| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiong Lin, Tianxing Yu, Xiaohua Li, Xin Lin, Yong Fan, Liyu X. Umbilical cord mesenchymal stem cells inhibited inflammation of bronchial epithelial cells by regulating Hedgehog pathway. European journal of histochemistry : EJH. vol 67. issue 4. 2023-12-12. PMID:38085254. |
compared with the control group, bronchial epithelial cells treated with tgf-β1 showed significantly decreased proliferation, increased apoptosis, increased secretion of tnf-α and il-6, increased expression of α-sma, shh, gli1 and snail and decreased e-cadherin expression. |
2023-12-12 |
2023-12-17 |
human |
| Jaqueline Isoppo da Cunha, Alessandra Maria Duarte Barauna, Ricardo Castilho Garce. Prechordal structures act cooperatively in early trabeculae development of gnathostome skull. Cells & development. 2023-10-16. PMID:37844659. |
pcp-secreted shh induces its expression in vm cells of the diencephalon, initiating a positive feedback loop involving six3 and gli1. |
2023-10-16 |
2023-11-08 |
Not clear |
| Xinling Zhang, Yujie Chen, Pengbing Ding, Zhiyu Lin, Zhixuan Sun, Mengying Jin, Chong Li, Zhenmin Zhao, Hongsen B. The SHH-GLI1 pathway is required in skin expansion and angiogenesis. Experimental dermatology. 2023-05-16. PMID:37190906. |
in vitro proliferation assays were performed to further validate the effects of shh (sonic hedgehog) and its downstream component gli1 on cell proliferation viability. |
2023-05-16 |
2023-08-14 |
mouse |
| Chenyi Gao, Yue Cao, Mengying He, Xuemin Zhang, Qi Zhong, Lijuan Tang, Ting Chen, Zongze Zhan. SAG treatment ameliorates memory impairment related to sleep loss by upregulating synaptic plasticity in adolescent mice. Behavioural brain research. 2023-05-06. PMID:37148913. |
chronic sleep deprivation impaired recognition and spatial memory, decreased the number of dendritic spines and mepscs of hippocampal ca1 pyramidal neurons, decreased the postsynaptic density, and reduced shh and glioma-associated oncogene homolog 1 (gli1) expression. |
2023-05-06 |
2023-08-14 |
mouse |
| Rosalinda Mejía-Rodríguez, Daniel Romero-Trejo, Rosa O González, José Segovi. Combined treatments with AZD5363, AZD8542, curcumin or resveratrol induce death of human glioblastoma cells by suppressing the PI3K/AKT and SHH signaling pathways. Biochemistry and biophysics reports. vol 33. 2023-01-30. PMID:36714540. |
we found that the combined treatments with azd5363+azd8542+curcumin and azd8542+curcumin+resveratrol inhibit the pi3k/akt and shh survival pathways by decreasing the activity of akt, the reduction of the expression of smo, pp70s6k, ps6k, gli1, p21 and p27, and the activation of caspase-3 as a marker of apoptosis. |
2023-01-30 |
2023-08-14 |
human |
| Hualin Chen, Donghong Yang, Yongcun Wang, Hua Tao, Yiping Luo, Aibing Wu, Shujun Li, Zhixiong Yang, Ming Che. Activation of the Hedgehog pathway mediates resistance to epidermal growth factor receptor inhibitors in non-small cell lung cancer. Journal of Cancer. vol 13. issue 3. 2022-02-14. PMID:35154464. |
shh stimulation promoted gli1 activation as well as cell motility in parental pc9 cells while suppressing gefitinib-induced apoptosis in gefitinib-resistant cells. |
2022-02-14 |
2023-08-13 |
Not clear |
| Manal T Hussein, Abdelraheim Attaai, Gamal Kamel, Doaa M Mokhta. Spatiotemporal expression of sonic hedgehog signalling molecules in the embryonic mesencephalic dopaminergic neurons. Gene expression patterns : GEP. vol 42. 2021-12-09. PMID:34767969. |
the present study attempted to elucidate the possible role(s) of some shh signaling components (ptch1, gli1, gli2 and gli3) in the spatiotemporal development of mda neurons along the rostrocaudal axis of the midbrain and their possible roles in differentiation and survival of mda neurons and the significance of using in vitro models for studying the development of mda neurons. |
