| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amit Kumar Madeshiya, Brandi Quintanilla, Carl Whitehead, Stephen Tomlinson, Anilkumar Pilla. Systemic Administration of a Site-Targeted Complement Inhibitor Attenuates Chronic Stress-Induced Social Behavior Deficits and Neuroinflammation in Mice. Cells. vol 13. issue 23. 2024-12-17. PMID:39682736. |
furthermore, c2-crry administration significantly decreased microglia/macrophage and astrocyte activation markers in the pfc and hippocampus. |
2024-12-17 |
2024-12-21 |
mouse |
| Lei Wu, Yan Sun, Zhangjie Wu, Ruiyi Liu, Ying Yin, Nga-Lee Wong, Wenzheng Ju, Hailou Zhan. A rich component of Fructus Aurantii, meranzin hydrate, exerts antidepressant effects via suppressing caspase4 to regulate glial cell and neuronal functions in the hippocampus. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 182. 2024-12-15. PMID:39675136. |
subsequently, activation of hippocampal caspase4 blocked mh's antidepressant effects and its effects on suppression of microglia and improvement of astrocyte in the hippocampus. |
2024-12-15 |
2024-12-21 |
mouse |
| Xiaoqian He, Ziying Lai, Xueyan Wang, Jingjing Li, Guangbing Duan, Junwen Wang, Zhao Qin, Shuchang Xu, Ying Huan. Role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity. Neural regeneration research. 2024-12-12. PMID:39665807. |
while 5-hydroxytryptamine type 3 receptors did not affect baseline neurogenesis in the hippocampal dentate gyrus, 5-hydroxytryptamine type 3 receptors were required for aerobic exercise-induced neurogenesis and astrocyte proliferation in this region. |
2024-12-12 |
2024-12-14 |
mouse |
| Xiaoqian He, Ziying Lai, Xueyan Wang, Jingjing Li, Guangbing Duan, Junwen Wang, Zhao Qin, Shuchang Xu, Ying Huan. Role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity. Neural regeneration research. 2024-12-12. PMID:39665807. |
these results suggest that aerobic exercise increases hippocampal dentate gyrus neurogenesis and astrocyte proliferation via the up-regulation of 5-hydroxytryptamine type 3 receptors, leading to more brain-derived neurotrophic factor production and release from these cells, which results in long-term potentiation facilitation in the hippocampal ca3 region and help improve memory. |
2024-12-12 |
2024-12-14 |
mouse |
| Delyse McCaffrey, Cynthia Shannon Weickert, Adam K Walke. Blood IL-1α and IL-6 predict specific breast cancer-induced increases in hippocampal pro-inflammatory cytokines in mice. Cytokine. vol 186. 2024-12-12. PMID:39667084. |
we observed region-specific glial cell reactivity, however, only astrocyte and oligodendrocyte markers were correlated with cytokine changes within the hippocampus. |
2024-12-12 |
2024-12-22 |
mouse |
| Lingmin Chen, Jiao Jiao, Fan Lei, Bin Zhou, Hong Li, Ping Liao, Xin Li, Yi Kang, Jin Liu, Ruotian Jian. Ezrin-mediated astrocyte-synapse signaling regulates cognitive function via astrocyte morphological changes in fine processes in male mice. Brain, behavior, and immunity. 2024-11-23. PMID:39580057. |
here, we found that ezrin expression and astrocyte fine process volume in the hippocampus of male mice increased after learning but decreased after lipopolysaccharide injection and in a mouse model of postoperative cognitive dysfunction, both of which involved models with impaired cognitive function. |
2024-11-23 |
2024-11-26 |
mouse |
| Maheedhar Kodali, Leelavathi N Madhu, Yogish Somayaji, Sahithi Attaluri, Charles Huard, Prashanta Kumar Panda, Goutham Shankar, Shama Rao, Bing Shuai, Jenny J Gonzalez, Chris Oake, Catherine Hering, Roshni Sara Babu, Sanya Kotian, Ashok K Shett. Residual microglia following short-term PLX5622 treatment in 5xFAD mice exhibit diminished NLRP3 inflammasome and mTOR signaling, and enhanced autophagy. Aging cell. 2024-11-21. PMID:39571180. |
however, short-term csf1r inhibition did not influence aβ plaques, soluble aβ-42 levels, astrocyte hypertrophy, or hippocampal neurogenesis. |
