| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G M Terwindt, R A Ophoff, J Haan, L A Sandkuijl, R R Frants, M D Ferrar. Migraine, ataxia and epilepsy: a challenging spectrum of genetically determined calcium channelopathies. Dutch Migraine Genetics Research Group. European journal of human genetics : EJHG. vol 6. issue 4. 1998-11-06. PMID:9781035. |
in the tottering and leaner mouse, which are characterised by epilepsy and ataxia, similar mutations were identified in the mouse homologue of the calcium channel alpha 1a subunit gene. |
1998-11-06 |
2023-08-12 |
mouse |
| G F Díaz, T Virués, M San Martín, M Ruiz, L Galán, L Paz, P Valdé. Generalized background qEEG abnormalities in localized symptomatic epilepsy. Electroencephalography and clinical neurophysiology. vol 106. issue 6. 1998-09-28. PMID:9741749. |
marked reduction of the energy in the alpha range and a mild increase in the theta range were found in the patients, unrelated to the syndromic variant of the epilepsy. |
1998-09-28 |
2023-08-12 |
Not clear |
| A Oldani, M Zucconi, R Asselta, M Modugno, M T Bonati, L Dalprà, M Malcovati, M L Tenchini, S Smirne, L Ferini-Stramb. Autosomal dominant nocturnal frontal lobe epilepsy. A video-polysomnographic and genetic appraisal of 40 patients and delineation of the epileptic syndrome. Brain : a journal of neurology. vol 121 ( Pt 2). 1998-05-08. PMID:9549500. |
in one large australian kindred, a missense mutation in the second transmembrane domain of the neuronal nicotinic acetylcholine receptor alpha 4 subunit (chrna4) gene, located on chromosome 20 q13.2-13.3, has been reported to be associated with nocturnal frontal lobe epilepsy. |
1998-05-08 |
2023-08-12 |
Not clear |
| D H Lowenstei. Recent advances related to basic mechanisms of epileptogenesis. Epilepsy research. Supplement. vol 11. 1997-10-24. PMID:9294727. |
also, new transgenic mouse lines with epilepsy phenotypes have introduced candidate genes, such as those encoding the serotonin 5-ht2c receptor or the alpha subunit of calcium/calmodulin kinase ii, that may be responsible for epileptogenesis. |
1997-10-24 |
2023-08-12 |
mouse |
| S F Berkovic, I E Scheffe. Epilepsies with single gene inheritance. Brain & development. vol 19. issue 1. 1997-06-05. PMID:9071484. |
in autosomal dominant nocturnal frontal lobe epilepsy a genetic defect in the alpha 4 subunit of the nicotinic acetylcholine receptor was found in one family. |
1997-06-05 |
2023-08-12 |
human |
| R S Vick, A Rafiq, D A Coulter, E R Jakoi, R J DeLorenz. GABAA alpha 2 mRNA levels are decreased following induction of spontaneous epileptiform discharges in hippocampal-entorhinal cortical slices. Brain research. vol 721. issue 1-2. 1996-11-27. PMID:8793090. |
the results document a decrease in gabaa alpha 2 gene expression following the induction of seds in the hec slice preparation and suggest that rapid changes in neuronal gene expression may contribute to long lasting excitability changes associated with the induction of epilepsy. |
1996-11-27 |
2023-08-12 |
Not clear |
| P Valtonen, A Haapalinna, P Riekkinen, T Halone. Effect of alpha 2-adrenergic drugs dexmedetomidine and atipamezole on extracellular amino acid levels in vivo. European journal of pharmacology. vol 285. issue 3. 1996-03-14. PMID:8575509. |
alpha 2-adrenoceptors are known to be involved in a variety of physiological functions and pathological conditions, including epilepsy and the extent of excitotoxin-induced cell death. |
1996-03-14 |
2023-08-12 |
rat |
| H Doose, E Castiglione, S Walt. Parental generalized EEG alpha activity predisposes to spike wave discharges in offspring. Human genetics. vol 96. issue 6. 1996-01-22. PMID:8522330. |
alpha i was found significantly more often in parents of children with primary generalized epilepsy (18%) compared with parents of children with focal epilepsy (8%) or controls (9%). |
1996-01-22 |
2023-08-12 |
human |
| M Yamatani, T Konishi, M Murakami, T Okud. Hyperventilation activation on EEG recording in children with epilepsy. Pediatric neurology. vol 13. issue 1. 1995-12-01. PMID:7575846. |
(2) there was a significant decrease in mean frequency (decrease in alpha power and increase in delta power) during hyperventilation in the epilepsy group, but no significant change in the controls. |
1995-12-01 |
2023-08-12 |
Not clear |
| O K Steinlein, J C Mulley, P Propping, R H Wallace, H A Phillips, G R Sutherland, I E Scheffer, S F Berkovi. A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Nature genetics. vol 11. issue 2. 1995-11-02. PMID:7550350. |
a missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. |
1995-11-02 |
2023-08-12 |
human |
| A L Gundlach, T C Burazin, T A Jenkins, S F Berkovi. Spatiotemporal alterations of central alpha 1-adrenergic receptor binding sites following amygdaloid kindling seizures in the rat: autoradiographic studies using [3H]prazosin. Brain research. vol 672. issue 1-2. 1995-06-22. PMID:7749743. |
in this study, quantitative in vitro autoradiography was used to investigate possible changes in the density of brain alpha 1-adrenergic receptors in a kindling model of epilepsy in the rat. |
1995-06-22 |
2023-08-12 |
rat |
| H K Wolf, M Spänle, M B Müller, C E Elger, J Schramm, O D Wiestle. Hippocampal loss of the GABAA receptor alpha 1 subunit in patients with chronic pharmacoresistant epilepsies. Acta neuropathologica. vol 88. issue 4. 1995-02-27. PMID:7839824. |
hippocampal loss of the gabaa receptor alpha 1 subunit in patients with chronic pharmacoresistant epilepsies. |
1995-02-27 |
2023-08-12 |
Not clear |
| J G Sheng, F A Boop, R E Mrak, W S Griffi. Increased neuronal beta-amyloid precursor protein expression in human temporal lobe epilepsy: association with interleukin-1 alpha immunoreactivity. Journal of neurochemistry. vol 63. issue 5. 1994-11-16. PMID:7931344. |
levels of immunoreactive beta-amyloid precursor protein and interleukin-1 alpha were found to be elevated in surgically resected human temporal lobe tissue from patients with intractable epilepsy compared with postmortem tissue from neurologically unaffected patients (controls). |
1994-11-16 |
2023-08-12 |
human |
| M Snyde. Revised epilepsy stressor inventory. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses. vol 25. issue 1. 1993-04-08. PMID:8445279. |
an alpha of .93 was found indicating high internal consistency of the revised epilepsy stressor inventory (esi-r). |
1993-04-08 |
2023-08-12 |
Not clear |
| L Bocket, F Delforge, P Wattré, J F Lemaitre, D Hober, A Dewild. [Value of interferon alpha determination in the diagnosis of meningoencephalitis presumed to be of viral origin]. La Revue de medecine interne. vol 13. issue 1. 1992-11-25. PMID:1329171. |
in 26 patients (11 children from 1 day to 6 year old and 15 adults from 17 to 70 year old) with central nervous system disorders (15 meningo-encephalitis, 5 meningitis, 1 myelitis, 1 polyradiculoneuritis, 1 dementia, 1 epilepsy and 2 other), alpha ifn is quantified using a cytopathic effect inhibition assay of vsv on mdbk cells. |
1992-11-25 |
2023-08-11 |
Not clear |
| H Doos. [Pathogenesis of epilepsy in childhood and adolescence]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde. vol 140. issue 7. 1992-09-17. PMID:1501610. |
expressed by generalized alpha rhythm, are involved in the complex pathogenesis of epilepsy. |
1992-09-17 |
2023-08-11 |
human |
| K Hongo, Y Naganuma, M Murakami, M Yamatani, T Okuda, T Konishi, T Okad. Development of EEG background activity in children with benign partial epilepsy. The Japanese journal of psychiatry and neurology. vol 44. issue 2. 1991-01-25. PMID:2124293. |
compared with the normal group, the epilepsy group showed a shift of the spectrum to slower frequencies, with an increase in delta and theta, and a decrease in alpha 2. |
1991-01-25 |
2023-08-11 |
Not clear |
| B P Barna, M L Estes, B S Jacobs, S Hudson, R M Ransohof. Human astrocytes proliferate in response to tumor necrosis factor alpha. Journal of neuroimmunology. vol 30. issue 2-3. 1990-12-19. PMID:2229411. |
two different human astrocytic cell lines derived from adult epilepsy surgical specimens were exposed in vitro to concentrations of 1-100 ng/ml recombinant tumor necrosis factor alpha (tnf alpha). |
1990-12-19 |
2023-08-11 |
human |
| W Löscher, S J Czuczwa. Comparison of drugs with different selectivity for central alpha 1-and alpha 2-adrenoceptors in animal models of epilepsy. Epilepsy research. vol 1. issue 3. 1989-01-17. PMID:2848694. |
comparison of drugs with different selectivity for central alpha 1-and alpha 2-adrenoceptors in animal models of epilepsy. |
1989-01-17 |
2023-08-11 |
mouse |
| W Löscher, S J Czuczwa. Comparison of drugs with different selectivity for central alpha 1-and alpha 2-adrenoceptors in animal models of epilepsy. Epilepsy research. vol 1. issue 3. 1989-01-17. PMID:2848694. |
the effects of two drugs which differ in selectivity for central alpha 1- and alpha 2-adrenoceptors were compared in different animal models of epilepsy. |
1989-01-17 |
2023-08-11 |
mouse |