2021-12-09 |
2023-08-13 |
Not clear |
| Chengliang Yang, Xiaoli Zheng, Ke Ye, Yanan Sun, Yufei Lu, Qingxia Fan, Hong G. miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo. Molecular therapy. Nucleic acids. vol 19. 2021-12-02. PMID:31981861. |
after that, the expression of mir-135a and hedgehog (hh) signaling pathway-related genes (smo, gli1, shh, and gli2) in tissues and cells was measured, accompanied by evaluation of cell viability, apoptosis, invasion, and migration. |
2021-12-02 |
2023-08-13 |
Not clear |
| Chengliang Yang, Xiaoli Zheng, Ke Ye, Yanan Sun, Yufei Lu, Qingxia Fan, Hong G. miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo. Molecular therapy. Nucleic acids. vol 19. 2021-12-02. PMID:31981861. |
in addition, overexpression of mir-135a or silencing of smo decreased the expression of gli1, gli2, and shh, thus inhibiting ec cell proliferation, migration, and invasion and promoting apoptosis. |
2021-12-02 |
2023-08-13 |
Not clear |
| Israt Jahan, Jennifer Kersigo, Karen L Elliott, Bernd Fritzsc. Smoothened overexpression causes trochlear motoneurons to reroute and innervate ipsilateral eyes. Cell and tissue research. vol 384. issue 1. 2021-10-22. PMID:33409653. |
our data suggest that shh signaling is involved in trochlear motoneuron projections and that the deflected trochlear projections after smom2 expression is likely due to the dorsal expression of gli1, which impedes the normal dorsal trajectory of these neurons. |
2021-10-22 |
2023-08-13 |
Not clear |
| Feng J Gao, Donna Klinedinst, Fabian-Xosé Fernandez, Bei Cheng, Alena Savonenko, Benjamin Devenney, Yicong Li, Dan Wu, Martin G Pomper, Roger H Reeve. Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates. Acta neuropathologica communications. vol 9. issue 1. 2021-10-15. PMID:34399854. |
here, with gli1-lacz reporter mice, we demonstrated that ts65dn had reduced levels of gli1, a sensitive readout of shh signaling, in both hippocampus and cerebellum at postnatal day 6. |
2021-10-15 |
2023-08-13 |
mouse |
| Ge Wang, Hongyang Zhang, Jiancong Sun, Yuwei Zhang, Fen He, Juntao Zo. Cyclosporin A impairs neurogenesis and cognitive abilities in brain development via the IFN-γ-Shh-BDNF pathway. International immunopharmacology. vol 96. 2021-06-22. PMID:33993101. |
here, we found that the immunosuppressant cyclosporin a (csa) decreased the number of brdu+, brdu+/dcx+, brdu+/neun + cells in the hippocampus, impaired learning and memory and inhibited protein levels of the shh signaling pathway, including shh, smo and gli1. |
2021-06-22 |
2023-08-13 |
Not clear |
| Mohd Tayyab, Shirin Farheen, Mubeena Mariyath P M, Nabeela Khanam, M Mobarak Hossain, Mehdi Hayat Shah. Antidepressant and Neuroprotective Effects of Naringenin via Sonic Hedgehog-GLI1 Cell Signaling Pathway in a Rat Model of Chronic Unpredictable Mild Stress. Neuromolecular medicine. vol 21. issue 3. 2021-01-22. PMID:31037465. |
furthermore, we observed brain-derived neurotrophic factor (bdnf), shh, gli1, nkx2.2, and pax6 were downregulated in the hippocampus of cums-exposed rats, which can be upregulated by nar pre-treatment. |
2021-01-22 |
2023-08-13 |
rat |
| Swati Midha, Shikha Chawla, Juhi Chakraborty, Shibu Chameettachal, Sourabh Ghos. Differential Regulation of Hedgehog and Parathyroid Signaling in Mulberry and Nonmulberry Silk Fibroin Textile Braids. ACS biomaterials science & engineering. vol 4. issue 2. 2021-01-11. PMID:33418748. |
