| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Timothy Wu, Caiwei Guo, Joshua M Shulma. Elucidating cellular contributions to tau-mediated neurodegeneration using drosophila and single-cell transcriptomics. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109262. |
alzheimer's dementia (ad) is neuropathologically defined by aggregations of amyloid-beta plaques and tau neurofibrillary tangles in the brain, with tau pathology being most strongly correlated with cognitive decline. |
2022-02-03 |
2023-08-13 |
human |
| Ashish Raj, Veronica Tora, Bruno Franch. Combining network spread with protein aggregation correctly recapitulates empirical spatio-temporal progression of Alzheimer's tau pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109265. |
combining network spread with protein aggregation correctly recapitulates empirical spatio-temporal progression of alzheimer's tau pathology. |
2022-02-03 |
2023-08-13 |
Not clear |
| Ashish Raj, Veronica Tora, Bruno Franch. Combining network spread with protein aggregation correctly recapitulates empirical spatio-temporal progression of Alzheimer's tau pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109265. |
alzheimer's disease involves widespread and progressive deposition of misfolded protein tau, likely via "prion-like" trans-neuronal transmission along the brain's structural connectome. |
2022-02-03 |
2023-08-13 |
Not clear |
| Ashish Raj, Veronica Tora, Bruno Franch. Combining network spread with protein aggregation correctly recapitulates empirical spatio-temporal progression of Alzheimer's tau pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109265. |
it is not well understood how tau aggregation and spread leads to stereotypical progression in the alzheimer brain. |
2022-02-03 |
2023-08-13 |
Not clear |
| Neil R Cashman, Ebrima Gibbs, Andrei Roman, Clay Shyu, Eugene M Williams, Xubiao Peng, Shawn Ching-Chung Hsueh, Aina Adekunle, Steven S Plotkin, Johanne Kapla. Conformational epitopes exposed on misfolded toxic forms of amyloid-beta, tau and alpha-synuclein directly contribute to their seeding activity. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109274. |
for example, toxic oligomers of amyloid-beta (abeta) as well as oligomers and small soluble fibrils of tau and alpha-synuclein (asyn) have been reported to contribute to neuronal damage and progression of alzheimer's disease as well as various tauopathies (e.g. |
2022-02-03 |
2023-08-13 |
Not clear |
| Annie G Bryant, Rachel E Bennett, David H Salat, Bruce R Rosen, Bradley T Hyman, Keith A Johnson, Susie Huang, Yi-Fen Ye. Heterogeneity of tau deposition and microvascular involvement in MCI and AD. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109281. |
recent preclinical and clinical studies have highlighted the role of tau pathology in the impaired cerebrovascular function frequently observed in mild cognitive impairment (mci) and alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
Not clear |
| Pablo Largo-Barrientos, Valerie Uytterhoeven, Joris de Wit, Bart De Strooper, Patrik Verstreke. Synaptic tau and synaptogyrin-3 are promising targets to tackle tauopathies. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109315. |
different pathogenic conditions (alzheimer's disease and other tauopathies) induce detachment of tau protein from microtubules. |
2022-02-03 |
2023-08-13 |
mouse |
| Soumya Mukherjee, Celine Dubois, Keyla Perez, Rebecca M Nisbet, Qiao-Xin Li, Shiji Varghese, Larissa Cristina Lago, Stephan Klatt, Ian Birchall, Liang Jin, Catriona McLean, Victor Streltsov, Kevin J Barnham, Laura J Vella, Colin L Master. Quantitative proteomics of detergent insoluble tangles derived from Alzheimer's disease brains. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109332. |
sarkosyl-insoluble pellets from alzheimer's disease (ad) brains yield fibrils made up of paired helical filaments (phfs) and straight helical filaments (shf) of microtubule associated protein tau (mapt), component of the neurofibrillary tangles in ad. |
2022-02-03 |
2023-08-13 |
human |
| Cara L Croft, Marshall S Goodwin, Daniel H Ryu, Christian B Lessard, Giancarlo Tejeda, Marc Marrero, Ava Vause, Giavanna Paterno, Pedro E Cruz, Jada Lewis, Benoit Giasson, Todd E Gold. Targeting aggregated tau turnover as a therapeutic strategy. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109342. |
the accumulation of microtubule-associated protein tau in intracellular inclusions is a common feature of alzheimer's disease and other tauopathies. |
2022-02-03 |
2023-08-13 |
Not clear |
| Wilber Romero Fernandez, Elena Solopova, Alena Shostak, Kylie M Balotin, Bret Mobley, Hannah Harmsen, Angela L Jefferson, Ethan S Lippmann, Timothy J Hohman, Matthew S Schra. RBFOX1 is regulated by the adenosine 2a receptor and is ubiquitinated in tau tangles in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109343. |
rbfox1 is regulated by the adenosine 2a receptor and is ubiquitinated in tau tangles in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
