| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lauren E McLane, Jennifer N Bourne, Angelina V Evangelou, Luipa Khandker, Wendy B Macklin, Teresa L Woo. Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 31. 2017-08-22. PMID:28694334. |
although the mammalian target of rapamycin (mtor) is an essential regulator of developmental oligodendrocyte differentiation and myelination, oligodendrocyte-specific deletion of tuberous sclerosis complex (tsc), a major upstream inhibitor of mtor, surprisingly also leads to hypomyelination during cns development. |
2017-08-22 |
2023-08-13 |
mouse |
| Marta Fumagalli, Elisabetta Bonfanti, Simona Daniele, Elisa Zappelli, Davide Lecca, Claudia Martini, Maria L Trincavelli, Maria P Abbracchi. The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization. Glia. vol 63. issue 12. 2016-07-19. PMID:26228571. |
the ubiquitin ligase mdm2 controls oligodendrocyte maturation by intertwining mtor with g protein-coupled receptor kinase 2 in the regulation of gpr17 receptor desensitization. |
2016-07-19 |
2023-08-13 |
Not clear |
| Marta Fumagalli, Elisabetta Bonfanti, Simona Daniele, Elisa Zappelli, Davide Lecca, Claudia Martini, Maria L Trincavelli, Maria P Abbracchi. The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization. Glia. vol 63. issue 12. 2016-07-19. PMID:26228571. |
after the immature oligodendrocyte stage, to enable cells to complete maturation, gpr17 is physiologically down-regulated via phosphorylation/desensitization by g protein-coupled receptor kinases (grks); conversely, grks are regulated by the "mammalian target of rapamycin" mtor. |
2016-07-19 |
2023-08-13 |
Not clear |
| Oscar Gomez, Maria A Sanchez-Rodriguez, Silvia Ortega-Gutierrez, Henar Vazquez-Villa, Carmen Guaza, Francisco Molina-Holgado, Eduardo Molina-Holgad. A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 2. 2016-04-01. PMID:25900077. |
a basal tone of 2-arachidonoylglycerol contributes to early oligodendrocyte progenitor proliferation by activating phosphatidylinositol 3-kinase (pi3k)/akt and the mammalian target of rapamycin (mtor) pathways. |
2016-04-01 |
2023-08-13 |
Not clear |
| Christina A Kearns, Andrew M Ravanelli, Kirsten Cooper, Bruce Appe. Fbxw7 Limits Myelination by Inhibiting mTOR Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 44. 2016-02-12. PMID:26538655. |
here, we provide evidence that mtor signaling activity is elevated in oligodendrocyte lineage cells of fbxw7 mutant zebrafish larvae. |
2016-02-12 |
2023-08-13 |
zebrafish |
| JinXiang Dai, Kathryn K Bercury, Wendy B Mackli. Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation. Glia. vol 62. issue 12. 2015-06-19. PMID:25060812. |
interaction of mtor and erk1/2 signaling to regulate oligodendrocyte differentiation. |
2015-06-19 |
2023-08-13 |
Not clear |
| JinXiang Dai, Kathryn K Bercury, Wendy B Mackli. Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation. Glia. vol 62. issue 12. 2015-06-19. PMID:25060812. |
previous work from our lab and others shows that akt, mtor, and erk 1/2 are major signaling pathways regulating oligodendrocyte differentiation and myelination in vitro and in vivo. |
2015-06-19 |
2023-08-13 |
Not clear |
| JinXiang Dai, Kathryn K Bercury, Wendy B Mackli. Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation. Glia. vol 62. issue 12. 2015-06-19. PMID:25060812. |
oligodendrocyte differentiation in vitro required akt, mtor, and erk 1/2 signaling, as inhibition of akt, mtor, or erk 1/2 resulted in a significant decrease of myelin basic protein mrna and protein expression. |
2015-06-19 |
2023-08-13 |
Not clear |
| Frédéric Lebrun-Julien, Lea Bachmann, Camilla Norrmén, Martin Trötzmüller, Harald Köfeler, Markus A Rüegg, Michael N Hall, Ueli Sute. Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 25. 2014-08-12. PMID:24948799. |
mtor has been associated with oligodendrocyte differentiation and myelination downstream of the pi3k/akt pathway, but the functional contributions of individual complexes are largely unknown. |
2014-08-12 |
2023-08-13 |
mouse |
| Stacey E Wahl, Lauren E McLane, Kathryn K Bercury, Wendy B Macklin, Teresa L Woo. Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 13. 2014-05-19. PMID:24671992. |
prior studies support a role for mammalian target of rapamycin (mtor) signaling in oligodendrocyte differentiation and myelination. |
2014-05-19 |
2023-08-12 |
mouse |
