| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter R Mouton, Jeffrey M Long, De-Liang Lei, Victor Howard, Mathias Jucker, Michael E Calhoun, Donald K Ingra. Age and gender effects on microglia and astrocyte numbers in brains of mice. Brain research. vol 956. issue 1. 2003-01-29. PMID:12426043. |
we also report that on average female b6 mice have 25-40% more astrocytes and microglia in dg and ca1 regions than age-matched male c57bl/6j mice. |
2003-01-29 |
2023-08-12 |
mouse |
| O T Wolf, V Dyakin, A Patel, C Vadasz, M J de Leon, B S McEwen, K Bulloc. Volumetric structural magnetic resonance imaging (MRI) of the rat hippocampus following kainic acid (KA) treatment. Brain research. vol 934. issue 2. 2002-08-07. PMID:11955471. |
the histological observations supported the mri data showing neuronal loss and neuronal degeneration in ca1 and ca3 of the hippocampus, which was accompanied by strong microglia activation. |
2002-08-07 |
2023-08-12 |
rat |
| S Haga, C Haga, T Aizawa, K Iked. Neuronal degeneration and glial cell-responses following trimethyltin intoxication in the rat. Acta neuropathologica. vol 103. issue 6. 2002-08-07. PMID:12012089. |
in parallel with the maximal neurodegeneration, large numbers of hypertrophied microglia and astrocytes were observed in the ca1 and ca3 by day 7. |
2002-08-07 |
2023-08-12 |
rat |
| D L Small, R Monette, M C Fournier, B Zurakowski, H Fiander, P Morle. Characterization of cyclin D1 expression in a rat global model of cerebral ischemia. Brain research. vol 900. issue 1. 2001-07-26. PMID:11325343. |
in contrast to the cytoplasmic expression of cyclin d1 in neurons, the cyclin d1 expression in the microglia and other non-neuronal cells in ca1 was both nuclear and cytosolic. |
2001-07-26 |
2023-08-12 |
rat |
| K Domańska-Janik, A Bronisz-Kowalczyk, H Zajac, B Zabłock. Interrelations between nuclear-factor kappa B activation, glial response and neuronal apoptosis in gerbil hippocampus after ischemia. Acta neurobiologiae experimentalis. vol 61. issue 1. 2001-05-21. PMID:11315321. |
these results evidence a preferential nf kappa b involvement in an early microglia activation in the apoptogenic ca1 sector, although its role in a later astrocytic response to ischemia could not be neglected too. |
2001-05-21 |
2023-08-12 |
Not clear |
| K Yamashita, Y Kataoka, Y Sakurai-Yamashita, K Shigematsu, A Himeno, M Niwa, K Taniyam. Involvement of glial endothelin/nitric oxide in delayed neuronal death of rat hippocampus after transient forebrain ischemia. Cellular and molecular neurobiology. vol 20. issue 5. 2000-12-07. PMID:10930131. |
in contrast to microglia, astrocytes presented a moderate level of et-1-like immunoreactivity, et(b) receptors, and nos activity in all areas of the damaged ca1 subfields, 7 days after the ischemia. |
2000-12-07 |
2023-08-12 |
rat |
| S Koponen, G Goldsteins, R Keinänen, J Koistinah. Induction of protein kinase Cdelta subspecies in neurons and microglia after transient global brain ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 20. issue 1. 2000-01-13. PMID:10616797. |
the selective and prolonged induction of the pkcdelta mrna and protein first in ca1 pyramidal neurons and at a later stage in activated microglia suggests that the pkcdelta isozyme may take part in regulation of the delayed death of ca1 neurons after transient global brain ischemia. |
2000-01-13 |
2023-08-12 |
rat |
| M Gottlieb, C Matut. Expression of nerve growth factor in astrocytes of the hippocampal CA1 area following transient forebrain ischemia. Neuroscience. vol 91. issue 3. 1999-10-08. PMID:10391480. |
immunohistochemical analysis of the distribution of nerve growth factor showed that its expression was up-regulated in astrocytes but not in microglia of the postischemic ca1 region and that the intensity and temporal profile of the changes in nerve growth factor immunostaining in these cells, was consistent with that observed in the immunoassay. |
1999-10-08 |
2023-08-12 |
rat |
| Y Kondo, M Asanuma, E Iwata, F Kondo, I Miyazaki, N Ogaw. Early treatment with cyclosporin A ameliorates the reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia. Neurochemical research. vol 24. issue 1. 1999-05-03. PMID:9973231. |
however, csa did not alter reactive changes of astrocytes and microglia in the ca1 area of the hippocampus, which had been suppressed by daily administration. |
1999-05-03 |
2023-08-12 |
Not clear |
| J M Long, A N Kalehua, N J Muth, M E Calhoun, M Jucker, J M Hengemihle, D K Ingram, P R Mouto. Stereological analysis of astrocyte and microglia in aging mouse hippocampus. Neurobiology of aging. vol 19. issue 5. 1999-03-11. PMID:9880052. |
