| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nuttanan Pholngam, Parinda Jamrus, Kittikun Viwatpinyo, Benjaporn Kiatpakdee, Jim Vadolas, Pornthip Chaichompoo, Sukonthar Ngampramuan, Saovaros Svast. Cognitive impairment and hippocampal neuronal damage in β-thalassaemia mice. Scientific reports. vol 14. issue 1. 2024-05-02. PMID:38698053. |
interestingly, impaired learning and memory function accessed by a morris water maze test was observed and correlated with a reduced number of living pyramidal neurons in hippocampus at the ca3 region in β-thalassaemia mice. |
2024-05-02 |
2024-05-05 |
mouse |
| R B Sasibhushana, B S Shankaranarayana Rao, Bettadapura N Srikuma. Anxiety-, and depression-like behavior following short-term finasteride administration is associated with impaired synaptic plasticity and cognitive behavior in male rats. Journal of psychiatric research. vol 174. 2024-04-30. PMID:38685188. |
further, finasteride induced hippocampal dependent spatial learning and memory impairment in the nolt. |
2024-04-30 |
2024-05-03 |
rat |
| Wenzhu Wang, Jingyu Zhao, Zihan Li, Xiaoyu Kang, Ting Li, Nickolay K Isaev, Elena A Smirnova, Hui Shen, Lixu Liu, Yan Y. L-DOPA ameliorates hippocampus-based mitochondria respiratory dysfunction caused by GCI/R injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-04-28. PMID:38678966. |
our previous researches demonstrated that levodopa (l-dopa) improves learning and memory impairment in gci/r rats by increasing synaptic plasticity of hippocampal neurons. |
2024-04-28 |
2024-05-01 |
rat |
| Anfei Liu, Yunting Li, Lifan Li, Kaiju Chen, Meitao Tan, Fei Zou, Xingmei Zhang, Xiaojing Men. Bile acid metabolism is altered in learning and memory impairment induced by chronic lead exposure. Journal of hazardous materials. vol 471. 2024-04-25. PMID:38663295. |
in addition, supplementation with tudca or int-777 significantly alleviated chronic lead exposure-induced learning and memory impairment, primarily through inhibition of the nlrp3 inflammasome in the hippocampus to relieve neuroinflammation. |
2024-04-25 |
2024-04-28 |
mouse |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
our findings reveal that co-exposure to mn and pb leads to severe learning and memory impairment in mice, which correlates with the accumulation of metals in the hippocampus and synergistic suppression of bdnf. |
2024-04-24 |
2024-04-28 |
mouse |
| You Yang, Dongyu Zhou, Su Min, Di Liu, Mou Zou, Chang Yu, Lihao Chen, Jia Huang, Ruiyang Hon. Ciprofol ameliorates ECS-induced learning and memory impairment by modulating aerobic glycolysis in the hippocampus of depressive-like rats. Pharmacology, biochemistry, and behavior. 2024-04-24. PMID:38657873. |
ciprofol ameliorates ecs-induced learning and memory impairment by modulating aerobic glycolysis in the hippocampus of depressive-like rats. |
2024-04-24 |
2024-04-28 |
rat |
| Vaibhav Walia, Pranay Wal, Shweta Mishra, Ankur Agrawal, Sourabh Kosey, Aditya Dilipkumar Pati. Potential Role of Oxytocin in the Regulation of Memories and Treatment of Memory Disorders. Peptides. 2024-04-22. PMID:38649032. |
hippocampus is the main region which regulates the learning and memory. |
2024-04-22 |
2024-04-26 |
Not clear |
| Ming-Yue Yu, Kai-Qi Su, Xin Shen, Huan-Huan Liu, Jing Gao, Jian Guo, Xiao-Dong Fen. Effect of electroacupuncture on proBDNF/mBDNF and synaptic plasticity in rats with learning and memory impairment after cerebral ischemia-reperfusion. Zhen ci yan jiu = Acupuncture research. vol 49. issue 4. 2024-04-22. PMID:38649207. |
