| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y G Jeong, B H Hyun, R Hawke. Abnormalities in cerebellar Purkinje cells in the novel ataxic mutant mouse, pogo. Brain research. Developmental brain research. vol 125. issue 1-2. 2001-05-03. PMID:11154761. |
these data suggest that the progressive ataxia seen in pogo mice may be due to a failure of normal purkinje cell activity. |
2001-05-03 |
2023-08-12 |
mouse |
| D Rossi, A Cozzio, E Flechsig, M A Klein, T Rülicke, A Aguzzi, C Weissman. Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain. The EMBO journal. vol 20. issue 4. 2001-04-12. PMID:11179214. |
onset of ataxia and purkinje cell loss in prp null mice inversely correlated with dpl level in brain. |
2001-04-12 |
2023-08-12 |
mouse |
| C Park, C M Longo, S L Ackerma. Genetic and physical mapping of the cerebellar deficient folia (cdf) locus on mouse chromosome 6. Genomics. vol 69. issue 1. 2001-01-11. PMID:11013084. |
cerebellar deficient folia (cdf) is a recessive mouse mutation causing ataxia and cerebellar cytoarchitectural abnormalities, including hypoplasia, foliation defects, and purkinje cell ectopia. |
2001-01-11 |
2023-08-12 |
mouse |
| A Li, S Sakaguchi, R Atarashi, B C Roy, R Nakaoke, K Arima, N Okimura, J Kopacek, K Shigemats. Identification of a novel gene encoding a PrP-like protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene. Cellular and molecular neurobiology. vol 20. issue 5. 2000-12-07. PMID:10930132. |
some, but not all, developed late-onset ataxia due to purkinje cell degeneration. |
2000-12-07 |
2023-08-12 |
mouse |
| B R Clark, M LaRegina, D L Tolber. X-linked transmission of the shaker mutation in rats with hereditary Purkinje cell degeneration and ataxia. Brain research. vol 858. issue 2. 2000-04-24. PMID:10708677. |
x-linked transmission of the shaker mutation in rats with hereditary purkinje cell degeneration and ataxia. |
2000-04-24 |
2023-08-12 |
human |
| C Strazielle, R Lalonde, C Hébert, T A Reade. Regional brain distribution of noradrenaline uptake sites, and of alpha1-alpha2- and beta-adrenergic receptors in PCD mutant mice: a quantitative autoradiographic study. Neuroscience. vol 94. issue 1. 2000-01-14. PMID:10613519. |
the mouse "purkinje cell degeneration" (pcd) is characterized by a primary loss of purkinje cells, as well as by retrograde and secondary partial degeneration of cerebellar granule cells and inferior olivary neurons; this neurological mutant can be considered as an animal model of human degenerative ataxia. |
2000-01-14 |
2023-08-12 |
mouse |
| C J Cummings, H T Orr, H Y Zoghb. Progress in pathogenesis studies of spinocerebellar ataxia type 1. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 354. issue 1386. 1999-08-26. PMID:10434309. |
mice lacking ataxin-1 display learning deficits and altered hippocampal synaptic plasticity but none of the abnormalities seen in human sca1; mice expressing ataxin-1 with an expanded cag tract (82 glutamine residues), however, develop purkinje cell pathology and ataxia. |
1999-08-26 |
2023-08-12 |
mouse |
| C J Cummings, H T Orr, H Y Zoghb. Progress in pathogenesis studies of spinocerebellar ataxia type 1. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 354. issue 1386. 1999-08-26. PMID:10434309. |
these mice developed ataxia and purkinje cell abnormalities similar to those seen in sca1 transgenic mice carrying full-length mutant ataxin-1, but lacked nis. |
1999-08-26 |
2023-08-12 |
mouse |
| I J Rhyu, S Oda, C S Uhm, H Kim, Y S Suh, L C Abbot. Morphologic investigation of rolling mouse Nagoya (tg(rol)/tg(rol)) cerebellar Purkinje cells: an ataxic mutant, revisited. Neuroscience letters. vol 266. issue 1. 1999-08-02. PMID:10336181. |
the correlation between the presence of altered purkinje cell synapses and ataxia in rolling mice warrants further investigation. |
1999-08-02 |
2023-08-12 |
mouse |
| N Nishida, P Tremblay, T Sugimoto, K Shigematsu, S Shirabe, C Petromilli, S P Erpel, R Nakaoke, R Atarashi, T Houtani, M Torchia, S Sakaguchi, S J DeArmond, S B Prusiner, S Katamin. A mouse prion protein transgene rescues mice deficient for the prion protein gene from purkinje cell degeneration and demyelination. Laboratory investigation; a journal of technical methods and pathology. vol 79. issue 6. 1999-07-09. PMID:10378511. |
