| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guo-Lin Chen, Gregory M Mille. Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 2. 2012-05-22. PMID:22241550. |
tryptophan hydroxylase (tph) is the rate-limiting enzyme in 5-ht biosynthesis, and the recent identification of a second, neuron-specific tph isoform (tph2) opened up a new area of research. |
2012-05-22 |
2023-08-12 |
monkey |
| Guo-Lin Chen, Gregory M Mille. Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 2. 2012-05-22. PMID:22241550. |
particularly, based on findings on rhesus monkey tph2 genetics and other relevant literature, we propose that: (i) upon activation of adrenal cortisol secretion, the cortisol surge induces tph2 expression and de novo 5-ht synthesis; (ii) the induced 5-ht in turn inhibits cortisol secretion by modulating the adrenal sensitivity to acth via the suprachiasmatic nuclei (scn)-sns-adrenal system, such that it contributes to the feedback inhibition of cortisol production; (iii) basal tph2 expression or 5-ht synthesis, as well as early-life experience, influence basal cortisol primarily via the hormonal hpa axis; and (iv) 5'- and 3'-regulatory polymorphisms of tph2 may differentially influence the stress response, presumably due to their differential roles in gene expression regulation. |
2012-05-22 |
2023-08-12 |
monkey |
| Qi Wu, Michael S Clark, Richard D Palmite. Deciphering a neuronal circuit that mediates appetite. Nature. vol 483. issue 7391. 2012-05-08. PMID:22419158. |
blockade of serotonin (5-ht(3)) receptor signalling in the nts by either the chronic administration of ondansetron or the genetic inactivation of tph2 in caudal serotonergic neurons that project to the nts protects against starvation when agrp neurons are ablated. |
2012-05-08 |
2023-08-12 |
mouse |
| Melinda Bence, Julia Koller, Maria Sasvari-Szekely, Gergely Keszle. Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 1. 2012-05-07. PMID:21785940. |
to this end, short-term parallel cultures of sk-nf-i neuroblastoma cells were treated with tsa either alone or in combination with hypoxia, and mrna levels of dopamine receptor d3 (drd3) and d4 (drd4), dopamine transporter (dat), dopamine hydroxylase (dbh), dopamine receptor regulating factor (drrf), catechol-o-methyltransferase (comt), serotonin receptor 1a (htr1a), monoamino oxidase a (mao-a), serotonin transporter (slc6a4) and tryptophan hydroxylase 2 (tph2) were determined by quantitative pcr. |
2012-05-07 |
2023-08-12 |
human |
| Kevin G Broadbelt, Keith D Rivera, David S Paterson, Jhodie R Duncan, Felicia L Trachtenberg, Joao A Paulo, Martha D Stapels, Natalia S Borenstein, Richard A Belliveau, Elisabeth A Haas, Christina Stanley, Henry F Krous, Hanno Steen, Hannah C Kinne. Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome. Molecular & cellular proteomics : MCP. vol 11. issue 1. 2012-05-01. PMID:21976671. |
previously we reported a deficiency of serotonin (5-ht) and its key biosynthetic enzyme, tryptophan hydroxylase (tph2), in sids infants in the medullary 5-ht system that modulates homeostatic responses during sleep. |
2012-05-01 |
2023-08-12 |
Not clear |
| Kevin G Broadbelt, Keith D Rivera, David S Paterson, Jhodie R Duncan, Felicia L Trachtenberg, Joao A Paulo, Martha D Stapels, Natalia S Borenstein, Richard A Belliveau, Elisabeth A Haas, Christina Stanley, Henry F Krous, Hanno Steen, Hannah C Kinne. Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome. Molecular & cellular proteomics : MCP. vol 11. issue 1. 2012-05-01. PMID:21976671. |
yet, the underlying basis of the tph2 and 5-ht deficiency is unknown. |
2012-05-01 |
2023-08-12 |
Not clear |
| Kevin G Broadbelt, Keith D Rivera, David S Paterson, Jhodie R Duncan, Felicia L Trachtenberg, Joao A Paulo, Martha D Stapels, Natalia S Borenstein, Richard A Belliveau, Elisabeth A Haas, Christina Stanley, Henry F Krous, Hanno Steen, Hannah C Kinne. Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome. Molecular & cellular proteomics : MCP. vol 11. issue 1. 2012-05-01. PMID:21976671. |
