| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Hong Hu, Kai-Yue Yu, Xin-Xin Li, Jin-Nan Zhang, Juan-Juan Jiao, Zhao-Jun Wang, Hong-Yan Cai, Lei Wang, Ye-Xin He, Mei-Na W. Selective orexin 2 receptor blockade alleviates cognitive impairments and the pathological progression of Alzheimer's disease in 3xTg-AD mice. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024-04-29. PMID:38682858. |
then, immunohistochemistry, western blotting and elisa were used to detect aβ deposition, tau phosphorylation and neuroinflammation, and electrophysiological and wheel-running activity recording were recorded to observe hippocampal synaptic plasticity and circadian rhythm. |
2024-04-29 |
2024-05-02 |
mouse |
| Karima Schwab, Dilyara Lauer, Mandy Magbagbeolu, Franz Theuring, Anna Gasiorowska, Maciej Zadrozny, Charles R Harrington, Claude M Wischik, Grażyna Niewiadomska, Gernot Riede. Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors. Brain research bulletin. 2024-04-27. PMID:38677558. |
interference of cholinesterase inhibition with hmtm was observed also in a tau transgenic mouse model, where rivastigmine reduced the pharmacological activity of hmtm at multiple brain levels including hippocampal acetylcholine release, synaptosomal glutamate release and mitochondrial activity. |
2024-04-27 |
2024-04-30 |
mouse |
| Bing-Yi Wang, Si-Yu Liu, Kai-Min Hao, Wen-Xiu Q. [Age-dependent expression of HSP90 in the hippocampus of APP/PS1 mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 2. 2024-04-25. PMID:38658375. |
the present study aims to observe the change in expression of heat shock protein 90 (hsp90) along with amyloid-β (aβ) and phosphorylated tau (p-tau) protein levels in the hippocampus tissue of alzheimer's disease (ad) transgenic animal model with age. |
2024-04-25 |
2024-04-28 |
mouse |
| Jayvik Joshi, Minmin Yao, Aaron Kakazu, Yuxiao Ouyang, Wenzhen Duan, Manisha Aggarwa. Distinguishing microgliosis and tau deposition in the mouse brain using paramagnetic and diamagnetic susceptibility source separation. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659855. |
significant bilateral increases in pcs and |dcs| were observed in specific hippocampal and cortical sub-regions of the tau mice relative to wt controls. |
2024-04-25 |
2024-04-28 |
mouse |
| Peter T Nelson, David W Fardo, Xian Wu, Khine Zin Aung, Matthew D Cykowski, Yuriko Katsumat. Limbic-predominant age-related TDP-43 encephalopathy (LATE-NC): Co-pathologies and genetic risk factors provide clues about pathogenesis. Journal of neuropathology and experimental neurology. 2024-04-13. PMID:38613823. |
although "pure" late-nc is not rare, late-nc often coexists in the same brains with alzheimer disease neuropathologic change, brain arteriolosclerosis, hippocampal sclerosis of aging, and/or age-related tau astrogliopathy (artag). |
2024-04-13 |
2024-04-16 |
human |
| Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. |
the strongest phenotypic reversal coincided with a normalization of the tau load in the cortex and hippocampus of l1, suggesting that tau accumulation underpins the loss of cholinergic markers in the basal forebrain and its projection targets. |
2024-04-12 |
2024-04-14 |
mouse |
| Benjamin Ongnok, Nanthip Prathumsap, Titikorn Chunchai, Patcharapong Pantiya, Busarin Arunsak, Nipon Chattipakorn, Siriporn C Chattipakor. Nicotinic and Muscarinic Acetylcholine Receptor Agonists Counteract Cognitive Impairment in a Rat Model of Doxorubicin-Induced Chemobrain via Attenuation of Multiple Programmed Cell Death Pathways. Molecular neurobiology. 2024-04-03. PMID:38568417. |
