| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melanie Feuerstein, Enaam Chleilat, Shokoufeh Khakipoor, Konstantinos Michailidis, Christian Ophoven, Eleni Rouss. Expression patterns of key Sonic Hedgehog signaling pathway components in the developing and adult mouse midbrain and in the MN9D cell line. Cell and tissue research. vol 370. issue 2. 2018-06-05. PMID:28799057. |
we study the expression of shh receptors ptch1 and gas1 (growth arrest-specific 1) and of the transcription factors gli1, gli2 and gli3 in mouse midbrain during embryonic development [embryonic day (e) 12.5 onwards)], in newborn and adult mice using in situ hybridization and immunohistochemistry. |
2018-06-05 |
2023-08-13 |
mouse |
| Joanna Pyczek, Rolf Buslei, David Schult, Annett Hölsken, Michael Buchfelder, Ina Heß, Heidi Hahn, Anja Uhman. Hedgehog signaling activation induces stem cell proliferation and hormone release in the adult pituitary gland. Scientific reports. vol 6. 2018-01-16. PMID:27109116. |
since hormone producing cells of the adenohypophysis as well as acth-, gh- and prl-immunopositive adenomas express shh and its target gli1, we furthermore propose that excess hh signaling is involved in the development/maintenance of hormone-producing pituitary adenomas. |
2018-01-16 |
2023-08-13 |
human |
| Hongchen Cai, Aimin Li. Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord. Developmental biology. vol 432. issue 1. 2017-12-18. PMID:28412462. |
furthermore, loss of spop restores the maximal shh pathway activation and ventral cell fate specification in the gli1;sufu double mutant spinal cord. |
2017-12-18 |
2023-08-13 |
mouse |
| Xiaoya Wang, Sanhua Wei, Yong Zhao, Changhong Shi, Peijuan Liu, Caiqin Zhang, Yingfeng Lei, Bo Zhang, Bing Bai, Yong Huang, Hai Zhan. Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death. Cancer letters. vol 385. 2017-08-08. PMID:27810405. |
itraconazole treatment inhibited hedgehog pathway key molecular expression, such as shh and gli1, resulting in promotion of apoptosis and autophagy. |
2017-08-08 |
2023-08-13 |
mouse |
| Xiaoya Wang, Sanhua Wei, Yong Zhao, Changhong Shi, Peijuan Liu, Caiqin Zhang, Yingfeng Lei, Bo Zhang, Bing Bai, Yong Huang, Hai Zhan. Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death. Cancer letters. vol 385. 2017-08-08. PMID:27810405. |
the anti-proliferation effect of itraconazole-induced apoptosis and autophagy via hedgehog pathway inhibition was confirmed with gli1 inhibitor gant61 and shh sirna, gant61 and shh sirna synergistically enhanced cytotoxicity induced by itraconazole. |
2017-08-08 |
2023-08-13 |
mouse |
| Kumi Suyama, Hideya Onishi, Akira Imaizumi, Kentaro Shinkai, Masayo Umebayashi, Makoto Kubo, Yusuke Mizuuchi, Yoshinao Oda, Masao Tanaka, Masafumi Nakamura, Mitsuo Katan. CD24 suppresses malignant phenotype by downregulation of SHH transcription through STAT1 inhibition in breast cancer cells. Cancer letters. vol 374. issue 1. 2016-07-13. PMID:26797459. |
suppression of shh decreased invasiveness through inhibition of matrix metalloproteinase (mmp)-2 expression, gli1 expression, anchorage-independent proliferation, tumorigenicity, and tumor volume in vivo in cd24 sirna transfected bccs. |
2016-07-13 |
2023-08-13 |
Not clear |
| Mohammed H Al-Wadei, Jheelam Banerjee, Hussein A N Al-Wadei, Hildegard M Schulle. Nicotine induces self-renewal of pancreatic cancer stem cells via neurotransmitter-driven activation of sonic hedgehog signalling. European journal of cancer (Oxford, England : 1990). vol 52. 2016-05-02. PMID:26689865. |
chronic nicotine significantly increased the production of stress neurotransmitters and sonic hedgehog (shh) while inducing gli1 protein and decreasing gaba. |
