| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amber Penning, Giorgia Tosoni, Hannah Walgrave, Oxana Garritsen, Sarah Snoeck, Katleen Craessaerts, Leen Wolfs, Nicky Thrupp, Mark Fiers, Carlo Sala Frigerio, Bart De Strooper, Evgenia Salt. Unbiased profiling of miR-132 targetome with implications in adult hippocampal neurogenesis and Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109102. |
microrna-132 (mir-132), a potent neuroimmune regulator, is robustly downregulated in the brain of alzheimer's disease (ad) patients and its deficiency has been functionally linked to amyloid deposition, tau hyperphosphorylation and memory decline, in both human and rodents. |
2022-02-03 |
2023-08-13 |
mouse |
| Sanaz Arezoumandan, Katheryn A Q Cousins, Jeffrey S Phillips, Daniel T Ohm, Claire Peterson, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul A Yushkevich, John Q Trojanowski, Eddie B Lee, Murray Grossman, David J Irwi. Regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of AD and FTLD-tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109105. |
non-amnestic presentations of alzheimer's disease (naad) correspond to focal cortical areas of high tau pathology that map to clinical symptoms. |
2022-02-03 |
2023-08-13 |
Not clear |
| Debomoy K Lahiri, Ruizhi Wang, Bryan Maloney, Nipun Chopra, John S Beck, Scott E Count. Alteration of a specific microRNA regulating neprilysin expression in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109106. |
alzheimer's disease (ad) is characterized by accumulation of amyloid β (aβ) plaques and aggregates of hyperphosphorylated tau protein. |
2022-02-03 |
2023-08-13 |
Not clear |
| Tulsi Patel, Evan Udine, Xue Wang, Mariet Allen, Ozkan Is, Frederick Q Tutor-New, Troy Carnwath, Kaancan Deniz, Sarah J Lincoln, Thuy Nguyen, Kimberly G Malphrus, Zachary Quicksall, Laura Lewis-Tuffin, Joseph S Reddy, Minerva M Carrasquillo, Julia E Crook, Takahisa Kanekiyo, Melissa E Murray, Guojun Bu, Dennis W Dickson, Nilufer Ertekin-Tane. Cell type-specific gene expression changes in Alzheimer's patients with varying levels of cerebral amyloid angiopathy. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109107. |
tau neurofibrillary tangles and senile plaques comprised of insoluble amyloid beta are the major histopathological hallmarks of alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
Not clear |
| Xiaoqing Huang, Nur Jury Garfe, Jiannan Liu, Cristian A Lasagna Reeves, Jie Zhan. Understand the uncoupling of tauopathy and dementia through comparative analysis of subgroups of atypical Alzheimer's disease patients. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109127. |
typical alzheimer's disease (ad) patient brains show characteristic neurofibrillary tangles (nfts), which protein tau aggregates to form bundles of microtubule-associated neurofibrillary tangle (nft). |
2022-02-03 |
2023-08-13 |
Not clear |
| Martina Gabrielli, Giulia D'Arrigo, Chiara Falcicchia, Nicola Origlia, Ottavio Arancio, Claudia Verderio, Ilaria Prad. Role of extracellular vesicles in early synaptic dysfunction in AD. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109130. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder associated with amyloid-β (aβ) and tau protein accumulation. |
2022-02-03 |
2023-08-13 |
Not clear |
| Chijioke Akunwafo, Jeiran Choupan, Farshid Sepehrban. Premortem perivascular space morphology is a predictor of postmortem glia tau pathology in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109135. |
premortem perivascular space morphology is a predictor of postmortem glia tau pathology in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Alexandre Henriques, Laura Rouvière, Anne Griesbeck, Ronny Schmidt, Christoph Schroeder, Clémence Farrugia, Philippe Poindron, Noelle Callizo. Neuroinflammation induced by amyloid beta 1-42 oligomers contributes to neuronal loss in an in vitro model of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109142. |
alzheimer's disease is characterized by the extracellular accumulation of senile plaques composed of amyloid beta and the intracellular deposition of neurofibrillary tangles composed of hyperphosphorylated tau. |
2022-02-03 |
2023-08-13 |
human |
| Yu Hirota, Yasufumi Sakakibara, Kyoko Ibaraki, Kimi Takei, Koichi M Iijima, Michiko Sekiy. Localization of AD biomarker phospho-tau proteins in the brains of an App knock-in mouse model of Aβ amyloidosis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109150. |
amyloid-β (aβ) plaques, neurofibrillary tangles composed of hyper-phosphorylated tau proteins and neurodegeneration are neuropathological hallmarks of alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
mouse |