2024-11-21 |
2024-11-24 |
mouse |
| Amanda da Silva, Larissa Daniele Bobermin, Camila Leite Santos, Rômulo Rodrigo de Souza Almeida, Lílian Juliana Lissner, Tiago Marcon Dos Santos, Marina Seady, Marina Concli Leite, Angela T S Wyse, Carlos-Alberto Gonçalves, André Quincozes-Santo. Glia-related Acute Effects of Risperidone and Haloperidol in Hippocampal Slices and Astrocyte Cultures from Adult Wistar Rats: A Focus on Inflammatory and Trophic Factor Release. Neurochemical research. vol 50. issue 1. 2024-11-19. PMID:39560678. |
glia-related acute effects of risperidone and haloperidol in hippocampal slices and astrocyte cultures from adult wistar rats: a focus on inflammatory and trophic factor release. |
2024-11-19 |
2024-11-22 |
rat |
| Amanda da Silva, Larissa Daniele Bobermin, Camila Leite Santos, Rômulo Rodrigo de Souza Almeida, Lílian Juliana Lissner, Tiago Marcon Dos Santos, Marina Seady, Marina Concli Leite, Angela T S Wyse, Carlos-Alberto Gonçalves, André Quincozes-Santo. Glia-related Acute Effects of Risperidone and Haloperidol in Hippocampal Slices and Astrocyte Cultures from Adult Wistar Rats: A Focus on Inflammatory and Trophic Factor Release. Neurochemical research. vol 50. issue 1. 2024-11-19. PMID:39560678. |
in the present study, we investigated the effects of acute treatments with the antipsychotics risperidone and haloperidol of hippocampal slices and astrocyte cultures, focusing on neuron-glia communication and how antipsychotics act in astrocytes. |
2024-11-19 |
2024-11-22 |
rat |
| Amanda da Silva, Larissa Daniele Bobermin, Camila Leite Santos, Rômulo Rodrigo de Souza Almeida, Lílian Juliana Lissner, Tiago Marcon Dos Santos, Marina Seady, Marina Concli Leite, Angela T S Wyse, Carlos-Alberto Gonçalves, André Quincozes-Santo. Glia-related Acute Effects of Risperidone and Haloperidol in Hippocampal Slices and Astrocyte Cultures from Adult Wistar Rats: A Focus on Inflammatory and Trophic Factor Release. Neurochemical research. vol 50. issue 1. 2024-11-19. PMID:39560678. |
for this, we obtained hippocampal slices and primary astrocyte cultures from 30-day-old wistar rats and incubated them with risperidone or haloperidol (1 and 10 μm) for 30 min and 24 h, respectively. |
2024-11-19 |
2024-11-22 |
rat |
| Isabel H Salas, Adrien Paumier, Tao Tao, Aksinya Derevyanko, Corey Switzler, Jillybeth Burgado, Melia Movsesian, Setareh Metanat, Trinity Dawoodtabar, Quinn Asbell, Arash Fassihi, Nicola J Alle. Astrocyte transcriptomic analysis identifies glypican 5 downregulation as a contributor to synaptic dysfunction in Alzheimer's disease models. bioRxiv : the preprint server for biology. 2024-11-18. PMID:39554197. |
to understand if synapse-supportive functions of astrocytes are altered in ad, we used astrocyte bactrap mice to generate a comprehensive dataset of hippocampal astrocyte transcriptional alterations in two mouse models of alzheimer's pathology (appswe/ps1de9 and tau p301s), characterizing sex and age-dependent changes. |
2024-11-18 |
2024-11-22 |
mouse |
| Mingsong Liu, Lei Li, Ruizhe Chen, Qilin Wang, Tongfei Zeng, Junhong Hu, Changzhi Yan, Jing Xiao, Xuewei Xi. Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats. Biogerontology. vol 26. issue 1. 2024-11-16. PMID:39546054. |
whole-body vibration elicits 40 hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats. |
2024-11-16 |
2024-11-18 |
rat |
| Ying Zhang, Jun Wang, Haibo Zhang, Zhenkun Tan, Yingyan Zheng, Junjiao Ping, Jie Zhang, Jiali Luo, Linsen Li, Liming Lu, Xinxia Li. Elevated circulating levels of GFAP associated with reduced volumes in hippocampal subregions linked to mild cognitive impairment among community-dwelling elderly individuals. Frontiers in aging neuroscience. vol 16. 2024-11-14. PMID:39534430. |
the aim of this study is to investigate whether astrocyte activation is correlated with hippocampal atrophy, and to assess the potential of glial fibrillary acidic protein (gfap) as a biomarker for diagnosing mci among community-dwelling older individuals. |
