| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Agustin Zapata, Vicki L Minney, Toni S Shippenber. Shift from goal-directed to habitual cocaine seeking after prolonged experience in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 46. 2010-12-23. PMID:21084602. |
shift from goal-directed to habitual cocaine seeking after prolonged experience in rats. |
2010-12-23 |
2023-08-12 |
rat |
| Agustin Zapata, Vicki L Minney, Toni S Shippenber. Shift from goal-directed to habitual cocaine seeking after prolonged experience in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 46. 2010-12-23. PMID:21084602. |
using a drug seeking/taking chained schedule of intravenous cocaine self-administration and reward devaluation methods in rats, the present studies examined whether drug seeking that is initially goal-directed becomes habitual after prolonged drug seeking and taking. |
2010-12-23 |
2023-08-12 |
rat |
| Agustin Zapata, Vicki L Minney, Toni S Shippenber. Shift from goal-directed to habitual cocaine seeking after prolonged experience in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 46. 2010-12-23. PMID:21084602. |
these studies provide direct evidence that cocaine seeking becomes habitual with prolonged drug experience and describe a rodent model with which to study the neural mechanisms underlying the transition from goal-directed to habitual drug seeking. |
2010-12-23 |
2023-08-12 |
rat |
| Marina E Wol. The Bermuda Triangle of cocaine-induced neuroadaptations. Trends in neurosciences. vol 33. issue 9. 2010-11-26. PMID:20655604. |
activation of medium spiny neurons (msns) of the nucleus accumbens is critical for goal-directed behaviors including cocaine seeking. |
2010-11-26 |
2023-08-12 |
Not clear |
| David H Root, Anthony T Fabbricatore, David J Barker, Sisi Ma, Anthony P Pawlak, Mark O Wes. Evidence for habitual and goal-directed behavior following devaluation of cocaine: a multifaceted interpretation of relapse. PloS one. vol 4. issue 9. 2010-02-01. PMID:19779607. |
evidence for habitual and goal-directed behavior following devaluation of cocaine: a multifaceted interpretation of relapse. |
2010-02-01 |
2023-08-12 |
Not clear |
| Fabio Fumagalli, Carlotta Franchi, Lucia Caffino, Giorgio Racagni, Marco A Riva, Luigi Cerv. Single session of cocaine intravenous self-administration shapes goal-oriented behaviours and up-regulates Arc mRNA levels in rat medial prefrontal cortex. The international journal of neuropsychopharmacology. vol 12. issue 3. 2009-06-08. PMID:19025723. |
self-administration is sufficient to shape rat behaviour towards goal-directed behaviours and selectively up-regulate arc expression in mpfc (of sa animals), providing the first evidence that the mpfc's function is already profoundly influenced by the first voluntary cocaine exposure. |
2009-06-08 |
2023-08-12 |
rat |
| Robert A Wheeler, Regina M Carell. Dissecting motivational circuitry to understand substance abuse. Neuropharmacology. vol 56 Suppl 1. 2009-04-15. PMID:18625253. |
likewise, the dynamic nature of nac cell firing is also reflected in the differential activation of distinct populations of nac neurons during goal-directed behaviors for natural versus drug rewards, and the heightened activation of some nac neurons following cocaine abstinence. |
2009-04-15 |
2023-08-12 |
Not clear |
| Regina M Carell. The nucleus accumbens and reward: neurophysiological investigations in behaving animals. Behavioral and cognitive neuroscience reviews. vol 1. issue 4. 2007-09-25. PMID:17712985. |
this report reviews electrophysiological studies that examined acb cell firing during goal-directed behaviors for natural reinforcers (food, water, sucrose) and drugs of abuse (cocaine, heroin, ethanol). |
2007-09-25 |
2023-08-12 |
Not clear |
| Regina M Carelli, Joyce Wondolowsk. Anatomic distribution of reinforcer selective cell firing in the core and shell of the nucleus accumbens. Synapse (New York, N.Y.). vol 59. issue 2. 2006-04-05. PMID:16270303. |
we have previously reported that distinct populations of nucleus accumbens (nac) neurons differentially encode information about goal-directed behaviors for "natural" (food/water) vs. cocaine reinforcement [j neurosci 20:4255-4266, (2000)]. |
2006-04-05 |
2023-08-12 |
rat |
| Regina M Carelli, Joyce Wondolowsk. Anatomic distribution of reinforcer selective cell firing in the core and shell of the nucleus accumbens. Synapse (New York, N.Y.). vol 59. issue 2. 2006-04-05. PMID:16270303. |
histological reconstruction of electrode placement revealed that nac patterned discharges, specific to goal-directed behaviors for water or cocaine, were not limited to one nac subregion but were evenly distributed and intermixed throughout the core and shell. |
