| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michela Marcatti, Anna Fracassi, Mauro Montalbano, Chandramouli Natarajan, Balaji Krishnan, Rakez Kayed, Giulio Taglialatel. Aβ/tau oligomer interplay at human synapses supports shifting therapeutic targets for Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 79. issue 4. 2022-04-04. PMID:35377002. |
alzheimer's disease (ad) is characterized by progressive cognitive decline due to accumulating synaptic insults by toxic oligomers of amyloid beta (aβo) and tau (tauo). |
2022-04-04 |
2023-08-13 |
human |
| Benita Wiatrak, Paulina Jawień, Agnieszka Matuszewska, Adam Szeląg, Adriana Kubis-Kubia. Effect of amyloid-β on the redox system activity in SH-SY5Y cells preincubated with lipopolysaccharide or co-cultured with microglia cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 149. 2022-04-03. PMID:35367762. |
amyloid deposits and hyperphosphorylation of the tau protein are still believed to be the two main causes of alzheimer's disease. |
2022-04-03 |
2023-08-13 |
Not clear |
| J Winny Yun, Caretia Washington, Joi McCormick, Emily Stevenson, J Steven Alexande. Amyloid Beta Peptides and Th1 Cytokines Modulate Human Brain Vascular Smooth Muscle Tonic Contractile Capacity In Vitro: Relevance to Alzheimer's Disease? Pathophysiology : the official journal of the International Society for Pathophysiology. vol 28. issue 1. 2022-04-02. PMID:35366270. |
alzheimer's disease (ad) is a neurodegenerative condition characterized both by the presence of tau protein neurofibrillary tangles and amyloid beta (aβ) containing extracellular "plaques". |
2022-04-02 |
2023-08-13 |
human |
| Michael Benatar, Joanne Wuu, Caroline McHutchison, Ronald B Postuma, Bradley F Boeve, Ronald Petersen, Christopher A Ross, Howard Rosen, Jalayne J Arias, Stephanie Fradette, Michael P McDermott, Jeremy Shefner, Christine Stanislaw, Sharon Abrahams, Stephanie Cosentino, Peter M Andersen, Richard S Finkel, Volkan Granit, Anne-Laure Grignon, Jonathan D Rohrer, Corey T McMillan, Murray Grossman, Ammar Al-Chalabi, Martin R Turne. Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases. Brain : a journal of neurology. vol 145. issue 1. 2022-04-01. PMID:34677606. |
the development of biomarkers reflecting amyloid and tau has led to a shift in defining alzheimer's disease based on inferred underlying histopathology. |
2022-04-01 |
2023-08-16 |
Not clear |
| Bruno Permanne, Astrid Sand, Solenne Ousson, Maud Nény, Jennifer Hantson, Ryan Schubert, Christoph Wiessner, Anna Quattropani, Dirk Behe. O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies. ACS chemical neuroscience. 2022-04-01. PMID:35357812. |
in alzheimer's disease and in rare tauopathies, aggregation of the microtubule-associated tau protein leads to the formation of neurofibrillary tangles (nft). |
2022-04-01 |
2023-08-13 |
Not clear |
| Lu Liu, Wen-Zhuo Dai, Xi-Chen Zhu, Tao M. A review of autophagy mechanism of statins in the potential therapy of Alzheimer's disease. Journal of integrative neuroscience. vol 21. issue 2. 2022-04-01. PMID:35364634. |
alzheimer's disease (ad) is a neurodegeneration csharacterized by amyloid-β (aβ) deposition and abnormally phosphorylated tau protein aggregation. |
2022-04-01 |
2023-08-13 |
Not clear |
| Shihong Li, Qiuzhi Zhou, Enjie Liu, Huiyun Du, Nana Yu, Haitao Yu, Weijin Wang, Mengzhu Li, Ying Weng, Yang Gao, Guilin Pi, Xin Wang, Dan Ke, Jian-Zhi Wan. Alzheimer-like tau accumulation in dentate gyrus mossy cells induces spatial cognitive deficits by disrupting multiple memory-related signaling and inhibiting local neural circuit. Aging cell. 2022-03-31. PMID:35355405. |
