| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| William A Tyler, Mohit Raja Jain, Stacey E Cifelli, Qing Li, Li Ku, Yue Feng, Hong Li, Teresa L Woo. Proteomic identification of novel targets regulated by the mammalian target of rapamycin pathway during oligodendrocyte differentiation. Glia. vol 59. issue 11. 2012-01-06. PMID:21858874. |
previous work from our laboratory demonstrated that the mammalian target of rapamycin (mtor) is active during and required for oligodendrocyte progenitor cell (opc) differentiation. |
2012-01-06 |
2023-08-12 |
Not clear |
| William A Tyler, Nitish Gangoli, Pradeepa Gokina, Haesun A Kim, Matthew Covey, Steven W Levison, Teresa L Woo. Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 19. 2009-05-28. PMID:19439614. |
activation of the mammalian target of rapamycin (mtor) is essential for oligodendrocyte differentiation. |
2009-05-28 |
2023-08-12 |
Not clear |
| William A Tyler, Nitish Gangoli, Pradeepa Gokina, Haesun A Kim, Matthew Covey, Steven W Levison, Teresa L Woo. Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 19. 2009-05-28. PMID:19439614. |
here, we provide evidence that activation of the mammalian target of rapamycin (mtor) is essential for oligodendrocyte differentiation. |
2009-05-28 |
2023-08-12 |
Not clear |
| William A Tyler, Nitish Gangoli, Pradeepa Gokina, Haesun A Kim, Matthew Covey, Steven W Levison, Teresa L Woo. Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 19. 2009-05-28. PMID:19439614. |
specifically, mtor regulates oligodendrocyte differentiation at the late progenitor to immature oligodendrocyte transition as assessed by the expression of stage specific antigens and myelin proteins including mbp and plp. |
2009-05-28 |
2023-08-12 |
Not clear |
| William A Tyler, Nitish Gangoli, Pradeepa Gokina, Haesun A Kim, Matthew Covey, Steven W Levison, Teresa L Woo. Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 19. 2009-05-28. PMID:19439614. |
we demonstrate that mtor exerts its effects on oligodendrocyte differentiation through two distinct signaling complexes, mtorc1 and mtorc2, defined by the presence of the adaptor proteins raptor and rictor, respectively. |
2009-05-28 |
2023-08-12 |
Not clear |
| William A Tyler, Nitish Gangoli, Pradeepa Gokina, Haesun A Kim, Matthew Covey, Steven W Levison, Teresa L Woo. Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 19. 2009-05-28. PMID:19439614. |
in opc-drg cocultures, inhibiting mtor potently abrogated oligodendrocyte differentiation and reduced numbers of myelin segments. |
2009-05-28 |
2023-08-12 |
Not clear |
| William A Tyler, Nitish Gangoli, Pradeepa Gokina, Haesun A Kim, Matthew Covey, Steven W Levison, Teresa L Woo. Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 19. 2009-05-28. PMID:19439614. |
these data support the hypothesis that mtor regulates commitment to oligodendrocyte differentiation before myelination. |
2009-05-28 |
2023-08-12 |
Not clear |