| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew M Swanson, Lauren M DePoy, Shannon L Gourle. Inhibiting Rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine. Nature communications. vol 8. issue 1. 2018-10-03. PMID:29187752. |
inhibiting rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine. |
2018-10-03 |
2023-08-13 |
mouse |
| Stanislav Koulchitsky, Charlotte Delairesse, Thom Beeken, Alexandre Monteforte, Julie Dethier, Etienne Quertemont, Rolf Findeisen, Eric Bullinger, Vincent Seuti. Activation of D2 autoreceptors alters cocaine-induced locomotion and slows down local field oscillations in the rat ventral tegmental area. Neuropharmacology. vol 108. 2017-07-07. PMID:27130904. |
in contrast, co-administration of low dose quinpirole with cocaine markedly altered the pattern of locomotion, from goal-directed exploratory behavior to recurrent motion resembling locomotor stereotypy. |
2017-07-07 |
2023-08-13 |
rat |
| Patricia Rosell-Negre, Juan-Carlos Bustamante, Paola Fuentes-Claramonte, Víctor Costumero, Juan-José Llopis-Llacer, Alfonso Barrós-Loscertale. Reward Contingencies Improve Goal-Directed Behavior by Enhancing Posterior Brain Attentional Regions and Increasing Corticostriatal Connectivity in Cocaine Addicts. PloS one. vol 11. issue 12. 2017-07-04. PMID:27907134. |
reward contingencies improve goal-directed behavior by enhancing posterior brain attentional regions and increasing corticostriatal connectivity in cocaine addicts. |
2017-07-04 |
2023-08-13 |
human |
| Patricia Rosell-Negre, Juan-Carlos Bustamante, Paola Fuentes-Claramonte, Víctor Costumero, Juan-José Llopis-Llacer, Alfonso Barrós-Loscertale. Reward Contingencies Improve Goal-Directed Behavior by Enhancing Posterior Brain Attentional Regions and Increasing Corticostriatal Connectivity in Cocaine Addicts. PloS one. vol 11. issue 12. 2017-07-04. PMID:27907134. |
we examine how the magnitude of the reward affects goal-directed processes in healthy control (hc) subjects and abstinent cocaine dependent (acd) patients by using functional magnetic resonance imaging (fmri) during a counting stroop task with blocked levels of monetary incentives of different magnitudes (€0, €0.01, €0.5, €1 or €1.5). |
2017-07-04 |
2023-08-13 |
human |
| Briac Halbout, Angela T Liu, Sean B Ostlun. A Closer Look at the Effects of Repeated Cocaine Exposure on Adaptive Decision-Making under Conditions That Promote Goal-Directed Control. Frontiers in psychiatry. vol 7. 2016-04-06. PMID:27047400. |
a closer look at the effects of repeated cocaine exposure on adaptive decision-making under conditions that promote goal-directed control. |
2016-04-06 |
2023-08-13 |
rat |
| Briac Halbout, Angela T Liu, Sean B Ostlun. A Closer Look at the Effects of Repeated Cocaine Exposure on Adaptive Decision-Making under Conditions That Promote Goal-Directed Control. Frontiers in psychiatry. vol 7. 2016-04-06. PMID:27047400. |
the current study more directly investigated the effects of cocaine pre-exposure on goal-directed learning and action selection using an approach that discourages habitual performance. |
2016-04-06 |
2023-08-13 |
rat |
| Briac Halbout, Angela T Liu, Sean B Ostlun. A Closer Look at the Effects of Repeated Cocaine Exposure on Adaptive Decision-Making under Conditions That Promote Goal-Directed Control. Frontiers in psychiatry. vol 7. 2016-04-06. PMID:27047400. |
thus, it appears that the tendency for repeated cocaine exposure to promote habit formation does not extend to a more complex behavioral scenario that encourages goal-directed control. |
2016-04-06 |
2023-08-13 |
rat |
| Briac Halbout, Angela T Liu, Sean B Ostlun. A Closer Look at the Effects of Repeated Cocaine Exposure on Adaptive Decision-Making under Conditions That Promote Goal-Directed Control. Frontiers in psychiatry. vol 7. 2016-04-06. PMID:27047400. |
to further explore this issue, we assessed how prior cocaine treatment would affect the rats' ability to learn about a selective reduction in the predictive relationship between one of the two actions and its outcome, which is another fundamental feature of goal-directed behavior. |
2016-04-06 |
2023-08-13 |
rat |
| Neil Schmitzer-Torbert, Steven Apostolidis, Romeo Amoa, Connor O'Rear, Michael Kaster, Josh Stowers, Robert Rit. Post-training cocaine administration facilitates habit learning and requires the infralimbic cortex and dorsolateral striatum. Neurobiology of learning and memory. vol 118. 2015-11-10. PMID:25460040. |
using sensory-specific satiety, extinction tests revealed that lever pressing for actions which were paired with saline were sensitive to devaluation (typical of goal-directed behaviors) while actions which were paired with cocaine were not sensitive to devaluation (typical of habitual behaviors). |
2015-11-10 |
2023-08-13 |
human |
| Courtney M Cameron, R Mark Wightman, Regina M Carell. Dynamics of rapid dopamine release in the nucleus accumbens during goal-directed behaviors for cocaine versus natural rewards. Neuropharmacology. vol 86. 2015-07-14. PMID:25174553. |
dynamics of rapid dopamine release in the nucleus accumbens during goal-directed behaviors for cocaine versus natural rewards. |
2015-07-14 |
2023-08-13 |
rat |