to observe the effect of electroacupuncture (ea) at "baihui" (gv20) and "shenting" (gv24) on the rats' behavior and the transforming precursor of brain-derived neurotrophic factor (probdnf) into mature brain-derived neurotrophic factor (mbdnf) in the hippocampus of rats with learning and memory impairment induced by cerebral ischemia-reperfusion (ir), so as to explore its mechanisms underlying improvement of learning and memory ability. |
2024-04-22 |
2024-04-26 |
rat |
| Ji-Yong Liu, Wen-Li Zhang, Jun Liao, Li-Juan Hu, Guo-Zuo Wang, Jin-Wen Ge, Zhi-Gang Me. [Effect of Naotaifang on microglial polarization and glial scar following cerebral ischemia reperfusion injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 4. 2024-04-15. PMID:38621906. |
compared with the sham, model 7 d and model 14 d groups showed cerebral infarction of different degrees, severe pathological injury of cerebral cortex and hippocampus, neurological impairment, reduced spatial learning and memory, cognitive dysfunction, severe anxiety, astrocyte hyperplasia, thickening penumbra glial scar, and up-regulated protein levels of il-1β, il-6, gfap, neurocan, phosphacan, cd206, and arg-1(p<0.01). |
2024-04-15 |
2024-04-18 |
rat |
| Zhehan Chang, Qi Liu, Peijia Fan, Wenqiang Xu, Yabin Xie, Kerui Gong, Chunyang Zhang, Zhijun Zhao, Kai Sun, Guo Sha. Hypoxia preconditioning increases Notch1 activity by regulating DNA methylation in vitro and in vivo. Molecular biology reports. vol 51. issue 1. 2024-04-15. PMID:38622406. |
adult hippocampal neurogenesis has been associated with learning and memory. |
2024-04-15 |
2024-04-18 |
mouse |
| Zhehan Chang, Qi Liu, Peijia Fan, Wenqiang Xu, Yabin Xie, Kerui Gong, Chunyang Zhang, Zhijun Zhao, Kai Sun, Guo Sha. Hypoxia preconditioning increases Notch1 activity by regulating DNA methylation in vitro and in vivo. Molecular biology reports. vol 51. issue 1. 2024-04-15. PMID:38622406. |
the neurogenic locus notch homolog protein (notch) was involved in adult hippocampal neurogenesis, as well as in learning and memory. |
2024-04-15 |
2024-04-18 |
mouse |
| Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zho. Study on the role and mechanism of Tan IIA in Alzheimer's disease based on CREB-BDNF-TrkB pathway. Neuroscience letters. 2024-04-14. PMID:38616003. |
these data suggest that tan iia may upregulate the expression of the creb-bdnf-trkb signaling pathway in the hippocampus of brain tissue, produce anti-neuroinflammatory, antioxidant stress, inhibit neuronal apoptosis effects, and improve cholinergic neurotransmitter disorder induced by stz, reduce the neuronal damage and learning and memory impairment caused by stz in rats, and improve the cognitive function of rats. |
2024-04-14 |
2024-04-17 |
rat |
| Jacob H Wilmot, Cassiano R A F Diniz, Ana P Crestani, Kyle R Puhger, Jacob Roshgadol, Lin Tian, Brian Joseph Wiltge. Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus. eLife. vol 12. 2024-04-09. PMID:38592773. |
locus coeruleus (lc) projections to the hippocampus play a critical role in learning and memory. |
2024-04-09 |
2024-04-11 |
mouse |
| Yongun Park, Yunn Me Me Paing, Namki Cho, Changyoun Kim, Jiho Yoo, Ji Woong Choi, Sung Hoon Le. Quinic Acid Alleviates Behavior Impairment by Reducing Neuroinflammation and MAPK Activation in LPS-Treated Mice. Biomolecules & therapeutics. 2024-04-08. PMID:38589292. |
