| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shang-Ling Zhu, Min-Qi Luo, Wei-Xiang Peng, Qiu-Xia Li, Zhi-Ying Feng, Zhao-Xia Li, Ming-Xia Wang, Xiao-Xue Feng, Fang Liu, Jian-Lin Huan. Sonic hedgehog signalling pathway regulates apoptosis through Smo protein in human umbilical vein endothelial cells. Rheumatology (Oxford, England). vol 54. issue 6. 2015-07-28. PMID:25406358. |
the aim of this study was to investigate the expression of smoothened protein (smo), a sonic hedgehog (shh) signalling component, in synovium of ra and its role in the survival and apoptosis of endothelial cells. |
2015-07-28 |
2023-08-13 |
human |
| Malay Chaklader, Prosun Das, Jacintha Archana Pereira, Samaresh Chaudhuri, Sujata La. Altered canonical hedgehog-gli signalling axis in pesticide-induced bone marrow aplasia mouse model. Arhiv za higijenu rada i toksikologiju. vol 63. issue 3. 2014-07-17. PMID:23152377. |
the results depicted pancytopenic feature of peripheral blood, developmental anomaly of neutrophils, depression of primitive stem and progenitor population along with shh, ptch1, smo and gli1 expression in aplasia group. |
2014-07-17 |
2023-08-12 |
mouse |
| Pascal Werminghaus, Matthias Haase, Peter J Hornsby, Sven Schinner, Matthias Schott, Ludwik K Malendowicz, Bernhard J Lammers, Peter E Goretzki, Volker Müller-Mattheis, Markus Giessing, Holger S Willenber. Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line. The Journal of steroid biochemistry and molecular biology. vol 139. 2014-02-03. PMID:24063979. |
we studied the expression of sonic hedgehog (shh), smoothened (smo), patched1 (ptch1) and gli family zinc finger 1 (gli1) in human adrenal and in adrenocortical tumors using immunohistochemistry and semi-quantitative reverse transcriptase-polymerase chain reaction. |
2014-02-03 |
2023-08-12 |
mouse |
| Pascal Werminghaus, Matthias Haase, Peter J Hornsby, Sven Schinner, Matthias Schott, Ludwik K Malendowicz, Bernhard J Lammers, Peter E Goretzki, Volker Müller-Mattheis, Markus Giessing, Holger S Willenber. Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line. The Journal of steroid biochemistry and molecular biology. vol 139. 2014-02-03. PMID:24063979. |
the hh-pathway components shh, gli1, ptch1 and smo were detectable in all adrenal glands. |
2014-02-03 |
2023-08-12 |
mouse |
| Pascal Werminghaus, Matthias Haase, Peter J Hornsby, Sven Schinner, Matthias Schott, Ludwik K Malendowicz, Bernhard J Lammers, Peter E Goretzki, Volker Müller-Mattheis, Markus Giessing, Holger S Willenber. Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line. The Journal of steroid biochemistry and molecular biology. vol 139. 2014-02-03. PMID:24063979. |
while in cortisol-producing adenomas (cpa), hh-signaling expression levels were comparable to that in normal adrenal cortex, a much higher mrna expression of gli1, smo and shh was observed in non-producing adenomas (npa). |
2014-02-03 |
2023-08-12 |
mouse |
| Boban M Erovic, Luke Harris, Mina Jamali, David P Goldstein, Jonathan C Irish, Sylvia L Asa, Ozgur Met. Biomarkers of parathyroid carcinoma. Endocrine pathology. vol 23. issue 4. 2013-05-23. PMID:23001705. |
we constructed a tissue microarray of parathyroid carcinomas from 10 patients as well as parathyroid adenomas from 25 patients and stained the slides for 34 proteins involved in angiogenesis (platelet-derived growth factor receptor (pdgfr)-α, pdgfr-β, vascular endothelial growth factor receptor-2 (vegfr-2), and epidermal growth factor receptor (egfr)), inflammation (cyclooxygenase (cox)-1 and cox-2), cell adhesion (matrix metalloproteinase (mmp)-1, cd9, and keratin 7), cell cycle (cdc2p34, cyclin d1, retinoblastoma (rb), p27, p21, parafibromin, bmi-1, 14-3-3σ, and p53), and apoptosis (bcl-2a, mcl-1, bcl-xl, and glutathione-s-transferase-isoenzyme π (gst-π)) along with some markers of the sonic hedgehog (smo, shh, gli-1, gli-2, gli-3, and patched), mtor (akt, mammalian target of rapamycin (mtor), and forkhead box o (foxo)-1), and wnt (wisp-1, wisp-2, and β-catenin) signal transduction pathways. |