2024-11-14 |
2024-11-17 |
Not clear |
| Leelavathi N Madhu, Maheedhar Kodali, Raghavendra Upadhya, Shama Rao, Yogish Somayaji, Sahithi Attaluri, Bing Shuai, Maha Kirmani, Shreyan Gupta, Nathaniel Maness, Xiaolan Rao, James J Cai, Ashok K Shett. Extracellular vesicles from human-induced pluripotent stem cell-derived neural stem cells alleviate proinflammatory cascades within disease-associated microglia in Alzheimer's disease. Journal of extracellular vesicles. vol 13. issue 11. 2024-11-05. PMID:39499013. |
the extent of astrocyte hypertrophy, amyloid-beta plaques, and p-tau were also reduced in the hippocampus. |
2024-11-05 |
2024-11-08 |
mouse |
| Shoichiro Omura, Rina Ogawa, Tomomi Kawachi, Aya Ogawa, Yuuki Arai, Natsumi Takayama, Aki Masui, Kumiko Kondo, Hiroki Sugimoto, Hiroshi M Shinohara, Tokiharu Takahashi, Hideyuki Maeda, Kyoji Ohyam. Olig2+/NG2+/BLBP+ astrocyte progenitors: a novel component of the neurovascular unit in the developing mouse hippocampus. Frontiers in cellular neuroscience. vol 18. 2024-11-01. PMID:39484182. |
olig2+/ng2+/blbp+ astrocyte progenitors: a novel component of the neurovascular unit in the developing mouse hippocampus. |
2024-11-01 |
2024-11-03 |
mouse |
| Mateus Eduardo Herpich, Leonardo de Oliveira Guarnieri, Antônio Carlos Pinheiro de Oliveira, Márcio Flávio Dutra Morae. Bacterial Lipopolysaccharide Post-Conditioning in The kainic acid animal model of Temporal Lobe epilepsy. Epilepsy & behavior : E&B. vol 161. 2024-10-28. PMID:39467457. |
animals were euthanized on day 26, and hippocampal slices were analyzed using fluoro-jade staining for cell death and immunofluorescence staining for iba-1 (microglia) and gfap (astrocyte) labeling. |
2024-10-28 |
2024-10-31 |
rat |
| Ritwick Mondal, Shramana Deb, Dipanjan Chowdhury, Shramana Sarkar, Aakash Guha Roy, Gourav Shome, Vramanti Sarkar, Durjoy Lahiri, Julián Benito-Leo. Neurometabolic substrate transport across brain barriers in diabetes Mellitus: Implications for cognitive function and neurovascular health. Neuroscience letters. 2024-10-26. PMID:39461703. |
furthermore, the critical role of insulin in the hippocampus is highlighted, where insulin enhances neuro-glial coupling and modulates astrocyte glucose uptake, supporting neuronal energy demands. |
2024-10-26 |
2024-10-30 |
Not clear |
| Bin Li, Longfei Du, Shusheng Wu, Yuye Yi. Protective effects of taurine on heat Stress-Induced cognitive impairment through Npas4 and Lcn2. International immunopharmacology. vol 143. issue Pt 1. 2024-10-15. PMID:39405930. |
the results revealed that taurine ameliorated cognitive deficits following hs in mice and mitigated hs-induced astrocyte and microglia activation as well as blood-brain barrier (bbb) damage in the hippocampus. |
2024-10-15 |
2024-10-18 |
mouse |
| Fanning Xu, Hui Chen, Yubo Gao, Xiaoxia Yang, Chun Zhang, Xinli N. Sodium Butyrate Ameliorates Postoperative Delirium by Regulating Gut Microbiota Dysbiosis to Inhibit Astrocyte Activation in Aged Mice. Neurochemical research. 2024-09-28. PMID:39340594. |
pre-treatment with sodium butyrate inhibited astrocyte activation in the hippocampus, reduced interleukin-1β (il-1β), interleukin-6 (il-6), and tumor necrosis factor-α (tnf-α) expression levels, and protected hippocampal neurons. |
2024-09-28 |
2024-10-01 |
mouse |
| ShuangFeng Chen, Cheng Han, XinHao Wang, QingXin Zhang, XiaoLi Yan. Alantolactone improves cognitive impairment in rats with Porphyromonas gingivalis infection by inhibiting neuroinflammation, oxidative stress, and reducing Aβ levels. Brain research. vol 1845. 2024-08-30. PMID:39208968. |
furthermore, al lowered the presence of il-6, il-1β, and tnfα in the hippocampal and cortical tissues of p. gingivalis-infected rats by inhibiting astrocyte and microglial activation and nf-κb phosphorylation. |
2024-08-30 |
2024-09-04 |
rat |