| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tyler R Bell, Carol E Franz, Lisa T Eyler, Christine Fennema-Notestine, Olivia K Puckett, Stephen M Dorros, Matthew S Panizzon, Rahul C Pearce, Donald J Hagler, Michael J Lyons, Asad Beck, Jeremy A Elman, William S Kreme. Probable chronic pain, brain structure, and Alzheimer's plasma biomarkers in older men. The journal of pain. 2024-01-10. PMID:38199594. |
in this study, we provide one of the first assessments in humans, examining the associations of probable chronic pain with hippocampal volume, integrity of the locus coeruleus (lc)-an upstream site of tau deposition-and alzheimer's disease (ad)-related plasma biomarkers. |
2024-01-10 |
2024-01-13 |
mouse |
| Yun-Chieh Tsai, Sheng-Min Huang, Hsu-Hsia Peng, Shu-Wha Lin, Shu-Rung Lin, Ting-Yu Chin, Shih-Ming Huan. Imbalance of synaptic and extrasynaptic NMDA receptors induced by the deletion of CRMP1 accelerates age-related cognitive decline in mice. Neurobiology of aging. vol 135. 2024-01-04. PMID:38176125. |
additionally, increasing levels of extrasynaptic nmda receptors and phosphorylation of tau were observed in middle-aged crmp1 ko mice, leading to synaptic and neuronal loss in the ca3 regions of hippocampus. |
2024-01-04 |
2024-01-07 |
mouse |
| Paige E Anton, Lauren N Rutt, Michael L Kaufman, Nicolas Busquet, Elizabeth J Kovacs, Rebecca L McCulloug. Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice. Brain, behavior, and immunity. 2023-12-27. PMID:38151165. |
binge ethanol exposure also promoted neuropathology in the hippocampus of aged mice, including tau hyperphosphorylation and neuronal death. |
2023-12-27 |
2023-12-30 |
mouse |
| Yue Zuo, Hui-Ting Liu, Lai-Biao Lin, Rui-Zhu Yue, Huan-Huan Liu, Hong-Wei Wang, Lu Wang, Ruan-Ling Hou, Wei-Zhen Liu, Chang-Zheng Li, Jian-Zhi Wang, Peng Li, Ya-Ling Yi. A new metal ion chelator attenuates human tau accumulation-induced neurodegeneration and memory deficits in mice. Experimental neurology. 2023-12-23. PMID:38141802. |
to explore whether abnormally phosphorylated tau causes metal ion deposition, we overexpressed human full-length tau (htau) in the hippocampal ca3 area of mice and primary cultured hippocampal neurons (cphn) and found that tau accumulation induced iron deposition and activated calcineurin (can), which dephosphorylates glycogen synthase kinase 3 beta (gsk3β), mediating tau hyperphosphorylation. |
2023-12-23 |
2023-12-25 |
mouse |
| Nicha Puangmalai, Nemil Bhatt, Alice Bittar, Cynthia Jerez, Nikita Shchankin, Rakez Kaye. Traumatic brain injury derived pathological tau polymorphs induce the distinct propagation pattern and neuroinflammatory response in wild type mice. Progress in neurobiology. 2023-12-22. PMID:38135105. |
our findings revealed that rb-bdtps induced cognitive and motor deficits, concurrently fostering the emergence of toxic tau aggregates within the injected hippocampus. |
2023-12-22 |
2023-12-25 |
mouse |
| Lucas Ronat, Alexandru Hanganu, Daphné Chylinski, Maxime Van Egroo, Justinas Narbutas, Gabriel Besson, Vincenzo Muto, Christina Schmidt, Mohamed Ali Bahri, Christophe Phillips, Eric Salmon, Pierre Maquet, Gilles Vandewalle, Fabienne Collette, Christine Basti. Prediction of cognitive decline in healthy aging based on neuropsychiatric symptoms and PET-biomarkers of Alzheimer's disease. Journal of neurology. 2023-12-20. PMID:38114820. |
moreover, depression together with prefrontal and hippocampal tau burden were associated with a decline in memory. |
2023-12-20 |
2023-12-23 |
human |