2013-05-23 |
2023-08-12 |
Not clear |
| Ronald S Petralia, Ya-Xian Wang, Mark P Mattson, Pamela J Ya. Subcellular distribution of patched and smoothened in the cerebellar neurons. Cerebellum (London, England). vol 11. issue 4. 2013-04-24. PMID:22477363. |
we previously have found that the shh signaling receptors, patched1 (ptch1) and smoothened (smo), are expressed in hippocampal neurons of developing and adult rats, suggesting the continued presence of shh signaling in postmitotic, differentiated neurons. |
2013-04-24 |
2023-08-12 |
rat |
| Zhimin Lao, G Praveen Raju, C Brian Bai, Alexandra L Joyne. MASTR: a technique for mosaic mutant analysis with spatial and temporal control of recombination using conditional floxed alleles in mice. Cell reports. vol 2. issue 2. 2013-02-26. PMID:22884371. |
the fate of single cells lacking fgf8 or shh signaling in the developing hindbrain was analyzed using mastr, and it was revealed that there is only a short time window when neural progenitors require fgfr1 for viability and that granule cell precursors differentiate rapidly when smo is lost. |
2013-02-26 |
2023-08-12 |
mouse |
| Ronald S Petralia, Ya-Xian Wang, Mark P Mattson, Pamela J Ya. Sonic hedgehog distribution within mature hippocampal neurons. Communicative & integrative biology. vol 4. issue 6. 2012-10-02. PMID:22446553. |
using immunoelectron microscopy, we have recently demonstrated the postsynaptic distribution of patched (ptch) and smoothened (smo), the receptors for shh, in hippocampal neurons of the adult rat brain. |
2012-10-02 |
2023-08-12 |
rat |
| Lijuan Song, Yuehui Liu, Yang Yu, Xin Duan, Shening Qi, Yaobo Li. Shh signaling guides spatial pathfinding of raphespinal tract axons by multidirectional repulsion. Cell research. vol 22. issue 4. 2012-09-24. PMID:22064698. |
downstream components of the shh pathway, patched 1 (ptch1) and smoothened (smo), were expressed in the serotonergic caudal raphe nuclei and enriched in the descending serotonergic rst axons. |
2012-09-24 |
2023-08-12 |
Not clear |
| Lijuan Song, Yuehui Liu, Yang Yu, Xin Duan, Shening Qi, Yaobo Li. Shh signaling guides spatial pathfinding of raphespinal tract axons by multidirectional repulsion. Cell research. vol 22. issue 4. 2012-09-24. PMID:22064698. |
diffusible shh repulsion of serotonergic rst axons was shown to be mediated by shh-ptch1 interactions and derepression of smo. |
2012-09-24 |
2023-08-12 |
Not clear |
| Lijuan Song, Yuehui Liu, Yang Yu, Xin Duan, Shening Qi, Yaobo Li. Shh signaling guides spatial pathfinding of raphespinal tract axons by multidirectional repulsion. Cell research. vol 22. issue 4. 2012-09-24. PMID:22064698. |
prominent pathfinding errors of serotonergic rst axons were observed in various shh, ptch1 and smo mutants. |
2012-09-24 |
2023-08-12 |
Not clear |
| Ronald S Petralia, Catherine M Schwartz, Ya-Xian Wang, Mark P Mattson, Pamela J Ya. Subcellular localization of Patched and Smoothened, the receptors for Sonic hedgehog signaling, in the hippocampal neuron. The Journal of comparative neurology. vol 519. issue 18. 2012-03-08. PMID:21618238. |
in this study, we investigate the expression and localization of the shh signaling receptors, patched (ptch) and smoothened (smo), in the hippocampal neurons of young and mature rats. |
2012-03-08 |
