| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guoqiang Du, Zixi Yang, Yin Wen, Xusheng Li, Wenhong Zhong, Zhuo Li, Shiying Zhang, Ensi Luo, Hongguang Ding, Weifeng L. Heat stress induces IL-1β and IL-18 overproduction via ROS-activated NLRP3 inflammasome: implication in neuroinflammation in mice with heat stroke. Neuroreport. 2024-04-30. PMID:38687900. |
we found that heat stress attack induced excessive ros in microglia and subsequently activated nlrp3 inflammasome in both mice and bv2 cells. |
2024-04-30 |
2024-05-03 |
mouse |
| Guoqiang Du, Zixi Yang, Yin Wen, Xusheng Li, Wenhong Zhong, Zhuo Li, Shiying Zhang, Ensi Luo, Hongguang Ding, Weifeng L. Heat stress induces IL-1β and IL-18 overproduction via ROS-activated NLRP3 inflammasome: implication in neuroinflammation in mice with heat stroke. Neuroreport. 2024-04-30. PMID:38687900. |
these results suggest that heat stress attack caused neuroinflammation via excessive ros activating the nlrp3 inflammasome in microglia cells. |
2024-04-30 |
2024-05-03 |
mouse |
| Bridget K Greuel, Dylan E Da Silva, Victoria N Robert-Gostlin, Andis Klegeri. Natural Compounds Oridonin and Shikonin Exhibit Potentially Beneficial Regulatory Effects on Select Functions of Microglia. Brain sciences. vol 14. issue 4. 2024-04-27. PMID:38671980. |
we hypothesized that some of the beneficial effects of oridonin and shikonin on microglia are independent of their suppression of nlrp3 inflammasomes. |
2024-04-27 |
2024-04-29 |
human |
| Dae Won Kim, Tae-Kyeong Lee, Ji Hyeon Ahn, Se-Ran Yang, Myoung Cheol Shin, Jun Hwi Cho, Moo-Ho Won, Il Jun Kang, Joon Ha Par. Porphyran Attenuates Neuronal Loss in the Hippocampal CA1 Subregion Induced by Ischemia and Reperfusion in Gerbils by Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation. Marine drugs. vol 22. issue 4. 2024-04-26. PMID:38667787. |
overall, our findings suggest that porphyran exerts neuroprotective effects against brain ir injury, potentially by reducing the reaction (activation) and proliferation of microglia and reducing nlrp3 inflammasome-mediated neuroinflammation. |
2024-04-26 |
2024-04-28 |
Not clear |
| Zhu Liang, Andreas Damianou, Iolanda Vendrell, Edward Jenkins, Frederik H Lassen, Sam J Washer, Athina Grigoriou, Guihai Liu, Gangshun Yi, Hantao Lou, Fangyuan Cao, Xiaonan Zheng, Ricardo A Fernandes, Tao Dong, Edward W Tate, Elena Di Daniel, Benedikt M Kessle. Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia. Cell reports. vol 43. issue 5. 2024-04-26. PMID:38669140. |
uch-l1 chemical inhibition with small molecules interfered with nlrp3 puncta formation and asc oligomerization, leading to altered il-1β cleavage and secretion, particularly in microglia cells, which exhibited elevated uch-l1 expression as compared to monocytes/macrophages. |
2024-04-26 |
2024-04-29 |
human |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
we also observe abnormal activation of microglia characterized by enhanced release of the nlrp3 inflammasome, casepase-1 and pro-inflammatory cytokines il-1β, in the hippocampus of mice and bv2 cells. |
2024-04-24 |
2024-04-28 |
mouse |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
