| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bente Jacobsen, Heidi Kleven, Wairimu Gatome, Liora Las, Nachum Ulanovsky, Menno P Witte. Organization of projections from the entorhinal cortex to the hippocampal formation of the Egyptian fruit bat Rousettus aegyptiacus. Hippocampus vol issue 2023 36869437 |
the hippocampal formation and entorhinal cortex are crucially involved in learning and memory as well as in spatial navigation. |
2023-03-04 |
2023-03-06 |
Not clear |
| Yoshiaki Shinohara, Keigo Kohar. Projections of hippocampal CA2 pyramidal neurons: Distinct innervation patterns of CA2 compared to CA3 in rodents. Hippocampus vol issue 2023 36855258 |
for decades, the trisynaptic circuit (entorhinal cortex layer ii-dentate gyrus\xc2\xa0- ca3-ca1) has been considered the neural network substrate responsible for learning and memory. |
2023-03-01 |
2023-03-06 |
Not clear |
| E B Engler-Chiurazzi, A E Russell, J M Povroznik, K O McDonald, K N Porter, D S Wang, J Hammock, B K Billig, C C Felton, A Yilmaz, B G Schreurs, J D O'Callaghan, K J Zwezdaryk, J W Simpkin. Intermittent systemic exposure to lipopolysaccharide-induced inflammation disrupts hippocampal long-term potentiation and impairs cognition in aging male mice. Brain, behavior, and immunity vol 108 issue 2023 36549577 |
though there was limited evidence for an ongoing inflammatory state in cortex and hippocampus, we observed impaired learning and memory and a disruption of hippocampal long-term potentiation. |
2023-01-23 |
2023-01-31 |
mouse |
| Andrew N Bubak, Laetitia Merle, Christy S Niemeyer, B Dnate' Baxter, Arianna Gentile Polese, Vijay Ramakrishnan, Johana Gomez, Lucia Madrigal, Andres Villegas-Lanau, Francisco Lopera, Wendy Macklin, Seth Frietze, Maria A Nagel, Diego Restrep. Signatures for viral infection and inflammation in the proximal olfactory system in familial Alzheimer's disease. Neurobiology of aging vol 123 issue 2023 36638683 |
in fad samples, rna sequencing showed: (1) viral infection in the ob; (2) inflammation in the ot that carries information via entorhinal cortex from the ob to hippocampus, a brain region essential for learning and memory; and (3) decreased oligodendrocyte deconvolved transcripts. |
2023-01-13 |
2023-01-30 |
Not clear |
| Farimah Beheshti, Masoumeh Gholami, Zahra Ghane, Seyedeh Elnaz Nazari, Maryam Salari, Sadegh Shabab, Mahmoud Hossein. PPAR\\xce\\xb3 activation improved learning and memory and attenuated oxidative stress in the hippocampus and cortex of aged rats. Physiological reports vol 10 issue 24 2022 36541251 |
ppar\xce\xb3 activation improved learning and memory and attenuated oxidative stress in the hippocampus and cortex of aged rats. |
2022-12-21 |
2023-01-30 |
rat |
| Farimah Beheshti, Masoumeh Gholami, Zahra Ghane, Seyedeh Elnaz Nazari, Maryam Salari, Sadegh Shabab, Mahmoud Hossein. PPAR\\xce\\xb3 activation improved learning and memory and attenuated oxidative stress in the hippocampus and cortex of aged rats. Physiological reports vol 10 issue 24 2022 36541251 |
it is concluded that ppar\xce\xb3 activation by pio as an agonist improved learning and memory in aged rats probably by attenuating oxidative stress in the hippocampus and cortex. |
2022-12-21 |
2023-01-30 |
rat |
| Qianwen Zang, Sanrong Wang, Yinqiang Qi, Lei Zhang, Chunxia Huang, Yun Xiu, Chunni Zhou, Yanmin Luo, Gongwei Jia, Shuangyu Li, Yi Zhang, Yong Tan. Running exercise improves spatial learning and memory ability and enhances angiogenesis in the cerebral cortex via endogenous nitric oxide. Behavioural brain research vol issue 2022 36462674 |
running exercise improves spatial learning and memory ability and enhances angiogenesis in the cerebral cortex via endogenous nitric oxide. |
2022-12-03 |
2023-01-30 |
Not clear |