although both silk braids enabled adequate cellular attachment, proliferation, and extracellular collagen matrix formation, superior expression of osteogenic markers (alp, vdr, runx2), matrix proteins (col1a2, opn), and signaling molecules (gli1, gli2, shh) with characteristic terminal osteocytic phenotype could only be observed in nonmulberry silk. |
2021-01-11 |
2023-08-13 |
human |
| Zhongxiao Lin, Hansong Sheng, Chaoguo You, Ming Cai, Yiping Zhang, Li Sheng Yu, Xiaoming Yu, Jian Lin, Nu Zhan. Inhibition of the CyclinD1 promoter in response to sonic hedgehog signaling pathway transduction is mediated by Gli1. Experimental and therapeutic medicine. vol 13. issue 1. 2020-10-01. PMID:28123507. |
therefore, the present study investigated whether the shh signaling pathway promotes the apoptosis of mb cells via downregulation of gli1. |
2020-10-01 |
2023-08-13 |
Not clear |
| Li Peng, Chengwei Yang, Jiangwen Yin, Mingyue Ge, Sheng Wang, Guixing Zhang, Qingtong Zhang, Feng Xu, Zhigang Dai, Liping Xie, Yan Li, Jun-Qiang Si, Ketao M. TGF-β2 Induces Gli1 in a Smad3-Dependent Manner Against Cerebral Ischemia/Reperfusion Injury After Isoflurane Post-conditioning in Rats. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31297044. |
if staining, qrt-pcr and western blot showed high expression levels of tgf-β2, shh and gli1 in the hippocampal ca1 of the iso group. |
2020-09-30 |
2023-08-13 |
rat |
| Zhonghua Yang, Linlin Gao, Huimin Jia, Yuzuo Bai, Weilin Wan. The Expression of Shh, Ptch1, and Gli1 in the Developing Caudal Spinal Cord of Fetal Rats With Anorectal Malformations. The Journal of surgical research. vol 233. 2019-11-13. PMID:30502245. |
the expression of shh, ptch1, and gli1 in the developing caudal spinal cord of fetal rats with anorectal malformations. |
2019-11-13 |
2023-08-13 |
rat |
| Samantha Medwid, Haiyan Guan, Kaiping Yan. Bisphenol A stimulates adrenal cortical cell proliferation via ERβ-mediated activation of the sonic hedgehog signalling pathway. The Journal of steroid biochemistry and molecular biology. vol 178. 2019-05-01. PMID:29307715. |
our main findings were: (1) bpa increased cell number and protein levels of proliferating cell nuclear antigen (pcna; a universal marker of cell proliferation), cyclin d1 and d2 (key proliferation factors), as well as shh and its key transcriptional regulator gli1; (2) cyclopamine, a shh pathway inhibitor, blocked these stimulatory effects of bpa on cell proliferation; (3) bpa increased the nuclear translocation of erβ; and (4) the erβ-specific agonist dpn mimicked while the erβ-specific antagonist phtpp abrogated the stimulatory effects of bpa on cell proliferation and shh signaling. |
2019-05-01 |
2023-08-13 |
mouse |
| Yuhong Zhang, Yangjia Zhan. Forkhead box C2 promotes the invasion ability of human trophoblast cells through Hedgehog (Hh) signaling pathway. Cell biology international. vol 42. issue 7. 2018-10-18. PMID:29465790. |
moreover, over-expression of foxc2 significantly promoted the expression of human leukocyte antigen-g (hla-g), matrix metalloproteinase-2 (mmp-2), vimentin, sonic hedgehog (shh), glioma-associated oncogene homolog 1 (gli1), and snail, and inhibited e-cadherin expression. |
2018-10-18 |
2023-08-13 |
human |
| Mohd Tayyab, Mehdi H Shahi, Shirin Farheen, Mubeena P M Mariyath, Nabeela Khanam, Javier S Castresana, M Mobarak Hossai. Sonic hedgehog, Wnt, and brain-derived neurotrophic factor cell signaling pathway crosstalk: potential therapy for depression. Journal of neuroscience research. vol 96. issue 1. 2018-06-22. PMID:28631844. |
the roles of monoamines, brain-derived neurotrophic factor (bdnf), and wnt signaling are well researched, but sonic hedgehog (shh) signaling and its downstream transcription factor gli1 are not well studied in depression. |
2018-06-22 |
2023-08-13 |
Not clear |