| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S D Schlussman, M Buonora, A J Brownstein, Y Zhang, A Ho, M J Kree. Regional mRNA expression of GABAergic receptor subunits in brains of C57BL/6J and 129P3/J mice: strain and heroin effects. Brain research. vol 1523. 2014-02-04. PMID:23732339. |
in this study, we examined the contribution of the gabaergic system in the cortex, nucleus accumbens (nac), caudate putamen (cpu) and the region containing the substantia nigra and ventral tegmental area (sn/vta) to heroin reward by measuring mrna levels of 7 of the most commonly expressed gaba-a receptor subunits, and both gaba-b receptor subunits, in these same mice following saline (control) or heroin administration in a cpp design. |
2014-02-04 |
2023-08-12 |
mouse |
| Thomas Enkel, Stefan M Berger, Kai Schönig, Björn Tews, Dusan Bartsc. Reduced expression of nogo-a leads to motivational deficits in rats. Frontiers in behavioral neuroscience. vol 8. 2014-01-30. PMID:24478657. |
in the current study, we extended the behavioral profile of the nogo-a deficient rat line with respect to reward sensitivity and motivation, and determined the concentrations of the monoamines dopamine and serotonin in the prefrontal cortex (pfc), dorsal striatum (dstr), and nucleus accumbens (nacc). |
2014-01-30 |
2023-08-12 |
mouse |
| R A Chambers, J N McClintick, A M Sentir, S A Berg, M Runyan, K H Choi, H J Edenber. Cortical-striatal gene expression in neonatal hippocampal lesion (NVHL)-amplified cocaine sensitization. Genes, brain, and behavior. vol 12. issue 5. 2014-01-27. PMID:23682998. |
rat genome-wide microarrays containing >24 000 probesets were used to examine separate and co-occurring effects of nvhls and cocaine sensitization (15 mg/kg/day × 5 days) on gene expression within medial prefrontal cortex (mpfc), nucleus accumbens (nac), and caudate-putamen (capu). |
2014-01-27 |
2023-08-12 |
rat |
| Marguerite Matthews, Corina Bondi, Gonzalo Torres, Bita Moghadda. Reduced presynaptic dopamine activity in adolescent dorsal striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 7. 2014-01-24. PMID:23358239. |
we combined molecular and dynamic indices of dopamine neurotransmission to assess dopamine function in adolescent rats in two functionally distinct striatal subregions: nucleus accumbens (nac) and dorsal striatum (ds). |
2014-01-24 |
2023-08-12 |
rat |
| Min Meng, Xinhan Zhao, Yonghui Dang, Jingyuan Ma, Lixu Li, Shanzhi G. Region-specific expression of brain-derived neurotrophic factor splice variants in morphine conditioned place preference in mice. Brain research. vol 1519. 2014-01-23. PMID:23623815. |
increased expression of bdnf splice variants ii, iv and vi in the hippocampus, caudate putamen (cpu) and nucleus accumbens (nacc). |
2014-01-23 |
2023-08-12 |
mouse |
| Mary Kay Lobo, Samir Zaman, Diane M Damez-Werno, Ja Wook Koo, Rosemary C Bagot, Jennifer A DiNieri, Alexandria Nugent, Eric Finkel, Dipesh Chaudhury, Ramesh Chandra, Efrain Riberio, Jacqui Rabkin, Ezekiell Mouzon, Roger Cachope, Joseph F Cheer, Ming-Hu Han, David M Dietz, David W Self, Yasmin L Hurd, Vincent Vialou, Eric J Nestle. ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 47. 2014-01-21. PMID:24259563. |
we make use of fluorescent reporter bac transgenic mice to evaluate induction of Δfosb in dopamine receptor 1 (d1) enriched and dopamine receptor 2 (d2) enriched msns in ventral striatum, nucleus accumbens (nac) shell and core, and in dorsal striatum (dstr) after chronic exposure to several drugs of abuse including cocaine, ethanol, Δ(9)-tetrahydrocannabinol, and opiates; the antipsychotic drug, haloperidol; juvenile enrichment; sucrose drinking; calorie restriction; the serotonin selective reuptake inhibitor antidepressant, fluoxetine; and social defeat stress. |
2014-01-21 |
2023-08-12 |
mouse |
| Edgardo Falcon, Angela Ozburn, Shibani Mukherjee, Kole Roybal, Colleen A McClun. Differential regulation of the period genes in striatal regions following cocaine exposure. PloS one. vol 8. issue 6. 2014-01-16. PMID:23776671. |
