| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ingeborg Winge, Jeffrey A McKinney, Ming Ying, Clive S D'Santos, Rune Kleppe, Per M Knappskog, Jan Haavi. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. The Biochemical journal. vol 410. issue 1. 2008-04-01. PMID:17973628. |
this indicates that 14-3-3 proteins could play a role in consolidating and strengthening the effects of phosphorylation on tph2 and that they may be important for the regulation of serotonin function in the nervous system. |
2008-04-01 |
2023-08-12 |
human |
| Jean-Martin Beaulieu, Xiaodong Zhang, Ramona M Rodriguiz, Tatyana D Sotnikova, Michael J Cools, William C Wetsel, Raul R Gainetdinov, Marc G Caro. Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 4. 2008-02-25. PMID:18212115. |
here, we generated knockin mice expressing a mutant form of the brain 5-ht synthesis enzyme, tryptophan hydroxylase 2 (tph2). |
2008-02-25 |
2023-08-12 |
mouse |
| Jean-Martin Beaulieu, Xiaodong Zhang, Ramona M Rodriguiz, Tatyana D Sotnikova, Michael J Cools, William C Wetsel, Raul R Gainetdinov, Marc G Caro. Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 4. 2008-02-25. PMID:18212115. |
expression of mutant tph2 in mice results in markedly reduced ( approximately 80%) brain 5-ht production and leads to behavioral abnormalities in tests assessing 5-ht-mediated emotional states. |
2008-02-25 |
2023-08-12 |
mouse |
| Jean-Martin Beaulieu, Xiaodong Zhang, Ramona M Rodriguiz, Tatyana D Sotnikova, Michael J Cools, William C Wetsel, Raul R Gainetdinov, Marc G Caro. Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 4. 2008-02-25. PMID:18212115. |
importantly, inactivation of gsk3beta in tph2 knockin mice, using pharmacological or genetic approaches, alleviates the aberrant behaviors produced by 5-ht deficiency. |
2008-02-25 |
2023-08-12 |
mouse |
| Jean-Martin Beaulieu, Xiaodong Zhang, Ramona M Rodriguiz, Tatyana D Sotnikova, Michael J Cools, William C Wetsel, Raul R Gainetdinov, Marc G Caro. Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 4. 2008-02-25. PMID:18212115. |
these findings establish a critical role of tph2 in the maintenance of brain serotonin homeostasis and identify gsk3beta signaling as an important pathway through which brain 5-ht deficiency induces abnormal behaviors. |
2008-02-25 |
2023-08-12 |
mouse |
| Sven Cichon, Ingeborg Winge, Manuel Mattheisen, Alexander Georgi, Anna Karpushova, Jan Freudenberg, Yun Freudenberg-Hua, Gulia Babadjanova, Ann Van Den Bogaert, Lilia I Abramova, Sofia Kapiletti, Per M Knappskog, Jeffrey McKinney, Wolfgang Maier, Rami Abou Jamra, Thomas G Schulze, Johannes Schumacher, Peter Propping, Marcella Rietschel, Jan Haavik, Markus M Nöthe. Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder. Human molecular genetics. vol 17. issue 1. 2008-02-11. PMID:17905754. |
in the brain, 5-ht production is controlled by tryptophan hydroxylase 2 (tph2). |
2008-02-11 |
2023-08-12 |
Not clear |
| Sven Cichon, Ingeborg Winge, Manuel Mattheisen, Alexander Georgi, Anna Karpushova, Jan Freudenberg, Yun Freudenberg-Hua, Gulia Babadjanova, Ann Van Den Bogaert, Lilia I Abramova, Sofia Kapiletti, Per M Knappskog, Jeffrey McKinney, Wolfgang Maier, Rami Abou Jamra, Thomas G Schulze, Johannes Schumacher, Peter Propping, Marcella Rietschel, Jan Haavik, Markus M Nöthe. Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder. Human molecular genetics. vol 17. issue 1. 2008-02-11. PMID:17905754. |
examination of the functional effects of tph2 pro206ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-ht production in the brain as a pathophysiological mechanism in bpad. |
2008-02-11 |
2023-08-12 |
Not clear |
| Kathrin Scheuch, Marion Lautenschlager, Maik Grohmann, Silke Stahlberg, Julia Kirchheiner, Peter Zill, Andreas Heinz, Diego J Walther, Josef Prille. Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biological psychiatry. vol 62. issue 11. 2008-01-28. PMID:17568567. |
tryptophan hydroxylase 2 (tph2) is the rate-limiting enzyme in brain serotonin (5-ht) biosynthesis. |
2008-01-28 |
2023-08-12 |
human |
| Kathrin Scheuch, Marion Lautenschlager, Maik Grohmann, Silke Stahlberg, Julia Kirchheiner, Peter Zill, Andreas Heinz, Diego J Walther, Josef Prille. Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biological psychiatry. vol 62. issue 11. 2008-01-28. PMID:17568567. |
although dysfunction of 5-ht neurotransmission has been implicated in a variety of neuropsychiatric conditions, the human tph2 promoter has not been characterized in vitro. |
2008-01-28 |
2023-08-12 |
human |
| Federico Remes Lenicov, Sylvie Lemonde, Margaret Czesak, Tera M Mosher, Paul R Alber. Cell-type specific induction of tryptophan hydroxylase-2 transcription by calcium mobilization. Journal of neurochemistry. vol 103. issue 5. 2008-01-03. PMID:17868301. |
alterations in brain serotonin levels are implicated in major depression and are regulated by tryptophan hydroxylase-2 (tph2). |
2008-01-03 |
2023-08-12 |
rat |