human |
| Marangelie Criado-Marrero, Lindsey B Shelton, Laura J Blai. Reduction in Aha1 chaperone preserves hippocampal neurons and prevents tau-related pathology in rTg4510 tau transgenic mice. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109351. |
several molecular chaperones have been identified as important modulators of tau protein in aging and neurodegenerative illnesses like alzheimer's diseases. |
2022-02-03 |
2023-08-13 |
mouse |
| Marangelie Criado-Marrero, Lindsey B Shelton, Laura J Blai. Reduction in Aha1 chaperone preserves hippocampal neurons and prevents tau-related pathology in rTg4510 tau transgenic mice. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109351. |
our laboratory demonstrated the activator of hsp90 atpase activity (aha1) potently promotes tau fibrilization and its expression positively correlates with features of tau pathology in brains from tau overexpressing mice and individuals with alzheimer's disease. |
2022-02-03 |
2023-08-13 |
mouse |
| Christina M Moloney, Sydney A Labuzan, Jessica Tranovich, Julia E Crook, Habeeba Siddiqui, Neill R Graff-Radford, Christian Lachner, Dennis W Dickson, Michelle M Mielke, Melissa E Murra. Characterizing neurofibrillary tangle maturity of phosphorylated tau fluid biomarkers in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109364. |
characterizing neurofibrillary tangle maturity of phosphorylated tau fluid biomarkers in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Christina M Moloney, Sydney A Labuzan, Jessica Tranovich, Julia E Crook, Habeeba Siddiqui, Neill R Graff-Radford, Christian Lachner, Dennis W Dickson, Michelle M Mielke, Melissa E Murra. Characterizing neurofibrillary tangle maturity of phosphorylated tau fluid biomarkers in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109364. |
phosphorylated tau (p-tau) cerebrospinal fluid and plasma biomarkers have become more accurate in predicting alzheimer's disease (ad) pathology. |
2022-02-03 |
2023-08-13 |
Not clear |
| Sehnaz Ferdosh, Senjuti Banerjee, Jayshree Singh, Chandana Bara. Amyloid protein-induced sequestration of the eukaryotic ribosome: effect of stoichiometry and polyphenolic inhibitors. FEBS letters. 2022-02-03. PMID:35114013. |
alzheimer's disease (ad) is characterized by the appearance of neurofibrillary tangles comprising of the tau protein and aggregation of amyloid-β peptides (aβ 1-40 and aβ 1-42). |
2022-02-03 |
2023-08-13 |
Not clear |
| Xiaobo Yu, Yisheng Cai, Xu Zhao, Chenyu Wu, Junqing Liu, Tingting Niu, Xu Shan, Yanjie Lu, Yanan Ruan, Jianwei H. Investigation of the chemical structure of anti-amyloidogenic constituents extracted from Thamnolia vermicularis. Journal of ethnopharmacology. 2022-02-03. PMID:35114341. |
recent research has highlighted that t. vermicularis may suppress aβ level and tau hyperphosphorylation to improve the pathological characteristics of alzheimer's disease, indicating that it might have the potential to treat alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Francesca Munari, Luca Mollica, Carlo Valente, Francesca Parolini, Elham Ataie Kachoie, Giorgio Arrigoni, Mariapina D'Onofrio, Stefano Capaldi, Michael Assfal. Structural Basis for Chaperone-Independent Ubiquitination of Tau Protein by its E3 Ligase CHIP. Angewandte Chemie (International ed. in English). 2022-02-02. PMID:35107860. |
the multi-site ubiquitination of tau protein found in alzheimer's disease filaments hints at the failed attempt of neurons to remove early toxic species. |
2022-02-02 |
2023-08-13 |
Not clear |
| Hariharakrishnan Chidambaram, Rashmi Das, Subashchandrabose Chinnathamb. G-protein coupled purinergic P2Y12 receptor interacts and internalizes Tau European journal of cell biology. vol 101. issue 2. 2022-02-01. PMID:35101770. |
g-protein coupled purinergic p2y12 receptor interacts and internalizes tau in alzheimer's disease, the microtubule-associated protein, tau misfolds to form aggregates and filaments in the intra- and extracellular region of neuronal cells. |
2022-02-01 |
2023-08-13 |
Not clear |
| Kaiwen Guo, Cuicui Yang, Lan Zhan. The Reduction of Tau Hyperphosphorylation by Cornel Iridoid Glycosides Is Mediated by Their Influence on Calpain Activity. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-01-31. PMID:35096120. |
alzheimer's disease (ad) is the most common type of dementia, and the abnormal hyperphosphorylation of the tau protein is the main component of its pathogenesis. |
2022-01-31 |
2023-08-13 |
mouse |
| Baruh Polis, Margherita Squillario, Vyacheslav Gurevich, Kolluru D Srikanth, Michael Assa, Abraham O Samso. Effects of Chronic Arginase Inhibition with Norvaline on Tau Pathology and Brain Glucose Metabolism in Alzheimer's Disease Mice. Neurochemical research. 2022-01-31. PMID:35098420. |
effects of chronic arginase inhibition with norvaline on tau pathology and brain glucose metabolism in alzheimer's disease mice. |
2022-01-31 |
2023-08-13 |
mouse |