thus, we wanted to determine the effects of chronic cocaine on the expression of several circadian genes in the nucleus accumbens (nac) and caudate putamen (cp), regions of the brain known to be involved in the behavioral responses to drugs of abuse. |
2014-01-16 |
2023-08-12 |
mouse |
| F Saint-Preux, L R Bores, I Tulloch, B Ladenheim, R Kim, P K Thanos, N D Volkow, J L Cade. Chronic co-administration of nicotine and methamphetamine causes differential expression of immediate early genes in the dorsal striatum and nucleus accumbens of rats. Neuroscience. vol 243. 2013-12-17. PMID:23562942. |
chronic co-administration of nicotine and methamphetamine causes differential expression of immediate early genes in the dorsal striatum and nucleus accumbens of rats. |
2013-12-17 |
2023-08-12 |
rat |
| F Saint-Preux, L R Bores, I Tulloch, B Ladenheim, R Kim, P K Thanos, N D Volkow, J L Cade. Chronic co-administration of nicotine and methamphetamine causes differential expression of immediate early genes in the dorsal striatum and nucleus accumbens of rats. Neuroscience. vol 243. 2013-12-17. PMID:23562942. |
chronic exposure to either nicotine or meth caused significant decreases in the expression of fosb, fra1, and fra2 in the nucleus accumbens (nac) but not in the dorsal striatum whereas the drug combination increased fra2 expression in both structures. |
2013-12-17 |
2023-08-12 |
rat |
| A Svensson, M L Carlsson, A Carlsso. Interactions between central glutamatergic, catecholaminergic and cholinergic systems with regard to locomotor activity in monoamine-depleted mice. Amino acids. vol 3. issue 2. 2013-11-06. PMID:24193024. |
likewise, in combination with systemically administered clonidine, a substantial locomotor stimulation was observed after application of the muscarine receptor antagonist methscopolamine (62µg) into the dorsal striatum but not into the prefrontal cortex.this study suggests that nmda receptors in the nucleus accumbens exert an inhibitory influence on locomotor activity. |
2013-11-06 |
2023-08-12 |
mouse |
| Taehyun Kim, David J Hinton, Sandy Johng, Jia Bei Wang, Doo-Sup Cho. Levo-tetrahydropalmatine decreases ethanol drinking and antagonizes dopamine D2 receptor-mediated signaling in the mouse dorsal striatum. Behavioural brain research. vol 244. 2013-09-30. PMID:23376703. |
our results indicated that a single injection of l-thp increased active phosphorylated forms of pka, akt and erk in the caudate-putamen (cpu), but not in the nucleus accumbens (nac), of alcohol naïve mice. |
2013-09-30 |
2023-08-12 |
mouse |
| J M Jansma, H H van Hell, L J M J Vanderschuren, M G Bossong, G Jager, R S Kahn, N F Ramse. THC reduces the anticipatory nucleus accumbens response to reward in subjects with a nicotine addiction. Translational psychiatry. vol 3. 2013-08-13. PMID:23443360. |
reward activity in the nucleus accumbens (nacc) and caudate putamen during anticipation and feedback of reward was compared after thc and placebo. |
2013-08-13 |
2023-08-12 |
human |
| Marie-Josèphe Salles, Denis Hervé, Jean-Michel Rivet, Sophie Longueville, Mark J Millan, Jean-Antoine Girault, Clotilde Mannoury la Cou. Transient and rapid activation of Akt/GSK-3β and mTORC1 signaling by D3 dopamine receptor stimulation in dorsal striatum and nucleus accumbens. Journal of neurochemistry. vol 125. issue 4. 2013-07-01. PMID:23410496. |
systemic administration of quinelorane, a d2r/d3r agonist, transiently increased phosphorylation of akt and gsk-3β in rat nucleus accumbens and dorsal striatum with maximal effects 10 min after injection. |
2013-07-01 |
2023-08-12 |
mouse |
| Florence R M Theberge, Charles L Pickens, Evan Goldart, Sanya Fanous, Bruce T Hope, Qing-Rong Liu, Yavin Shaha. Association of time-dependent changes in mu opioid receptor mRNA, but not BDNF, TrkB, or MeCP2 mRNA and protein expression in the rat nucleus accumbens with incubation of heroin craving. Psychopharmacology. vol 224. issue 4. 2013-05-10. PMID:22790874. |
