| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fudong Li, Xiaofei Sun, Kaiqiang Sun, Fanqi Kong, Xin Jiang, Qingjie Kon. Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway. Neural regeneration research. vol 19. issue 8. 2023-12-16. PMID:38103247. |
furthermore, lupenone decreased nlrp3 inflammasome activation, nlrp3-induced microglial cell polarization, and microglia pyroptosis by inhibiting the nuclear factor kappa b pathway. |
2023-12-16 |
2023-12-19 |
mouse |
| Jingwei Zhao, Mingming Zhang, Huamin Zhang, Ying Wang, Bingyu Chen, Jing Sha. Diosmin ameliorates LPS-induced depression-like behaviors in mice: inhibition of inflammation and oxidative stress in the prefrontal cortex. Brain research bulletin. 2023-12-13. PMID:38092305. |
specifically, diosmin treatment significantly suppressed the secretion of pro-inflammatory cytokines (tnf-α, il-6 and il-1β), reduced the activation of microglia, and inhibited the expression of nlrp3 inflammasome and its downstream effector caspase-1 in both pfc of mice and bv2 microglial cells exposed to lps. |
2023-12-13 |
2023-12-17 |
mouse |
| Hongxia Che, Xiyu Wang, Shusen He, Xiufang Dong, Liangtao Lv, Wancui Xie, Hongyan L. Orally administered selenium-containing α-D-1,6-glucan and α-D-1,6-glucan relief early cognitive deficit in APP/PS1 mice. International journal of biological macromolecules. 2023-12-04. PMID:38048923. |
the results of the morris water maze and open-field test revealed that se-cpa exerted more significant effects than cpa in improving cognitive function and depressive-like behavior by attenuating the oxidative stress, decreasing serum lps level, downregulating the inflammation of astrocytes and microglia through inhibiting the activation of nlrp3 inflammasome, mitigating neuronal cells loss and improving synaptic plasticity. |
2023-12-04 |
2023-12-10 |
mouse |
| Yunfeng Li, Xiongjin Chen, Mulan Zhou, Sifan Feng, Xiaoping Peng, Yan Wan. Microglial TLR4/NLRP3 Inflammasome Signaling in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-12-03. PMID:38043010. |
in the pathological context of ad, the complex interplay between tlr4 and the nlrp3 inflammasomes in microglia influences ad pathology via neuroinflammation. |
2023-12-03 |
2023-12-10 |
Not clear |
| Yunfeng Li, Xiongjin Chen, Mulan Zhou, Sifan Feng, Xiaoping Peng, Yan Wan. Microglial TLR4/NLRP3 Inflammasome Signaling in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-12-03. PMID:38043010. |
in this review, the effect of the activation and inhibition of tlr4 and nlrp3 in microglia on ad pathology, as well as the cross-talk between tlr4 and the nlrp3 inflammasome, and the influence of essential molecules in the relevant signaling pathway on ad pathology, were expounded. |
2023-12-03 |
2023-12-10 |
Not clear |
| Yongri Hong, Caichuan Wei, Miaoying Fu, Xinyang Li, Haiju Zhang, Baozhen Ya. MCC950 alleviates seizure severity and angiogenesis by inhibiting NLRP3/ IL-1β signaling pathway-mediated pyroptosis in mouse model of epilepsy. International immunopharmacology. vol 126. 2023-12-01. PMID:38039716. |
in addition, immunofluorescence staining, rt-qpcr, and western blot demonstrated that mcc950 inhibited the expression of the nlrp3 inflammasome and its related proteins in microglia, whereas microangiogenesis was found to be increased in the cerebral cortex and hippocampus of epileptic mice, and these effects could be reversed by mcc950. |
2023-12-01 |
2023-12-10 |
mouse |
| Lu Yu, Zuohui Zhang, Hao Chen, Miao Wang, Wenqi Mao, Jinxia Hu, Dandan Zuo, Bingchen Lv, Weifeng Wu, Suhua Qi, Guiyun Cu. Remote limb ischemic postconditioning inhibits microglia pyroptosis by modulating HGF after acute ischemia stroke. Bioengineering & translational medicine. vol 8. issue 6. 2023-12-01. PMID:38023701. |