| M Izikki, N Hanoun, E Marcos, L Savale, A M Barlier-Mur, F Saurini, S Eddahibi, M Hamon, S Adno. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. American journal of physiology. Lung cellular and molecular physiology. vol 293. issue 4. 2007-11-27. PMID:17675372. |
serotonin [5-hydroxytryptamine (5-ht)] biosynthesis depends on two rate-limiting tryptophan hydroxylases (tph): tph1, which is expressed in peripheral organs, and tph2, which is expressed in neurons. |
2007-11-27 |
2023-08-12 |
mouse |
| M Izikki, N Hanoun, E Marcos, L Savale, A M Barlier-Mur, F Saurini, S Eddahibi, M Hamon, S Adno. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. American journal of physiology. Lung cellular and molecular physiology. vol 293. issue 4. 2007-11-27. PMID:17675372. |
because 5-ht is involved in pulmonary hypertension (ph), we investigated whether genetic variations in tph1 and/or tph2 affected ph development in mice. |
2007-11-27 |
2023-08-12 |
mouse |
| M Izikki, N Hanoun, E Marcos, L Savale, A M Barlier-Mur, F Saurini, S Eddahibi, M Hamon, S Adno. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. American journal of physiology. Lung cellular and molecular physiology. vol 293. issue 4. 2007-11-27. PMID:17675372. |
these results provide evidence that dysregulation of 5-ht synthesis is closely linked to the hypoxic ph phenotype in mice and that tph1 and tph2 may contribute to ph development. |
2007-11-27 |
2023-08-12 |
mouse |
| M S Clark, R A McDevitt, B J Hoplight, J F Neumaie. Chronic low dose ovine corticotropin releasing factor or urocortin II into the rostral dorsal raphe alters exploratory behavior and serotonergic gene expression in specific subregions of the dorsal raphe. Neuroscience. vol 146. issue 4. 2007-10-25. PMID:17467184. |
following behavioral testing, 5-ht1a, 5-ht1b, 5-ht transporter (sert), and tryptophan hydroxylase-2 (tph2) expression was examined through the drn by in situ hybridization. |
2007-10-25 |
2023-08-12 |
human |
| Paresh D Patel, Daniel A Bochar, David L Turner, Fan Meng, Helena M Mueller, Crystal G Pontrell. Regulation of tryptophan hydroxylase-2 gene expression by a bipartite RE-1 silencer of transcription/neuron restrictive silencing factor (REST/NRSF) binding motif. The Journal of biological chemistry. vol 282. issue 37. 2007-10-19. PMID:17613521. |
tryptophan hydroxylase-2 (tph2) is the rate-limiting enzyme in raphe serotonin biosynthesis, and polymorphisms of tph2 are implicated in vulnerability to psychiatric disorders. |
2007-10-19 |
2023-08-12 |
mouse |
| Yi-Mei J Lin, Shin-Chih Chao, Tsung-Ming Chen, Te-Jen Lai, Jia-Shing Chen, H Sunny Su. Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese. Archives of general psychiatry. vol 64. issue 9. 2007-09-28. PMID:17768266. |
the tryptophan hydroxylase 2 (tph2) gene encodes the first (also the rate-limiting) enzyme in the serotonin biosynthetic pathway. |
2007-09-28 |
2023-08-12 |
human |
| Margaret Czesak, Ariel M Burns, Federico Remes Lenicov, Paul R Alber. Characterization of rat rostral raphe primary cultures: multiplex quantification of serotonergic markers. Journal of neuroscience methods. vol 164. issue 1. 2007-09-27. PMID:17498810. |
the standard error of tph2 rna levels between cultures was <20%, indicating a consistent purity of 5-ht neurons. |
2007-09-27 |
2023-08-12 |
rat |
| Peter Zill, Ulrich W Preuss, Gabrielle Koller, Brigitta Bondy, Michael Soyk. SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 8. 2007-09-26. PMID:17251907. |
recent studies have indicated that a newly identified second isoform of the tryptophan hydroxylase gene (tph2) is preferentially involved in the rate limiting synthesis of neuronal serotonin. |
2007-09-26 |
2023-08-12 |
Not clear |
| Lise Gutknecht, Christian Jacob, Alexander Strobel, Claudia Kriegebaum, Johannes Müller, Yong Zeng, Christoph Markert, Andrea Escher, Jens Wendland, Andreas Reif, Rainald Mössner, Cornelius Gross, Burkhard Brocke, Klaus-Peter Lesc. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. The international journal of neuropsychopharmacology. vol 10. issue 3. 2007-07-20. PMID:17176492. |
variation in the tryptophan hydroxylase-2 gene (tph2) coding for the rate-limiting enzyme of serotonin (5-ht) synthesis in the brain modulates responses of limbic circuits to emotional stimuli and has been linked to a spectrum of clinical populations characterized by emotional dysregulation. |
2007-07-20 |
2023-08-12 |
Not clear |
| Lise Gutknecht, Christian Jacob, Alexander Strobel, Claudia Kriegebaum, Johannes Müller, Yong Zeng, Christoph Markert, Andrea Escher, Jens Wendland, Andreas Reif, Rainald Mössner, Cornelius Gross, Burkhard Brocke, Klaus-Peter Lesc. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. The international journal of neuropsychopharmacology. vol 10. issue 3. 2007-07-20. PMID:17176492. |
these findings implicate alterations of 5-ht synthesis in emotion regulation and confirm tph2 as a susceptibility and/or modifier gene of affective spectrum disorders. |
2007-07-20 |
2023-08-12 |
Not clear |