| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenqiong Wang, Rui Chang, Yan Wang, Liyan Hou, Qingshan Wan. Mitophagy-dependent mitochondrial ROS mediates 2,5-hexanedione-induced NLRP3 inflammasome activation in BV2 microglia. Neurotoxicology. 2023-09-18. PMID:37722613. |
mitophagy-dependent mitochondrial ros mediates 2,5-hexanedione-induced nlrp3 inflammasome activation in bv2 microglia. |
2023-09-18 |
2023-10-07 |
Not clear |
| Wenqiong Wang, Rui Chang, Yan Wang, Liyan Hou, Qingshan Wan. Mitophagy-dependent mitochondrial ROS mediates 2,5-hexanedione-induced NLRP3 inflammasome activation in BV2 microglia. Neurotoxicology. 2023-09-18. PMID:37722613. |
here, we investigated whether mitochondrial reactive oxygen species (mtros) was involved in hd-elicited nlrp3 inflammasome activation in microglia. |
2023-09-18 |
2023-10-07 |
Not clear |
| Wenqiong Wang, Rui Chang, Yan Wang, Liyan Hou, Qingshan Wan. Mitophagy-dependent mitochondrial ROS mediates 2,5-hexanedione-induced NLRP3 inflammasome activation in BV2 microglia. Neurotoxicology. 2023-09-18. PMID:37722613. |
furthermore, inhibition of mitophagy by 3-methyladenine (3-ma) greatly reduced production of mtros, expression of mitochondrial fission-related proteins, dynamin-related protein 1 (drp1) and fission protein 1 (fis1) and activation of nlrp3 inflammasome in hd-intoxicated microglia. |
2023-09-18 |
2023-10-07 |
Not clear |
| Wenqiong Wang, Rui Chang, Yan Wang, Liyan Hou, Qingshan Wan. Mitophagy-dependent mitochondrial ROS mediates 2,5-hexanedione-induced NLRP3 inflammasome activation in BV2 microglia. Neurotoxicology. 2023-09-18. PMID:37722613. |
blocking mitochondrial fission by mdivi-1 also prevented hd-induced mtros production and nlrp3 inflammasome activation in microglia. |
2023-09-18 |
2023-10-07 |
Not clear |
| Feng Zhang, Ruo-Lin Cao, Peng Liu, Tian-Yan Chi, Xue-Fei Ji, Zhong-Hui Zheng, Guo-Liang Chen, Li-Bo Zo. The bexarotene derivative OAB-14 ameliorates cognitive decline in APP/PS1 transgenic mice by suppressing microglia-mediated neuroinflammation through the PPAR-γ pathway. International immunopharmacology. vol 124. issue Pt A. 2023-09-11. PMID:37696142. |
simultaneously, oab-14 dramatically inhibited the activation of microglia in the cerebral cortex and hippocampus of ad mice and dose-dependently downregulated the expression of nuclear factor kappa b (nf-κb) and nod-like receptor protein 3 (nlrp3) in the cerebral cortex. |
2023-09-11 |
2023-10-07 |
mouse |
| Xiaomei Lu, Lixuan Zhan, Guorong Chai, Meiyan Chen, Weiwen Sun, En X. Hypoxic Preconditioning Attenuates Neuroinflammation via Inhibiting NF-κB/NLRP3 Axis Mediated by p-MLKL after Transient Global Cerebral Ischemia. Molecular neurobiology. 2023-09-08. PMID:37682454. |
we found that hpc decreased nlrp3 inflammasome in microglia and inhibited m1 polarization of microglia in ca1 after tgci. |
2023-09-08 |
2023-10-07 |
rat |
| Xiaomei Lu, Lixuan Zhan, Guorong Chai, Meiyan Chen, Weiwen Sun, En X. Hypoxic Preconditioning Attenuates Neuroinflammation via Inhibiting NF-κB/NLRP3 Axis Mediated by p-MLKL after Transient Global Cerebral Ischemia. Molecular neurobiology. 2023-09-08. PMID:37682454. |
additionally, the knockdown of p-mlkl by short hairpin rna (shrna) administration inhibited the activation of the nf-κb signaling pathway and reduced the formation of nlrp3 inflammasome, thus attenuating m1 polarization of microglia and decreasing the release of interleukin 1 beta (il-1β) and necrosis factor alpha (tnf-α) in ca1 post ischemia. |