disruption of both alleles of the prion protein gene, prnp, renders mice resistant to prions; in a prnp o/o line reported by some of us, mice progressively developed ataxia and purkinje cell loss. |
1999-07-09 |
2023-08-12 |
mouse |
| P Krémarik, C Strazielle, R Lalond. Regional brain variations of cytochrome oxidase activity and motor coordination in hot-foot mutant mice. The European journal of neuroscience. vol 10. issue 9. 1999-06-07. PMID:9758150. |
hot-foot mutant mice are characterized by defective arborization of purkinje cell dendrites, resulting in ataxia of gait and deficits of equilibrium. |
1999-06-07 |
2023-08-12 |
mouse |
| H P Lipp, M Stagliar-Bozicevic, M Fischer, D P Wolfe. A 2-year longitudinal study of swimming navigation in mice devoid of the prion protein: no evidence for neurological anomalies or spatial learning impairments. Behavioural brain research. vol 95. issue 1. 1998-12-29. PMID:9754876. |
however, another prn-p knockout mouse was reported to show ataxia and purkinje cell degeneration developing after 70 weeks of age. |
1998-12-29 |
2023-08-12 |
mouse |
| H P Lipp, M Stagliar-Bozicevic, M Fischer, D P Wolfe. A 2-year longitudinal study of swimming navigation in mice devoid of the prion protein: no evidence for neurological anomalies or spatial learning impairments. Behavioural brain research. vol 95. issue 1. 1998-12-29. PMID:9754876. |
surviving prp-null mutants (n = 4) and controls (n = 6) did not differ in any measure, nor were there indications of ataxia and purkinje cell degeneration. |
1998-12-29 |
2023-08-12 |
mouse |
| M C Athanasiou, W Yunis, N Coleman, R Ehlenfeldt, H B Clark, H T Orr, R M Fedderse. The transcription factor E2F-1 in SV40 T antigen-induced cerebellar Purkinje cell degeneration. Molecular and cellular neurosciences. vol 12. issue 1-2. 1998-12-09. PMID:9770337. |
although e2f-1 itself did not affect purkinje cells, it did accelerate tag-induced ataxia and purkinje cell loss, suggesting that e2f-1 can contribute to the mechanism of tag-induced purkinje cell degeneration. |
1998-12-09 |
2023-08-12 |
mouse |
| D L Tolbert, J Heckrot. Purkinje cell transplants in Shaker mutant rats with hereditary Purkinje cell degeneration and ataxia. Experimental neurology. vol 153. issue 2. 1998-11-25. PMID:9784285. |
purkinje cell transplants in shaker mutant rats with hereditary purkinje cell degeneration and ataxia. |
1998-11-25 |
2023-08-12 |
rat |
| I A Klement, P J Skinner, M D Kaytor, H Yi, S M Hersch, H B Clark, H Y Zoghbi, H T Or. Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. Cell. vol 95. issue 1. 1998-11-02. PMID:9778246. |
these mice developed ataxia and purkinje cell pathology similar to the original sca1 mice. |
1998-11-02 |
2023-08-12 |
mouse |
| U Tauer, R Knoth, B Vol. Phenytoin alters Purkinje cell axon morphology and targeting in vitro. Acta neuropathologica. vol 95. issue 6. 1998-10-15. PMID:9650750. |
in adult mice, administration of the anticonvulsive drug phenytoin caused focal swellings along the purkinje cell axon correlated with ataxia and incoordination of movements. |
1998-10-15 |
2023-08-12 |
mouse |
| M Tanaka, K Tanaka, S Tsuj. No ataxia and no Purkinje cell loss in newborn young of SJL mice with anti-Yo antibody. Experimental neurology. vol 149. issue 1. 1998-03-06. PMID:9454640. |
no ataxia and no purkinje cell loss in newborn young of sjl mice with anti-yo antibody. |
1998-03-06 |
2023-08-12 |
mouse |
| P J Vig, S H Subramony, E N Burright, J D Fratkin, D O McDaniel, D Desaiah, Z Qi. Reduced immunoreactivity to calcium-binding proteins in Purkinje cells precedes onset of ataxia in spinocerebellar ataxia-1 transgenic mice. Neurology. vol 50. issue 1. 1998-02-06. PMID:9443466. |
cerebellar purkinje cells of 6-week-old tm-b05, which exhibit no ataxia and even lack demonstrable purkinje cell loss, also revealed reduction in pv ir. |
1998-02-06 |
2023-08-12 |
mouse |
| R M Feddersen, W S Yunis, M A O'Donnell, T J Ebner, L Shen, C Iadecola, H T Orr, H B Clar. Susceptibility to cell death induced by mutant SV40 T-antigen correlates with Purkinje neuron functional development. Molecular and cellular neurosciences. vol 9. issue 1. 1997-09-05. PMID:9204479. |
strong embryonic and postnatal transgene expression in three lines alters purkinje cell development and function during the second postnatal week, causing ataxia without purkinje cell loss. |
1997-09-05 |
2023-08-12 |
Not clear |