| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert Coukos, Dimitri Krain. Key genes and convergent pathogenic mechanisms in Parkinson disease. Nature reviews. Neuroscience. 2024-04-10. PMID:38600347. |
parkinson disease (pd) is a neurodegenerative disorder marked by the preferential dysfunction and death of dopaminergic neurons in the substantia nigra. |
2024-04-10 |
2024-04-13 |
Not clear |
| Dario Arnaldi, Pietro Mattioli, Stefano Raffa, Matteo Pardini, Federico Massa, Alex Iranzo, Andres Perissinotti, Aida Niñerola-Baizán, Carles Gaig, Monica Serradell, Amaia Muñoz-Lopetegi, Gerard Mayà, Claudio Liguori, Mariana Fernandes, Fabio Placidi, Agostino Chiaravalloti, Karel Šonka, Petr Dušek, David Zogala, Jiri Trnka, Bradley F Boeve, Toji Miyagawa, Val J Lowe, Tomoyuki Miyamoto, Masayuki Miyamoto, Monica Puligheddu, Michela Figorilli, Alessandra Serra, Michele T Hu, Johannes C Klein, Frederik Bes, Dieter Kunz, Valérie Cochen De Cock, Delphine de Verbizier, Giuseppe Plazzi, Elena Antelmi, Michele Terzaghi, Irene Bossert, Kristína Kulcsárová, Alessio Martino, Alessandro Giuliani, Marco Pagani, Flavio Nobili, Silvia Morbell. Presynaptic Dopaminergic Imaging Characterizes Patients with REM Sleep Behavior Disorder Due to Synucleinopathy. Annals of neurology. 2024-03-11. PMID:38466158. |
to apply a machine learning analysis to clinical and presynaptic dopaminergic imaging data of patients with rapid eye movement (rem) sleep behavior disorder (rbd) to predict the development of parkinson disease (pd) and dementia with lewy bodies (dlb). |
2024-03-11 |
2024-03-14 |
Not clear |
| József Attila Szász, Adriana Octaviana Dulamea, Viorelia Adelina Constantin, Dafin Fior Mureşanu, Lăcrămioara Perju Dumbravă, Cristina Tiu, Dragoş Cătălin Jianu, Mihaela Simu, Amalia Ene, Any Axelerad, Cristian Falup-Pecurariu, Mihaela Lungu, Adina Gabriela Danci, Monica Sabau, Ştefan Strilciuc, Bogdan Ovidiu Popesc. Levodopa-Carbidopa-Entacapone Intestinal Gel in Advanced Parkinson Disease: A Multicenter Real-Life Experience. American journal of therapeutics. 2024-03-09. PMID:38460175. |
for parkinson disease (pd) patients who have been diagnosed with advanced disease that can no longer be effectively controlled with optimized oral or transdermal medications, a range of device-aided therapies (dat) are available, comprising either deep brain stimulation or infusion therapies providing continuous dopaminergic stimulation. |
2024-03-09 |
2024-03-12 |
Not clear |
| Hayder M Al-Kuraishy, Sadiq M Al-Hamash, Majid S Jabir, Ali I Al-Gareeb, Ali K Albuhadily, Salim Albukhaty, Ghassan M Sulaima. The classical and non-classical axes of renin-angiotensin system in Parkinson disease: The bright and dark side of the moon. Ageing research reviews. 2024-01-18. PMID:38237699. |
parkinson disease (pd) is a common brain neurodegenerative disease due to progressive degeneration of the dopaminergic neurons in the substantia nigra pars compacta (snpc). |
2024-01-18 |
2024-01-21 |
Not clear |
| Christian Adrián González-May, María Del Rosario Barradas-Castillo, Javier Humberto Perera-Rios, Santiago Gallegos-Tintoré, Odette Pérez-Izquierdo, Irma Isela Aranda-Gonzále. Dietary flavonoids may have a protective and therapeutic effect in Parkinson disease: A systematic review. Nutrition research (New York, N.Y.). vol 121. 2023-12-01. PMID:38039600. |
parkinson disease (pd) is characterized by the loss of dopaminergic neurons because of oxidative stress and neuroinflammation. |
2023-12-01 |
2023-12-10 |
Not clear |
| Jihoon Lee, Dabin Yoon, Ki Woon Sung, Eun-Jin Bae, Da-Ha Park, Young Ho Suh, Yong Tae Kwo. Targeted degradation of SNCA/α-synuclein aggregates in neurodegeneration using the AUTOTAC chemical platform. Autophagy. 2023-11-02. PMID:37915239. |