| Muhan Li, Qiaoyu Shi, Xueyi Jiang, Xuanyi Liu, Wei Han, Xiuqin Fan, Ping Li, Kemin Q. Paternal preconceptional diet enriched with n-3 polyunsaturated fatty acids affects offspring brain function in mice. Frontiers in nutrition vol 9 issue 2022 36386900 |
the results showed that paternal n-3 pufa supplementation in preconception reduced the anxiety- and depressive-like behavior, and improved sociability, learning and memory in the offspring, along with increased synaptic number, upregulated expressions of neuron specific enolase, myelin basic protein, glial fibrillary acidic protein, brain-derived neurotrophic factor in the hippocampus and cerebral cortex, and altered expressions of genes associated with mitochondria biogenesis, fusion, fission and autophagy. |
2022-11-17 |
2023-01-30 |
mouse |
| Cheng-Long Ge, Wei Chen, Li-Na Zhang, Yu-Hang Ai, Yu Zou, Qian-Yi Pen. Hippocampus-prefrontal cortex inputs modulate spatial learning and memory in a mouse model of sepsis induced by cecal ligation puncture. CNS neuroscience & therapeutics vol issue 2022 36377471 |
hippocampus-prefrontal cortex inputs modulate spatial learning and memory in a mouse model of sepsis induced by cecal ligation puncture. |
2022-11-15 |
2023-01-30 |
mouse |
| Jingjing Zhang, Yanling Tang, Wanjing Xu, Zeyu Hu, Shangzhi Xu, Qiang Ni. Fluoride-Induced Cortical Toxicity in Rats: the Role of Excessive Endoplasmic Reticulum Stress and Its Mediated Defective Autophagy. Biological trace element research vol issue 2022 36327065 |
the cerebral cortex is closely associated with learning and memory, and fluoride is capable of inducing cortical toxicity, but its mechanism is unclear. |
2022-11-03 |
2023-01-30 |
rat |
| Bolu Zhou, Kristin E Claflin, Kyle H Flippo, Andrew I Sullivan, Arvand Asghari, Satya M Tadinada, Sharon O Jensen-Cody, Ted Abel, Matthew J Potthof. Central FGF21 production regulates memory but not peripheral metabolism. Cell reports vol 40 issue 8 2022 36001982 |
using a mouse model that drives cre recombinase in fgf21-expressing cells, we demonstrate that fgf21 is not expressed in the hypothalamus, but instead is produced from the retrosplenial cortex (rsc), an essential brain region for spatial learning and memory. |
2022-08-24 |
2023-01-30 |
mouse |
| Callum Walsh, Thomas Ridler, Gabriella Margetts-Smith, Maria Garcia Garrido, Jonathan Witton, Andrew D Randall, Jonathan T Brow. Beta bursting in the retrosplenial cortex is a neurophysiological correlate of environmental novelty which is disrupted in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience vol issue 2022 35927034 |
the retrosplenial cortex (rsc) plays a significant role in spatial learning and memory and is functionally disrupted in the early stages of alzheimer's disease. |
2022-08-04 |
2023-01-30 |
mouse |
| Peirong Liu, Juan Wang, Sheng Peng, Dan Zhang, Lin Zhuang, Chunliang Liu, Yu Zhang, Xiaowei Sh. Suppression of phosphodiesterase IV enzyme by Roflumilast ameliorates cognitive dysfunction in aged rats after sevoflurane anesthesia via PKA-CREB and MEK/ERK pathways. The European journal of neuroscience vol issue 2022 35767003 |
after treatment with rf, rats had better learning and memory function, and the activity of neurons in hippocampus and cortex was improved. |
2022-06-29 |
2023-01-27 |
rat |
| Stephanie V Koebele, Mallori L Poisson, Justin M Palmer, Claire Berns-Leone, Steven N Northup-Smith, Veronica L Pe\\xc3\\xb1a, Isabel M Strouse, Haidyn L Bulen, Shruti Patel, Corissa Croft, Heather A Bimonte-Nelso. Evaluating the Cognitive Impacts of Drospirenone, a Spironolactone-Derived Progestin, Independently and in Combination With Ethinyl Estradiol in Ovariectomized Adult Rats. Frontiers in neuroscience vol 16 issue 2022 35692432 |
the hippocampus, entorhinal cortex, and perirhinal cortex were then probed for proteins known to elicit estrogen- and progestin- mediated effects on learning and memory, including glutamate decarboxylase (gad)65, gad67, and insulin-like growth factor receptor protein expression, using western blot. |