we found that ripostc suppressed the activation of nlrp3 inflammasome to reduce the maturation of gsdmd, leading to decreased pyroptosis in microglia after ais. |
2023-12-01 |
2023-12-07 |
mouse |
| Lu Yu, Zuohui Zhang, Hao Chen, Miao Wang, Wenqi Mao, Jinxia Hu, Dandan Zuo, Bingchen Lv, Weifeng Wu, Suhua Qi, Guiyun Cu. Remote limb ischemic postconditioning inhibits microglia pyroptosis by modulating HGF after acute ischemia stroke. Bioengineering & translational medicine. vol 8. issue 6. 2023-12-01. PMID:38023701. |
we found that ripostc suppressed the activation of nlrp3 inflammasome to reduce the maturation of gsdmd, leading to decreased pyroptosis in microglia after ais. |
2023-11-29 |
2023-12-07 |
mouse |
| Na Li, Mengdi Li, Minfang Guo, Tao Meng, Bingtao Mu, Jingwen Yu, Jiwei Wang, Lijuan Song, Cungen Ma, Jiezhong We. [Eriodictyol improves cognitive function in 5×FAD mice of Alzheimer's disease by inhibiting the microglia NLRP3 inflammasome signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 11. 2023-11-19. PMID:37980548. |
[eriodictyol improves cognitive function in 5×fad mice of alzheimer's disease by inhibiting the microglia nlrp3 inflammasome signaling pathway]. |
2023-11-19 |
2023-11-20 |
mouse |
| Na Li, Mengdi Li, Minfang Guo, Tao Meng, Bingtao Mu, Jingwen Yu, Jiwei Wang, Lijuan Song, Cungen Ma, Jiezhong We. [Eriodictyol improves cognitive function in 5×FAD mice of Alzheimer's disease by inhibiting the microglia NLRP3 inflammasome signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 11. 2023-11-19. PMID:37980548. |
objective to investigate the therapeutic effects of eriodictyol on transgenic mice with five familial alzheimer's disease (5×fad) and the modulation of nod-like receptor-pyrin domain containing 3 (nlrp3) inflammasome in microglia. |
2023-11-19 |
2023-11-20 |
mouse |
| Na Li, Mengdi Li, Minfang Guo, Tao Meng, Bingtao Mu, Jingwen Yu, Jiwei Wang, Lijuan Song, Cungen Ma, Jiezhong We. [Eriodictyol improves cognitive function in 5×FAD mice of Alzheimer's disease by inhibiting the microglia NLRP3 inflammasome signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 11. 2023-11-19. PMID:37980548. |
results compared with the wt group and the eriodictyol-treated wt group, cognitive function was significantly impaired in the ad group mice, and the expression of nlrp3, caspase-1, il-18, asc, il-1β and iba1 were increased in microglia of mouse brain tissue. |
2023-11-19 |
2023-11-20 |
mouse |
| Na Li, Mengdi Li, Minfang Guo, Tao Meng, Bingtao Mu, Jingwen Yu, Jiwei Wang, Lijuan Song, Cungen Ma, Jiezhong We. [Eriodictyol improves cognitive function in 5×FAD mice of Alzheimer's disease by inhibiting the microglia NLRP3 inflammasome signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 11. 2023-11-19. PMID:37980548. |
conclusion eriodictyol may improve cognitive function in animal models of ad by inhibiting the activation of the nlrp3 signaling pathway in microglia. |
2023-11-19 |
2023-11-20 |
mouse |
| Jing Wang, Qiao-Min Ru, Xiao-Hui Yu, Changlong Wang, Kai Li, Chao-Zhen-Yi Han, Na Li, Jing Zhao, John N Wood, Xin Liu, Rui Wang, Yuan Wan. Direct inhibition of microglial activation by a μ receptor selective agonist alleviates inflammatory-induced pain hypersensitivity. European journal of pharmacology. 2023-11-11. PMID:37951488. |
the nlr family pyrin domain containing 3 (nlrp3) related signaling pathway may be involved in the interaction between mel-0614 and microglia. |
2023-11-11 |
2023-11-20 |
mouse |
| Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Imane Ghafir El Idrissi, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kai. Microglia Depletion Attenuates the Pro-Resolving Activity of the Formyl Peptide Receptor 2 Agonist AMS21 Related to Inhibition of Inflammasome NLRP3 Signalling Pathway: A Study of Organotypic Hippocampal Cultures. Cells. vol 12. issue 21. 2023-11-10. PMID:37947648. |
microglia depletion attenuates the pro-resolving activity of the formyl peptide receptor 2 agonist ams21 related to inhibition of inflammasome nlrp3 signalling pathway: a study of organotypic hippocampal cultures. |
2023-11-10 |
2023-11-20 |
Not clear |
| Peiting Huang, Zhanyu Zhang, Piao Zhang, Jiezhu Feng, Jianwei Xie, Yinjuan Zheng, Xiaomei Liang, Baoyu Zhu, Zhenzhen Chen, Shujun Feng, Lijuan Wang, Jiahong Lu, Yawei Liu, Yuhu Zhan. TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells. Molecular neurobiology. 2023-11-02. PMID:37917301. |
after trem2 knockdown, the number of activated microglia was significantly increased, and the expression of cleaved caspase-1, nlrp3 inflammasome, il-1β, gsdmd, and gsdmd-n was increased. |
2023-11-02 |
2023-11-08 |
mouse |
| Ru-Huei Fu, Hui-Jye Chen, Syuan-Yu Hon. Glycine-Alanine Dipeptide Repeat Protein from C9-ALS Interacts with Sulfide Quinone Oxidoreductase (SQOR) to Induce the Activity of the NLRP3 Inflammasome in HMC3 Microglia: Irisflorentin Reverses This Interaction. Antioxidants (Basel, Switzerland). vol 12. issue 10. 2023-10-30. PMID:37891975. |
glycine-alanine dipeptide repeat protein from c9-als interacts with sulfide quinone oxidoreductase (sqor) to induce the activity of the nlrp3 inflammasome in hmc3 microglia: irisflorentin reverses this interaction. |
2023-10-30 |
2023-11-08 |
Not clear |
| Leilei Yang, Peng Lu, Xiangyu Qi, Qian Yang, Luna Liu, Tao Dou, Qingbo Guan, Chunxiao Y. Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice. iScience. vol 26. issue 10. 2023-10-20. PMID:37860765. |
further mechanistic analysis revealed that metformin inhibited the expression and activation of sting and nlrp3 in microglia. |
2023-10-20 |
2023-11-08 |
mouse |
| Hui He, Xiaofang Xie, Xixi Kang, Jinqiang Zhang, Lu Wang, Nan Hu, Lei Xie, Cheng Peng, Zili Yo. Ginsenoside Rg1 ameliorates depressive-like behavior by inhibiting NLRP3 inflammasome activation in mice exposed to chronic stress. European journal of pharmacology. 2023-10-20. PMID:37863415. |
grg1 exert antidepressant effects by preventing stress from activating the nlrp3 inflammasome in microglia, promoting a proneurogenic phenotype and allowing adult hippocampal neurogenesis. |
2023-10-20 |
2023-11-08 |
mouse |
| Qianhui Huang, Pei Yang, Yang Liu, Jianhua Ding, Ming Lu, Gang H. The interplay between α-Synuclein and NLRP3 inflammasome in Parkinson's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-10-18. PMID:37852103. |
it has been reported that abnormal aggregation of α-syn can induce the activation of nlrp3 inflammasome in microglia, increase the production of il-1β, and aggravate neuroinflammation. |
2023-10-18 |
2023-11-08 |
Not clear |
| Suzanne M Green-Fulgham, Jayson B Ball, Andrew J Kwilasz, Michael E Harland, Matthew Frank, Joseph Dragavon, Peter M Grace, Linda R Watkin. Interleukin-1beta and inflammasome expression in spinal cord following chronic constriction injury in male and female rats. Brain, behavior, and immunity. 2023-10-14. PMID:37838078. |
we have discovered that intrathecal il-1 receptor antagonist reverses established pain in both sexes, and increased gene expression of inflammasome nlrp3 is specific to microglia and astrocytes rather than neurons, while il-1beta is specific to microglia in both sexes. |
2023-10-14 |
2023-11-08 |
human |