parkinson disease (pd) characterized by dopaminergic neuronal loss is caused by aggregation of misfolded snca/α-synuclein. |
2023-11-02 |
2023-11-08 |
mouse |
| Tao Pan, Qi Xiao, Hui-Jie Fan, Lei Xu, Shao-Chen Qin, Li-Xia Yang, Xiao-Ming Jin, Bao-Guo Xiao, Bo Zhang, Cun-Gen Ma, Zhi Cha. Wuzi Yanzong Pill relieves MPTP-induced motor dysfunction and neuron loss by inhibiting NLRP3 inflammasome-mediated neuroinflammation. Metabolic brain disease. 2023-07-20. PMID:37470879. |
parkinson disease (pd) is an age-related neurodegenerative disease, which is associated with the loss of dopaminergic neurons (da neurons) in the substantia nigra pars compacta (snpc), and neuroinflammation may lead to the occurrence of pd. |
2023-07-20 |
2023-08-14 |
mouse |
| A M Schonhoff, D A Figge, G P Williams, A Jurkuvenaite, N J Gallups, G M Childers, J M Webster, D G Standaert, J E Goldman, A S Harm. Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease. Nature communications. vol 14. issue 1. 2023-06-26. PMID:37365181. |
dopaminergic cell loss due to the accumulation of α-syn is a core feature of the pathogenesis of parkinson disease. |
2023-06-26 |
2023-08-14 |
Not clear |
| Jihye Yoo, In Kook Chu. Extrastriatal Accumulation of 18F-FP-CIT at Cerebral Infarction in a Patient With Suspected Parkinson Disease. Clinical nuclear medicine. 2023-06-19. PMID:37335267. |
18f-fp-cit pet/ct is a useful diagnostic tool for differentiating between idiopathic parkinson disease and atypical parkinson syndrome by visualizing the striatum, where the nerve endings of nigrostriatal dopaminergic neurons are located. |
2023-06-19 |
2023-08-14 |
Not clear |
| Natalia Jiménez-Moreno, Jon D Lan. ATG8 proteins are co-factors for human dopaminergic neuronal transcriptional control: implications for neuronal resilience in Parkinson disease. Autophagy. 2023-06-14. PMID:37312406. |
atg8 proteins are co-factors for human dopaminergic neuronal transcriptional control: implications for neuronal resilience in parkinson disease. |
2023-06-14 |
2023-08-14 |
human |
| Natalia Jiménez-Moreno, Jon D Lan. ATG8 proteins are co-factors for human dopaminergic neuronal transcriptional control: implications for neuronal resilience in Parkinson disease. Autophagy. 2023-06-14. PMID:37312406. |
parkinson disease (pd) is caused by the loss of ventral midbrain dopaminergic neurons (mdans) in the substantia nigra pars compacta (snpc). |
2023-06-14 |
2023-08-14 |
human |
| Ardeshir Moayeri, Rafieh Alizadeh, Hatef Ghasemi Hamidabadi, Maryam Nazm Bojnordi, Ali Niapour, Azim Hedayatpour, Marzieh Darvishi, Fatemeh Heidari, Maryam Soleimani, Leila Elyas. Transdifferentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Dopaminergic Neurons in a Three-Dimensional Culture. Basic and clinical neuroscience. vol 13. issue 5. 2023-06-14. PMID:37313021. |
the induction of human umbilical cord-derived mesenchymal stem cells (huc-mscs) toward dopaminergic neurons is a major challenge in tissue engineering and experimental and clinical treatments of various neurodegenerative diseases, including parkinson disease. |
2023-06-14 |
2023-08-14 |
human |
| Khojasteh Rahimi Jaberi, Manouchehr Safari, Vahid Semnani, Hamid Reza Sameni, Sam Zarbakhsh, Laya Ghahar. Caffeic Acid Phenethyl Ester With Mesenchymal Stem Cells Improves Behavioral and Histopathological Changes in the Rat Model of Parkinson Disease. Basic and clinical neuroscience. vol 13. issue 5. 2023-06-14. PMID:37313025. |
parkinson disease (pd) results from the destruction of dopaminergic neurons in the brain. |
2023-06-14 |
2023-08-14 |
rat |