2006-04-05 |
2023-08-12 |
rat |
| Jonathan A Hollander, Regina M Carell. Abstinence from cocaine self-administration heightens neural encoding of goal-directed behaviors in the accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 8. 2005-11-29. PMID:15856078. |
abstinence from cocaine self-administration heightens neural encoding of goal-directed behaviors in the accumbens. |
2005-11-29 |
2023-08-12 |
rat |
| Yukiori Goto, Anthony A Grac. Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: disruption by cocaine sensitization. Neuron. vol 47. issue 2. 2005-10-11. PMID:16039567. |
repeated cocaine administration disrupted this synaptic plasticity at hippocampal and prefrontal cortical inputs and goal-directed behavior in the spatial maze task. |
2005-10-11 |
2023-08-12 |
Not clear |
| Regina M Carell. Nucleus accumbens cell firing and rapid dopamine signaling during goal-directed behaviors in rats. Neuropharmacology. vol 47 Suppl 1. 2004-12-20. PMID:15464136. |
these later findings indicate that separate neural circuits selectively process information about goal-directed behaviors for cocaine versus natural reward. |
2004-12-20 |
2023-08-12 |
rat |
| Eugene A Kiyatkin, P Leon Brow. Brain temperature fluctuations during passive vs. active cocaine administration: clues for understanding the pharmacological determination of drug-taking behavior. Brain research. vol 1005. issue 1-2. 2004-06-22. PMID:15044070. |
while it is generally assumed that cocaine self-administration (sa) is determined and maintained by the pharmacological actions of cocaine in the brain, it is also a drug-motivated and drug-reinforced goal-directed behavior, which is determined by concurrent learning and behavioral performance. |
2004-06-22 |
2023-08-12 |
rat |
| Regina M Carelli, Joyce Wondolowsk. Selective encoding of cocaine versus natural rewards by nucleus accumbens neurons is not related to chronic drug exposure. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 35. 2003-12-23. PMID:14657180. |
we reported previously that subsets of nucleus accumbens (acb) neurons differentially encode information about goal-directed behaviors for "natural" (food and water) versus cocaine reward in animals well trained to self-administer the drug (carelli et al., 2000). |
2003-12-23 |
2023-08-12 |
Not clear |
| Regina M Carell. Nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. 'natural' reinforcement. Physiology & behavior. vol 76. issue 3. 2002-10-08. PMID:12117574. |
nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. 'natural' reinforcement. |
2002-10-08 |
2023-08-12 |
rat |
| M C Olmstead, M V Lafond, B J Everitt, A Dickinso. Cocaine seeking by rats is a goal-directed action. Behavioral neuroscience. vol 115. issue 2. 2001-09-27. PMID:11345964. |
cocaine seeking by rats is a goal-directed action. |
2001-09-27 |
2023-08-12 |
rat |
| A V Azarov, A V Kotov, E I Pevtsova, S M Tolpygo, S Iu Lesnikov. [A comparative analysis of the complex realization of the goal-directed behavior of animals under chronic morphine and cocaine administration]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 45. issue 4. 1996-02-06. PMID:8540261. |
[a comparative analysis of the complex realization of the goal-directed behavior of animals under chronic morphine and cocaine administration]. |
1996-02-06 |
2023-08-12 |
Not clear |
| E A Kiyatki. Dopamine mechanisms of cocaine addiction. The International journal of neuroscience. vol 78. issue 1-2. 1995-02-23. PMID:7829294. |
since a large body of neuropharmacological evidence suggest that the mesocorticolimbic dopamine (da) system has exclusive importance for the development and maintenance of cocaine addictive behavior, and cocaine is known to interfere in activity of this brain system, examination of mesocorticolimbic da activity during cocaine self-administration behavior may provide some clues for understanding the drug's additive properties and regulation of this maladaptive goal-directed behavior. |
1995-02-23 |
2023-08-12 |
Not clear |
| J Y Chang, S F Sawyer, R S Lee, D J Woodwar. Electrophysiological and pharmacological evidence for the role of the nucleus accumbens in cocaine self-administration in freely moving rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 3 Pt 1. 1994-04-07. PMID:8120621. |
taken together, these results suggest that the role of the nas in cocaine self-administration may consist of two different mechanisms: (1) an initiation or trigger mechanism, as represented by the anticipatory neuronal responses, in which the nas participates in triggering or mediating the goal-directed behaviors (e.g., lever pressing) that lead to the acquisition of the reinforcing agent (e.g., cocaine). |
1994-04-07 |
2023-08-12 |
rat |