| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan-Jian Yang, Yan-Kun Li, Wei Wang, Jian-Guo Wan, Bin Yu, Mei-Zhen Wang, Bin H. Small-molecule TrkB agonist 7,8-dihydroxyflavone reverses cognitive and synaptic plasticity deficits in a rat model of schizophrenia. Pharmacology, biochemistry, and behavior. vol 122. 2015-01-26. PMID:24662915. |
after intraperitoneal administration with 7,8-dhf (5 mg/kg) once daily for a consecutive 14days, we found that chronic 7,8-dhf treatment significantly enhanced the activation of phosphorylated trkb at the y515 and y816 sites, increased the phosphorylation levels of trkb downstream signal cascades including erk1/2, camkii, creb and glur1, and promoted hippocampal synaptic plasticity, which in turn rescued performance in spatial working learning. |
2015-01-26 |
2023-08-12 |
rat |
| Maryam Moosavi, Leila Abbasi, Asadollah Zarifkar, Karim Rastega. The role of nitric oxide in spatial memory stages, hippocampal ERK and CaMKII phosphorylation. Pharmacology, biochemistry, and behavior. vol 122. 2015-01-26. PMID:24704435. |
the role of nitric oxide in spatial memory stages, hippocampal erk and camkii phosphorylation. |
2015-01-26 |
2023-08-13 |
rat |
| Maryam Moosavi, Leila Abbasi, Asadollah Zarifkar, Karim Rastega. The role of nitric oxide in spatial memory stages, hippocampal ERK and CaMKII phosphorylation. Pharmacology, biochemistry, and behavior. vol 122. 2015-01-26. PMID:24704435. |
in addition, regarding the roles of erk and camkii in hippocampal plasticity, the hippocampal erk and camkii activities were assessed to identify the effect of l-name on those proteins during each phase of memory. |
2015-01-26 |
2023-08-13 |
rat |
| Maryam Moosavi, Leila Abbasi, Asadollah Zarifkar, Karim Rastega. The role of nitric oxide in spatial memory stages, hippocampal ERK and CaMKII phosphorylation. Pharmacology, biochemistry, and behavior. vol 122. 2015-01-26. PMID:24704435. |
the hippocampi were isolated after behavioural studies and western blotting analysis on hippocampal lysates was performed to illustrate the levels of phosphorylated erk and camkii. |
2015-01-26 |
2023-08-13 |
rat |
| Maryam Moosavi, Leila Abbasi, Asadollah Zarifkar, Karim Rastega. The role of nitric oxide in spatial memory stages, hippocampal ERK and CaMKII phosphorylation. Pharmacology, biochemistry, and behavior. vol 122. 2015-01-26. PMID:24704435. |
additionally l-name treatment decreased the amount of phosphorylated (activated) erk and camkii in the hippocampus. |
2015-01-26 |
2023-08-13 |
rat |
| Maryam Moosavi, Leila Abbasi, Asadollah Zarifkar, Karim Rastega. The role of nitric oxide in spatial memory stages, hippocampal ERK and CaMKII phosphorylation. Pharmacology, biochemistry, and behavior. vol 122. 2015-01-26. PMID:24704435. |
this study showed that endogenous nitric oxide is involved not only in all stages of memory, but also in erk and camkii activation in the hippocampus during all 3 stages of memory. |
2015-01-26 |
2023-08-13 |
rat |
| Biao Wang, Jiuhan Zhao, Meng Yu, Xin Meng, Xin Cui, Yan Zhao, Yuyan Zhu, Wei Xing, Yifu Gua. Disturbance of intracellular calcium homeostasis and CaMKII/CREB signaling is associated with learning and memory impairments induced by chronic aluminum exposure. Neurotoxicity research. vol 26. issue 1. 2015-01-06. PMID:24366850. |
examination of the associated protein molecules essential for induction and maintenance of long-term potentiation revealed that aluminum exposure could increase the expression level of calmodulin (cam), but the expression levels of cam-dependent protein kinase ii (camkii), and phosphorylated camp-responsive element binding protein (creb) were significantly reduced, whereas the total protein levels of camkii and creb did not change in the aluminum-treated hippocampus. |
2015-01-06 |
2023-08-12 |
rat |
| Shigeki Moriguchi, Tomoya Tanaka, Toshio Narahashi, Kohji Fukunag. Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor. Hippocampus. vol 23. issue 10. 2014-12-23. PMID:23733502. |
enhancement of pkcα activity triggers to potentiate hippocampal ltp through camkii activation. |
2014-12-23 |
2023-08-12 |
mouse |
| Lei Zhang, Hu-Qin Zhang, Xiang-Yan Liang, Hai-Feng Zhang, Ting Zhang, Fang-E Li. Melatonin ameliorates cognitive impairment induced by sleep deprivation in rats: role of oxidative stress, BDNF and CaMKII. Behavioural brain research. vol 256. 2014-12-18. PMID:23933144. |
the expression of brain-derived neurotrophic factor (bdnf) and calcium-calmodulin dependent kinase ii (camkii) proteins in cc and hippocampus was assayed by means of immunohistochemistry. |
2014-12-18 |
2023-08-12 |
rat |
| Lei Zhang, Hu-Qin Zhang, Xiang-Yan Liang, Hai-Feng Zhang, Ting Zhang, Fang-E Li. Melatonin ameliorates cognitive impairment induced by sleep deprivation in rats: role of oxidative stress, BDNF and CaMKII. Behavioural brain research. vol 256. 2014-12-18. PMID:23933144. |
the possible mechanism may be attributed to its ability to reduce oxidative stress and increase the levels of camkii and bdnf in cc and hippocampus. |
2014-12-18 |
2023-08-12 |
rat |
