| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Filipa Gouveia, Antoni Camins, Miren Ettcheto, Joana Bicker, Amílcar Falcão, M Teresa Cruz, Ana Fortun. Targeting Brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: past, present and future. Ageing research reviews. 2022-03-29. PMID:35346852. |
alzheimer's disease (ad) is a well-known neurodegenerative disease characterized by the presence of two main hallmarks - tau hyperphosphorylation and aβ deposits. |
2022-03-29 |
2023-08-13 |
Not clear |
| Alessandro Soloperto, Deborah Quaglio, Paola Baiocco, Isabella Romeo, Mattia Mori, Matteo Ardini, Caterina Presutti, Ida Sannino, Silvia Ghirga, Antonia Iazzetti, Rodolfo Ippoliti, Giancarlo Ruocco, Bruno Botta, Francesca Ghirga, Silvia Di Angelantonio, Alberto Boff. Rational design and synthesis of a novel BODIPY-based probe for selective imaging of tau tangles in human iPSC-derived cortical neurons. Scientific reports. vol 12. issue 1. 2022-03-29. PMID:35347170. |
numerous studies have shown a strong correlation between the number of neurofibrillary tangles of the tau protein and alzheimer's disease progression, making the quantitative detection of tau very promising from a clinical point of view. |
2022-03-29 |
2023-08-13 |
human |
| Mónica Rosselli, Idaly Vélez Uribe, Emily Ahne, Layaly Shihade. Culture, Ethnicity, and Level of Education in Alzheimer's Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-03-29. PMID:35347644. |
alzheimer's disease (ad) is the most frequent cause of dementia, where the abnormal accumulation of beta-amyloid (aβ) and tau lead to neurodegeneration as well as loss of cognitive, behavioral, and functional abilities. |
2022-03-29 |
2023-08-13 |
Not clear |
| Saloua Fray, Afef Achouri Achouri-Rassas, Sondes Hadj Fredj, Taieb Messaoud, Samir Bela. Association between H2 haplotype of microtubule associated protein tau gene (deletion / insertion) with Alzheimer Disease in Tunisian patients. Neurological research. 2022-03-29. PMID:35348036. |
association between h2 haplotype of microtubule associated protein tau gene (deletion / insertion) with alzheimer disease in tunisian patients. |
2022-03-29 |
2023-08-13 |
Not clear |
| Hyunjun Park, Yeong-Bae Lee, Keun-A Chan. miR-200c suppression increases tau hyperphosphorylation by targeting 14-3-3γ in early stage of 5xFAD mouse model of Alzheimer's disease. International journal of biological sciences. vol 18. issue 5. 2022-03-28. PMID:35342350. |
mir-200c suppression increases tau hyperphosphorylation by targeting 14-3-3γ in early stage of 5xfad mouse model of alzheimer's disease. |
2022-03-28 |
2023-08-13 |
mouse |
| Qiuzhi Zhou, Shihong Li, Mengzhu Li, Dan Ke, Qun Wang, Ying Yang, Gong-Ping Liu, Xiao-Chuan Wang, Enjie Liu, Jian-Zhi Wan. Human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: A vicious cycle in Alzheimer neurodegeneration. EBioMedicine. vol 78. 2022-03-27. PMID:35339896. |
human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: a vicious cycle in alzheimer neurodegeneration. |
2022-03-27 |
2023-08-13 |
human |
| Qiuzhi Zhou, Shihong Li, Mengzhu Li, Dan Ke, Qun Wang, Ying Yang, Gong-Ping Liu, Xiao-Chuan Wang, Enjie Liu, Jian-Zhi Wan. Human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: A vicious cycle in Alzheimer neurodegeneration. EBioMedicine. vol 78. 2022-03-27. PMID:35339896. |
glycogen synthase kinase-3β (gsk-3β) is one of the most effective kinases in promoting tau hyperphosphorylation and accumulation in alzheimer's disease (ad). |
2022-03-27 |
2023-08-13 |
human |
| Kathryn V Papp, Rachel F Buckley, Heidi I L Jacobs, Aaron P Schultz, Michael J Properzi, Patrizia Vannini, Bernard J Hanseeuw, Dorene M Rentz, Keith A Johnson, Reisa A Sperlin. Association of Emerging β-Amyloid and Tau Pathology With Early Cognitive Changes in Clinically Normal Older Adults. Neurology. 2022-03-26. PMID:35338074. |
alzheimer's disease (ad) clinical trials are moving earlier in the disease process, based on emerging signs of beta-amyloid (aβ) and tau pathology. |
2022-03-26 |
2023-08-13 |
Not clear |
| Francisca Villavicencio-Tejo, Margrethe A Olesen, Alejandra Aránguiz, Rodrigo A Quintanill. Activation of the Nrf2 Pathway Prevents Mitochondrial Dysfunction Induced by Caspase-3 Cleaved Tau: Implications for Alzheimer's Disease. Antioxidants (Basel, Switzerland). vol 11. issue 3. 2022-03-25. PMID:35326165. |
activation of the nrf2 pathway prevents mitochondrial dysfunction induced by caspase-3 cleaved tau: implications for alzheimer's disease. |
2022-03-25 |
2023-08-13 |
Not clear |
| Francisca Villavicencio-Tejo, Margrethe A Olesen, Alejandra Aránguiz, Rodrigo A Quintanill. Activation of the Nrf2 Pathway Prevents Mitochondrial Dysfunction Induced by Caspase-3 Cleaved Tau: Implications for Alzheimer's Disease. Antioxidants (Basel, Switzerland). vol 11. issue 3. 2022-03-25. PMID:35326165. |
alzheimer's disease (ad) is characterized by memory and cognitive impairment, accompanied by the accumulation of extracellular deposits of amyloid β-peptide (aβ) and the presence of neurofibrillary tangles (nfts) composed of pathological forms of tau protein. |
