| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Dalmau, B Finsen, J Zimmer, B González, B Castellan. Development of microglia in the postnatal rat hippocampus. Hippocampus. vol 8. issue 5. 1999-01-22. PMID:9825958. |
the differentiation and appearance of microglia in the various hippocampal and dentate subregions often correspond to the developmental stage of intrinsic and extrinsic afferent nerve fiber projections. |
1999-01-22 |
2023-08-12 |
rat |
| A Hagendorff, C Dettmers, P Danos, M Hümmelgen, C Vahlhaus, C Martin, G Heusch, B Lüderit. Cerebral vasoconstriction during sustained ventricular tachycardia induces an ischemic stress response of brain tissue in rats. Journal of molecular and cellular cardiology. vol 30. issue 10. 1998-12-16. PMID:9826520. |
hsp 72 and activated microglia were found in hippocampal regions only after mht-vt (p<0.05 v control and mhh). |
1998-12-16 |
2023-08-12 |
rat |
| E J Beilharz, V C Russo, G Butler, N L Baker, B Connor, E S Sirimanne, M Dragunow, G A Werther, P D Gluckman, C E Williams, A Scheepen. Co-ordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic-ischemic injury. Brain research. Molecular brain research. vol 59. issue 2. 1998-10-28. PMID:9729323. |
igfbp-2 mrna was strongly induced in reactive astrocytes throughout the injured hemisphere, and igfbp-3 and igfbp-5 mrna were moderately induced in reactive microglia and neurones of the injured hippocampus, respectively. |
1998-10-28 |
2023-08-12 |
rat |
| A Bruccoleri, H Brown, G J Harr. Cellular localization and temporal elevation of tumor necrosis factor-alpha, interleukin-1 alpha, and transforming growth factor-beta 1 mRNA in hippocampal injury response induced by trimethyltin. Journal of neurochemistry. vol 71. issue 4. 1998-10-14. PMID:9751191. |
to study the role of cytokines in the early stages of brain injury, we examined alterations in the 17-day-old mouse hippocampus during trimethyltin-induced neurodegeneration characterized by neuronal necrosis, microglia activation in the dentate, and astrocyte reactivity throughout the hippocampus. |
1998-10-14 |
2023-08-12 |
mouse |
| Y Matsuoka, Y Kitamura, M Okazaki, J Kakimura, I Tooyama, H Kimura, T Taniguch. Kainic acid induction of heme oxygenase in vivo and in vitro. Neuroscience. vol 85. issue 4. 1998-10-01. PMID:9681959. |
in the rat hippocampus, cells expressing heme oxygenase-1 in vivo were predominately microglia and only a few astrocytes. |
1998-10-01 |
2023-08-12 |
rat |
| B M Bradt, W P Kolb, N R Coope. Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide. The Journal of experimental medicine. vol 188. issue 3. 1998-09-08. PMID:9687521. |
large numbers of neuritic plaques (np), largely composed of a fibrillar insoluble form of the beta-amyloid peptide (abeta), are found in the hippocampus and neocortex of alzheimer's disease (ad) patients in association with damaged neuronal processes, increased numbers of activated astrocytes and microglia, and several proteins including the components of the proinflammatory complement system. |
1998-09-08 |
2023-08-12 |
Not clear |
| D L Price, P C Wong, D R Borchelt, C A Pardo, G Thinakaran, A P Doan, M K Lee, L J Martin, S S Sisodi. Amyotrophic lateral sclerosis and Alzheimer disease. Lessons from model systems. Revue neurologique. vol 153. issue 8-9. 1998-08-10. PMID:9683997. |
models of ad include: aged monkeys that show both cognitive/memory deficits and cellular abnormalities (amyloid deposition/cytoskeletal abnormalities of neurons) in cortex and hippocampus; and tg mice that express mutant human fad-linked genes (i.e., app and ps1) and show increased levels of a.42, amyloid deposits, dystrophic neurites, and local responses of astrocytes and microglia. |
1998-08-10 |
2023-08-12 |
mouse |
| B Lin, M D Ginsberg, R Busto, W D Dietric. Sequential analysis of subacute and chronic neuronal, astrocytic and microglial alterations after transient global ischemia in rats. Acta neuropathologica. vol 95. issue 5. 1998-07-13. PMID:9600598. |
in the ca1 hippocampus, a decreased number of normal neurons was seen at 1 week post ischemia, together with a significant increase in immunoreactive microglia at that time; the latter normalized after 2 weeks. |
1998-07-13 |
2023-08-12 |
rat |
| H Neumann, T Misgeld, K Matsumuro, H Wekerl. Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 10. 1998-06-19. PMID:9576961. |
we studied the conditions leading to the induction of mhc class ii molecules in microglia by using explant cultures of neonatal rat hippocampus, a model of interacting neuronal networks. |
1998-06-19 |
2023-08-12 |
rat |
| H Neumann, T Misgeld, K Matsumuro, H Wekerl. Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 10. 1998-06-19. PMID:9576961. |
interferon-gamma (ifn-gamma)-dependent mhc class ii inducibility in microglia cells was very low, but strongly increased in the hippocampal slices after the blockade of neuronal activity by neurotoxins [tetrodotoxin (ttx), omega-conotoxin] or glutamate antagonists. |
1998-06-19 |
2023-08-12 |
rat |
| Y Kitamur. [Functional activation of glial cells in early and delayed episodes of the brain damage]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 111. issue 3. 1998-06-05. PMID:9583078. |