2022-06-13 |
2023-01-27 |
rat |
| Goran \\xc5\\xa0imi\\xc4\\x87, \\xc5\\xbdeljka Krsnik, Vinka Knezovi\\xc4\\x87, Zlatko Kelovi\\xc4\\x87, Mathias Lysholt Mathiasen, Alisa Junakovi\\xc4\\x87, Milan Rado\\xc5\\xa1, Damir Mulc, Ena \\xc5\\xa0pani\\xc4\\x87, Giulia Quattrocolo, Vanessa Jane Hall, Laszlo Zaborszky, Mario Vuk\\xc5\\xa1i\\xc4\\x87, Francisco Olucha Bordonau, Ivica Kostovi\\xc4\\x87, Menno P Witter, Patrick R Ho. Prenatal development of the human entorhinal cortex. The Journal of comparative neurology vol issue 2022 35603771 |
little is known about the development of the human entorhinal cortex (ec), a major hub in a widespread network for learning and memory, spatial navigation, high-order processing of object information, multimodal integration, attention and awareness, emotion, motivation, and perception of time. |
2022-05-23 |
2023-01-27 |
human |
| Ting Jin, Ranran Wang, Shiqiao Peng, Xin Liu, Hanyi Zhang, Xue He, Weiping Teng, Xiaochun Ten. Developmental Hypothyroidism Influences the Development of the Entorhinal-Dentate Gyrus Pathway of Rat Offspring. Endocrinology and metabolism (Seoul, Korea) vol issue 2022 35390249 |
developmental hypothyroidism impairs learning and memory in offspring, which depend on extensive neuronal circuits in the entorhinal cortex, together with the hippocampus and neocortex. |
2022-04-07 |
2023-01-27 |
rat |
| Lingli Chen, Yuye Liu, Penghuan Jia, Hongli Zhang, Zhihong Yin, Dongfang Hu, Hongmei Ning, Yaming G. Acute lead acetate induces neurotoxicity through decreased synaptic plasticity-related protein expression and disordered dendritic formation in nerve cells. Environmental science and pollution research international vol issue 2022 35377123 |
lead (pb) is a widespread environmental heavy metal that can damage the cerebral cortex and hippocampus, and reduce the learning and memory ability in humans and animals. |
2022-04-04 |
2023-01-27 |
mouse |
| Luting Yu, Shixi Liu, Ruixi Zhou, Hao Sun, Xiaojuan Su, Qian Liu, Shiping Li, Junjie Ying, Fengyan Zhao, Dezhi Mu, Yi Q. Atorvastatin inhibits neuronal apoptosis via activating cAMP/PKA/p-CREB/BDNF pathway in hypoxic-ischemic neonatal rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 36 issue 4 2022 35303316 |
in vivo, atorvastatin reduced cerebral infarction, improved learning and memory ability, decreased the number of tunel-positive neurons, inhibited the expression of cleaved caspase-3 and bax/bcl2, and activated the camp/pka/p-creb/bdnf pathway in the cerebral cortex after hibd. |
2022-03-18 |
2023-01-27 |
rat |
| Jiamou Ren, Shuli Zhang, Xiaoling Wang, Yuxin Deng, Yi Zhao, Yan Xiao, Jian Liu, Liangzhao Chu, Xiaolan Q. MEF2C ameliorates learning, memory, and molecular pathological changes in Alzheimer's disease and. Acta biochimica et biophysica Sinica vol 54 issue 1 2022 35130621 |
in addition, knockdown of enhances the generation and aggregation of a\xce\xb2 in the cortex of app/ps1_dt mice, reduces the expression of synaptic proteins, exacerbates the ability of learning and memory of app/ps1_dt mice, damages the structure of mitochondria, increases the oxidative stress (os) level, and inhibits the expression levels of members of the nrf2-are signal pathway. |
2022-02-07 |
2023-01-27 |
mouse |
| Mariana Angoa-P\\xc3\\xa9rez, John H Anneken, Donald M Kuh. The Role of Brain-Derived Neurotrophic Factor in the Pathophysiology of Psychiatric and Neurological Disorders. Journal of psychiatry and psychiatric disorders vol 1 issue 5 2022 35098038 |
bdnf is highly expressed in limbic structures and cerebral cortex, making it a crucial factor in the regulation of learning and memory, affective behaviors and reward processes. |
2022-01-31 |
2023-01-27 |
human |