| Kirsten E J Wesenhagen, Charlotte E Teunissen, Johan Gobom, Stephanie J B Vos, Kaj Blennow, Henrik Zetterberg, Philip Scheltens, Betty M Tijms, Pieter Jelle Visse. Immune protein levels in cerebrospinal fluid: Associations with memory scores across the AD spectrum. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109166. |
alzheimer's disease (ad) is characterized by amyloid and tau aggregation. |
2022-02-03 |
2023-08-13 |
Not clear |
| Allie N Greene, Matia B Solomon, Lisa M Privette Vinnedg. Elucidating a mechanism of tau hyperphosphorylation after DEK loss in vitro. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109167. |
the purpose of the current study is to elucidate the mechanism by which dek loss leads to tau pathology in vitro, with the goal of illuminating novel pathways of tauopathy in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Grant Kauwe, Kristeen Pareja-Navarro, Jackson Chen, Yaqiao Li, David Le, Yungui Zhou, Li Gan, Tara E Trac. Effect of KIBRA on tau-mediated synaptic and memory deficits. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109173. |
alzheimer's disease (ad) is characterized by an accumulation of tau in the brain and progressive memory decline. |
2022-02-03 |
2023-08-13 |
mouse |
| Rebecca Panitch, Junming Hu, Lindsay A Farrer, Gyungah R Ju. Multivariate analysis of blood and brain transcriptome in Alzheimer's reveals unique APOE ε4-related immune pathways. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109177. |
while alzheimer's disease (ad) is generally considered a brain disease, plasma levels of ad-related proteins including amyloid-β, phosphorylated tau, and neurofilament light chain are associated with neurodegeneration and neuroinflammation. |
2022-02-03 |
2023-08-13 |
Not clear |
| Gleb Bezgin, Tharick A Pascoal, Joseph Therriault, Firoza Z Lussier, Min Su Kang, Cécile Tissot, Stijn Servaes, Yi-Ting Wang, Peter Kunach, Jenna Stevenson, Serge Gauthier, Pedro Rosa-Net. Profiling tau accumulation with SPReAD: Sub-stages for propagation regions in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109182. |
profiling tau accumulation with spread: sub-stages for propagation regions in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Prita Riana Asih, Kristie Stefanoska, Arne Ittne. Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109187. |
hyperphosphorylation of the neuronal tau protein contributes to alzheimer's disease (ad) by promoting tau pathology and neuronal and cognitive deficits. |
2022-02-03 |
2023-08-13 |
mouse |
| Alexandre Henriques, Pierrick Jégo, Clémence Farrugia, Noelle Callizo. Intra-hippocampal injections of Aβ oligomers induce cognitive impairments associated with neurodegeneration and activation of microglia in senescent mice: Characterization of a novel animal model of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109200. |
alzheimer's disease is characterized by the extracellular accumulation of senile plaques composed of amyloid beta and the intracellular deposition of neurofibrillary tangles composed of hyperphosphorylated tau. |
2022-02-03 |
2023-08-13 |
mouse |
| Alexandra J Weigand, Kelsey R Thomas, Katherine J Bangen, Graham M L Eglit, Adam M Brickman, Mark W Bond. Evidence for the progression of tau and neurodegeneration beyond the medial temporal lobe in amyloid-negative older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109203. |
despite the important role of tau in alzheimer's disease (ad), tau in the absence of amyloid (aβ) is typically considered as separable from the ad continuum. |
2022-02-03 |
2023-08-13 |
Not clear |
| Michael Kelberman, David Weinshenke. Altered locus coeruleus activity and neurochemistry in the presence of Alzheimer's disease-like hyperphosphorylated tau pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109220. |
altered locus coeruleus activity and neurochemistry in the presence of alzheimer's disease-like hyperphosphorylated tau pathology. |
2022-02-03 |
2023-08-13 |
Not clear |
| Michael Kelberman, David Weinshenke. Altered locus coeruleus activity and neurochemistry in the presence of Alzheimer's disease-like hyperphosphorylated tau pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109220. |
the locus coeruleus (lc), the main source of norepinephrine (ne) in the brain, develops tau pathology prior to other brain regions and later degenerates in alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
Not clear |
| Michela Marcatti, Anna Fracassi, Nemil Bhatt, Chandramouli Natarajan, Balaji Krishnan, Rakez Kayed, Giulio Taglialatel. AD- and PSP-specific brain-derived tau oligomers engage synapses with different dynamic. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109245. |
alzheimer's disease (ad) is characterized by gradual cognitive decline driven by the targeting of synapses by small oligomers of both aβ (aβo) and tau (tauo), which results in synaptic dysfunction that ultimately underscores disease progression. |
2022-02-03 |
2023-08-13 |
human |