| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Gao, Shuai Li, Xueyan Liu, Daoyuan Si, Weiwei Chen, Fenghua Yang, Huan Sun, Ping Yan. RyR2 Stabilizer Attenuates Cardiac Hypertrophy by Downregulating TNF-α/NF-κB/NLRP3 Signaling Pathway through Inhibiting Calcineurin. Journal of cardiovascular translational research. 2024-04-23. PMID:38652413. |
ryr2 stabilizer attenuates cardiac hypertrophy by downregulating tnf-α/nf-κb/nlrp3 signaling pathway through inhibiting calcineurin. |
2024-04-23 |
2024-04-26 |
mouse |
| Yi Gao, Shuai Li, Xueyan Liu, Daoyuan Si, Weiwei Chen, Fenghua Yang, Huan Sun, Ping Yan. RyR2 Stabilizer Attenuates Cardiac Hypertrophy by Downregulating TNF-α/NF-κB/NLRP3 Signaling Pathway through Inhibiting Calcineurin. Journal of cardiovascular translational research. 2024-04-23. PMID:38652413. |
the effect of ryanodine receptor2 (ryr2) and its stabilizer on cardiac hypertrophy is not well known. |
2024-04-23 |
2024-04-26 |
mouse |
| Yi Gao, Shuai Li, Xueyan Liu, Daoyuan Si, Weiwei Chen, Fenghua Yang, Huan Sun, Ping Yan. RyR2 Stabilizer Attenuates Cardiac Hypertrophy by Downregulating TNF-α/NF-κB/NLRP3 Signaling Pathway through Inhibiting Calcineurin. Journal of cardiovascular translational research. 2024-04-23. PMID:38652413. |
the present study shows for the first time that ryr2 stabilizer dantrolene attenuates cardiac hypertrophy by inhibiting the calcineurin, therefore downregulating the tnf-α/nf-κb/nlrp3 pathway. |
2024-04-23 |
2024-04-26 |
mouse |
| Z Y Fang, H Wang, Y B Wang, T Sun, F Cao, Y Y Ba. [Hypertrophic cardiomyopathy complicating with ventricular tachycardia induced by MYBPC3 and RYR2 double gene mutations: a case report]. Zhonghua xin xue guan bing za zhi. vol 51. issue 10. 2023-10-20. PMID:37859363. |
[hypertrophic cardiomyopathy complicating with ventricular tachycardia induced by mybpc3 and ryr2 double gene mutations: a case report]. |
2023-10-20 |
2023-11-08 |
Not clear |
| Reiko Iida, Misuzu Ueki, Toshihiro Yasud. Knockout of M-LP/Mpv17L, a newly identified atypical PDE, induces physiological afferent cardiac hypertrophy in mice. Transgenic research. 2023-10-18. PMID:37851308. |
western blot analysis revealed increased phosphorylation of molecules downstream of the camp/pka signaling pathway, such as β-catenin, ryanodine receptor 2 (ryr2), phospholamban (pln) and troponin i (ctni), as well as members of the mek1-erk1/2 signaling pathway, which is strongly involved in afferent cardiac hypertrophy. |
2023-10-18 |
2023-11-08 |
mouse |
| Junya Nawata, Takeshi Yamamoto, Shinji Tanaka, Yasutake Yano, Tomoyuki Uchida, Shohei Fujii, Yoshihide Nakamura, Takeshi Suetomi, Hitoshi Uchinoumi, Tetsuro Oda, Shigeki Kobayashi, Masafumi Yan. Dantrolene improves left ventricular diastolic property in mineralcorticoid-salt-induced hypertensive rats. Biochemistry and biophysics reports. vol 34. 2023-03-17. PMID:36926278. |
we recently reported that dantrolene (dan) attenuates pressure-overload induced hypertrophic signaling through stabilization of tetrameric structure of cardiac ryanodine receptor (ryr2). |
2023-03-17 |
2023-08-14 |
rat |
| Stephen Baine, Ingrid Bonilla, Andriy Belevych, Andrei Stepanov, Lisa E Dorn, Radmila Terentyeva, Dmitry Terentyev, Federica Accornero, Cynthia A Carnes, Sandor Gyork. Pyridostigmine improves cardiac function and rhythmicity through RyR2 stabilization and inhibition of STIM1-mediated calcium entry in heart failure. Journal of cellular and molecular medicine. vol 25. issue 10. 2021-10-04. PMID:33755308. |
tac mice exhibited characteristic adverse structural (left ventricular hypertrophy) and functional remodelling (reduced ejection fraction, altered myocyte calcium (ca) handling, increased arrhythmogenesis) with enhanced predisposition to arrhythmogenic aberrant sarcoplasmic reticulum (sr) ca release, cardiac ryanodine receptor (ryr2) hyper-phosphorylation and up-regulated store-operated ca entry (soce). |