| Weiya Liu, Lirong Chang, Yizhi Song, Xianghong Gao, Wei Ling, Tao Lu, Yali Zhang, Yan W. Immunolocalization of CaMKII and NR2B in hippocampal subregions of rat during postnatal development. Acta histochemica. vol 115. issue 3. 2014-12-14. PMID:22906554. |
immunolocalization of camkii and nr2b in hippocampal subregions of rat during postnatal development. |
2014-12-14 |
2023-08-12 |
rat |
| Weiya Liu, Lirong Chang, Yizhi Song, Xianghong Gao, Wei Ling, Tao Lu, Yali Zhang, Yan W. Immunolocalization of CaMKII and NR2B in hippocampal subregions of rat during postnatal development. Acta histochemica. vol 115. issue 3. 2014-12-14. PMID:22906554. |
although the expression of camkii and synaptic-associated proteins has been widely studied, the temporospatial distribution of camkii and nmdar subunits in different hippocampal subregions during postnatal development still lacks detailed information. |
2014-12-14 |
2023-08-12 |
rat |
| Weiya Liu, Lirong Chang, Yizhi Song, Xianghong Gao, Wei Ling, Tao Lu, Yali Zhang, Yan W. Immunolocalization of CaMKII and NR2B in hippocampal subregions of rat during postnatal development. Acta histochemica. vol 115. issue 3. 2014-12-14. PMID:22906554. |
in this study, we used immunofluorescent staining to assess camkii and nr2b expressions and the relationship between them in ca1, ca3, and dg of rat hippocampus on postnatal (p) days: p0, p4, p7, p10, p14, p21, p28, and p56. |
2014-12-14 |
2023-08-12 |
rat |
| Mehdi Kadivar, Maryam Farahmandfar, Faezeh Esmaeli Ranjbar, Mohammad-Reza Zarrindas. Increased calcium/calmodulin-dependent protein kinase II activity by morphine-sensitization in rat hippocampus. Behavioural brain research. vol 267. 2014-12-11. PMID:24675163. |
in the present study, we investigated the effect of morphine sensitization on mrna expression of α and β isoforms and activity of camkii in the hippocampus of male rats. |
2014-12-11 |
2023-08-12 |
rat |
| Mehdi Kadivar, Maryam Farahmandfar, Faezeh Esmaeli Ranjbar, Mohammad-Reza Zarrindas. Increased calcium/calmodulin-dependent protein kinase II activity by morphine-sensitization in rat hippocampus. Behavioural brain research. vol 267. 2014-12-11. PMID:24675163. |
in addition, repeated morphine treatment increased mrna expression of both α and β isoforms of camkii in the hippocampus. |
2014-12-11 |
2023-08-12 |
rat |
| Mehdi Kadivar, Maryam Farahmandfar, Faezeh Esmaeli Ranjbar, Mohammad-Reza Zarrindas. Increased calcium/calmodulin-dependent protein kinase II activity by morphine-sensitization in rat hippocampus. Behavioural brain research. vol 267. 2014-12-11. PMID:24675163. |
however, acute administration of morphine (5mg/kg) did not alter either α and β camkii mrna expression or camkii activity in the hippocampus. |
2014-12-11 |
2023-08-12 |
rat |
| Mehdi Kadivar, Maryam Farahmandfar, Faezeh Esmaeli Ranjbar, Mohammad-Reza Zarrindas. Increased calcium/calmodulin-dependent protein kinase II activity by morphine-sensitization in rat hippocampus. Behavioural brain research. vol 267. 2014-12-11. PMID:24675163. |
our data demonstrated that induction of morphine sensitization could effectively modulate the activity and the mrna expression of camkii in the hippocampus and this effect of morphine was exerted by the activation of opioid receptors. |
2014-12-11 |
2023-08-12 |
rat |
| Osnat Melamed, Tamar Levav-Rabkin, Chava Zukerman, Gerard Clarke, John F Cryan, Timothy G Dinan, Yoram Grossman, Hava M Gola. Long-lasting glutamatergic modulation induced by neonatal GABA enhancement in mice. Neuropharmacology. vol 79. 2014-12-03. PMID:24462620. |
early exposure to gvg induced differential effects on synaptic proteins in the hippocampus and the cerebral cortex, including the downregulation of glur1/glur2 and nr2a/nr2b ratios in the hippocampus cytoplasm, a minute effect on the regulatory proteins camkii and pka in the cerebral cortex, and increases in pglur1, camkii, pka and reelin levels. |
2014-12-03 |
2023-08-12 |
mouse |
| Shamseddin Ahmadi, Shahin Amiri, Fatemeh Rafieenia, Jalal Rostamzade. Gene Expression Profile of Calcium/Calmodulin-Dependent Protein Kinase IIα in Rat's Hippocampus during Morphine Withdrawal. Basic and clinical neuroscience. vol 4. issue 2. 2014-10-22. PMID:25337341. |
calcium/calmodulin-dependent protein kinase ii (camkii) which is highly expressed in the hippocampus is known to play a pivotal role in reward-related memories and morphine dependence. |
2014-10-22 |
2023-08-13 |
rat |
| Wei Lu, Latika Khatri, Edward B Zif. Trafficking of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) receptor subunit GluA2 from the endoplasmic reticulum is stimulated by a complex containing Ca2+/calmodulin-activated kinase II (CaMKII) and PICK1 protein and by release of Ca2+ from internal stores. The Journal of biological chemistry. vol 289. issue 27. 2014-10-14. PMID:24831007. |
here we show that glua2 trafficking from the endoplasmic reticulum (er) to the plasma membrane of cultured hippocampal neurons requires ca(2+) release from internal stores, the activity of ca(2+)/calmodulin activated kinase ii (camkii), and glua2 interaction with the pdz protein, pick1. |
2014-10-14 |
2023-08-13 |
Not clear |