in this study, we tested the hypothesis that proteomics would uncover previously unrecognized abnormal levels of proteins related to tph2 and 5-ht regulation in sids cases compared with controls, which could provide novel insight into the basis of their deficiency. |
2012-05-01 |
2023-08-12 |
Not clear |
| Kevin G Broadbelt, Keith D Rivera, David S Paterson, Jhodie R Duncan, Felicia L Trachtenberg, Joao A Paulo, Martha D Stapels, Natalia S Borenstein, Richard A Belliveau, Elisabeth A Haas, Christina Stanley, Henry F Krous, Hanno Steen, Hannah C Kinne. Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome. Molecular & cellular proteomics : MCP. vol 11. issue 1. 2012-05-01. PMID:21976671. |
we first performed a discovery proteomic analysis of the gigantocellularis of the medullary 5-ht system in the same data set with deficiencies of tph2 and 5-ht levels. |
2012-05-01 |
2023-08-12 |
Not clear |
| Kevin G Broadbelt, Keith D Rivera, David S Paterson, Jhodie R Duncan, Felicia L Trachtenberg, Joao A Paulo, Martha D Stapels, Natalia S Borenstein, Richard A Belliveau, Elisabeth A Haas, Christina Stanley, Henry F Krous, Hanno Steen, Hannah C Kinne. Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome. Molecular & cellular proteomics : MCP. vol 11. issue 1. 2012-05-01. PMID:21976671. |
abnormalities in 5-ht and tph2 levels and 5-ht(1a) receptor binding were associated with the 14-3-3 deficits in the same sids cases. |
2012-05-01 |
2023-08-12 |
Not clear |
| Margaret Czesak, Brice Le François, Anne M Millar, Mariam Deria, Mireille Daigle, Jane E Visvader, Hymie Anisman, Paul R Alber. Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in deformed epidermal autoregulatory factor-1 (Deaf-1) gene knock-out mice. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22232550. |
in the dorsal raphe, deaf-1 knock-out mice displayed increased 5-ht1a mrna, protein, and 5-ht1a-positive cell counts but reduced 5-ht levels, whereas other serotonergic markers, such as tryptophan hydroxylase (tph)- or 5-ht-positive cells and tph2 rna levels, were unchanged. |
2012-04-25 |
2023-08-12 |
mouse |
| X Zhang, P J Nicholls, G Laje, T D Sotnikova, R R Gainetdinov, P R Albert, G Rajkowska, C A Stockmeier, M C Speer, D C Steffens, M C Austin, F J McMahon, K R R Krishnan, M A Garcia-Blanco, M G Caro. A functional alternative splicing mutation in human tryptophan hydroxylase-2. Molecular psychiatry. vol 16. issue 12. 2012-03-27. PMID:20856248. |
the tryptophan hydroxylase-2 (tph2) gene is the rate-limiting enzyme in brain 5-ht synthesis, and thus is an ideal candidate gene for understanding the role of dysregulation of brain serotonergic homeostasis. |
2012-03-27 |
2023-08-12 |
human |
| X Zhang, P J Nicholls, G Laje, T D Sotnikova, R R Gainetdinov, P R Albert, G Rajkowska, C A Stockmeier, M C Speer, D C Steffens, M C Austin, F J McMahon, K R R Krishnan, M A Garcia-Blanco, M G Caro. A functional alternative splicing mutation in human tryptophan hydroxylase-2. Molecular psychiatry. vol 16. issue 12. 2012-03-27. PMID:20856248. |
tph2-tr, which lacks tph2 enzyme activity, dominant-negatively affects full-length tph2 function, causing reduced 5-ht production. |
2012-03-27 |
2023-08-12 |
human |
| Michael L Huynh, Elena Rivkin, Ryan Mui, Sabine P Corde. A tryptophan hydroxlyase 1 reporter that directs Cre recombinase extinguishable placental alkaline phosphatase expression in serotonergic (5-HT) neurons and peripheral tissues. Genesis (New York, N.Y. : 2000). vol 49. issue 11. 2012-02-24. PMID:21438125. |
while, in tph1-lox-plap mice, most plap-expressing neurons are monoaminergic, plap was expressed in only 5-10% of neurons expressing the predominant neuronal 5-ht biosynthetic enzyme tph2, serotonin transporter (sert) or aromatic amino acid decarboxylase (aadc). |
2012-02-24 |
2023-08-12 |
mouse |
| Matthew W Hale, Anantha Shekhar, Christopher A Lowr. Development by environment interactions controlling tryptophan hydroxylase expression. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21640184. |
