| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hajime Nishio, Noriyuki Okudaira, Kazufumi Matsushita, Tomohiro Yoshimoto, Takako Sato, Koichi Suzuk. Hypertrophy of lymphoid organs is a possible phenotypic characteristic of R420W mutation of the cardiac ryanodine receptor gene: a study using a knock-in mouse model. Legal medicine (Tokyo, Japan). vol 16. issue 6. 2015-06-16. PMID:25087098. |
the present study examined whether r420w mutation of ryr2 causes hypertrophy of lymphoid organs by generating a mouse model carrying the mutation. |
2015-06-16 |
2023-08-13 |
mouse |
| Hajime Nishio, Noriyuki Okudaira, Kazufumi Matsushita, Tomohiro Yoshimoto, Takako Sato, Koichi Suzuk. Hypertrophy of lymphoid organs is a possible phenotypic characteristic of R420W mutation of the cardiac ryanodine receptor gene: a study using a knock-in mouse model. Legal medicine (Tokyo, Japan). vol 16. issue 6. 2015-06-16. PMID:25087098. |
these findings show that mice with r420w mutation of ryr2 exhibit hypertrophy of lymphoid organs. |
2015-06-16 |
2023-08-13 |
mouse |
| Liang Shi, Hao Xu, Jinhong Wei, Xingfeng Ma, Jianbao Zhan. Caffeine induces cardiomyocyte hypertrophy via p300 and CaMKII pathways. Chemico-biological interactions. vol 221. 2015-02-05. PMID:25093688. |
the caffeine-induced myocyte enhancer factor-2 (mef2) expression and hypertrophy can be completely abolished by the inhibition of cardiac ryanodine receptor (ryr2), as well as kn93 and curcumin treatments. |
2015-02-05 |
2023-08-13 |
rat |
| Juan José Arnáiz-Cot, Brooke James Damon, Xiao-Hua Zhang, Lars Cleemann, Naohiro Yamaguchi, Gerhard Meissner, Martin Mora. Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor. The Journal of physiology. vol 591. issue 17. 2015-01-02. PMID:23836685. |
point mutations in the cam-binding domain of ryr2 (w3587a/l3591d/f3603a, ryr2(ada)) in mice result in severe cardiac hypertrophy, poor left ventricle contraction and death by postnatal day 16, suggesting that cam inhibition of ryr2 is required for normal cardiac function. |
2015-01-02 |
2023-08-12 |
mouse |
| Jingqun Zhang, Biyi Chen, Xiaowei Zhong, Tao Mi, Ang Guo, Qiang Zhou, Zhen Tan, Guogen Wu, Alexander W Chen, Michael Fill, Long-Sheng Song, S R Wayne Che. The cardiac ryanodine receptor luminal Ca2+ sensor governs Ca2+ waves, ventricular tachyarrhythmias and cardiac hypertrophy in calsequestrin-null mice. The Biochemical journal. vol 461. issue 1. 2014-08-12. PMID:24758151. |
in the present study, we assessed the role of the newly identified ryr2 (ryanodine receptor 2)-resident luminal ca2+ sensor in determining scw propensity, cpvt susceptibility and cardiac hypertrophy in casq2-ko (knockout) mice. |
2014-08-12 |
2023-08-13 |
mouse |
| Thomas H Fischer, Jonas Herting, Theodor Tirilomis, André Renner, Stefan Neef, Karl Toischer, David Ellenberger, Anna Förster, Jan D Schmitto, Jan Gummert, Friedrich A Schöndube, Gerd Hasenfuss, Lars S Maier, Samuel Sossall. Ca2+/calmodulin-dependent protein kinase II and protein kinase A differentially regulate sarcoplasmic reticulum Ca2+ leak in human cardiac pathology. Circulation. vol 128. issue 9. 2013-10-28. PMID:23877259. |
sarcoplasmic reticulum (sr) ca(2+) leak through ryanodine receptor type 2 (ryr2) dysfunction is of major pathophysiological relevance in human heart failure (hf); however, mechanisms underlying progressive ryr2 dysregulation from cardiac hypertrophy to hf are still controversial. |
2013-10-28 |
2023-08-12 |
human |
| Naohiro Yamaguchi, Asima Chakraborty, Tai-Qin Huang, Le Xu, Angela C Gomez, Daniel A Pasek, Gerhard Meissne. Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1. American journal of physiology. Heart and circulatory physiology. vol 305. issue 1. 2013-09-12. PMID:23666671. |
