| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C D McColl, M K Horne, D I Finkelstein, J Y F Wong, S F Berkovic, J Drag. Electroencephalographic characterisation of pentylenetetrazole-induced seizures in mice lacking the alpha 4 subunit of the neuronal nicotinic receptor. Neuropharmacology. vol 44. issue 2. 2003-04-02. PMID:12623222. |
autosomal dominant nocturnal frontal lobe epilepsy (adnfle) is associated in some kindreds with mutations in the genes encoding the alpha 4 or beta 2 subunits of the neuronal nicotinic acetylcholine receptor (nachr). |
2003-04-02 |
2023-08-12 |
mouse |
| Mario Raggenbass, Daniel Bertran. Nicotinic receptors in circuit excitability and epilepsy. Journal of neurobiology. vol 53. issue 4. 2003-01-13. PMID:12436422. |
some forms of autosomal dominant nocturnal frontal lobe epilepsy (adnfle) have been found to be associated with mutations in the genes coding for the alpha 4 or beta2 subunits of the nicotinic receptor. |
2003-01-13 |
2023-08-12 |
Not clear |
| Takeharu Kunieda, Michael J Zuscik, Atthaporn Boongird, Dianne M Perez, Hans O Lüders, Imad M Naj. Systemic overexpression of the alpha 1B-adrenergic receptor in mice: an animal model of epilepsy. Epilepsia. vol 43. issue 11. 2002-12-13. PMID:12423381. |
systemic overexpression of the alpha 1b-adrenergic receptor in mice: an animal model of epilepsy. |
2002-12-13 |
2023-08-12 |
mouse |
| John Y F Wong, Shelley A Ross, Craig McColl, Jim S Massalas, Emma Powney, David I Finkelstein, Malcolm Clark, Malcolm K Horne, Samuel F Berkovic, John Drag. Proconvulsant-induced seizures in alpha(4) nicotinic acetylcholine receptor subunit knockout mice. Neuropharmacology. vol 43. issue 1. 2002-11-21. PMID:12213259. |
three mutations of the alpha(4) subunit of the neuronal nicotinic acetylcholine receptor (nachr) have been identified in autosomal dominant nocturnal frontal lobe epilepsy. |
2002-11-21 |
2023-08-12 |
mouse |
| Nobuaki Matsushima, Shinichi Hirose, Hiromi Iwata, Goryu Fukuma, Minako Yonetani, Chiaki Nagayama, Wakako Hamanaka, Yukiko Matsunaka, Masatoshi Ito, Sunao Kaneko, Akihisa Mitsudome, Hiroyuki Sugiyam. Mutation (Ser284Leu) of neuronal nicotinic acetylcholine receptor alpha 4 subunit associated with frontal lobe epilepsy causes faster desensitization of the rat receptor expressed in oocytes. Epilepsy research. vol 48. issue 3. 2002-08-16. PMID:11904236. |
mutation (ser284leu) of neuronal nicotinic acetylcholine receptor alpha 4 subunit associated with frontal lobe epilepsy causes faster desensitization of the rat receptor expressed in oocytes. |
2002-08-16 |
2023-08-12 |
rat |
| Christoph Lossin, Dao W Wang, Thomas H Rhodes, Carlos G Vanoye, Alfred L Georg. Molecular basis of an inherited epilepsy. Neuron. vol 34. issue 6. 2002-07-22. PMID:12086636. |
in generalized epilepsy with febrile seizures plus, an autosomal dominant epilepsy syndrome, mutations in three genes coding for voltage-gated sodium channel alpha or beta1 subunits (scn1a, scn2a, scn1b) and one gaba receptor subunit gene (gabrg2) have been identified. |
2002-07-22 |
2023-08-12 |
human |
| A Djamshidian, R Grassl, M Seltenhammer, T Czech, C Baumgartner, M Schmidbauer, W Ulrich, F Zimpric. Altered expression of voltage-dependent calcium channel alpha(1) subunits in temporal lobe epilepsy with Ammon's horn sclerosis. Neuroscience. vol 111. issue 1. 2002-07-18. PMID:11955712. |
in epilepsy specimens an increased immunoreactivity was observed for alpha(1a), alpha(1b), alpha(1d) and alpha(1e) in the neuropil of the dentate gyrus molecular layer. |
2002-07-18 |
2023-08-12 |
Not clear |
| M Ito, H Nagafuji, H Okazawa, K Yamakawa, T Sugawara, E Mazaki-Miyazaki, S Hirose, G Fukuma, A Mitsudome, K Wada, S Kanek. Autosomal dominant epilepsy with febrile seizures plus with missense mutations of the (Na+)-channel alpha 1 subunit gene, SCN1A. Epilepsy research. vol 48. issue 1-2. 2002-04-02. PMID:11823106. |
autosomal dominant epilepsy with febrile seizures plus with missense mutations of the (na+)-channel alpha 1 subunit gene, scn1a. |
2002-04-02 |
2023-08-12 |
Not clear |
| E Tribollet, D Bertrand, M Raggenbas. Role of neuronal nicotinic receptors in the transmission and processing of information in neurons of the central nervous system. Pharmacology, biochemistry, and behavior. vol 70. issue 4. 2002-03-12. PMID:11796145. |
mutations in the gene coding for the alpha 4 subunit are responsible for a particular form of nocturnal epilepsy. |
2002-03-12 |
2023-08-12 |
mouse |
| E Asano, D C Chugani, C Juhász, O Muzik, H T Chugan. Surgical treatment of West syndrome. Brain & development. vol 23. issue 7. 2002-02-20. PMID:11701275. |
another recently developed pet probe, alpha[(11)c]methyl-l-tryptophan (amt) which is a precursor for the serotonin and the kynurenine metabolism pathways, is capable of differentiating between epileptogenic and non-epileptogenic tubers in patients with tuberous sclerosis complex and intractable epilepsy (including infantile spasms). |