abnormal tau accumulation and spatial memory loss constitute characteristic pathology and symptoms of alzheimer disease (ad). |
2022-03-31 |
2023-08-13 |
mouse |
| Deepti Putcha, Ryan Eckbo, Yuta Katsumi, Bradford C Dickerson, Alexandra Touroutoglou, Jessica A Collin. Tau and the fractionated default mode network in atypical Alzheimer's disease. Brain communications. vol 4. issue 2. 2022-03-31. PMID:35356035. |
tau and the fractionated default mode network in atypical alzheimer's disease. |
2022-03-31 |
2023-08-13 |
human |
| Deepti Putcha, Ryan Eckbo, Yuta Katsumi, Bradford C Dickerson, Alexandra Touroutoglou, Jessica A Collin. Tau and the fractionated default mode network in atypical Alzheimer's disease. Brain communications. vol 4. issue 2. 2022-03-31. PMID:35356035. |
in the present study, we first sought to determine if tau pathology is consistently present in the posterior cingulate cortex and other posterior nodes of the default mode network across the atypical alzheimer's disease syndromic spectrum. |
2022-03-31 |
2023-08-13 |
human |
| Deepti Putcha, Ryan Eckbo, Yuta Katsumi, Bradford C Dickerson, Alexandra Touroutoglou, Jessica A Collin. Tau and the fractionated default mode network in atypical Alzheimer's disease. Brain communications. vol 4. issue 2. 2022-03-31. PMID:35356035. |
we studied a sample of 25 amyloid-positive atypical alzheimer's disease participants examined with high-resolution mri, tau ( |
2022-03-31 |
2023-08-13 |
human |
| Toru Tanaka, Sachiyo Ohashi, Akihiko Takashima, Shunsuke Kobayash. Dendritic distribution of CDK5 mRNA and p35 mRNA, and a glutamate-responsive increase of CDK5/p25 complex contribute to tau hyperphosphorylation. Biochimica et biophysica acta. General subjects. 2022-03-31. PMID:35358667. |
in alzheimer's disease (ad), abnormally phosphorylated tau in the somatodendrite compartment of brain neurons causes synaptic loss, resulting in neuron death. |
2022-03-31 |
2023-08-13 |
Not clear |
| Jeremy F Strain, Nicolas Barthelemy, Kanta Horie, Brian A Gordon, Collin Kilgore, Andrew Aschenbrenner, Carlos Cruchaga, Chengjie Xiong, Nelly Joseph-Mathurin, Jason Hassenstab, Anne M Fagan, Yan Li, Celeste M Karch, Richard Perrin, Sarah B Berman, Jasmeer P Chhatwal, Neill R Graff-Radford, Hiroshi Mori, Johannes Levin, James M Noble, Ricardo Allegri, Peter R Schofield, Daniel S Marcus, David M Holtzman, John C Morris, Tammie L S Benzinger, Eric M McDade, Randall J Bateman, Beau M Ance. CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer's disease. Neurobiology of disease. 2022-03-31. PMID:35358703. |
csf tau phosphorylation at thr205 is associated with loss of white matter integrity in autosomal dominant alzheimer's disease. |
2022-03-31 |
2023-08-13 |
Not clear |
| Jeremy F Strain, Nicolas Barthelemy, Kanta Horie, Brian A Gordon, Collin Kilgore, Andrew Aschenbrenner, Carlos Cruchaga, Chengjie Xiong, Nelly Joseph-Mathurin, Jason Hassenstab, Anne M Fagan, Yan Li, Celeste M Karch, Richard Perrin, Sarah B Berman, Jasmeer P Chhatwal, Neill R Graff-Radford, Hiroshi Mori, Johannes Levin, James M Noble, Ricardo Allegri, Peter R Schofield, Daniel S Marcus, David M Holtzman, John C Morris, Tammie L S Benzinger, Eric M McDade, Randall J Bateman, Beau M Ance. CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer's disease. Neurobiology of disease. 2022-03-31. PMID:35358703. |
hyperphosphorylation of tau leads to conformational changes that destabilize microtubules and hinder axonal transport in alzheimer's disease (ad). |
2022-03-31 |
2023-08-13 |
Not clear |
| Laetitia Miguel, Anne Rovelet-Lecrux, Pascal Chambon, Géraldine Joly-Helas, Stéphane Rousseau, David Wallon, Stéphane Epelbaum, Thierry Frébourg, Dominique Campion, Gaël Nicolas, Magalie Lecourtoi. Generation of 17q21.31 duplication iPSC-derived neurons as a model for primary tauopathies. Stem cell research. vol 61. 2022-03-31. PMID:35358831. |