2016-05-02 |
2023-08-13 |
Not clear |
| Mohammed H Al-Wadei, Jheelam Banerjee, Hussein A N Al-Wadei, Hildegard M Schulle. Nicotine induces self-renewal of pancreatic cancer stem cells via neurotransmitter-driven activation of sonic hedgehog signalling. European journal of cancer (Oxford, England : 1990). vol 52. 2016-05-02. PMID:26689865. |
gaba treatment inhibited the induction of shh and gli1. |
2016-05-02 |
2023-08-13 |
Not clear |
| Jheelam Banerjee, Arokya M S Papu John, Hildegard M Schulle. Regulation of nonsmall-cell lung cancer stem cell like cells by neurotransmitters and opioid peptides. International journal of cancer. vol 137. issue 12. 2016-01-25. PMID:26088878. |
in the current study, epinephrine increased the number of cancer stem cell like cells (cscs) from three nsclc cell lines in spheroid formation assays while enhancing intracellular camp and the stem cell markers sonic hedgehog (shh), aldehyde dehydrogenase-1 (aldh-1) and gli1, effects reversed by gaba or dynorphin b via gαi -mediated inhibition of camp formation. |
2016-01-25 |
2023-08-13 |
mouse |
| B Sandor, K Fintor, Sz Felszeghy, T Juhasz, D Reglodi, L Mark, P Kiss, A Jungling, B D Fulop, A D Nagy, H Hashimoto, R Zakany, A Nagy, A Tama. Structural and morphometric comparison of the molar teeth in pre-eruptive developmental stage of PACAP-deficient and wild-type mice. Journal of molecular neuroscience : MN. vol 54. issue 3. 2015-07-14. PMID:25112419. |
we also obtained altered shh, ptch1 and gli1 expression level in secretory ameloblasts of pacap-deficient mice compared to wild-type littermates suggesting that pacap might play an important role in molar tooth development and matrix mineralization involving influence on shh signaling cascade. |
2015-07-14 |
2023-08-13 |
mouse |
| Malay Chaklader, Prosun Das, Jacintha Archana Pereira, Samaresh Chaudhuri, Sujata La. Altered canonical hedgehog-gli signalling axis in pesticide-induced bone marrow aplasia mouse model. Arhiv za higijenu rada i toksikologiju. vol 63. issue 3. 2014-07-17. PMID:23152377. |
the results depicted pancytopenic feature of peripheral blood, developmental anomaly of neutrophils, depression of primitive stem and progenitor population along with shh, ptch1, smo and gli1 expression in aplasia group. |
2014-07-17 |
2023-08-12 |
mouse |
| Shiori Kanda, Takeshi Mitsuyasu, Yu Nakao, Shintaro Kawano, Yuichi Goto, Ryota Matsubara, Seiji Nakamur. Anti-apoptotic role of the sonic hedgehog signaling pathway in the proliferation of ameloblastoma. International journal of oncology. vol 43. issue 3. 2014-04-07. PMID:23835807. |
furthermore, in the presence of shh neutralizing antibody, nuclear translocation of gli1 and gli2 was abolished, apoptosis was induced, bcl-2 expression decreased and bax expression increased. |
2014-04-07 |
2023-08-12 |
Not clear |
| Deirdre Brennan, Seamus Gile. Sonic hedgehog expression is disrupted following in ovo ethanol exposure during early chick eye development. Reproductive toxicology (Elmsford, N.Y.). vol 41. 2014-03-18. PMID:23751449. |
surprisingly, none of the downstream shh pathway members (ptc, gli1 and gli3) were significantly altered by ethanol exposure. |
2014-03-18 |
2023-08-12 |
chicken |
| Pascal Werminghaus, Matthias Haase, Peter J Hornsby, Sven Schinner, Matthias Schott, Ludwik K Malendowicz, Bernhard J Lammers, Peter E Goretzki, Volker Müller-Mattheis, Markus Giessing, Holger S Willenber. Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line. The Journal of steroid biochemistry and molecular biology. vol 139. 2014-02-03. PMID:24063979. |