to test the hypothesis that the number of microglia and astrocytes increase in the hippocampus during normal aging, unbiased stereological techniques were used to estimate total cell number in hippocampal subregions (ca1, dentate gyrus and hilus) of male c57bl/6j mice of different ages: 4-5 months, 13-14 months and 27-28 months. |
1999-03-11 |
2023-08-12 |
mouse |
| J M Long, A N Kalehua, N J Muth, J M Hengemihle, M Jucker, M E Calhoun, D K Ingram, P R Mouto. Stereological estimation of total microglia number in mouse hippocampus. Journal of neuroscience methods. vol 84. issue 1-2. 1999-01-26. PMID:9821640. |
in the present study, immunocytochemistry was combined with unbiased stereology to estimate the mean total number of microglia in dentate gyrus and ca1 regions of the mouse hippocampus. |
1999-01-26 |
2023-08-12 |
mouse |
| J M Long, A N Kalehua, N J Muth, J M Hengemihle, M Jucker, M E Calhoun, D K Ingram, P R Mouto. Stereological estimation of total microglia number in mouse hippocampus. Journal of neuroscience methods. vol 84. issue 1-2. 1999-01-26. PMID:9821640. |
the mean total number of microglia in the mouse ca1 was estimated to be 43,200 (cv = 0.24) with a ce = 0.11. |
1999-01-26 |
2023-08-12 |
mouse |
| B Lin, M D Ginsberg, R Busto, W D Dietric. Sequential analysis of subacute and chronic neuronal, astrocytic and microglial alterations after transient global ischemia in rats. Acta neuropathologica. vol 95. issue 5. 1998-07-13. PMID:9600598. |
in the ca1 hippocampus, a decreased number of normal neurons was seen at 1 week post ischemia, together with a significant increase in immunoreactive microglia at that time; the latter normalized after 2 weeks. |
1998-07-13 |
2023-08-12 |
rat |
| K M Walton, R DiRocco, B A Bartlett, E Koury, V R Marcy, B Jarvis, E M Schaefer, R V Bha. Activation of p38MAPK in microglia after ischemia. Journal of neurochemistry. vol 70. issue 4. 1998-04-23. PMID:9523596. |
phosphorylated p38mapk immunoreactivity was observed in microglia in regions adjacent to, but not in, the dying ca1 neurons. |
1998-04-23 |
2023-08-12 |
Not clear |
| U Boschert, M Muda, M Camps, R Dickinson, S Arkinstal. Induction of the dual specificity phosphatase PAC1 in rat brain following seizure activity. Neuroreport. vol 8. issue 14. 1997-11-26. PMID:9331917. |
recurrent seizure activity leads to delayed neuronal death as well as to inflammatory responses involving microglia in hippocampal subfields ca1, ca3 and ca4. |
1997-11-26 |
2023-08-12 |
rat |
| Y Nakajima, M Fujimiya, T Maeda, A Mor. Morphological investigation of the neuroprotective effects of graded hypothermia after diverse periods of global cerebral ischemia in gerbils. Brain research. vol 765. issue 1. 1997-11-06. PMID:9310401. |
in contrast, the distribution of activated microglia was much more restricted to the ca1 region and they were always accompanied by dnd at 7 days postischemia. |
1997-11-06 |
2023-08-12 |
Not clear |
| K Kumar, A T Evan. Effect of hypothermia on microglial reaction in ischemic brain. Neuroreport. vol 8. issue 4. 1997-07-14. PMID:9141070. |
ischemia under hypothermic conditions was not associated with activation of microglia, and these brains showed no significant neuronal damage, whereas the brains subjected to normothermic ischemia showed extensive neuronal necrosis in the ca1 region after 1 and 7 days reperfusion. |
1997-07-14 |
2023-08-12 |
Not clear |
| K Yamashita, Y Kataoka, Y S Yamashita, A Himeno, K Tsutsumi, M Niwa, K Taniyam. Glial endothelin/nitric oxide system participates in hippocampus CA1 neuronal death of SHRSP following transient forebrain ischaemia. Clinical and experimental pharmacology & physiology. Supplement. vol 22. issue 1. 1997-03-25. PMID:9072389. |
there was a dramatic increase in nitric oxide synthase (nos) activity in astrocytes and microglia in the damaged hippocampus ca1 subfields. |
1997-03-25 |
2023-08-12 |
rat |
| H Kato, K Kogure, T Araki, Y Itoyam. Graded expression of immunomolecules on activated microglia in the hippocampus following ischemia in a rat model of ischemic tolerance. Brain research. vol 694. issue 1-2. 1996-12-27. PMID:8974668. |
this length of ischemia produced ca1 neuronal destruction after 3 and 7 days when we observed phagocytic transformation of microglia and increased expression of immunomolecules including ox6 and ed1 however, no staining was seen with w3/13. |
1996-12-27 |
2023-08-12 |
rat |
| E K Speliotes, N W Kowall, B F Shanti, B Kosofsky, S P Finklestein, D Leife. Myocyte-specific enhancer binding factor 2C expression in gerbil brain following global cerebral ischemia. Neuroscience. vol 70. issue 1. 1996-10-24. PMID:8848137. |
in addition, mef2c-immunoreactivity is present in microglia, and, after ischemia, there were increased numbers of mef2c-immunoreactive microglia in ca1, so mef2c-immunoreactivity is a marker of both resting and activated microglia. |
1996-10-24 |
2023-08-12 |
Not clear |