| Entesar Yaseen Abdo Qaid, Zuraidah Abdullah, Rahimah Zakaria, Idris Lon. Minocycline mitigates tau pathology via modulating the TLR-4/NF-кβ signalling pathway in the hippocampus of neuroinflammation rat model. Neurological research. 2023-12-20. PMID:38122814. |
minocycline mitigates tau pathology via modulating the tlr-4/nf-кβ signalling pathway in the hippocampus of neuroinflammation rat model. |
2023-12-20 |
2023-12-23 |
rat |
| Entesar Yaseen Abdo Qaid, Zuraidah Abdullah, Rahimah Zakaria, Idris Lon. Minocycline mitigates tau pathology via modulating the TLR-4/NF-кβ signalling pathway in the hippocampus of neuroinflammation rat model. Neurological research. 2023-12-20. PMID:38122814. |
this study aims to investigate the molecular mechanism of minocycline in reducing phosphorylated tau protein formation in the hippocampus of lipopolysaccharide (lps)-induced rats. |
2023-12-20 |
2023-12-23 |
rat |
| Ya-Lan Chang, Chan-Chih Yang, Yun-Yu Huang, Yi-An Chen, Chia-Wei Yang, Chia-Yu Liao, Hsun Li, Ching-Shyi Wu, Chin-Hsien Lin, Shu-Chun Ten. The HSP40 family chaperone isoform DNAJB6b prevents neuronal cells from tau aggregation. BMC biology. vol 21. issue 1. 2023-12-19. PMID:38110916. |
the pathologic hallmarks of ad include tau neurofibrillary tangles and amyloid plaque depositions in the hippocampus and associated neocortex. |
2023-12-19 |
2023-12-21 |
Not clear |
| Ling Lei, Yong Luo, Dongkun Kang, Fumin Yang, Dongli Meng, Jian-Zhi Wang, Rong Liu, Xiaochuan Wang, Hong-Lian L. Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer's disease-like neuropathology and cognitive deficits. Aging. vol 15. 2023-12-14. PMID:38095632. |
in the current study, we used staurosporine (stp), an inducer of apoptosis and causing tau hyperphosphorylation, to mimic ad models, and explored the role and mechanism of gypenoside ix (one of the extracts of gynostemma, gp for short name in our experiments) in stp treated primary hippocampal neurons and rats. |
2023-12-14 |
2023-12-17 |
rat |
| Dina Rodrigues Martins, Fern Sha, Wim Van der Elst, Pei-Yu Shih, Jens Devoght, Kristof Van Kolen, Marc Mercken, Bianca Van Broeck, Paul Declerck, Clara Theuni. Anti-tau intrabodies: From anti-tau immunoglobulins to the development of functional scFv intrabodies. Molecular therapy. Methods & clinical development. vol 31. 2023-12-11. PMID:38074413. |
subsequently, we show their capacity to interfere with either mouse or mutant human tau aggregation in two different primary mouse neuron models and organotypic hippocampal slice cultures. |
2023-12-11 |
2023-12-17 |
mouse |
| Justin Torok, Pedro D Maia, Chaitali Anand, Ashish Ra. Cellular underpinnings of the selective vulnerability to tauopathic insults in Alzheimer's disease. bioRxiv : the preprint server for biology. 2023-12-11. PMID:38076913. |
hippocampal glutamatergic neurons as a whole were strongly positively associated with regional tau deposition, suggesting vulnerability, while cortical glutamatergic and gabaergic neurons were negatively associated. |
2023-12-11 |
2023-12-17 |
mouse |
| Etienne Aumont, Aurélie Bussy, Marc-André Bedard, Gleb Bezgin, Joseph Therriault, Melissa Savard, Jaime Fernandez Arias, Viviane Sziklas, Paolo Vitali, Nina Margherita Poltronetti, Vanessa Pallen, Emilie Thomas, Serge Gauthier, Eliane Kobayashi, Nesrine Rahmouni, Jenna Stevenson, Cecile Tissot, Mallar M Chakravarty, Pedro Rosa-Net. Hippocampal subfield associations with memory depend on stimulus modality and retrieval mode. Brain communications. vol 5. issue 6. 2023-11-30. PMID:38035364. |
amyloid-β and hippocampal tau positivity were assessed using [ |
2023-11-30 |
2023-12-10 |
human |