dox insult also mediated hyperphosphorylation of tau and simultaneously induced various pcd, including apoptosis, necroptosis, and pyroptosis in the hippocampus. |
2024-04-03 |
2024-04-05 |
rat |
| Fanglin Qin, Yiming Yan, Ningxi Yang, Yarong Ha. Beneficial effects of Echinacoside on cognitive impairment and diabetes in type 2 diabetic db/db mice. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2024-04-03. PMID:38569512. |
in db/db mice, ech alleviates diabetes symptoms, memory loss, and hippocampal neuronal damage.following the step, we found cd44 and phosphorylated tau expression upregulated in diabetic mice. |
2024-04-03 |
2024-04-06 |
mouse |
| Wu Lun, Guo Xingyu, Gao Yue, Yu Wenting, Qin Wen, Kuang Haixue, Su Yan. Untargeted metabolomics reveals intervention effects of wine-processed Schisandra chinensis polysaccharide on Alzheimer's disease mice. International journal of biological macromolecules. 2024-04-02. PMID:38565361. |
the results demonstrate that wscp exerts significant therapeutic effects on ad mice by enhancing learning and memory abilities, mitigating hippocampal neuronal damage, reducing abnormal amyloid-beta (aβ) deposition, and attenuating hyperphosphorylation of tau. |
2024-04-02 |
2024-04-05 |
mouse |
| Dina W Yakout, Ankit Shroff, Wei Wei, Vishrut Thaker, Zachary D Allen, Mathew Sajish, Taras Y Nazarko, Angela M Mab. Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway. The Journal of biological chemistry. 2024-03-29. PMID:38552740. |
importantly, arc protein was upregulated in the hippocampus of tau knockout (tau ko) mice and dendrites of tau ko primary hippocampal neurons. |
2024-03-29 |
2024-04-01 |
mouse |
| Tuancheng Feng, Huan Du, Cha Yang, Ya Wang, Fenghua H. Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice. Acta neuropathologica. vol 147. issue 1. 2024-03-25. PMID:38526799. |
here we show that loss of tmem106b enhances the accumulation of pathological tau, especially in the neuronal soma in the hippocampus, resulting in severe neuronal loss in the ps19 tau transgenic mice. |
2024-03-25 |
2024-03-28 |
mouse |
| Katharina Schindowsk. Differential Regulation of Neurotrophic Factors During Pathogenic Tau-Aggregation in a Tau Transgenic Mouse Model for Alzheimer's Disease: A Protocol for Double-Labeling mRNA by In Situ Hybridization and Protein Epitopes by Immunohistochemistry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512677. |
interestingly, both, the mrna and protein levels of nerve growth factor (ngf) were significantly increased in hippocampal neurons in the tau models as demonstrated by ish, immunofluorescence, and western blotting. |
2024-03-21 |
2024-03-24 |
mouse |
| Sarah Buchholz, Michael Bell-Simons, Natja Haag, Hans Zempe. Tracking Tau in Neurons: How to Grow, Fix, and Stain Primary Neurons for the Investigation of Tau in All Developmental Stages. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512686. |
here, we describe (i) a relatively cheap and easy cell culture procedure for the cultivation of forebrain neurons from embryonic mice (e13.5) based on a commercially available neuronal supplement (ns21), (ii) a protocol for the cultivation of hippocampal and cortical neurons from postnatal (p0-p3) animals, and (iii) basic fixation and immunofluorescence techniques for the staining of neuronal markers and endogenous tau. |
2024-03-21 |
2024-03-24 |
mouse |
| Chaitali Anand, Justin Torok, Farras Abdelnour, Pedro D Maia, Ashish Ra. Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496606. |
