| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lindsay Hayes, Zhiwei Zhang, Paul Albert, Mark Zervas, Sohyun Ah. Timing of Sonic hedgehog and Gli1 expression segregates midbrain dopamine neurons. The Journal of comparative neurology. vol 519. issue 15. 2012-01-12. PMID:21713771. |
our findings demonstrate that the early shh and gli1 lineages specify mda neurons of the substantia nigra pars compacta while the late shh and gli1 lineages maintain their progenitor state longer in the posterior vmb to extend the production of mda neurons in the ventral tegmental area. |
2012-01-12 |
2023-08-12 |
Not clear |
| Leah E Colvin Wanshura, Katherine E Galvin, Hong Ye, Martin E Fernandez-Zapico, Cynthia Wetmor. Sequential activation of Snail1 and N-Myc modulates sonic hedgehog-induced transformation of neural cells. Cancer research. vol 71. issue 15. 2011-10-03. PMID:21646478. |
activation of the sonic hedgehog (shh) pathway and increased expression of gli1 play an important role in proliferation and transformation of granule cell progenitors (gcp) in the developing cerebellum. |
2011-10-03 |
2023-08-12 |
human |
| Hideya Onishi, Masaya Kai, Seiichi Odate, Hironori Iwasaki, Yoshihiro Morifuji, Toshitatsu Ogino, Takafumi Morisaki, Yutaka Nakashima, Mitsuo Katan. Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer. Cancer science. vol 102. issue 6. 2011-07-20. PMID:21338440. |
hypoxia upregulated the transcription of sonic hedgehog (shh), smoothened (smo), gli1 and matrix metalloproteinase9 (mmp9) and increased the invasiveness of pdac. |
2011-07-20 |
2023-08-12 |
human |
| Reem Malek, Jennifer Matta, Natalie Taylor, Mary Ellen Perry, Susan M Mendrys. The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation. PloS one. vol 6. issue 3. 2011-07-05. PMID:21437245. |
the p53 tumor suppressor has been shown to negatively regulate the activity of the shh effector, gli1, in neural stem cells; however, the contribution of p53 to the regulation of shh signaling in gnps during cerebellar development has not been determined. |
2011-07-05 |
2023-08-12 |
mouse |
| Marissa C Blank, Inessa Grinberg, Emmanuel Aryee, Christine Laliberte, Victor V Chizhikov, R Mark Henkelman, Kathleen J Mille. Multiple developmental programs are altered by loss of Zic1 and Zic4 to cause Dandy-Walker malformation cerebellar pathogenesis. Development (Cambridge, England). vol 138. issue 6. 2011-05-02. PMID:21307096. |
expression of the shh-downstream genes ptch1, gli1 and mycn was downregulated in zic1/4 mutants, although shh production and purkinje cell gene expression were normal. |
2011-05-02 |
2023-08-12 |
mouse |
| Saunders Ching, Eric Vilai. Targeted disruption of Sonic Hedgehog in the mouse adrenal leads to adrenocortical hypoplasia. Genesis (New York, N.Y. : 2000). vol 47. issue 9. 2010-01-05. PMID:19536807. |
we show that shh and its downstream effectors gli1, gli2, and gli3 are expressed in the adrenal cortex throughout development, and that shh is required for normal adrenal organogenesis. |
2010-01-05 |
2023-08-12 |
mouse |
| Jing Zhang, Yi Li, Zheng Gang Zhang, Mei Lu, Jade Borneman, Ben Buller, Smita Savant-Bhonsale, Stanton B Elias, Michael Chop. Bone marrow stromal cells increase oligodendrogenesis after stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 29. issue 6. 2009-06-26. PMID:19384336. |
immunohistochemistry was carried out to measure the oligodendrocyte progenitor cells, oligodendrocytes, myelin, and expressions of shh and gli1 at 14 days after mcao. |
2009-06-26 |
2023-08-12 |
rat |
| Jin-Hyeok Hwang, Sang Hyub Lee, Kwang Hyuck Lee, Keung Youp Lee, Haeryoung Kim, Ji Kon Ryu, Yong Bum Yoon, Yong-Tae Ki. Cathepsin B is a target of Hedgehog signaling in pancreatic cancer. Cancer letters. vol 273. issue 2. 2009-01-19. PMID:19004543. |
cyclopamine (hh signal inhibitor) suppressed expression of shh, as well as hh-induced transcription factor gli1, and induced apoptosis in shh-positive pancreatic cancer cell line (panc-1). |
2009-01-19 |
2023-08-12 |
human |
| Katherine E Galvin, Hong Ye, Derek J Erstad, Rod Feddersen, Cynthia Wetmor. Gli1 induces G2/M arrest and apoptosis in hippocampal but not tumor-derived neural stem cells. Stem cells (Dayton, Ohio). vol 26. issue 4. 2008-08-15. PMID:18276799. |
whereas gli1, gli2, and gli3, the primary mediators of shh signaling, were all expressed in hippocampal neural progenitors, shh treatment of nscs induced only gli1 expression. |
2008-08-15 |
2023-08-12 |
Not clear |
| Sohyun Ahn, Alexandra L Joyne. In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature. vol 437. issue 7060. 2005-10-27. PMID:16208373. |
here we adopted an in vivo genetic fate-mapping strategy, using gli1 (gli-kruppel family member) as a sensitive readout of shh activity, to systematically mark and follow the fate of shh-responding cells in the adult mouse forebrain. |
2005-10-27 |
2023-08-12 |
mouse |