we investigated whether this incubation is associated with time-dependent changes in brain-derived neurotrophic factor (bdnf) and methyl-cpg binding protein 2 (mecp2) signaling and mu opioid receptor (mor) expression in nucleus accumbens (nac), dorsal striatum (ds), and medial prefrontal cortex (mpfc). |
2013-05-10 |
2023-08-12 |
rat |
| Janine M Prast, Kai K Kummer, Constanze M Barwitz, Christian Humpel, Georg Dechant, Gerald Zerni. Acetylcholine, drug reward and substance use disorder treatment: intra- and interindividual striatal and accumbal neuron ensemble heterogeneity may explain apparent discrepant findings. Pharmacology. vol 90. issue 5-6. 2013-04-23. PMID:23018268. |
in this commentary, we try to reconcile apparently discrepant animal behavioral, human behavioral and clinical data with a unifying hypothesis positing that the modulation of drug-versus natural stimuli-mediated reward by cholinergic interneurons in the nucleus accumbens (and the dorsal striatum) is restricted to distinct neuron ensembles that show considerable intra- and interindividual variation with respect to their spatial distribution. |
2013-04-23 |
2023-08-12 |
human |
| M L Perreault, A Hasbi, M Alijaniaram, B F O'Dowd, S R Georg. Reduced striatal dopamine D1-D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats. Neuroscience. vol 225. 2013-04-16. PMID:22986162. |
in adult rat striatum the dopamine d1-d2 receptor heteromer is expressed selectively in a subset of medium spiny neurons (msns) that coexpress the dopamine d1 and d2 receptors (d1r and d2r) as well as dynorphin (dyn) and enkephalin (enk), with higher coexpression in nucleus accumbens (nac) and much lower in the caudate putamen (cp). |
2013-04-16 |
2023-08-12 |
rat |
| Russell W Brown, Benjamin A Hughes, Andrew B Hughes, A Brianna Sheppard, Marla K Perna, W Lee Ragsdale, Ross L Roeding, Brooks B Pon. Sex and dose-related differences in methylphenidate adolescent locomotor sensitization and effects on brain-derived neurotrophic factor. Journal of psychopharmacology (Oxford, England). vol 26. issue 11. 2013-03-18. PMID:22833365. |
this study analyzed repeated methylphenidate (mph) administration and its effects on brain-derived neurotrophic factor (bdnf) in the dorsal striatum and nucleus accumbens of male and female adolescent rats. |
2013-03-18 |
2023-08-12 |
rat |
| Russell W Brown, Benjamin A Hughes, Andrew B Hughes, A Brianna Sheppard, Marla K Perna, W Lee Ragsdale, Ross L Roeding, Brooks B Pon. Sex and dose-related differences in methylphenidate adolescent locomotor sensitization and effects on brain-derived neurotrophic factor. Journal of psychopharmacology (Oxford, England). vol 26. issue 11. 2013-03-18. PMID:22833365. |
dorsal striatum and nucleus accumbens tissue was assayed for bdnf at p50. |
2013-03-18 |
2023-08-12 |
rat |
| Ming-Lei Guo, Bing Xue, Dao-Zhong Jin, Zhen-Guo Liu, Eugene E Fibuch, Li-Min Mao, John Q Wan. Upregulation of Npas4 protein expression by chronic administration of amphetamine in rat nucleus accumbens in vivo. Neuroscience letters. vol 528. issue 2. 2012-12-20. PMID:22884934. |
we found that acute systemic injection of amph had a minimal effect on protein levels of npas4 in the caudate putamen (cpu) and nucleus accumbens (nac), while amph readily increased protein products of the immediate early gene c-fos in these regions. |
2012-12-20 |
2023-08-12 |
rat |
| Kayo Nishizawa, Ryoji Fukabori, Kana Okada, Nobuyuki Kai, Motokazu Uchigashima, Masahiko Watanabe, Akira Shiota, Masatsugu Ueda, Yuji Tsutsui, Kazuto Kobayash. Striatal indirect pathway contributes to selection accuracy of learned motor actions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 39. 2012-12-10. PMID:23015433. |
the dorsal striatum, which contains the dorsolateral striatum (dls) and dorsomedial striatum (dms), integrates the acquisition and implementation of instrumental learning in cooperation with the nucleus accumbens (nac). |
2012-12-10 |
2023-08-12 |
rat |