in particular, the hippocampus is the central region for learning and memory and is highly susceptible to oxidative stress. |
2024-04-08 |
2024-04-11 |
mouse |
| Chu-Yun Teng, Ning-Jo Kao, Thi Kim Ngan Nguyen, Ching-I Lin, Tzu-Wen L Cross, Shyh-Hsiang Li. Effects of xylo-oligosaccharide on gut microbiota, brain protein expression, and lipid profile induced by high-fat diet. The Journal of nutritional biochemistry. 2024-04-07. PMID:38583497. |
additionally, xos elevated spatial learning and memory function, decreased amyloid plaques accumulation, increased brain-derived neurotrophic factor levels, and improved neuroinflammation status in hippocampus. |
2024-04-07 |
2024-04-10 |
mouse |
| Chu-Yun Teng, Ning-Jo Kao, Thi Kim Ngan Nguyen, Ching-I Lin, Tzu-Wen L Cross, Shyh-Hsiang Li. Effects of xylo-oligosaccharide on gut microbiota, brain protein expression, and lipid profile induced by high-fat diet. The Journal of nutritional biochemistry. 2024-04-07. PMID:38583497. |
in conclusion, xos improved gut dysbiosis and ameliorated spatial learning and memory dysfunction caused by hfd by decreasing cognitive decline-associated biomarkers and changing lipid composition in hippocampus. |
2024-04-07 |
2024-04-10 |
mouse |
| Norazirah Mat Nayan, Siti Hamimah Sheikh Abd Kadir, Andrean Husin, Rosfaiizah Sira. Neurodevelopmental Effects of Prenatal Bisphenol A Exposure on the Role of MicroRNA Regulating NMDA Receptor Subunits in the Male Rat Hippocampus. Physiology & behavior. 2024-04-07. PMID:38583549. |
this study investigates the effect of prenatal bpa exposure on the hippocampal mir-19a and mir-539, which are responsible for regulating nmda receptor subunits as well as learning and memory functions. |
2024-04-07 |
2024-04-10 |
rat |
| Weizhen Hua, Xuejingping Han, Fuping Li, Lu Lu, Yiqiong Sun, Hossein Hassanian-Moghaddam, Meiping Tian, Yanyang Lu, Qingyu Huan. Transgenerational Effects of Arsenic Exposure on Learning and Memory in Rats: Crosstalk between Arsenic Methylation, Hippocampal Metabolism, and Histone Modifications. Environmental science & technology. 2024-04-05. PMID:38578163. |
transgenerational effects of arsenic exposure on learning and memory in rats: crosstalk between arsenic methylation, hippocampal metabolism, and histone modifications. |
2024-04-05 |
2024-04-07 |
rat |
| Wu Lun, Guo Xingyu, Gao Yue, Yu Wenting, Qin Wen, Kuang Haixue, Su Yan. Untargeted metabolomics reveals intervention effects of wine-processed Schisandra chinensis polysaccharide on Alzheimer's disease mice. International journal of biological macromolecules. 2024-04-02. PMID:38565361. |
the results demonstrate that wscp exerts significant therapeutic effects on ad mice by enhancing learning and memory abilities, mitigating hippocampal neuronal damage, reducing abnormal amyloid-beta (aβ) deposition, and attenuating hyperphosphorylation of tau. |
2024-04-02 |
2024-04-05 |
mouse |
| Lei Shen, Xiaokuang Ma, Yuanyuan Wang, Zhihao Wang, Yi Zhang, Hoang Quoc Hai Pham, Xiaoqun Tao, Yuehua Cui, Jing Wei, Dimitri Lin, Tharindumala Abeywanada, Swanand Hardikar, Levon Halabelian, Noah Smith, Taiping Chen, Dalia Barsyte-Lovejoy, Shenfeng Qiu, Yi Xing, Yanzhong Yan. Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing. Nature communications. vol 15. issue 1. 2024-04-01. PMID:38561334. |
knockout of prmt9 in hippocampal neurons causes alternative splicing of ~1900 genes, which likely accounts for the aberrant synapse development and impaired learning and memory in the prmt9 cko mice. |
2024-04-01 |
2024-04-04 |
mouse |