| Stacey E Wahl, Lauren E McLane, Kathryn K Bercury, Wendy B Macklin, Teresa L Woo. Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 13. 2014-05-19. PMID:24671992. |
we provide evidence that mtor is necessary for proper oligodendrocyte differentiation and myelination in the spinal cord. |
2014-05-19 |
2023-08-12 |
mouse |
| Stacey E Wahl, Lauren E McLane, Kathryn K Bercury, Wendy B Macklin, Teresa L Woo. Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 13. 2014-05-19. PMID:24671992. |
these data demonstrate that mtor promotes oligodendrocyte differentiation and cns myelination in vivo and show that the requirement for mtor varies by region with the spinal cord most dependent on mtor. |
2014-05-19 |
2023-08-12 |
mouse |
| Kathryn K Bercury, JinXiang Dai, Hilary H Sachs, Jared T Ahrendsen, Teresa L Wood, Wendy B Mackli. Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 13. 2014-05-19. PMID:24671993. |
to establish whether the impact of mtor on cns myelination results from unique functions of mtorc1 or mtorc2 during cns myelination, we conditionally ablated either raptor or rictor in the oligodendrocyte lineage, in vivo. |
2014-05-19 |
2023-08-12 |
mouse |
| Shalini Kumar, Rhusheet Patel, Spencer Moore, Daniel K Crawford, Nirut Suwanna, Mario Mangiardi, Seema K Tiwari-Woodruf. Estrogen receptor β ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis. Neurobiology of disease. vol 56. 2014-01-10. PMID:23603111. |
dpn treatment of eae animals resulted in phosphorylated erβ and activated the phosphatidylinositol 3-kinase (pi3k)/serine-threonine-specific protein kinase (akt)/mammalian target of rapamycin (mtor) signaling pathway, a pathway required for oligodendrocyte survival and axon myelination. |
2014-01-10 |
2023-08-12 |
mouse |
| Hebe M Guardiola-Diaz, Akihiro Ishii, Rashmi Bansa. Erk1/2 MAPK and mTOR signaling sequentially regulates progression through distinct stages of oligodendrocyte differentiation. Glia. vol 60. issue 3. 2013-11-01. PMID:22144101. |
erk1/2 mapk and mtor signaling sequentially regulates progression through distinct stages of oligodendrocyte differentiation. |
2013-11-01 |
2023-08-12 |
Not clear |
| Teresa L Wood, Kathryn K Bercury, Stacey E Cifelli, Lauren E Mursch, Jungsoo Min, Jinxiang Dai, Wendy B Mackli. mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development. ASN neuro. vol 5. issue 1. 2013-09-10. PMID:23421405. |
mtor: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development. |
2013-09-10 |
2023-08-12 |
Not clear |
| Teresa L Wood, Kathryn K Bercury, Stacey E Cifelli, Lauren E Mursch, Jungsoo Min, Jinxiang Dai, Wendy B Mackli. mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development. ASN neuro. vol 5. issue 1. 2013-09-10. PMID:23421405. |
this review describes the known functions of mtor as they relate to oligodendrocyte development, and its recently discovered impact on oligodendrocyte differentiation and myelination. |
2013-09-10 |
2023-08-12 |
Not clear |
| Cinzia Dello Russo, Lucia Lisi, Douglas L Feinstein, Pierluigi Navarr. mTOR kinase, a key player in the regulation of glial functions: relevance for the therapy of multiple sclerosis. Glia. vol 61. issue 3. 2013-07-03. PMID:23044764. |
in contrast, mtor plays an important role in the regulation of oligodendrocyte development and myelination process as well as several neuronal functions, which may limit this therapeutic approach. |
2013-07-03 |
2023-08-12 |
Not clear |
| Takuya Ito, Kiyoe Funamoto, Naoaki Sato, Ai Nakamura, Kaori Tanabe, Tetsuro Hoshiai, Kaori Suenaga, Junichi Sugawara, Satoru Nagase, Kunihiro Okamura, Nobuo Yaegashi, Yoshitaka Kimur. Maternal undernutrition induces the expression of hypoxia-related genes in the fetal brain. The Tohoku journal of experimental medicine. vol 226. issue 1. 2012-04-23. PMID:22186035. |
in conclusion, maternal undernutrition induces the expression of hif1α in oligodendrocyte precursor cells at the subventricular zone, and it also induces the expression of hypoxia-related genes in the fetal brain probably via activation of the mtor pathway. |
2012-04-23 |
2023-08-12 |
Not clear |
| O Gomez, A Sanchez-Rodriguez, Mqu Le, C Sanchez-Caro, F Molina-Holgado, E Molina-Holgad. Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of rapamycin (mTOR) pathways. British journal of pharmacology. vol 163. issue 7. 2012-01-18. PMID:21480865. |
cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating pi3k/akt and the mammalian target of rapamycin (mtor) pathways. |
2012-01-18 |
2023-08-12 |
Not clear |