we studied the expression of sonic hedgehog (shh), smoothened (smo), patched1 (ptch1) and gli family zinc finger 1 (gli1) in human adrenal and in adrenocortical tumors using immunohistochemistry and semi-quantitative reverse transcriptase-polymerase chain reaction. |
2014-02-03 |
2023-08-12 |
mouse |
| Pascal Werminghaus, Matthias Haase, Peter J Hornsby, Sven Schinner, Matthias Schott, Ludwik K Malendowicz, Bernhard J Lammers, Peter E Goretzki, Volker Müller-Mattheis, Markus Giessing, Holger S Willenber. Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line. The Journal of steroid biochemistry and molecular biology. vol 139. 2014-02-03. PMID:24063979. |
the hh-pathway components shh, gli1, ptch1 and smo were detectable in all adrenal glands. |
2014-02-03 |
2023-08-12 |
mouse |
| Pascal Werminghaus, Matthias Haase, Peter J Hornsby, Sven Schinner, Matthias Schott, Ludwik K Malendowicz, Bernhard J Lammers, Peter E Goretzki, Volker Müller-Mattheis, Markus Giessing, Holger S Willenber. Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line. The Journal of steroid biochemistry and molecular biology. vol 139. 2014-02-03. PMID:24063979. |
while in cortisol-producing adenomas (cpa), hh-signaling expression levels were comparable to that in normal adrenal cortex, a much higher mrna expression of gli1, smo and shh was observed in non-producing adenomas (npa). |
2014-02-03 |
2023-08-12 |
mouse |
| Xiao-Dong Sun, Xing-E Liu, Dong-Sheng Huan. Curcumin reverses the epithelial-mesenchymal transition of pancreatic cancer cells by inhibiting the Hedgehog signaling pathway. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23563640. |
the growth inhibition rate of the cells was measured by mtt assay, apoptosis was detected by flow cytometry, the expression levels of shh, gli1, e-cadherin and vimentin were detected by western blot analysis, and cell invasion and migration ability were examined by transwell cell invasion assay and wound healing assay. |
2013-10-29 |
2023-08-12 |
Not clear |
| Xiao-Dong Sun, Xing-E Liu, Dong-Sheng Huan. Curcumin reverses the epithelial-mesenchymal transition of pancreatic cancer cells by inhibiting the Hedgehog signaling pathway. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23563640. |
the tgf-β1-stimulated panc-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited tgf-β1-stimulated panc-1 cell proliferation and induced apoptosis, compared with other groups (p<0.01), and the expression levels of shh, gli1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (p<0.01, respectively). |
2013-10-29 |
2023-08-12 |
Not clear |
| Hong Ding, Dong Zhou, Sha Hao, Lili Zhou, Weichun He, Jing Nie, Fan Fan Hou, Youhua Li. Sonic hedgehog signaling mediates epithelial-mesenchymal communication and promotes renal fibrosis. Journal of the American Society of Nephrology : JASN. vol 23. issue 5. 2012-06-25. PMID:22302193. |
in cultured renal fibroblasts, recombinant shh protein activated gli1 and induced α-smooth muscle actin (α-sma), desmin, fibronectin, and collagen i expression, suggesting that shh signaling promotes myofibroblast activation and matrix production. |
2012-06-25 |
2023-08-12 |
mouse |
| Wenxia Su, Fankai Meng, Lifang Huang, Miao Zheng, Wenli Liu, Hanying Su. Sonic hedgehog maintains survival and growth of chronic myeloid leukemia progenitor cells through β-catenin signaling. Experimental hematology. vol 40. issue 5. 2012-06-12. PMID:22240607. |
c-myc, gli1, bcl-2, and p21 were also found to be downstream targets of shh signaling, mediating apoptosis or g(2)/m cell cycle arrest of progenitor cells. |
2012-06-12 |
2023-08-12 |
human |