microglia, the resident immune cells of the central nervous system (cns), play a dual role in neurotoxicity by releasing the nlr family pyrin domain containing 3 (nlrp3) inflammasome and brain-derived neurotrophic factor (bdnf) in response to environmental stress. |
2024-04-24 |
2024-04-28 |
mouse |
| Sheng-Jie Hou, Ya-Ru Huang, Jie Zhu, Ying-Bo Jia, Xiao-Yun Niu, Jin-Ju Yang, Xiao-Lin Yu, Xiao-Yu Du, Shi-Yu Liang, Fang Cui, Ling-Jie Li, Chen Tian, Rui-Tian Li. Mouse serum albumin induces neuronal apoptosis and tauopathies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-23. PMID:38654316. |
moreover, msa-activated microglia triggered remarkable tau phosphorylation at multiple sites through nlrp3 inflammasome pathway. |
2024-04-23 |
2024-04-26 |
mouse |
| Debashis Dutta, Jianuo Liu, Enquan Xu, Huangui Xion. Methamphetamine Enhancement of HIV-1 gp120-Mediated NLRP3 Inflammasome Activation and Resultant Proinflammatory Responses in Rat Microglial Cultures. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612400. |
meth also augmented the co-localization of nlrp3 and caspase-1, increased the numbers of nlrp3 puncta and ros production, increased the levels of inos expression and no production, and increased the levels of cleaved gasdermind (gsdmd-n; an executor of pyroptosis) in gp120-primed microglia. |
2024-04-13 |
2024-04-15 |
human |
| Juan Yu, Zhanghong Zhao, Yuanyuan Li, Jian Chen, Nanqu Huang, Yong Lu. Role of NLRP3 in Parkinson's disease: Specific activation especially in dopaminergic neurons. Heliyon. vol 10. issue 7. 2024-04-10. PMID:38596076. |
previous studies have demonstrated that the over-activation of nlrp3 inflammasome in microglia indirectly leads to the loss of dans, which can worsen pd. |
2024-04-10 |
2024-04-12 |
Not clear |
| Xinyue Li, Kai Ma, Tiantian Tian, Huan Pang, Tianxiang Liu, Meng Li, Jiali Li, Zhixuan Luo, Huiyuan Hu, Shanshan Hou, Jing Yu, Qiaohong Hou, Xiuling Song, Chao Zhao, Haiying Du, Jinhua Li, Zhongjun Du, Minghua Ji. Methylmercury induces inflammatory response and autophagy in microglia through the activation of NLRP3 inflammasome. Environment international. vol 186. 2024-04-08. PMID:38588609. |
methylmercury induces inflammatory response and autophagy in microglia through the activation of nlrp3 inflammasome. |
2024-04-08 |
2024-04-11 |
mouse |
| Wenwen Zhu, Haoqiang Zhang, Tong Niu, Kunyu Liu, Huzaifa Fareeduddin Mohammed Farooqui, Ruoyu Sun, Xiu Chen, Yang Yuan, Shaohua Wan. Microglial SCAP deficiency protects against diabetes-associated cognitive impairment through inhibiting NLRP3 inflammasome-mediated neuroinflammation. Brain, behavior, and immunity. 2024-04-03. PMID:38570101. |
these findings indicate an important regulatory axis of microglial responses from scap to the nlrp3 inflammasome pathway in microglia. |
2024-04-03 |
2024-04-06 |
mouse |
| Tahmineh Mokhtari, Elnaz Irandoost, Fatemeh Sheikhbahae. Stress, pain, anxiety, and depression in endometriosis-Targeting glial activation and inflammation. International immunopharmacology. vol 132. 2024-04-02. PMID:38565045. |
the activation of glial cells, particularly the polarization of microglia, leads to the activation of the nlrp3 inflammasome and the overproduction of inflammatory cytokines. |
2024-04-02 |
2024-04-05 |
Not clear |