2023-09-08 |
2023-10-07 |
rat |
| Jing Yao, Zhe Wang, Weihong Song, Yun Zhan. Targeting NLRP3 inflammasome for neurodegenerative disorders. Molecular psychiatry. 2023-09-05. PMID:37670126. |
as a member of nlrs, the nacht, lrr and pyd domains-containing protein 3 (nlrp3) is predominantly expressed in microglia, the principal innate immune cells in the central nervous system (cns). |
2023-09-05 |
2023-10-07 |
Not clear |
| Jing Yao, Zhe Wang, Weihong Song, Yun Zhan. Targeting NLRP3 inflammasome for neurodegenerative disorders. Molecular psychiatry. 2023-09-05. PMID:37670126. |
microglia release proinflammatory cytokines to cause pyroptosis through activating nlrp3 inflammasome. |
2023-09-05 |
2023-10-07 |
Not clear |
| Pengxin Ge, Huijie Duan, Chunrong Tao, Sensen Niu, Yiran Hu, Rui Duan, Aizong Shen, Yancai Sun, Wen Su. TMAO Promotes NLRP3 Inflammasome Activation of Microglia Aggravating Neurological Injury in Ischemic Stroke Through FTO/IGF2BP2. Journal of inflammation research. vol 16. 2023-09-04. PMID:37663757. |
tmao promotes nlrp3 inflammasome activation of microglia aggravating neurological injury in ischemic stroke through fto/igf2bp2. |
2023-09-04 |
2023-09-07 |
Not clear |
| Liu Yang, Yajun Zhang, Xuefei Yu, Danni Li, Na Liu, Xindong Xue, Jianhua F. Periventricular Microglia Polarization and Morphological Changes Accompany NLRP3 Inflammasome-Mediated Neuroinflammation after Hypoxic-Ischemic White Matter Damage in Premature Rats. Journal of immunology research. vol 2023. 2023-08-28. PMID:37636861. |
periventricular microglia polarization and morphological changes accompany nlrp3 inflammasome-mediated neuroinflammation after hypoxic-ischemic white matter damage in premature rats. |
2023-08-28 |
2023-09-07 |
rat |
| Liu Yang, Yajun Zhang, Xuefei Yu, Danni Li, Na Liu, Xindong Xue, Jianhua F. Periventricular Microglia Polarization and Morphological Changes Accompany NLRP3 Inflammasome-Mediated Neuroinflammation after Hypoxic-Ischemic White Matter Damage in Premature Rats. Journal of immunology research. vol 2023. 2023-08-28. PMID:37636861. |
the activation of nlrp3 inflammatory bodies, microglia m1/m2 polarization, myelination, and synaptic development in our model were monitored 7, 14, and 21 days after birth. |
2023-08-28 |
2023-09-07 |
rat |
| Liu Yang, Yajun Zhang, Xuefei Yu, Danni Li, Na Liu, Xindong Xue, Jianhua F. Periventricular Microglia Polarization and Morphological Changes Accompany NLRP3 Inflammasome-Mediated Neuroinflammation after Hypoxic-Ischemic White Matter Damage in Premature Rats. Journal of immunology research. vol 2023. 2023-08-28. PMID:37636861. |
nlrp3 inhibition can play an anti-inflammatory role by inhibiting the differentiation of microglia into the m1 phenotype, thereby improving myelination and synapse formation. |
2023-08-28 |
2023-09-07 |
rat |
| Marta Lovotti, Matthew S J Mangan, Róisín M McManus, Kateryna Shkarina, Matilde B Vasconcelos, Eicke Lat. Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 1: Cell Preparation and Inflammasome Stimulation. Methods in molecular biology (Clifton, N.J.). vol 2713. 2023-08-28. PMID:37639139. |
in these two chapters, we detail methods to isolate and differentiate human macrophages, murine bone marrow-derived macrophages, and murine microglia and stimulate the inflammasomes known to be expressed in macrophages, including the aim2, nlrp3, nlrc4, nlrp1, and non-canonical inflammasomes. |
2023-08-28 |
2023-09-07 |
human |