| Courtney M Cameron, R Mark Wightman, Regina M Carell. Dynamics of rapid dopamine release in the nucleus accumbens during goal-directed behaviors for cocaine versus natural rewards. Neuropharmacology. vol 86. 2015-07-14. PMID:25174553. |
electrophysiological studies show that distinct subsets of nucleus accumbens (nac) neurons differentially encode information about goal-directed behaviors for intravenous cocaine versus natural (food/water) rewards. |
2015-07-14 |
2023-08-13 |
rat |
| Laura H Corbit, Billy C Chieng, Bernard W Ballein. Effects of repeated cocaine exposure on habit learning and reversal by N-acetylcysteine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 8. 2015-02-12. PMID:24531561. |
cocaine treatment produced a deficit in goal-directed action, as assessed by outcome devaluation, and increased the frequency of spontaneous and miniature excitatory postsynaptic currents (epscs) in the dms but not in the dls. |
2015-02-12 |
2023-08-12 |
human |
| Laura H Corbit, Billy C Chieng, Bernard W Ballein. Effects of repeated cocaine exposure on habit learning and reversal by N-acetylcysteine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 8. 2015-02-12. PMID:24531561. |
the promotion of goal-directed control has the potential to improve treatment outcomes in human cocaine addicts. |
2015-02-12 |
2023-08-12 |
human |
| Helen Fox, Rajita Sinh. The role of guanfacine as a therapeutic agent to address stress-related pathophysiology in cocaine-dependent individuals. Advances in pharmacology (San Diego, Calif.). vol 69. 2014-11-06. PMID:24484979. |
the pathophysiology of cocaine addiction is linked to changes within neural systems and brain regions that are critical mediators of stress system sensitivity and behavioral processes associated with the regulation of adaptive goal-directed behavior. |
2014-11-06 |
2023-08-12 |
Not clear |
| Gregory Z Tau, Rachel Marsh, Zhishun Wang, Tania Torres-Sanchez, Barbara Graniello, Xuejun Hao, Dongrong Xu, Mark G Packard, Yunsuo Duan, Alayar Kangarlu, Diana Martinez, Bradley S Peterso. Neural correlates of reward-based spatial learning in persons with cocaine dependence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 3. 2014-09-10. PMID:23917430. |
the functioning of the brain circuits for episodic memory or learning that support goal-directed behavior has not been studied previously in persons with cocaine dependence (cd). |
2014-09-10 |
2023-08-12 |
human |
| Matthew D Puhl, Matthew Boisvert, Zhiwei Guan, Jidong Fang, Patricia S Grigso. A novel model of chronic sleep restriction reveals an increase in the perceived incentive reward value of cocaine in high drug-taking rats. Pharmacology, biochemistry, and behavior. vol 109. 2014-01-07. PMID:23603033. |
previously, our laboratory has shown that acute sleep deprivation increases the rate and efficiency (i.e., the goal-directed nature of responding) of cocaine self-administration using a progressive ratio (pr) schedule of reinforcement. |
2014-01-07 |
2023-08-12 |
rat |
| Jennifer E Murray, David Belin, Barry J Everit. Double dissociation of the dorsomedial and dorsolateral striatal control over the acquisition and performance of cocaine seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 11. 2013-02-26. PMID:22739470. |
these results show that dopamine transmission in the pdms is required for initial performance of goal-directed cocaine seeking, and that its role is ultimately subverted and devolves instead to the adls only following training with high rates of cocaine-seeking behavior, supporting the theory of dynamic shifts in the striatal control over cocaine seeking between goal-directed and habitual performance. |
2013-02-26 |
2023-08-12 |
rat |
| Matthew D Puhl, Angie M Cason, Francis H E Wojnicki, Rebecca L Corwin, Patricia S Grigso. A history of bingeing on fat enhances cocaine seeking and taking. Behavioral neuroscience. vol 125. issue 6. 2012-08-20. PMID:21988520. |
rats with the mwf history tended to take more cocaine late in fixed ratio (fr) training, they persisted in their efforts to obtain cocaine in the face of signaled non-availability, worked harder for cocaine on a pr schedule of reinforcement, and exhibited more goal-directed behavior toward the cocaine-associated operandum. |
2012-08-20 |
2023-08-12 |
rat |
| Courtney M Cameron, Regina M Carell. Cocaine abstinence alters nucleus accumbens firing dynamics during goal-directed behaviors for cocaine and sucrose. The European journal of neuroscience. vol 35. issue 6. 2012-07-18. PMID:22356698. |
cocaine abstinence alters nucleus accumbens firing dynamics during goal-directed behaviors for cocaine and sucrose. |
2012-07-18 |
2023-08-12 |
rat |
| H C Lasseter, X Xie, D R Ramirez, R A Fuch. Sub-region specific contribution of the ventral hippocampus to drug context-induced reinstatement of cocaine-seeking behavior in rats. Neuroscience. vol 171. issue 3. 2011-10-31. PMID:20870011. |
these results indicate that the vh contributes to drug context-induced cocaine seeking in a subregion-specific manner, with the functional integrity of the vhp being necessary for memory or motivational aspects of drug-paired environmental stimuli that sustain stimulus control over goal-directed behavior. |
2011-10-31 |
2023-08-12 |
rat |