| Wensheng Lin, April Kemper, Ken D McCarthy, Peter Pytel, Jian-Ping Wang, Iain L Campbell, Manuel F Utset, Brian Popk. Interferon-gamma induced medulloblastoma in the developing cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 45. 2005-06-10. PMID:15537876. |
more than 80% of these mice display severe ataxia and develop cerebellar tumors that express synaptophysin, the mouse atonal homolog math1, sonic hedgehog (shh), and gli1. |
2005-06-10 |
2023-08-12 |
mouse |
| Paul Buxton, Megan G Davey, I Robert Paton, David R Morrice, Philippa H Francis-West, David W Burt, Cheryll Tickl. Craniofacial development in the talpid3 chicken mutant. Differentiation; research in biological diversity. vol 72. issue 7. 2005-05-19. PMID:15554946. |
we show that shh expression domains are lost from the talpid(3) head--in hindbrain, midbrain, zona limitans intrathalamica, and stomodeal ectoderm--and that direct targets of hedgehog signaling, ptc1, ptc2, and gli1, are also absent even in areas associated with primary shh expression. |
2005-05-19 |
2023-08-12 |
chicken |
| D Suwelack, A Hurtado-Lorenzo, E Millan, V Gonzalez-Nicolini, K Wawrowsky, P R Lowenstein, M G Castr. Neuronal expression of the transcription factor Gli1 using the Talpha1 alpha-tubulin promoter is neuroprotective in an experimental model of Parkinson's disease. Gene therapy. vol 11. issue 24. 2005-02-16. PMID:15573088. |
recently, recombinant adenovirus-derived vectors encoding the differentiation factor sonic hedgehog (shh) and its downstream transcriptional activator (gli1) were shown to protect dopaminergic neurons in the substantia nigra pars compacta from 6-ohda-induced neurotoxicity in rats in vivo. |
2005-02-16 |
2023-08-12 |
mouse |
| JoMichelle D Corrales, Gina L Rocco, Sandra Blaess, Qiuxia Guo, Alexandra L Joyne. Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development. Development (Cambridge, England). vol 131. issue 22. 2005-01-18. PMID:15496441. |
expression of the shh target gene gli1 is also highest in the anterior medial cerebellum, but is restricted to proliferating gcps and bergmann glia. |
2005-01-18 |
2023-08-12 |
mouse |
| Carly Leung, Merel Lingbeek, Olga Shakhova, James Liu, Ellen Tanger, Parvin Saremaslani, Maarten Van Lohuizen, Silvia Marin. Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature. vol 428. issue 6980. 2004-04-07. PMID:15029199. |
together with the rapid induction of bmi1 expression on addition of shh or on overexpression of the shh target gli1 in cerebellar granule cell cultures, these findings implicate bmi1 overexpression as an alternative or additive mechanism in the pathogenesis of medulloblastomas, and highlight a role for bmi1-containing polycomb complexes in proliferation of cerebellar precursor cells. |
2004-04-07 |
2023-08-12 |
mouse |
| Arnaud Nicot, Vincent Lelièvre, Jimmy Tam, James A Waschek, Emanuel DiCicco-Bloo. Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 21. 2002-11-25. PMID:12417650. |
we now show that in the developing cerebellum, pac1 mrna colocalizes with gene transcripts for shh receptor patched 1 and target gene gli1 in the external germinal layer. |
2002-11-25 |
2023-08-12 |
mouse |
| Masanori Takahashi, Noriko Osum. Pax6 regulates specification of ventral neurone subtypes in the hindbrain by establishing progenitor domains. Development (Cambridge, England). vol 129. issue 6. 2002-04-19. PMID:11880342. |
shh was similarly expressed in the floor plate of the mutant hindbrain, while the expressions of ptc1, gli1 and gli2 were altered only in the progenitor domains for the motoneurones. |
2002-04-19 |
2023-08-12 |
rat |
| Dorota Charytoniuk, Betina Porcel, José Rodríguez Gomez, Hélène Faure, Martial Ruat, Elisabeth Traiffor. Sonic Hedgehog signalling in the developing and adult brain. Journal of physiology, Paris. vol 96. issue 1-2. 2002-04-16. PMID:11755778. |
in the postnatal cerebellum, shh expressed by purkinje cells may act on its target receptor complex localized in the external germinative layer to activate gli1. |
2002-04-16 |
2023-08-12 |
rat |
| E Traiffort, D Charytoniuk, L Watroba, H Faure, N Sales, M Rua. Discrete localizations of hedgehog signalling components in the developing and adult rat nervous system. The European journal of neuroscience. vol 11. issue 9. 1999-11-24. PMID:10510184. |
we have performed a detailed localization of cells expressing transcripts of shh, ptc, smo and gli1 in brain and spinal cord of the adult rat as well as in the developing cerebellum. |
1999-11-24 |
2023-08-12 |
rat |
| V A Wallac. Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum. Current biology : CB. vol 9. issue 8. 1999-06-01. PMID:10226030. |
i show here that pcs in the developing mouse cerebellum express the gene encoding the morphogen sonic hedgehog (shh) and that dividing cells in the egl express patched (ptc) and gli1, two target genes of which expression is upregulated in response to hedgehog signalling (see [5] and references therein). |
1999-06-01 |
2023-08-12 |
mouse |