2021-10-04 |
2023-08-13 |
mouse |
| S Bahadoran, H Hassanpour, S Arab, S Abbasnia, A Kian. Changes in the expression of cardiac genes responsive to thyroid hormones in the chickens with cold-induced pulmonary hypertension. Poultry science. vol 100. issue 8. 2021-07-28. PMID:34225204. |
the data determined that cold stress could increase thyroid hormones and the gene expression of their receptor (thrα) in the pick of chicken growth (21 d) that they themselves elevates the expression of many genes related to contractile elements (mhcα, ryr2, and serca2), leading to adaptive right ventricle hypertrophy. |
2021-07-28 |
2023-08-13 |
chicken |
| Tai-Qin Huang, Min-Xu Zou, Daniel A Pasek, Gerhard Meissne. mTOR signaling in mice with dysfunctional cardiac ryanodine receptor ion channel. Journal of receptor, ligand and channel research. vol 8. 2020-10-01. PMID:26312014. |
simultaneous substitution of three amino acid residues in the calmodulin binding domain (w3587a/l3591d/f3603a, ada) of the cardiac ryanodine receptor ion channel (ryr2) impairs calmodulin inhibition of ryr2 and causes cardiac hypertrophy and early death of |
2020-10-01 |
2023-08-13 |
mouse |
| Francisco J Alvarado, J Martijn Bos, Zhiguang Yuchi, Carmen R Valdivia, Jonathan J Hernández, Yan-Ting Zhao, Dawn S Henderlong, Yan Chen, Talia R Booher, Cherisse A Marcou, Filip Van Petegem, Michael J Ackerman, Héctor H Valdivi. Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2. JCI insight. vol 5. 2020-09-14. PMID:30835254. |
this study is relevant to continue elucidating the possible causes of genotype-negative hcm and the role of ryr2 in cardiac hypertrophy. |
2020-09-14 |
2023-08-13 |
mouse |
| Sören Brandenburg, Jan Pawlowitz, Benjamin Eikenbusch, Jonas Peper, Tobias Kohl, Gyuzel Y Mitronova, Samuel Sossalla, Gerd Hasenfuss, Xander Ht Wehrens, Peter Kohl, Eva A Rog-Zielinska, Stephan E Lehnar. Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis. JCI insight. vol 4. issue 12. 2020-08-24. PMID:31217359. |
junctophilin-2 knockdown in mice disrupted atrial ryr2 clustering and contractility without hypertrophy or interstitial fibrosis. |
2020-08-24 |
2023-08-13 |
mouse |
| Sören Brandenburg, Jan Pawlowitz, Benjamin Eikenbusch, Jonas Peper, Tobias Kohl, Gyuzel Y Mitronova, Samuel Sossalla, Gerd Hasenfuss, Xander Ht Wehrens, Peter Kohl, Eva A Rog-Zielinska, Stephan E Lehnar. Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis. JCI insight. vol 4. issue 12. 2020-08-24. PMID:31217359. |
in contrast, aortic pressure overload resulted in left atrial hypertrophy with decreased junctophilin-2 and ryr2 expression, disrupted axial junctions, and atrial fibrosis. |
2020-08-24 |
2023-08-13 |
mouse |
| Tetsuro Oda, Takeshi Yamamoto, Takayoshi Kato, Hitoshi Uchinoumi, Go Fukui, Yoriomi Hamada, Takuma Nanno, Hironori Ishiguchi, Yoshihide Nakamura, Yoko Okamoto, Michiaki Kono, Shinichi Okuda, Shigeki Kobayashi, Donald M Bers, Masafumi Yan. Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin. Journal of molecular and cellular cardiology. vol 125. 2019-10-28. PMID:30359562. |
knock-in mice expressing ryr2 unable to bind cam also developed hypertrophy and early death. |
2019-10-28 |
2023-08-13 |
mouse |
| Tetsuro Oda, Takeshi Yamamoto, Takayoshi Kato, Hitoshi Uchinoumi, Go Fukui, Yoriomi Hamada, Takuma Nanno, Hironori Ishiguchi, Yoshihide Nakamura, Yoko Okamoto, Michiaki Kono, Shinichi Okuda, Shigeki Kobayashi, Donald M Bers, Masafumi Yan. Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin. Journal of molecular and cellular cardiology. vol 125. 2019-10-28. PMID:30359562. |
