. |
based on proteomic and bioinformatic data linking the huntingtin protein (htt) and kcc2, which is required for hyperpolarizing gabaergic inhibition, and the important role of inhibition in learning and memory, we hypothesized that aberrant kcc2 function contributes to the hippocampal-associated learning and memory deficits in hd. |
2018-09-03 |
2023-08-13 |
mouse |
| Xiaoyu Dong, Shuyan Con. Identification of differentially expressed genes and regulatory relationships in Huntington's disease by bioinformatics analysis. Molecular medicine reports. vol 17. issue 3. 2018-08-16. PMID:29328442. |
huntington's disease (hd) is an inherited, progressive neurodegenerative disease caused by a cag expansion in the huntingtin (htt) gene; various dysfunctions of biological processes in hd have been proposed. |
2018-08-16 |
2023-08-13 |
Not clear |
| Khaled S Abd-Elrahman, Alison Hamilton, Shaunessy R Hutchinson, Fang Liu, Ryan C Russell, Stephen S G Ferguso. mGluR5 antagonism increases autophagy and prevents disease progression in the Science signaling. vol 10. issue 510. 2018-08-02. PMID:29259100. |
mglur5 antagonism increases autophagy and prevents disease progression in the huntington's disease (hd) is a neurodegenerative disease caused by an expansion in the huntingtin protein (also called htt) that induces neuronal cell death with age. |
2018-08-02 |
2023-08-13 |
Not clear |
| Dmitry Perminov, Ludmila Voložonoka, Liene Korņejeva, Evija Jokste-Pțmane, Arita Blumberga, Sandra Krasucka, Nellija Seimuškina, Irina Kovaļova, Violeta Fodin. First preimplantation genetic testing case for monogenic disease in Latvia. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 33. issue sup1. 2018-07-31. PMID:29264979. |
huntington's disease (hd) is fatal neurodegenerative disease caused by a (cag) triplet repeat expansion in the huntingtin (htt) gene. |
2018-07-31 |
2023-08-13 |
Not clear |
| Caitlin S Latimer, Margaret E Flanagan, Patrick J Cimino, Suman Jayadev, Marie Davis, Zachary S Hoffer, Thomas J Montine, Luis F Gonzalez-Cuyar, Thomas D Bird, C Dirk Keen. Neuropathological Comparison of Adult Onset and Juvenile Huntington's Disease with Cerebellar Atrophy: A Report of a Father and Son. Journal of Huntington's disease. vol 6. issue 4. 2018-07-30. PMID:29036832. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by a trinucleotide (cag) repeat expansion in huntingtin (htt) on chromosome 4. |
2018-07-30 |
2023-08-13 |
Not clear |
| Rana Soylu-Kucharz, Barbara Baldo, Åsa Petersé. Metabolic and behavioral effects of mutant huntingtin deletion in Sim1 neurons in the BACHD mouse model of Huntington's disease. Scientific reports. vol 6. 2018-05-31. PMID:27334347. |
hypothalamic pathology, metabolic dysfunction and psychiatric symptoms are part of huntington disease (hd), which is caused by an expanded cag repeat in the huntingtin (htt) gene. |
2018-05-31 |
2023-08-13 |
mouse |
| Mingchen Chen, Peter G Wolyne. Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 17. 2018-05-15. PMID:28400517. |
huntington's disease (hd) is a neurodegenerative disease caused by an abnormal expansion in the polyglutamine (polyq) track of the huntingtin (htt) protein. |
2018-05-15 |
2023-08-13 |
mouse |
| Leili Zhang, Hongsuk Kang, Francisco X Vázquez, Leticia Toledo-Sherman, Binquan Luan, Ruhong Zho. Molecular Mechanism of Stabilizing the Helical Structure of Huntingtin N17 in a Micellar Environment. The journal of physical chemistry. B. vol 121. issue 18. 2018-05-08. PMID:28413881. |
huntington's disease is a deadly neurodegenerative disease caused by the fibrilization of huntingtin (htt) exon-1 protein mutants. |
2018-05-08 |
2023-08-13 |
Not clear |