2002-02-20 |
2023-08-12 |
Not clear |
| C E Adkins, G V Pillai, J Kerby, T P Bonnert, C Haldon, R M McKernan, J E Gonzalez, K Oades, P J Whiting, P B Simpso. alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential. The Journal of biological chemistry. vol 276. issue 42. 2001-12-04. PMID:11495904. |
selective modulators of gamma-aminobutyric acid, type a (gaba(a)) receptors containing alpha(4) subunits may provide new treatments for epilepsy and premenstrual syndrome. |
2001-12-04 |
2023-08-12 |
mouse |
| D Weinshenker, P Szot, N S Miller, R D Palmite. Alpha(1) and beta(2) adrenoreceptor agonists inhibit pentylenetetrazole-induced seizures in mice lacking norepinephrine. The Journal of pharmacology and experimental therapeutics. vol 298. issue 3. 2001-09-13. PMID:11504801. |
we conclude that activation of the alpha(1)ar is primarily responsible for the anticonvulsant activity of endogenous ne in the murine ptz model of epilepsy. |
2001-09-13 |
2023-08-12 |
mouse |
| H Liu, R A Prayson, M L Estes, J A Drazba, G H Barnett, W Bingaman, J Liu, B S Jacobs, B P Barn. In vivo expression of the interleukin 4 receptor alpha by astrocytes in epilepsy cerebral cortex. Cytokine. vol 12. issue 11. 2001-03-01. PMID:11052816. |
in vivo expression of the interleukin 4 receptor alpha by astrocytes in epilepsy cerebral cortex. |
2001-03-01 |
2023-08-12 |
Not clear |
| H Liu, R A Prayson, M L Estes, J A Drazba, G H Barnett, W Bingaman, J Liu, B S Jacobs, B P Barn. In vivo expression of the interleukin 4 receptor alpha by astrocytes in epilepsy cerebral cortex. Cytokine. vol 12. issue 11. 2001-03-01. PMID:11052816. |
we reported previously that non-neoplastic astrocytes (derived from brain tissues of patients with epilepsy) expressed interleukin 4 receptor alpha (il-4ralpha) and responded to interleukin 4 (il-4) in culture. |
2001-03-01 |
2023-08-12 |
Not clear |
| A Nanobashvili, M S Airaksinen, M Kokaia, J Rossi, F Asztély, K Olofsdotter, P Mohapel, M Saarma, O Lindvall, Z Kokai. Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor alpha 2. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 22. 2000-11-28. PMID:11050250. |
development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor alpha 2. |
2000-11-28 |
2023-08-12 |
mouse |
| A Nanobashvili, M S Airaksinen, M Kokaia, J Rossi, F Asztély, K Olofsdotter, P Mohapel, M Saarma, O Lindvall, Z Kokai. Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor alpha 2. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 22. 2000-11-28. PMID:11050250. |
these results provide evidence that signaling through gfr alpha 2 is involved in mechanisms regulating the development and persistence of kindling epilepsy. |
2000-11-28 |
2023-08-12 |
mouse |
| J J Plomp, M N Vergouwe, A M Van den Maagdenberg, M D Ferrari, R R Frants, P C Molenaa. Abnormal transmitter release at neuromuscular junctions of mice carrying the tottering alpha(1A) Ca(2+) channel mutation. Brain : a journal of neurology. vol 123 Pt 3. 2000-03-16. PMID:10686170. |
tottering (tg) alpha(1a) mutant mice display ataxia and epilepsy. |
2000-03-16 |
2023-08-12 |
mouse |
| D Bertran. Neuronal nicotinic acetylcholine receptors: their properties and alterations in autosomal dominant nocturnal frontal lobe epilepsy. Revue neurologique. vol 155. issue 6-7. 1999-10-05. PMID:10472659. |
furthermore, the recent linkage analysis between a form of autosomal dominant nocturnal frontal lobe epilepsy (adnfle) with a mutation in the gene coding for the alpha 4 subunit of the neuronal nachrs constituted the first demonstration that alteration of these receptors may be at the origin of epileptic discharges. |
1999-10-05 |
2023-08-12 |
Not clear |
| E Bourinet, T W Soong, K Sutton, S Slaymaker, E Mathews, A Monteil, G W Zamponi, J Nargeot, T P Snutc. Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nature neuroscience. vol 2. issue 5. 1999-05-25. PMID:10321243. |
the alpha 1a calcium channel has been implicated in the etiologies of conditions such as episodic ataxia, epilepsy and familial migraine, and shares several properties with native p- and q-type channels. |
1999-05-25 |
2023-08-12 |
Not clear |
| J Bengzon, S Okabe, O Lindvall, R D McKa. Suppression of epileptogenesis by modification of N-methyl-D-aspartate receptor subunit composition. The European journal of neuroscience. vol 11. issue 3. 1999-04-26. PMID:10103085. |
the effects of altered n-methyl-d-aspartate (nmda) receptor subunit composition on seizure development in kindling epilepsy were assessed in transgenic mice expressing high neuronal levels of nr2d under control of the calcium/calmodulin kinase ii alpha subunit (alphacamkii) promoter. |
1999-04-26 |
2023-08-12 |
mouse |