thus cam dissociation from ryr2 may be an important step in driving pathological hypertrophic gene transcription. |
2019-10-28 |
2023-08-13 |
mouse |
| Shinichi Okuda, Yoko Sufu-Shimizu, Takayoshi Kato, Masakazu Fukuda, Shigehiko Nishimura, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Sachio Morimoto, Masafumi Yan. CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca Biochemical and biophysical research communications. vol 496. issue 4. 2018-03-14. PMID:29402414. |
camkii-mediated phosphorylation of ryr2 plays a crucial role in aberrant ca cardiac troponin t (tnt) mutation-linked familial hypertrophic cardiomyopathy (fhc) is known to cause sudden cardiac death at a young age. |
2018-03-14 |
2023-08-13 |
Not clear |
| Sören Brandenburg, Tobias Kohl, George S B Williams, Konstantin Gusev, Eva Wagner, Eva A Rog-Zielinska, Elke Hebisch, Miroslav Dura, Michael Didié, Michael Gotthardt, Viacheslav O Nikolaev, Gerd Hasenfuss, Peter Kohl, Christopher W Ward, W Jonathan Lederer, Stephan E Lehnar. Axial tubule junctions control rapid calcium signaling in atria. The Journal of clinical investigation. vol 126. issue 10. 2017-09-11. PMID:27643434. |
moreover, left atrial hypertrophy led to at proliferation, with a marked increase in the highly phosphorylated ryr2-ps2808 cluster fraction, thereby maintaining cytosolic ca2+ signaling despite decreases in ryr2 cluster density and ryr2 protein expression. |
2017-09-11 |
2023-08-13 |
mouse |
| Tai-Qin Huang, Monte S Willis, Gerhard Meissne. IL-6/STAT3 signaling in mice with dysfunctional type-2 ryanodine receptor. JAK-STAT. vol 4. issue 4. 2016-05-24. PMID:27217982. |
mice with genetically modified cardiac ryanodine receptor (ryr2 (ada/ada) mice) are impaired in regulation by calmodulin, develop severe cardiac hypertrophy and die about 2 weeks after birth. |
2016-05-24 |
2023-08-13 |
mouse |
| Tai-Qin Huang, Monte S Willis, Gerhard Meissne. IL-6/STAT3 signaling in mice with dysfunctional type-2 ryanodine receptor. JAK-STAT. vol 4. issue 4. 2016-05-24. PMID:27217982. |
we hypothesized that the interleukin 6 (il-6)/signal transducer and activator of transcription-3 (stat3) signaling pathway has a role in the development of the ryr2 (ada/ada) cardiac hypertrophy phenotype, and determined cardiac function and protein levels of il-6, phosphorylation levels of stat3, and downstream targets c-fos and c-myc in wild-type and ryr2 (ada/ada) mice, mice with a disrupted il-6 gene, and mice treated with stat3 inhibitor nsc74859. |
2016-05-24 |
2023-08-13 |
mouse |
| Manuela Lavorato, Tai-Qin Huang, Venkat Ramesh Iyer, Stefano Perni, Gerhard Meissner, Clara Franzini-Armstron. Dyad content is reduced in cardiac myocytes of mice with impaired calmodulin regulation of RyR2. Journal of muscle research and cell motility. vol 36. issue 2. 2016-02-04. PMID:25694159. |
three engineered amino acid substitutions in the cam binding site of the cardiac ryanodine receptor (ryr2) in mice (ryr2 (ada/ada) ) strongly affect cardiac function, with impaired cam inhibition of ryr2, reduced sr ca(2+) sequestration, and early cardiac hypertrophy and death (yamaguchi et al., j clin invest 117:1344-1353, 2007). |
2016-02-04 |
2023-08-13 |
mouse |
| Asima Chakraborty, Daniel A Pasek, Tai-Qin Huang, Angela C Gomez, Naohiro Yamaguchi, Mark E Anderson, Gerhard Meissne. Inhibition of CaMKII does not attenuate cardiac hypertrophy in mice with dysfunctional ryanodine receptor. PloS one. vol 9. issue 8. 2015-11-09. PMID:25093823. |
substitution of three amino acid residues in the cam binding domain of ryr2 (ryr2-w3587a/l3591d/f3603a, ryr2ada) impairs inhibition of ryr2 by cam and results in cardiac hypertrophy and early death of mice carrying the ryr2ada mutation. |
2015-11-09 |
2023-08-13 |
mouse |