recent studies suggest that tph2 expression and brain serotonin turnover are upregulated in depressed suicide patients, and drug-free depressed patients, respectively. |
2012-02-22 |
2023-08-12 |
Not clear |
| Cynthia L Bethea, Fernanda B Lima, Maria L Centeno, Karin V Weissheimer, Olga Senashova, Arubala P Reddy, Judy L Camero. Effects of citalopram on serotonin and CRF systems in the midbrain of primates with differences in stress sensitivity. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21683135. |
examination of the serotonin system revealed that ss monkeys had significantly lower fev (fifth ewing variant, rodent pet1), tph2 (tryptophan hydroxylase 2), 5ht1a autoreceptor and sert (serotonin reuptake transporter) expression in the dorsal raphe than sr monkeys. |
2012-02-22 |
2023-08-12 |
monkey |
| Ali Jahanshahi, Erwan Le Maitre, Yasin Temel, Laurence Lanfumey, Michel Hamon, Klaus-Peter Lesch, Rosa M Tordera, Joaquín Del Río, Ester Aso, Rafael Maldonado, Tomas Hökfelt, Harry W M Steinbusc. Altered expression of neuronal tryptophan hydroxylase-2 mRNA in the dorsal and median raphe nuclei of three genetically modified mouse models relevant to depression and anxiety. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21704153. |
the expression, turnover and distribution of tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme in 5-ht biosynthesis in the drn and mrn are complex, in keeping with the existence of different subpopulations of 5-ht neurons in this area. |
2012-02-22 |
2023-08-12 |
mouse |
| Ali Jahanshahi, Erwan Le Maitre, Yasin Temel, Laurence Lanfumey, Michel Hamon, Klaus-Peter Lesch, Rosa M Tordera, Joaquín Del Río, Ester Aso, Rafael Maldonado, Tomas Hökfelt, Harry W M Steinbusc. Altered expression of neuronal tryptophan hydroxylase-2 mRNA in the dorsal and median raphe nuclei of three genetically modified mouse models relevant to depression and anxiety. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21704153. |
thus, there were significant decreases in tph2 transcript levels in 5-ht transporter (5-htt)-/- mutant mice, whereas increases were observed in the vesicular glutamate transporter 1 hemi knock out (vglut1+/-) and cannabinoid receptor 1 mutant (cb1r-/-) mice. |
2012-02-22 |
2023-08-12 |
mouse |
| Ali Jahanshahi, Erwan Le Maitre, Yasin Temel, Laurence Lanfumey, Michel Hamon, Klaus-Peter Lesch, Rosa M Tordera, Joaquín Del Río, Ester Aso, Rafael Maldonado, Tomas Hökfelt, Harry W M Steinbusc. Altered expression of neuronal tryptophan hydroxylase-2 mRNA in the dorsal and median raphe nuclei of three genetically modified mouse models relevant to depression and anxiety. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21704153. |
based on these findings, we suggest that tph2 mrna expression is under the influence of multiple messenger systems in relation to presynaptic and/or postsynaptic feedback control of serotonin synthesis that, 5-htt, vglut1 and cb1r seem to be involved in these feedback mechanisms. |
2012-02-22 |
2023-08-12 |
mouse |
| Jukka M Leppänen, Mikko J Peltola, Kaija Puura, Mirjami Mäntymaa, Nina Mononen, Terho Lehtimäk. Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants. Journal of child psychology and psychiatry, and allied disciplines. vol 52. issue 11. 2012-02-01. PMID:21418063. |
allelic variation in the promoter region of a gene that encodes tryptophan hydroxylase isoform 2 (tph2), a rate-limiting enzyme of serotonin synthesis in the central nervous system, has been associated with variations in cognitive function and vulnerability to affective spectrum disorders. |
2012-02-01 |
2023-08-12 |
Not clear |
| C L Bethea, A W Smith, M L Centeno, A P Redd. Long-term ovariectomy decreases serotonin neuron number and gene expression in free ranging macaques. Neuroscience. vol 192. 2012-01-18. PMID:21763405. |
in macaques, ovarian steroid administration to ovariectomized (ovx) individuals improves serotonin neural function through actions on pivotal serotonin-related genes and proteins, such as tph2 (tryptophan hydroxylase 2), sert (serotonin reuptake transporter), and the 5ht1a autoreceptor. |
2012-01-18 |
2023-08-12 |
Not clear |