| Meewhi Kim, Ilya Bezprozvann. Potential direct role of synuclein in dopamine transport and its implications for Parkinson's disease pathogenesis. Biochemical and biophysical research communications. vol 671. 2023-06-08. PMID:37290280. |
parkinson disease (pd) is a progressive neurodegenerative disorder that is caused by dysfunction and death of dopaminergic neurons. |
2023-06-08 |
2023-08-14 |
Not clear |
| Rachel J Boyd, Sarah A McClymont, Nelson B Barrientos, Paul W Hook, William D Law, Rebecca J Rose, Eric L Waite, Jay Rathinavelu, Dimitrios Avramopoulos, Andrew S McCallio. Evaluating the mouse neural precursor line, SN4741, as a suitable proxy for midbrain dopaminergic neurons. BMC genomics. vol 24. issue 1. 2023-06-07. PMID:37286935. |
here, we are using a combination of classic and contemporary genomic techniques - karyotyping, rt-qpcr, single cell rna-seq, bulk rna-seq, and atac-seq - to characterize the transcriptional landscape, chromatin landscape, and genomic architecture of this cell line, and evaluate its suitability as a proxy for midbrain dopaminergic neurons in the study of parkinson disease. |
2023-06-07 |
2023-08-14 |
mouse |
| Shadi Ghourchian, Ann L Gruber-Baldini, Sunita Shakya, Stephen G Reich, Rainer von Coelln, Joseph M Savitt, Lisa M Shulma. Spirituality in Parkinson's Disease within a Sample from the USA. Journal of religion and health. 2023-04-26. PMID:37099054. |
the dopaminergic system is involved in reward behavior, and its dysfunction in parkinson disease (pd) raises questions about religiosity and spirituality in people with pd. |
2023-04-26 |
2023-08-14 |
Not clear |
| Yuanzhang Zhou, Yang Liu, Zhengwei Kang, Hang Yao, Nanshan Song, Min Wang, Chenghuan Song, Kezhong Zhang, Jianhua Ding, Juanjuan Tang, Gang Hu, Ming L. Autophagy. 2023-04-04. PMID:37014258. |
despite growing evidence that has declared the importance of circrnas in neurodegenerative diseases, the clinical significance of circrnas in dopaminergic (da) neuronal degeneration in the pathogenesis of parkinson disease (pd) remains unclear. |
2023-04-04 |
2023-08-14 |
Not clear |
| Adekunle T Bademosi, Marianna Decet, Sabine Kuenen, Carles Calatayud, Jef Swerts, Sandra F Gallego, Nils Schoovaerts, Spyridoula Karamanou, Nikolaos Louros, Ella Martin, Jean-Baptiste Sibarita, Katlijn Vints, Natalia V Gounko, Frédéric A Meunier, Anastassios Economou, Wim Versées, Frederic Rousseau, Joost Schymkowitz, Sandra-F Soukup, Patrik Verstreke. EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation. Neuron. 2023-02-24. PMID:36827984. |
balanced stimulation-induced autophagy is required for dopagminergic neuron survival, and a variant in the human endoa1 disordered loop conferring risk to parkinson disease also blocks nanodomain protein mobility and autophagy both in vivo and in human-induced dopaminergic neurons. |
2023-02-24 |
2023-08-14 |
human |
| Robert A Hauser, Peter A LeWitt, Cheryl H Waters, Donald G Grosset, Burkhard Blan. The Clinical Development of Levodopa Inhalation Powder. Clinical neuropharmacology. 2023-01-30. PMID:36715241. |
the pivotal span-pd trial in patients experiencing off periods on oral dopaminergic therapy showed that levodopa inhalation powder 84 mg produced significant improvement in unified parkinson disease rating scale part iii score, as measured 30 minutes postdose at week 12, and improvement was seen as early as 10 minutes. |
2023-01-30 |
2023-08-14 |
Not clear |
| Busra Akta. Gut Microbial Alteration in MPTP Mouse Model of Parkinson Disease is Administration Regimen Dependent. Cellular and molecular neurobiology. 2023-01-28. PMID:36708421. |
parkinson disease (pd) is one of the most common neurodegenerative disorders characterized by loss of dopaminergic neurons involved in motor functions. |
2023-01-28 |
2023-08-14 |
mouse |