2022-03-25 |
2023-08-13 |
Not clear |
| Michael Rullmann, Matthias Brendel, Matthias L Schroeter, Dorothee Saur, Johannes Levin, Robert G Perneczky, Solveig Tiepolt, Marianne Patt, Andre Mueller, Victor L Villemagne, Joseph Classen, Andrew W Stephens, Osama Sabri, Henryk Barthel, On Behalf Of The German Imaging Initiative For Tauopathies Gii . Multicenter Biomolecules. vol 12. issue 3. 2022-03-25. PMID:35327650. |
multicenter tau aggregates accumulate in the alzheimer's disease (ad) brain according to the established braak staging scheme and spread from transentorhinal over limbic regions to the neocortex. |
2022-03-25 |
2023-08-13 |
Not clear |
| Teresa Gómez-Isla, Matthew P Frosc. Lesions without symptoms: understanding resilience to Alzheimer disease neuropathological changes. Nature reviews. Neurology. 2022-03-25. PMID:35332316. |
since the original description of amyloid-β plaques and tau tangles more than 100 years ago, these lesions have been considered the neuropathological hallmarks of alzheimer disease (ad). |
2022-03-25 |
2023-08-13 |
Not clear |
| Seong Su Kang, Lanxia Meng, Xingyu Zhang, Zhiping Wu, Ariana Mancieri, Boer Xie, Xia Liu, David Weinshenker, Junmin Peng, Zhentao Zhang, Keqiang Y. Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation. Nature structural & molecular biology. 2022-03-25. PMID:35332321. |
the noradrenergic locus ceruleus (lc) is the first site of detectable tau pathology in alzheimer's disease (ad), but the mechanisms underlying the selective vulnerability of the lc in ad have not been completely identified. |
2022-03-25 |
2023-08-13 |
mouse |
| Isabelle Guisle, Geoffrey Canet, Séréna Pétry, Parissa Fereydouni-Forouzandeh, Françoise Morin, Rémi Kérauden, Robert A Whittington, Frédéric Calon, Sébastien S Hébert, Emmanuel Plane. Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia. Neurobiology of aging. vol 113. 2022-03-25. PMID:35334439. |
in alzheimer's disease (ad), hyper-phosphorylation and aggregation of tau correlate with clinical progression and represent a valid therapeutic target. |
2022-03-25 |
2023-08-13 |
mouse |
| Prokopis C Prokopiou, Nina Engels-Domínguez, Kathryn V Papp, Matthew R Scott, Aaron P Schultz, Christoph Schneider, Michelle E Farrell, Rachel F Buckley, Yakeel T Quiroz, Georges El Fakhri, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Heidi I L Jacob. Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals. Nature communications. vol 13. issue 1. 2022-03-24. PMID:35322012. |
animal and human imaging research reported that the presence of cortical alzheimer's disease's (ad) neuropathology, beta-amyloid and neurofibrillary tau, is associated with altered neuronal activity and circuitry failure, together facilitating clinical progression. |
2022-03-24 |
2023-08-13 |
human |
| M Catarina Silva, Ghata Nandi, Katherine A Donovan, Quan Cai, Bethany C Berry, Radoslaw P Nowak, Eric S Fischer, Nathanael S Gray, Fleur M Ferguson, Stephen J Haggart. Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy. Frontiers in cellular neuroscience. vol 16. 2022-03-23. PMID:35317195. |
an important class of these are tauopathies, such as frontotemporal dementia (ftd) and alzheimer's disease (ad), associated with accumulation of aberrant forms of tau protein in the brain. |
2022-03-23 |
2023-08-13 |
human |
| Yuxue Feng, Hanxiao Jiang, Gongbo Li, Guiqiong He, Xiaofeng L. Decreased Expression of Protein O-linked Mannose β 1,2-N-Acetylglucosaminyltransferase 1 Contributes to Alzheimer's Disease-like Pathologies. Journal of neurophysiology. 2022-03-23. PMID:35320023. |
alzheimer's disease (ad) is pathologically characterized by senile plaques and neurofibrillary tangles composed of β-amyloid peptide (aβ) and tau hyperphosphorylation, respectively. |
2022-03-23 |
2023-08-13 |
mouse |
| Sagun Jonchhe, Wei Pan, Pravin Pokhrel, Hanbin Ma. Small Molecules Modulate Liquid-to-Solid Transitions in Phase-separated Tau Condensates. Angewandte Chemie (International ed. in English). 2022-03-23. PMID:35320624. |
in tau protein condensates formed by the liquid-liquid phase separation (llps) process, liquid-to-solid transitions lead to the formation of fibrils implicated in alzheimer's disease. |
2022-03-23 |
2023-08-13 |
Not clear |
| Michael Tran Duong, Sandhitsu R Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X Xie, Paul A Yushkevich, David A Wolk, Ilya M Nasralla. Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer's disease. Nature communications. vol 13. issue 1. 2022-03-22. PMID:35314672. |
dissociation of tau pathology and neuronal hypometabolism within the atn framework of alzheimer's disease. |
2022-03-22 |
2023-08-13 |
Not clear |
| Michael Tran Duong, Sandhitsu R Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X Xie, Paul A Yushkevich, David A Wolk, Ilya M Nasralla. Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer's disease. Nature communications. vol 13. issue 1. 2022-03-22. PMID:35314672. |
alzheimer's disease (ad) is defined by amyloid (a) and tau (t) pathologies, with t better correlated to neurodegeneration (n). |
2022-03-22 |
2023-08-13 |
Not clear |