| Ya Zhao, Qian Li, Jingyan Niu, Erliang Guo, Chenchen Zhao, Jian Zhang, Xue Liu, Lihua Wang, Lang Rao, Xiaoyuan Chen, Kuikun Yan. Neutrophil Membrane-Camouflaged Polyprodrug Nanomedicine for Inflammation Suppression in Ischemic Stroke Therapy. Advanced materials (Deerfield Beach, Fla.). 2024-03-22. PMID:38519052. |
in addition, single-cell rna-sequencing analysis identifies that the nanomedicine attenuates post-stroke inflammation by reprogramming microglia toward anti-inflammatory phenotypes, which is realized via modulating cebpb-regulated activation of nlrp3 inflammasomes and secretion of cxcl2 chemokine. |
2024-03-22 |
2024-03-25 |
Not clear |
| Ping Gao, Haowei Shi, Xiaofei Jin, Shuhan Guo, Xiaohong Zhou, Weijuan Ga. Mechanism of astragaloside IV regulating NLRP3 through LOC102555978 to attenuate cerebral ischemia reperfusion induced microglia pyroptosis. International immunopharmacology. vol 131. 2024-03-21. PMID:38513574. |
mechanism of astragaloside iv regulating nlrp3 through loc102555978 to attenuate cerebral ischemia reperfusion induced microglia pyroptosis. |
2024-03-21 |
2024-03-24 |
rat |
| Xiao-Mei Xia, Yu Duan, Yue-Ping Wang, Rui-Xue Han, Yin-Feng Dong, Si-Yuan Jiang, Yu Zheng, Chen Qiao, Lei Cao, Xiao Lu, Ming L. Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α7nAchR-dependent inactivation of microglial NLRP3 inflammasome. Acta pharmacologica Sinica. 2024-03-20. PMID:38504011. |
we found that tmcao activated microglia in the ischemic core and penumbra regions of the brain, followed by the nlrp3 inflammasome activation-induced neuroinflammation, which finally triggered neuronal death. |
2024-03-20 |
2024-03-23 |
mouse |
| Cagla Kiser, Ceren Perihan Gonul, Sermin Gen. Nrf2 activator Diethyl Maleate attenuates ROS mediated NLRP3 inflammasome activation in murine microglia. Cytotechnology. vol 76. issue 2. 2024-03-18. PMID:38495294. |
nrf2 activator diethyl maleate attenuates ros mediated nlrp3 inflammasome activation in murine microglia. |
2024-03-18 |
2024-03-20 |
Not clear |
| Cagla Kiser, Ceren Perihan Gonul, Sermin Gen. Nrf2 activator Diethyl Maleate attenuates ROS mediated NLRP3 inflammasome activation in murine microglia. Cytotechnology. vol 76. issue 2. 2024-03-18. PMID:38495294. |
in this study, nlrp3 inflammasome was activated in n9 murine microglia via 1 µg/ml lps (lipopolysaccharide) for 4 h and 5 mm atp (adenosine 5'-triphosphate) for 1 h, respectively. |
2024-03-18 |
2024-03-20 |
Not clear |
| Nan-Shi-Yu Yang, Wen-Jing Zhong, Han-Xi Sha, Chen-Yu Zhang, Ling Jin, Jia-Xi Duan, Jian-Bing Xiong, Zhi-Jian You, Yong Zhou, Cha-Xiang Gua. mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice. International journal of biological sciences. vol 20. issue 5. 2024-03-14. PMID:38481801. |
the activation of nlrp3 inflammasome in microglia is critical for neuroinflammation during postoperative cognitive dysfunction (pocd) induced by sevoflurane. |
2024-03-14 |
2024-03-16 |
mouse |
| Nan-Shi-Yu Yang, Wen-Jing Zhong, Han-Xi Sha, Chen-Yu Zhang, Ling Jin, Jia-Xi Duan, Jian-Bing Xiong, Zhi-Jian You, Yong Zhou, Cha-Xiang Gua. mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice. International journal of biological sciences. vol 20. issue 5. 2024-03-14. PMID:38481801. |
however, the molecular mechanism by which sevoflurane activates the nlrp3 inflammasome in microglia remains unclear. |
2024-03-14 |
2024-03-16 |
mouse |