| Jaqueline S Generoso, Cristiano Julio Faller, Allan Collodel, Carlos Henrique Rocha Catalão, Diogo Dominguini, Fabricia Petronilho, Tatiana Barichello, Vijayasree V Giridhara. NLRP3 Activation Contributes to Memory Impairment in an Experimental Model of Pneumococcal Meningitis. Molecular neurobiology. 2023-08-21. PMID:37603152. |
for the acute protocol, 24 h after induction, brain structures were collected to evaluate cytokines, nlrp3, and microglia. |
2023-08-21 |
2023-09-07 |
rat |
| Marie-Laure Clénet, James Keaney, Gaëlle Gillet, Jorge S Valadas, Julie Langlois, Alvaro Cardenas, Julien Gasser, Irena Kadi. Divergent functional outcomes of NLRP3 blockade downstream of multi-inflammasome activation: therapeutic implications for ALS. Frontiers in immunology. vol 14. 2023-08-14. PMID:37575265. |
we assess therapeutic potential and limitations of nlrp3 inhibition in multi-inflammasome activation contexts utilizing various human cellular systems including cell lines expressing gain of function (gof) mutations for several inflammasomes, primary human monocytes, macrophages, healthy and amyotrophic lateral sclerosis (als) patient induced pluripotent stem cells (ipsc)-derived microglia (imgl) stimulated for canonical and non-canonical inflammasome pathways. |
2023-08-14 |
2023-08-16 |
human |
| Yueting Guo, Shiyi Wang, Li Li, Hengce Zhang, Xiaoyang Chen, Zihan Huang, Yingchun Li. Immunoproteasome Subunit Low Molecular Mass Peptide 2 (LMP2) Deficiency Ameliorates LPS/Aβ Molecular neurobiology. 2023-08-11. PMID:37568045. |
we showed that the lack of lmp2 significantly decreased nlrp3 expression and downstream cytokine release in microglia, resulting in partially blocking aβ |
2023-08-11 |
2023-08-16 |
mouse |
| Yang Yang, Zhong-Fei Gao, Gui-Ge Hou, Qing-Guo Meng, Yun Ho. Discovery of anti-neuroinflammatory agents from 1,4,5,6-tetrahydrobenzo[2,3]oxepino[4,5-d]pyrimidin-2-amine derivatives by regulating microglia polarization. European journal of medicinal chemistry. vol 259. 2023-08-06. PMID:37544188. |
also, 29 inhibited the nod-like receptor nlrp3 inflammasome formation, and down-regulated the expression of m2 isoform of pyruvate kinase in lps-induced bv2 microglia cells. |
2023-08-06 |
2023-08-14 |
mouse |
| Yan Cheng, Rachael Elizabeth Dempsey, Soheil Kazemi Roodsari, Dorela D Shuboni-Mulligan, Olivier George, Larry D Sanford, Ming-Lei Gu. Cocaine Regulates NLRP3 Inflammasome Activity and CRF Signaling in a Region- and Sex-Dependent Manner in Rat Brain. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509440. |
to further characterize the effects of cocaine on microglia and neuroimmune signaling in vivo, we utilized the brains from both sexes of outbred rats with cocaine self-administration to explore the activation status of microglia, nod-, lrr-, and pyrin domain-containing protein 3 (nlrp3) inflammasome activity, corticotropin-releasing factor (crf) signaling, and nf-κb levels in the striatum and hippocampus (hp). |
2023-07-29 |
2023-08-14 |
mouse |
| Guanghong Shen, Chengjian Lou, Qunfeng Li, Bingxin Zhao, Yuhuan Luo, Fei Wu, Dian Jiao, Marong Fang, Yu Gen. Edaravone dexborneol alleviates cerebral ischemia-reperfusion injury through NF-κB/NLRP3 signal pathway. Anatomical record (Hoboken, N.J. : 2007). 2023-07-21. PMID:37475155. |
the expression of the nuclear factor kappa-b (nf-κb)/ the nod-like receptor protein (nlrp3) inflammasome signal pathway and microglia polarization were detected by immunofluorescence and western blotting. |
2023-07-21 |
2023-08-14 |
rat |