2023-08-12 |
rat |
| Lynette A Desouza, Malini Sathanoori, Richa Kapoor, Neha Rajadhyaksha, Luis E Gonzalez, Andreas H Kottmann, Shubha Tole, Vidita A Vaidy. Thyroid hormone regulates the expression of the sonic hedgehog signaling pathway in the embryonic and adult Mammalian brain. Endocrinology. vol 152. issue 5. 2011-07-22. PMID:21363934. |
we provide novel evidence that thyroid hormone regulates expression of the key developmental morphogen sonic hedgehog (shh), and its coreceptors patched (ptc) and smoothened (smo), in the early embryonic and adult forebrain. |
2011-07-22 |
2023-08-12 |
mouse |
| Stefania Trazzi, Valentina Maria Mitrugno, Emanuele Valli, Claudia Fuchs, Simona Rizzi, Sandra Guidi, Giovanni Perini, Renata Bartesaghi, Elisabetta Cian. APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome. Human molecular genetics. vol 20. issue 8. 2011-07-21. PMID:21266456. |
by using an in vitro model of npcs obtained from the subventricular zone and hippocampus, we found that trisomic npcs had an increased expression of the shh receptor patched1 (ptch1), a membrane protein that suppresses the action of a second receptor, smoothened (smo), thereby maintaining the pathway in a repressed state. |
2011-07-21 |
2023-08-12 |
mouse |
| Hideya Onishi, Masaya Kai, Seiichi Odate, Hironori Iwasaki, Yoshihiro Morifuji, Toshitatsu Ogino, Takafumi Morisaki, Yutaka Nakashima, Mitsuo Katan. Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer. Cancer science. vol 102. issue 6. 2011-07-20. PMID:21338440. |
hypoxia upregulated the transcription of sonic hedgehog (shh), smoothened (smo), gli1 and matrix metalloproteinase9 (mmp9) and increased the invasiveness of pdac. |
2011-07-20 |
2023-08-12 |
human |
| Mercedes Barzi, Dorota Kostrz, Anghara Menendez, Sebastian Pon. Sonic Hedgehog-induced proliferation requires specific Gα inhibitory proteins. The Journal of biological chemistry. vol 286. issue 10. 2011-05-11. PMID:21209076. |
proliferation of cerebellar granular neuronal precursors (cgnps) is mediated by sonic hedgehog (shh), which activates the patched and smoothened (smo) receptor complex. |
2011-05-11 |
2023-08-12 |
rat |
| Nobunari Sasaki, Junko Kurisu, Mineko Kengak. Sonic hedgehog signaling regulates actin cytoskeleton via Tiam1-Rac1 cascade during spine formation. Molecular and cellular neurosciences. vol 45. issue 4. 2011-02-07. PMID:20654717. |
shh signaling molecules patched (ptc) and smoothened (smo) are expressed in several types of postmitotic neurons, including cerebellar purkinje cells and hippocampal pyramidal neurons. |
2011-02-07 |
2023-08-12 |
mouse |
| Rajeev Rajendran, Shanker Jha, Kimberly A Fernandes, Sunayana B Banerjee, Farhan Mohammad, Brian G Dias, Vidita A Vaidy. Monoaminergic regulation of Sonic hedgehog signaling cascade expression in the adult rat hippocampus. Neuroscience letters. vol 453. issue 3. 2009-06-22. PMID:19429033. |
however, selective depletion of serotonin, using the serotonergic neurotoxin 5,7-dihyrdroxytryptamine (5,7-dht), or norepinephrine, using the noradrenergic neurotoxin dsp-4, did not alter expression of shh and its co-receptors, smo and ptc. |
2009-06-22 |
2023-08-12 |
rat |
| Munekazu Komada, Hirotomo Saitsu, Masato Kinboshi, Takashi Miura, Kohei Shiota, Makoto Ishibash. Hedgehog signaling is involved in development of the neocortex. Development (Cambridge, England). vol 135. issue 16. 2008-11-25. PMID:18614579. |
to clarify the roles of shh signaling in dorsal pallium (neocortex primordium) development, we have knocked out the shh and smo genes specifically in the early developing dorsal telencephalon by using emx1cre mice. |
2008-11-25 |
2023-08-12 |
mouse |