the microinjection of interferon-gamma and lipopolysaccharide into rat hippocampus induced mhc class ii and inos in microglia. |
1998-06-05 |
2023-08-12 |
rat |
| Y Kitamur. [Functional activation of glial cells in early and delayed episodes of the brain damage]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 111. issue 3. 1998-06-05. PMID:9583078. |
subsequently, neuronal cell death occurred in the hippocampus, but cell death was undetectable in both microglia and astrocytes that expressed ho-1. |
1998-06-05 |
2023-08-12 |
rat |
| T Stojkovic, C Colin, F Le Saux, C Jacqu. Specific pattern of nitric oxide synthase expression in glial cells after hippocampal injury. Glia. vol 22. issue 4. 1998-05-05. PMID:9517565. |
despite the large expression of nos detected by nadph-diaphorase histochemistry after lesioning the hippocampus, immunostaining for inos was confined to microglia. |
1998-05-05 |
2023-08-12 |
mouse |
| T Yamada, Y Yoshiyama, N Kawaguchi, A Ichinose, T Iwaki, S Hirose, W A Jefferie. Possible roles of transglutaminases in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 9. issue 2. 1998-05-05. PMID:9524802. |
on the other hand, few factor-xiiia-positive microglia were found in the parietal cortices from non-neurological cases, but moderate numbers were found in their hippocampal tissues. |
1998-05-05 |
2023-08-12 |
human |
| B Hauss-Wegrzyniak, P Dobrzanski, J D Stoehr, G L Wen. Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease. Brain research. vol 780. issue 2. 1998-05-04. PMID:9507169. |
chronic infusion of lps (0.25 microgram/h) into the 4th ventricle for four weeks produced (1) an increase in the number of glial fibrillary acidic protein-positive activated astrocytes and ox-6-positive reactive microglia distributed throughout the brain, with the greatest increase occurring within the temporal lobe, particularly the hippocampus, (2) an induction in interleukin-1 beta, tumor necrosis factor-alpha and beta-amyloid precursor protein mrna levels within the basal forebrain region and hippocampus, (3) the degeneration of hippocampal ca3 pyramidal neurons, and (4) a significant impairment in spatial memory as determined by decreased spontaneous alternation behavior on a t-maze. |
1998-05-04 |
2023-08-12 |
rat |
| E L Conway, A L Gundlach, J A Crave. Temporal changes in glial fibrillary acidic protein messenger RNA and [3H]PK11195 binding in relation to imidazoline-I2-receptor and alpha 2-adrenoceptor binding in the hippocampus following transient global forebrain ischaemia in the rat. Neuroscience. vol 82. issue 3. 1998-04-09. PMID:9483537. |
in this study the spatial changes in glial fibrillary acidic protein messenger rna levels in the hippocampus have been mapped four, eight, 12, 16 and 20 days following 10 min of global forebrain ischaemia in the rat and related to changes in [3h]pk11195 binding to peripheral benzodiazepine receptors, a putative marker of activated microglia. |
1998-04-09 |
2023-08-12 |
rat |
| Y Kitamura, M Furukawa, Y Matsuoka, I Tooyama, H Kimura, Y Nomura, T Taniguch. In vitro and in vivo induction of heme oxygenase-1 in rat glial cells: possible involvement of nitric oxide production from inducible nitric oxide synthase. Glia. vol 22. issue 2. 1998-04-09. PMID:9537834. |
in in vivo rat hippocampus, microinjection of lps plus ifn-gamma, or snap after 24 h also induced ho-1 immunoreactivity in reactive microglia and astrocytes. |
1998-04-09 |
2023-08-12 |
rat |
| A G Woods, K M Guthrie, M A Kurlawalla, C M Gal. Deafferentation-induced increases in hippocampal insulin-like growth factor-1 messenger RNA expression are severely attenuated in middle aged and aged rats. Neuroscience. vol 83. issue 3. 1998-04-02. PMID:9483550. |
insulin-like growth factor-1 may play a role in sprouting because it (i) promotes axonal growth, (ii) is expressed at elevated levels by microglia just prior to sprouting onset, and (iii) is expressed with better spatiotemporal correspondence to hippocampal sprouting than other trophic factors examined. |
1998-04-02 |
2023-08-12 |
rat |
| A D Rogove, S E Tsirk. Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus. Current biology : CB. vol 8. issue 1. 1998-03-24. PMID:9427623. |
neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus. |
1998-03-24 |
2023-08-12 |
mouse |
| E Garcion, L Sindji, C Montero-Menei, C Andre, P Brachet, F Darc. Expression of inducible nitric oxide synthase during rat brain inflammation: regulation by 1,25-dihydroxyvitamin D3. Glia. vol 22. issue 3. 1998-03-24. PMID:9482214. |
after stab lesion, inos mrnas, expressed at 5 h mainly in cells in the interventricular junction and in a few cells in brain parenchyma, were no more detectable from 15 h onwards, whereas the protein was faintly expressed in parenchymal cells at 15 h and 24 h. in contrast, after lps injection, inos-mrnas were detected from 5 to 24 h. inos-immunoreactivity was highly induced and sequentially observed first in choroid plexus and ependymal cells at 5 h, in monocytes and activated/reactive microglia at 15 h and 24 h, and finally in astrocytes at 72 h. in order to investigate potential regulatory effects of 1,25-dihydroxyvitamin d3 (1,25-d3) on inos expression, we have delivered this hormone with lps or buffer into the rat hippocampus. |
1998-03-24 |
2023-08-12 |
rat |