tau accumulates in patients' brain in several neurodegenerative diseases, including fronto-temporal dementia and alzheimer's disease. |
2022-03-31 |
2023-08-13 |
Not clear |
| Simon Dujardin, Analiese Fernandes, Riley Bannon, Caitlin Commins, Mark De Los Santos, Tarun V Kamath, Mansuo Hayashi, Bradley T Hyma. Tau propagation is dependent on the genetic background of mouse strains. Brain communications. vol 4. issue 2. 2022-03-30. PMID:35350555. |
progressive cognitive decline in alzheimer's disease correlates closely with the spread of tau protein aggregation across neural networks of the cortical mantle. |
2022-03-30 |
2023-08-13 |
mouse |
| Simon Dujardin, Analiese Fernandes, Riley Bannon, Caitlin Commins, Mark De Los Santos, Tarun V Kamath, Mansuo Hayashi, Bradley T Hyma. Tau propagation is dependent on the genetic background of mouse strains. Brain communications. vol 4. issue 2. 2022-03-30. PMID:35350555. |
genetic factors may contribute to tau pathology progression across brain networks, which could help refine mechanisms underlying tau cell-to-cell transfer and accumulation, and potentially provide targets for understanding patient-to-patient variability in the rate of disease progression in alzheimer's disease. |
2022-03-30 |
2023-08-13 |
mouse |
| Xinyang Feng, Frank A Provenzano, Scott A Smal. A deep learning MRI approach outperforms other biomarkers of prodromal Alzheimer's disease. Alzheimer's research & therapy. vol 14. issue 1. 2022-03-30. PMID:35351193. |
the three core pathologies of alzheimer's disease (ad) are amyloid pathology, tau pathology, and neurodegeneration. |
2022-03-30 |
2023-08-13 |
Not clear |
| Emrah Düzel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schütze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Björn-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jesse. Amyloid pathology but not APOE ε4 status is permissive for tau-related hippocampal dysfunction. Brain : a journal of neurology. 2022-03-30. PMID:35352105. |
apoe status (presence of the e4 allele), a known genetic risk factor for alzheimer's disease, did not mediate the relationship between tau pathology and hippocampal function and memory performance. |
2022-03-30 |
2023-08-13 |
human |
| Pieter Jelle Visser, Lianne M Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J van der Lee, Magda Tsolaki, Frans R J Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Simon Lovestone, Johannes Streffer, Stephanie J B Vos, Isabelle Bos, August B Smit, Kaj Blennow, Philip Scheltens, Charlotte E Teunissen, Lars Bertram, Henrik Zetterberg, Betty M Tijm. Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease. Molecular neurodegeneration. vol 17. issue 1. 2022-03-29. PMID:35346299. |
cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in alzheimer's disease. |
2022-03-29 |
2023-08-13 |
Not clear |
| Pieter Jelle Visser, Lianne M Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J van der Lee, Magda Tsolaki, Frans R J Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Simon Lovestone, Johannes Streffer, Stephanie J B Vos, Isabelle Bos, August B Smit, Kaj Blennow, Philip Scheltens, Charlotte E Teunissen, Lars Bertram, Henrik Zetterberg, Betty M Tijm. Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease. Molecular neurodegeneration. vol 17. issue 1. 2022-03-29. PMID:35346299. |
increased total tau (t-tau) in cerebrospinal fluid (csf) is a key characteristic of alzheimer's disease (ad) and is considered to result from neurodegeneration. |
2022-03-29 |
2023-08-13 |
Not clear |