simultaneous substitution of three amino acid residues (w3587a, l3591d, f3603a; ryr2ada) in the cam binding domain of ryr2 results in loss of cam inhibition at submicromolar (diastolic) and micromolar (systolic) ca²⁺, cardiac hypertrophy, and heart failure in ryr2ada/ada mice. |
2013-09-12 |
2023-08-12 |
mouse |
| Naohiro Yamaguchi, Asima Chakraborty, Tai-Qin Huang, Le Xu, Angela C Gomez, Daniel A Pasek, Gerhard Meissne. Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1. American journal of physiology. Heart and circulatory physiology. vol 305. issue 1. 2013-09-12. PMID:23666671. |
to address whether cardiac hypertrophy results from the elimination of cam and s100a1 inhibition at diastolic or systolic ca²⁺, a mutant mouse was generated with a single ryr2 amino acid substitution (l3591d; ryr2d). |
2013-09-12 |
2023-08-12 |
mouse |
| Naohiro Yamaguchi, Asima Chakraborty, Daniel A Pasek, Jeffery D Molkentin, Gerhard Meissne. Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. American journal of physiology. Heart and circulatory physiology. vol 300. issue 6. 2011-08-23. PMID:21421818. |
mice with three amino acid mutations in the calmodulin binding domain of type-2 ryanodine receptor ion channel (ryr2(ada/ada) mice) have impaired intracellular ca(2+) handling and cardiac hypertrophy with death at an early age. |
2011-08-23 |
2023-08-12 |
mouse |
| Naohiro Yamaguchi, Asima Chakraborty, Daniel A Pasek, Jeffery D Molkentin, Gerhard Meissne. Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. American journal of physiology. Heart and circulatory physiology. vol 300. issue 6. 2011-08-23. PMID:21421818. |
in this report, the role of signaling molecules implicated in cardiac hypertrophy of ryr2(ada/ada) mice was investigated. |
2011-08-23 |
2023-08-12 |
mouse |
| Naohiro Yamaguchi, Asima Chakraborty, Daniel A Pasek, Jeffery D Molkentin, Gerhard Meissne. Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. American journal of physiology. Heart and circulatory physiology. vol 300. issue 6. 2011-08-23. PMID:21421818. |
ablation of cna-β extended the life span of ryr2(ada/ada) mice and enhanced cardiac function without improving sarcoplasmic reticulum ca(2+) handling or suppressing the expression of genes implicated in cardiac hypertrophy. |
2011-08-23 |
2023-08-12 |
mouse |
| Naohiro Yamaguchi, Asima Chakraborty, Daniel A Pasek, Jeffery D Molkentin, Gerhard Meissne. Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. American journal of physiology. Heart and circulatory physiology. vol 300. issue 6. 2011-08-23. PMID:21421818. |
the results indicate that an impaired calmodulin regulation of ryr2 was neither associated with an altered cna-β/nfat, class ii histone deacetylase (hdac)/mef2, nor akt signaling in embryonic day 16.5 hearts; rather increased erk1/2 and p90rsk phosphorylation levels likely leading to reduced gsk-3β activity were found to precede development of cardiac hypertrophy in mice expressing dysfunctional ryanodine receptor ion channel. |
2011-08-23 |
2023-08-12 |
mouse |
| Jérémy Fauconnier, Jean-Luc Pasquié, Patrice Bideaux, Alain Lacampagne, Sylvain Richar. Cardiomyocytes hypertrophic status after myocardial infarction determines distinct types of arrhythmia: role of the ryanodine receptor. Progress in biophysics and molecular biology. vol 103. issue 1. 2010-12-02. PMID:20109482. |
the occurrence of spontaneous ca(2+) sparks, reflecting ryanodine receptor (ryr2) diastolic activity, increased with hypertrophy. |
2010-12-02 |
2023-08-12 |
rat |
| Danijel Juric, Xinghai Yao, Sijo Thandapilly, Xavier Louis, Elliott Cantor, Brian Chaze, Peter Wojciechowski, Zainisha Vasanji, Tonghua Yang, Jeffrey Wigle, Thomas Netticada. Defects in ryanodine receptor function are associated with systolic dysfunction in rats subjected to volume overload. Experimental physiology. vol 95. issue 8. 2010-10-20. PMID:20472646. |
