| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeffrey McKinney, Per M Knappskog, Jan Haavi. Different properties of the central and peripheral forms of human tryptophan hydroxylase. Journal of neurochemistry. vol 92. issue 2. 2005-05-26. PMID:15663479. |
the differences between tph1 and tph2 have important implications for the regulation of serotonin production in the brain and the periphery and may provide an explanation for some of the diverging results reported for tph from different sources in the past. |
2005-05-26 |
2023-08-12 |
human |
| Xiaodong Zhang, Jean-Martin Beaulieu, Tatyana D Sotnikova, Raul R Gainetdinov, Marc G Caro. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science (New York, N.Y.). vol 305. issue 5681. 2004-08-02. PMID:15247473. |
we report a functional (c1473g) single-nucleotide polymorphism in mouse tph2 that results in the substitution of pro447 with arg447 and leads to decreased serotonin levels in pc12 cells. |
2004-08-02 |
2023-08-12 |
mouse |
| Xiaodong Zhang, Jean-Martin Beaulieu, Tatyana D Sotnikova, Raul R Gainetdinov, Marc G Caro. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science (New York, N.Y.). vol 305. issue 5681. 2004-08-02. PMID:15247473. |
our data provide direct evidence for a fundamental role of tph2 in brain serotonin synthesis. |
2004-08-02 |
2023-08-12 |
mouse |
| Francine Côté, Cécile Fligny, Jacques Mallet, Guilan Vodjdan. [Abnormal cardiac activity in mice in the absence of peripheral serotonin synthesis]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146950. |
the rate limiting enzyme of 5-ht synthesis, tryptophan hydroxylase (tph), is encoded by two genes: the well characterized tph1 gene and a recently identified tph2 gene. |
2004-07-19 |
2023-08-12 |
mouse |
| Francine Côté, Etienne Thévenot, Cécile Fligny, Yves Fromes, Michèle Darmon, Marie-Anne Ripoche, Elisa Bayard, Naima Hanoun, Francoise Saurini, Philippe Lechat, Luisa Dandolo, Michel Hamon, Jacques Mallet, Guilan Vodjdan. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14597720. |
the rate-limiting enzyme of 5-ht synthesis, tryptophan hydroxylase (tph), is encoded by two genes, the well characterized tph1 gene and a recently identified tph2 gene. |
2004-01-05 |
2023-08-12 |
mouse |