| Hong Cheng, Lu Gan, Yan Wang, Lin Li, Yongle L. Effect of sleep deprivation by MMP-WM on rat neurological function and Tau protein in hippocampus. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015534. |
effect of sleep deprivation by mmp-wm on rat neurological function and tau protein in hippocampus. |
2023-11-28 |
2023-11-29 |
human |
| Hong Cheng, Lu Gan, Yan Wang, Lin Li, Yongle L. Effect of sleep deprivation by MMP-WM on rat neurological function and Tau protein in hippocampus. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015534. |
this study aims to explore the effect of sleep deprivation by modified multiple platform-water maze (mmp-wm) on rat neurological function and tau protein in the hippocampus, as well as the intervention effect of remimazolam. |
2023-11-28 |
2023-11-29 |
human |
| Hong Cheng, Lu Gan, Yan Wang, Lin Li, Yongle L. Effect of sleep deprivation by MMP-WM on rat neurological function and Tau protein in hippocampus. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015534. |
after that, the rats were executed, the hippocampus was isolated for nissl staining, and the protein expression of phosphorylated tau (p-tau) in the ca1 region of the hippocampus was measured by immunohistochemistry. |
2023-11-28 |
2023-11-29 |
human |
| Mohammad Mehdi Ommati, Heresh Rezaei, Retana-Márquez Socorro, Weishun Tian, Jing Zhao, Ayeh Rouhani, Samira Sabouri, Fatemeh Ghaderi, Amir Mohammad Niknahad, Asma Najibi, Sahra Mazloomi, Moslem Safipour, Zahra Honarpishefard, Hong-Wei Wang, Hossein Niknahad, Reza Heidar. Pre/postnatal taurine supplementation improves neurodevelopment and brain function in mice offspring: A persistent developmental study from puberty to maturity. Life sciences. 2023-11-26. PMID:38008208. |
moreover, the effects of tau on mitochondrial function and oxidative stress biomarkers as plausible mechanisms of its action in the whole brain and hippocampus have been evaluated. |
2023-11-26 |
2023-11-28 |
mouse |
| Mohammad Mehdi Ommati, Heresh Rezaei, Retana-Márquez Socorro, Weishun Tian, Jing Zhao, Ayeh Rouhani, Samira Sabouri, Fatemeh Ghaderi, Amir Mohammad Niknahad, Asma Najibi, Sahra Mazloomi, Moslem Safipour, Zahra Honarpishefard, Hong-Wei Wang, Hossein Niknahad, Reza Heidar. Pre/postnatal taurine supplementation improves neurodevelopment and brain function in mice offspring: A persistent developmental study from puberty to maturity. Life sciences. 2023-11-26. PMID:38008208. |
tau measurement in the brain and hippocampus revealed higher levels of this amino acid. |
2023-11-26 |
2023-11-28 |
mouse |
| Mohammad Mehdi Ommati, Heresh Rezaei, Retana-Márquez Socorro, Weishun Tian, Jing Zhao, Ayeh Rouhani, Samira Sabouri, Fatemeh Ghaderi, Amir Mohammad Niknahad, Asma Najibi, Sahra Mazloomi, Moslem Safipour, Zahra Honarpishefard, Hong-Wei Wang, Hossein Niknahad, Reza Heidar. Pre/postnatal taurine supplementation improves neurodevelopment and brain function in mice offspring: A persistent developmental study from puberty to maturity. Life sciences. 2023-11-26. PMID:38008208. |
tau and atp levels were also significantly higher in the mitochondria isolated from the whole brain and hippocampus. |
2023-11-26 |
2023-11-28 |
mouse |
| Hansol Lee, Jessie Fanglu Fu, Kyla Gaudet, Annie G Bryant, Julie C Price, Rachel E Bennett, Keith A Johnson, Bradley T Hyman, Trey Hedden, David H Salat, Yi-Fen Yen, Susie Y Huan. Aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and Alzheimer's disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2023-11-24. PMID:38000018. |
aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and alzheimer's disease. |
2023-11-24 |
2023-11-28 |
mouse |