on the basis of the results, we conclude that the progression of hypertrophy due to vo in rats is accompanied by the impairment of systolic function, which in turn is associated with defects in ryr2 expression and function. |
2010-10-20 |
2023-08-12 |
rat |
| Yan Cheng, Qin Zhan, Jiangmin Zhao, Junjie Xia. Stabilizing ryanodine receptor type 2: a novel strategy for the treatment of atrial fibrillation. Medical science monitor : international medical journal of experimental and clinical research. vol 16. issue 7. 2010-09-21. PMID:20581784. |
hypertrophy, hyperthyroidism and heart failure, three common pathological conditions associated with af, result in increased sr ca(2+) leak via ryr2. |
2010-09-21 |
2023-08-12 |
Not clear |
| Jaya Pal Gangopadhyay, Noriaki Ikemot. Intracellular translocation of calmodulin and Ca2+/calmodulin-dependent protein kinase II during the development of hypertrophy in neonatal cardiomyocytes. Biochemical and biophysical research communications. vol 396. issue 2. 2010-07-07. PMID:20433809. |
we have recently shown that stimulation of cultured neonatal cardiomyocytes with endothelin-1 (et-1) first produces conformational disorder within the ryanodine receptor (ryr2) and diastolic ca(2+) leak from the sarcoplasmic reticulum (sr), then develops hypertrophy (ht) in the cardiomyocytes (hamada et al., 2009 [3]). |
2010-07-07 |
2023-08-12 |
Not clear |
| Ralph J van Oort, Jonathan L Respress, Na Li, Corey Reynolds, Angela C De Almeida, Darlene G Skapura, Leon J De Windt, Xander H T Wehren. Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension (Dallas, Tex. : 1979). vol 55. issue 4. 2010-04-09. PMID:20157052. |
we hypothesized that pathological sarcoplasmic reticulum ca(2+) leak through defective cardiac intracellular ca(2+) release channels/ryanodine receptors (ryr2) accelerates heart failure development by stimulating ca(2+)-dependent hypertrophic signaling. |
2010-04-09 |
2023-08-12 |
mouse |
| Tomoyo Hamada, Jaya P Gangopadhyay, Adel Mandl, Peter Erhardt, Noriaki Ikemot. Defective regulation of the ryanodine receptor induces hypertrophy in cardiomyocytes. Biochemical and biophysical research communications. vol 380. issue 3. 2009-04-20. PMID:19284993. |
recent studies on cardiac hypertrophy animal model suggest that inter-domain interactions within the ryanodine receptor (ryr2) become defective concomitant with the development of hypertrophy (e.g. |
2009-04-20 |
2023-08-12 |
rat |
| Tomoyo Hamada, Jaya P Gangopadhyay, Adel Mandl, Peter Erhardt, Noriaki Ikemot. Defective regulation of the ryanodine receptor induces hypertrophy in cardiomyocytes. Biochemical and biophysical research communications. vol 380. issue 3. 2009-04-20. PMID:19284993. |
to determine if de-stabilization of the inter-domain interaction in fact causes hypertrophy, we introduced dpc10 (a peptide corresponding to the g(2460)-p(2495) region of ryr2, which is known to de-stabilize the n-terminal/central domain interaction) into rat neonatal cardiomyocytes by mediation of peptide carrier bioporter. |
2009-04-20 |
2023-08-12 |
rat |
| Tomoyo Hamada, Jaya P Gangopadhyay, Adel Mandl, Peter Erhardt, Noriaki Ikemot. Defective regulation of the ryanodine receptor induces hypertrophy in cardiomyocytes. Biochemical and biophysical research communications. vol 380. issue 3. 2009-04-20. PMID:19284993. |
these results suggest that disruption of the normal n-terminal/central inter-domain interaction within the ryr2 is a causative mechanism of cardiomyocyte hypertrophy. |
2009-04-20 |
2023-08-12 |
rat |