brain regions in alzheimer's (ad) exhibit distinct vulnerability to the disease's hallmark pathology, with the entorhinal cortex and hippocampus succumbing early to tau tangles while others like primary sensory cortices remain resilient. |
2024-03-18 |
2024-03-20 |
Not clear |
| Julian D Dallmeier, Ryan Gober, Regina T Vontell, Ayled Barreda, Daniel A Dorfsman, David A Davis, Xiaoyan Sun, Daniel Brzostowicki, Illiana Bennett, Susanna P Garamszegi, Connor M Wander, Todd Cohen, William K Scot. Corpora amylacea negatively correlate with hippocampal tau pathology in Alzheimer's disease. Frontiers in neuroscience. vol 18. 2024-03-15. PMID:38486969. |
corpora amylacea negatively correlate with hippocampal tau pathology in alzheimer's disease. |
2024-03-15 |
2024-03-17 |
Not clear |
| Zhongying Shao, Yanjun Lu, Aihong Xing, Xiying He, Hongyan Xie, Ming H. Effect of outer membrane vesicles of Lactobacillus pentosus on Tau phosphorylation and CDK5-Calpain pathway in mice. Experimental gerontology. 2024-03-14. PMID:38484904. |
immunohistochemistry and western blot assessments unveiled elevated levels of hyperphosphorylated tau in the cortex and hippocampus of mice treated with ad-omvs. |
2024-03-14 |
2024-03-17 |
mouse |
| Hui-Yang Lei, Gui-Lin Pi, Ting He, Rui Xiong, Jing-Ru Lv, Jia-Le Liu, Dong-Qin Wu, Meng-Zhu Li, Kun Shi, Shi-Hong Li, Na-Na Yu, Yang Gao, Hui-Ling Yu, Lin-Yu Wei, Xin Wang, Qiu-Zhi Zhou, Pei-Lin Zou, Jia-Yang Zhou, Ying-Zhou Liu, Nai-Ting Shen, Jie Yang, Dan Ke, Qun Wang, Gong-Ping Liu, Xi-Fei Yang, Jian-Zhi Wang, Ying Yan. Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss. Military Medical Research. vol 11. issue 1. 2024-03-11. PMID:38462603. |
episodic memory loss is a prominent clinical manifestation of alzheimer's disease (ad), which is closely related to tau pathology and hippocampal impairment. |
2024-03-11 |
2024-03-14 |
mouse |
| Hao Chen, Kaitlyn Hinz, Chen Zhang, Yssa Rodriguez, Sha Neisha Williams, Mengwei Niu, Xiaowen Ma, Xiaojuan Chao, Alexandria L Frazier, Kenneth E McCarson, Xiaowan Wang, Zheyun Peng, Wanqing Liu, Hong-Min Ni, Jianhua Zhang, Russell H Swerdlow, Wen-Xing Din. Late-Life Alcohol Exposure Does Not Exacerbate Age-Dependent Reductions in Mouse Spatial Memory and Brain TFEB Activity. bioRxiv : the preprint server for biology. 2024-03-11. PMID:38464149. |
in young mice, alcohol decreased hippocampal nuclear tfeb staining but increased sqstm1/p62, lc3-ii, ubiquitinated proteins, and phosphorylated tau. |
2024-03-11 |
2024-03-14 |
mouse |
| Danira Toral-Rios, Justin M Long, Jason D Ulrich, Jinsheng Yu, Michael R Strickland, Xianlin Han, David M Holtzman, Anil G Cashikar, Steven M Pau. Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. The Journal of experimental medicine. vol 221. issue 4. 2024-03-05. PMID:38442267. |
here, we show that in the absence of ch25h and the resultant reduction in 25-hc, there is strikingly reduced age-dependent neurodegeneration and neuroinflammation in the hippocampus and entorhinal/piriform cortex of ps19 mice, which express the p301s mutant human tau transgene. |
2024-03-05 |
2024-03-08 |
mouse |
| Ayane Ninomiya, Izuki Amano, Hiraku Suzuki, Yuki Fujiwara, Asahi Haijima, Noriyuki Koibuch. Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice. The journal of physiological sciences : JPS. vol 74. issue 1. 2024-03-05. PMID:38443820. |
in the hippocampus, the expression of tau protein was significantly increased. |
2024-03-05 |
2024-03-08 |
mouse |